Internal Medicine | Page 165 of 487 | Links Medicus Content Curation & Alerts in Medicine

Cohort study: Statin therapy initiation linked to increased risk of diabetes progression.

5 Oct, 2021 | 08:56h | UTC

Association of Statin Therapy Initiation With Diabetes Progression: A Retrospective Matched-Cohort Study – JAMA Internal Medicine

Commentaries:

Statin Therapy Initiation and Diabetes Progression – American College of Cardiology

Statin Initiation Linked to Greater Progression of Diabetes – HealthDay

Diabetes progression with initiation of statins – MedicalRessearch.com

Meta-Analysis: Medications that Reduce or Increase the Risk of New Onset Diabetes

Observational Study Points to an Increased Risk of Diabetes Among Patients Using Statins

Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus

Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes

Commentary on Twitter

Large retrospective matched-cohort study found that #statin use was associated with a higher risk of #diabetes treatment escalation and an increased risk of #hyperglycemic complications https://t.co/lFLz7rVfpd

— JAMA Internal Medicine (@JAMAInternalMed) October 4, 2021

Review: Optimizing care for critically ill older adults.

5 Oct, 2021 | 08:51h | UTC

Optimizing care for critically ill older adults – Canadian Medical Association Journal

Addressing Biased Patient Behavior: A Teachable Moment.

5 Oct, 2021 | 08:54h | UTC

Addressing Biased Patient Behavior: A Teachable Moment – JAMA Internal Medicine

Podcast: Urinary Stone Disease.

5 Oct, 2021 | 08:50h | UTC

#298 Urinary Stone Disease Will Rock Your World – The Curbsiders

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

3 Oct, 2021 | 23:02h | UTC

Merck and Ridgeback’s Investigational Oral Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate COVID-19 in Positive Interim Analysis of Phase 3 Study

Commentaries:

Expert reaction to interim analysis of oral antiviral molnupiravir – Science Media Centre

Merck’s antiviral pill reduces hospitalization of Covid patients, a possible game-changer for treatment – STAT

Covid antiviral pill can halve risk of hospitalization – BBC

Why Merck’s Covid-19 pill molnupiravir could be so important – Vox

‘Unquestionably a game changer!’ Antiviral pill cuts COVID-19 hospitalization risk – Researchers excited about Merck drug, but caution data are preliminary and price is high – Science

Commentaries on Twitter

.@DrEricDing convinced many that stopping the #molnupiravir trial early for benefit was a good idea

But it was NOT

Large body of evidence suggests that stopping early for benefit biases the results: overestimates the benefits of the treatment #EBM https://t.co/b3tHEtliO0 https://t.co/LwuCgqcY0C pic.twitter.com/vyPWc0nd37

— Kari Tikkinen (@KariTikkinen) October 2, 2021

(thread – click for more)

💡BREAKING—New oral anti-viral drug *molnupiravir* cuts risk of #COVID19 hospitalization and death **in HALF** in a randomized trial. Results so astounding that the trial is being stopped early, and Merck plans to apply for emergency authorization ASAP. 🧵 https://t.co/g8JGNzvuRg pic.twitter.com/K1SwC3QFXS

— Eric Feigl-Ding (@DrEricDing) October 1, 2021

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

3 Oct, 2021 | 22:59h | UTC

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance – The BMJ

Original Guidance: NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues.

3 Oct, 2021 | 22:58h | UTC

Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues – Science

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

3 Oct, 2021 | 22:41h | UTC

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 – Intensive Care Medicine

Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.

3 Oct, 2021 | 22:49h | UTC

Covid-19 vaccination: evidence of waning immunity is overstated – The BMJ

COVID vaccine immunity is waning — how much does that matter? – “As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving”.

COVID vaccine effects wane over time but still prevent death and severe illness.

Perspective | What we actually know about waning immunity.

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

Systematic Review: Is exercise an effective therapy to treat long-lasting low back pain?

3 Oct, 2021 | 22:32h | UTC

Summary: Is exercise an effective therapy to treat long-lasting low back pain? – Cochrane Library

Original Study: Exercise therapy for chronic low back pain – Cochrane Library

Commentary on Twitter

https://twitter.com/CochraneUK/status/1444221879502483456

ADA Consensus Report: The Management of Type 1 Diabetes in Adults.

3 Oct, 2021 | 22:38h | UTC

The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) – Diabetologia

News release: New comprehensive Consensus Report to manage type 1 diabetes launched by major diabetes organisations EASD and ADA – American Associatio of Diabetes

Commentary on Twitter

What a fantastic symposium on the management of #T1D at #EASD2021! Read the full ADA–EASD consensus report here https://t.co/8cEm8N0Enr pic.twitter.com/uMj2R64CkK

— Diabetologia (@DiabetologiaJnl) October 1, 2021

Physician Well-being 2.0: Where Are We and Where Are We Going?

