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Internal Medicine

Review: Counting the neurological cost of COVID-19.

19 Nov, 2021 | 10:52h | UTC

Counting the neurological cost of COVID-19 – Nature Reviews Neurology

 

Commentary on Twitter

 

Consensus and expert recommendations: basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population.

19 Nov, 2021 | 10:37h | UTC

Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine

 

Commentary on Twitter

 

What is the functional/organic distinction actually doing in psychiatry and neurology?

19 Nov, 2021 | 10:29h | UTC

What is the functional/organic distinction actually doing in psychiatry and neurology? – Wellcome Open Research

 

Commentary on Twitter

 

M-A: Intravenous iron is associated with increased risk of infection when compared with oral iron or no iron, which must be balanced with the potential benefits of reducing blood transfusion requirements.

19 Nov, 2021 | 10:31h | UTC

Risk of Infection Associated With Administration of Intravenous Iron: A Systematic Review and Meta-analysis – JAMA Network Open

Invited Commentary: Intravenous Iron and Infection Risk—Still an Unanswered Question – JAMA Network Open

 

Commentary on Twitter

 

RCT: In patients with heart failure and preserved ejection fraction, Sacubitril/Valsartan reduced NT-proBNP, but did not improve exercise capacity and was associated with increased risk of hypotension (14.1% vs 5.5%).

19 Nov, 2021 | 10:27h | UTC

Effect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Quality of Life and Exercise Ability in Heart Failure With Preserved Ejection Fraction: No Time for Therapeutic Complacency – JAMA (free for a limited period)

 

Commentary on Twitter

 

Observational study finds the effectiveness of mRNA vaccination against Covid-19 hospitalization was lower (77%) among immunocompromised adults than among immunocompetent adults (90%).

18 Nov, 2021 | 08:52h | UTC

Effectiveness of 2-Dose Vaccination with mRNA COVID-19 Vaccines Against COVID-19–Associated Hospitalizations Among Immunocompromised Adults — Nine States, January–September 2021 – CDC Morbidity and Mortality Weekly Report

Related:

CDC Guidance: Immunocompromised may need a fourth Covid-19 shot.

 

Commentary on Twitter (thread – click for more)

 

NICE Guideline | Heart valve disease presenting in adults: investigation and management.

18 Nov, 2021 | 08:44h | UTC

Heart valve disease presenting in adults: investigation and management – National Institute for Health and Care Excellence

Related Guidelines:

#ESCCongress – 2021 ESC/EACTS Guidelines for the management of valvular heart disease – in the new guidelines, more patients are eligible for surgical and transcatheter interventions, based not only on symptoms but also on imaging criteria.

2020 ACC/AHA Guideline for the management of patients with valvular heart disease

 

Demystifying the EEG report for intensivists.

18 Nov, 2021 | 08:36h | UTC

Demystifying the EEG Report – NeuroEMCrit

 

What Is the best maintenance therapy for ANCA vasculitis?

18 Nov, 2021 | 08:34h | UTC

What Is the Best Maintenance Therapy for ANCA Vasculitis? – Clinical Journal of the American Society of Nephrology

 

Case-control study: sleep disorders linked to more severe outcomes from COVID-19, study suggests.

17 Nov, 2021 | 08:50h | UTC

News Release: Sleep disorders linked with more severe outcomes from COVID-19, study suggests – Cleveland Clinic

Original Study: Association of Sleep-Related Hypoxia With Risk of COVID-19 Hospitalizations and Mortality in a Large Integrated Health System – JAMA Network Open

Commentary: Some sleep disorders may lead to worse COVID-19 outcomes – CIDRAP

 

Commentary on Twitter

 

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic.

17 Nov, 2021 | 08:56h | UTC

ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic – European Heart Journal

Part 1—epidemiology, pathophysiology, and diagnosis

Part 2—care pathways, treatment, and follow-up

News release: European Society of Cardiology COVID-19 guidance launched – European Society of Cardiology

 

Commentaries on Twitter

 

Observational study found monitoring outpatients with Covid-19 using text messages that allowed the report of worsening symptoms was associated with improved outcomes.

