Internal Medicine
RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.
19 Oct, 2021 | 10:14h | UTCRelated:
Systematic Review: Colchicine for the treatment of COVID‐19 – not beneficial for hospitalized patients; inconclusive evidence for the treatment of non-hospitalized patients, “probably slightly reduces the need for hospitalization or death within 28 days compared to placebo”.
19 Oct, 2021 | 10:13h | UTCColchicine for the treatment of COVID‐19 – Cochrane Library
Related:
Commentary on Twitter
JUST PUBLISHED – Is #colchicine (often used to treat #gout) an effective treatment for people with #COVID19? ➡️ https://t.co/IF1enksFpn New @CochraneHaem systematic review includes evidence from 4 RCTS with 11,525 hospitalised & 4488 non‐hospitalised people.
— The Cochrane Library (@CochraneLibrary) October 18, 2021
Another observational study suggests Rivaroxaban is associated with higher rates of gastrointestinal bleeding than other direct oral anticoagulants.
19 Oct, 2021 | 09:47h | UTCRivaroxaban Is Associated with Higher Rates of Gastrointestinal Bleeding Than Other Direct Oral Anticoagulants: A Nationwide Propensity Score–Weighted Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Rivaroxaban Again Linked to More Bleeding vs Other DOACs – TCTMD
Commentary on Twitter
A new study from @uni_iceland and @Landspitali finds that #Rivaroxaban is associated with a higher risk of GI bleeding compared to other direct oral anticoagulants. https://t.co/2J451CN5dD #afib #bleedingrisk #DOAC pic.twitter.com/Q6VSv5Taqg
— Annals of Int Med (@AnnalsofIM) October 13, 2021
Guideline: Management of anticoagulants and antiplatelet agents in cutaneous surgery.
19 Oct, 2021 | 09:50h | UTC
Systematic Review: Calcium channel blockers versus other classes of drugs for hypertension – “there is moderate certainty evidence that diuretics reduce major cardiovascular events and congestive heart failure more than CCBs”.
19 Oct, 2021 | 08:56h | UTCSummary: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Original Study: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Commentary on Twitter
How do calcium channel blockers compare to other #antihypertensive drugs for #hypertension?💊
Our @CochraneLibrary systematic review looks at evidence from 23 RCTs involving 153,849 participants with #highbloodpressure
👉🏾https://t.co/dDLCY1RoOT#SystematicReviews #SysRev pic.twitter.com/zJ4JNRRf0L
— Cochrane Hypertension (@CochraneHTN) October 17, 2021
Urolithiasis: ED presentations, evaluation, management, and disposition.
19 Oct, 2021 | 08:53h | UTCUrolithiasis: ED Presentations, Evaluation, Management, and Disposition – emDocs
Podcast: Diagnosis and treatment of Celiac Disease.
19 Oct, 2021 | 08:54h | UTC#300 Celiac Disease with Dr. Amy Oxentenko – The Curbsiders
Preoperative hypertension: perioperative implications and management.
19 Oct, 2021 | 08:51h | UTCPreoperative hypertension: perioperative implications and management – BJA Education
Bioethics | The Reluctant Patient and the Insistent Doctor.
19 Oct, 2021 | 08:50h | UTCThe Reluctant Patient and the Insistent Doctor – The American Journal of Medicine
Opinion | Multi-cancer screening tests: communicating about risks should be prioritized.
19 Oct, 2021 | 08:49h | UTC
RCT supports the use of therapeutic heparin in moderately ill patients admitted to the hospital with Covid-19.
17 Oct, 2021 | 21:35h | UTCRelated studies (some conflicting results)
Commentary on Twitter
What are the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital? #BMJResearch by @sholzberg and colleagues.
Includes a #VisualAbstract summarising the study #BMJInfographichttps://t.co/82VisuBKSU pic.twitter.com/b06TdIJvLX
— The BMJ (@bmj_latest) October 15, 2021
Review: Stroke prevention after cryptogenic stroke.
19 Oct, 2021 | 08:46h | UTCStroke Prevention After Cryptogenic Stroke – Current Cardiology Reports
Related:
Canadian Stroke Best Practice Recommendations for Acute Stroke Management
M-A: Risk factors for invasive candida infection in critically ill patients – The risk factors associated with the highest risk for ICI were broad spectrum antibiotics (OR 5.6), blood transfusion (OR 4.9), Candida colonization (OR 4.7), central venous catheter (OR 4.7) and total parenteral nutrition (OR 4.6).
19 Oct, 2021 | 08:47h | UTC
J&J COVID-19 Vaccine: FDA recommends booster shot for all adults aged 18 and older at least two months following initial vaccination with the single-shot vaccine.
17 Oct, 2021 | 21:32h | UTCCommentaries:
FDA panel endorses booster shot for J&J COVID-19 vaccine – Associated Press
FDA advisers recommend J&J Covid-19 vaccine boosters, talk mix and match boosters – CNN
[Preprint] Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 – “Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%”.