3 Oct, 2021 | 22:36h | UTC

Physician Well-being 2.0: Where Are We and Where Are We Going? – Mayo Clinic Proceedings

Consensus Study – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being – National Academies of Medicine

[Abstract Only] Assessment of Risk Factors for Suicide Among US Health Care Professionals

Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care

Perspective: Hospital Administration Response to Physician Stress and Burnout

Opinion: It’s Time to Talk About Physician Burnout and Moral Injury

Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout

Perspective: The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution)

Physician Burnout: A Global Crisis (several resources on the subject)

Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?

3 Oct, 2021 | 22:33h | UTC

Summary: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness? – Cochrane Library

Original article: Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with unprovoked VTE – Cochrane Library

RCT: Early computed tomography coronary angiography in patients with suspected acute coronary syndrome did not improve one year clinical outcomes.

3 Oct, 2021 | 22:35h | UTC

Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial – The BMJ

Commentary on Twitter

In this RCT, early CT coronary angiography in the emergency department for patients with suspected / provisional diagnosis of acute coronary syndrome had no effect on rate of death or subsequent non-fatal #heartattack at 1 year.@bmj_latest #Wondrmedical https://t.co/usNKEGPDa4

— Prof Chris P Gale (@cpgale3) October 1, 2021

Coronary microvascular dysfunction: Considerations for diagnosis and treatment.

3 Oct, 2021 | 22:29h | UTC

Coronary microvascular dysfunction: Considerations for diagnosis and treatment – Cleveland Clinic Journal of Medicine

Cohort study: Clinical characteristics and prognosis of patients with microvascular angina.

Position Paper on ‘Coronary Microvascular Dysfunction in Cardiovascular Disease’

Ketogenic diets in the management of type 1 diabetes: Safe or safety concern?

3 Oct, 2021 | 22:28h | UTC

Ketogenic diets in the management of type 1 diabetes: Safe or safety concern? – Cleveland Clinic Journal of Medicine

Transition to endemicity: Understanding COVID-19.

1 Oct, 2021 | 10:30h | UTC

Transition to endemicity: Understanding COVID-19 – Cell

COVID will likely shift from pandemic to endemic — but what does that mean?

Perspective | How Endemic COVID Becomes a Manageable Risk – “Businesses and schools must adapt, because the dual threat from the coronavirus and the flu will be too severe”.

Another meta-analysis suggests standard-dose prophylactic anticoagulation is the best option for patients hospitalized with Covid-19.

1 Oct, 2021 | 10:35h | UTC

A Systematic Review and a Meta-Analysis Comparing Prophylactic and Therapeutic Low Molecular Weight Heparins for Mortality Reduction in 32,688 COVID-19 Patients – Frontiers in Pharmacology

WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections.

1 Oct, 2021 | 10:24h | UTC

WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections – World Journal of Emergency Surgery

The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections

The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections – World Journal of Emergency Surgery

Review: COVID-19 in older adults.

1 Oct, 2021 | 10:27h | UTC

COVID-19 in older adults – Cleveland Clinic Journal of Medicine

M-A: Non-alcoholic fatty liver disease linked to increased risk of fatal and non-fatal cardiovascular events.

1 Oct, 2021 | 10:19h | UTC

Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary on Twitter

https://twitter.com/LancetGastroHep/status/1440164633805918224

Cohort Study: Women treated with radiation therapy for left-sided breast cancer had over twice the risk of subsequent coronary artery disease compared with women treated with radiation therapy for right-sided breast cancer.

1 Oct, 2021 | 10:21h | UTC

Coronary Artery Disease in Young Women After Radiation Therapy for Breast Cancer: The WECARE Study – JACC: CardioOncology

Commentaries:

Left Breast Radiation Therapy Doubles CV Disease Risk vs. Right Breast Radiation Therapy in Young Women – American College of Cardiology

CAD in Young Women After Radiation Therapy for Breast Cancer – American College of Cardiology

Commentary on Twitter

According to a study from #JACCCardioOnc, women with left-sided breast cancer undergoing radiation therapy between 1985 and 2008 had over twice the risk of subsequent #cvCAD compared to women with right-sided breast cancer. Learn more here: https://t.co/5q9tToSSRp #CardioOnc

— American College of Cardiology (@ACCinTouch) September 22, 2021