17 Nov, 2021 | 08:53h | UTC

Comparative Effectiveness of an Automated Text Messaging Service for Monitoring COVID-19 at Home – Annals of Internal Medicine

News Release: Automated Texting System Saved Lives Weekly During First COVID Surge – Penn Medicine

Commentaries:

Monitoring outpatients by text appeared to reduce mortality from COVID-19 – ACP Internist

Texting saved lives during Covid. What does that mean for health care’s future? – STAT

 

Commentary from the author on Twitter (thread – click for more)

 

The big questions about Covid-19 booster shots – “From the why to the who, we still need a lot of answers about booster shots”.

17 Nov, 2021 | 08:48h | UTC

The big questions about Covid-19 booster shots – Vox

 

Commentary on Twitter

 

AAN Guideline: Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease.

17 Nov, 2021 | 08:32h | UTC

Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary – Neurology

News Release: AAN Issues Guideline for Treatment of Early Parkinson’s Disease – American Academy of Neurology

 

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

17 Nov, 2021 | 08:42h | UTC

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians – The Journal of the American Board of Family Medicine

Related:

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Individual participant data meta-analysis of major randomized trials showed that treatment of hypertension with ACEIs or ARBs reduced the risk of new-onset type 2 diabetes compared to other drugs.

17 Nov, 2021 | 08:29h | UTC

Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis – The Lancet

Commentaries:

Expert reaction to an individual participant data meta-analysis on blood pressure lowering and risk of onset of type-2 diabetes – Science Media Centre

Blood pressure drugs could prevent type 2 diabetes, study finds – The Guardian

 

Position Statement: Preoperative Care for Cataract Surgery – “In spite of evidence debunking the utility of testing before cataract surgery, studies suggest that medical testing and the use of medical consultations before cataract surgery continue to increase”.

17 Nov, 2021 | 08:33h | UTC

Preoperative Care for Cataract Surgery: The Society for Ambulatory Anesthesia Position Statement – Anesthesia & Analgesia

 

Commentary on Twitter

 

Randomized, crossover clinical trial: In patients with heart failure with preserved ejection fraction and chronotropic incompetence, betablocker withdrawal improved maximal functional capacity.

17 Nov, 2021 | 08:27h | UTC

Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction – Journal of the American College of Cardiology

Commentary: Peak VO2 Improved After Beta-Blocker Withdrawal in Some HFpEF Patients: Beta-blockers may not benefit HFpEF patients with chronotropic incompetence – MedPage Today (free registration required)

 

Phase 2 RCT: Once-weekly cagrilintide is effective for weight management in people with overweight and obesity.

17 Nov, 2021 | 08:23h | UTC

Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial – The Lancet (link to abstract – $ for full-text)

 

RCT: Adjustable intragastric balloon resulted in significant weight loss at 32 weeks, but intolerance caused early removal of the device in 17% of patients, and device-related serious adverse events were observed in 4% of patients.

17 Nov, 2021 | 08:26h | UTC

Adjustable intragastric balloon for treatment of obesity: a multicentre, open-label, randomised clinical trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.

17 Nov, 2021 | 08:19h | UTC

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps – Nature Medicine

 

Commentary on Twitter

 

Real-world ethics in palliative care: A systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice.

17 Nov, 2021 | 08:18h | UTC

Real-world ethics in palliative care: A systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice – Palliative Medicine

 

Commentary on Twitter

 

Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomized controlled trials.

17 Nov, 2021 | 08:12h | UTC

Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomised controlled trials – PLOS Medicine

 

RCT: Intravenous immunoglobulins do not improve outcomes in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome.

16 Nov, 2021 | 08:48h | UTC

Intravenous immunoglobulins in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome (ICAR): multicentre, double-blind, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

Review: Vaccine-induced immune thrombotic thrombocytopenia.

16 Nov, 2021 | 08:46h | UTC

Vaccine-induced immune thrombotic thrombocytopenia – The Lancet Haematology

Related:

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

Commentary on Twitter

 

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