17 Oct, 2021 | 21:29h | UTCRelated:
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Commentary on Twitter
New on breakthrough infections in 620,000 Veterans
"Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%"https://t.co/xonBb4aEqJ highest reduction with J&J vaccine pic.twitter.com/rbhXOREFPP— Eric Topol (@EricTopol) October 15, 2021
Management of Diabetes Mellitus in patients with CKD: Core Curriculum 2022.
17 Oct, 2021 | 21:23h | UTC
What can masks do? Part 2: What makes for a good mask study — and why most fail.
17 Oct, 2021 | 21:25h | UTCCOMMENTARY: What can masks do? Part 2: What makes for a good mask study — and why most fail – CIDRAP
See also: COMMENTARY: What can masks do? Part 1: The science behind COVID-19 protection – CIDRAP
Viewpoint: Surgical overtreatment and shared decision-making—the limits of choice. – “Payment models further incentivize surgical intervention. Fee-for-service payment plans reward surgeons for operating, not for ensuring that surgery is right for a patient”.
17 Oct, 2021 | 21:17h | UTCSurgical Overtreatment and Shared Decision-making—The Limits of Choice – JAMA Surgery (free for a limited period)
Commentary on Twitter
“Adjusting payment models to mitigate financial incentives..to overtreat is a start. However..greater focus should be given to the myriad other causes of overtreatment,” such as triggers of care cascades, write Clapp, Schwarze & @LeeAFleisher. https://t.co/f4mPsnxyVB
— Ben Harder #BlackLivesMatter (@benharder) October 14, 2021
M-A: Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis – although Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be most effective treatments, topical diclofenac 70-81 mg/day is safer and should be considered as first line treatment.
17 Oct, 2021 | 21:14h | UTCNews release: Topical pain-killers more effective, safer than opioids for knee osteoarthritis pain – St. Michael’s Hospital
Commentary: Network meta-analysis compares analgesic regimens for osteoarthritis – medwire News
Commentary on Twitter
Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be the most effective oral NSAIDs for knee and hip osteoarthritis pain and physical function, but might not be appropriate in the presence of comorbidities or for long term use, concludes #BMJResearchhttps://t.co/rrtX3BnQE5
— The BMJ (@bmj_latest) October 16, 2021
RCT: After third molar surgery, Ibuprofen doses above 400 mg did not significantly increase the analgesic effect, and Paracetamol 1000/codeine 60 mg was not more effective than ibuprofen 400 mg.
17 Oct, 2021 | 21:16h | UTC
Review: Management of infectious emergencies for the inpatient dermatologist.
17 Oct, 2021 | 21:06h | UTCManagement of Infectious Emergencies for the Inpatient Dermatologist – Current Dermatology Reports (if this link is paywalled, try this one)
Review: Timing of antibiotic therapy in the ICU.
17 Oct, 2021 | 21:05h | UTCTiming of antibiotic therapy in the ICU – Critical Care
Study evaluated several heterologous SARS-CoV-2 vaccine regimens; no efficacy data but there was increased antibody production on study days 15 and 29 after booster shots from Moderna and Pfizer.
15 Oct, 2021 | 02:49h | UTCHeterologous SARS-CoV-2 Booster Vaccinations: Preliminary Report – medRxiv
Commentary: Study: Mixing and Matching COVID-19 Booster Shots Is Effective, Safe – U.S. News
Commentary on Twitter
So yes, mRNA vaccines are great at generating antibodies but what does that mean? Where is the efficacy data? How come JnJ gets really great efficacy at preventing symptomatic COVID and severe disease with low antibodies? T-cells? Still much to learn. https://t.co/YwKUyogAhQ
— Daniel Griffin MD PhD (@DanielGriffinMD) October 13, 2021
Statins linked to reduced risk of death from COVID-19 in major population study – “Randomized studies will be needed to ascertain whether there is a causal relationship, note the researchers”.
15 Oct, 2021 | 02:47h | UTCNews release: Statins linked to reduced risk of death from COVID-19 in major population study – Karolinska Institutet
Original study: HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study – PLOS Medicine
Commentaries:
Expert reaction to study looking at statins and risk of death from COVID-19 – Science Media Centre
People taking statins less likely to die from Covid, study suggests – The Guardian
FDA issues food industry guidance for reduction of sodium in processed and packaged foods.
15 Oct, 2021 | 02:29h | UTCGuidance for Industry: Voluntary Sodium Reduction Goals – U.S. Food & Drug Administration
Commentaries:
FDA Issues New Guidance on Sodium Targets for Food Industry – TCTMD
Reducing Sodium Intake in the US: Healthier Lives, Healthier Future – JAMA
FDA Reduces Recommended Salt Levels in Americans’ Food – HealthDay
FDA guidance to food industry aims to reduce sodium consumption – American Heart Association
New FDA guidance aims to drastically cut salt in food supply – NBC News