Internal Medicine

Global strategy for the diagnosis and management of acute kidney injury in patients with liver cirrhosis.

10 Dec, 2021 | 09:58h | UTC

Global strategy for the diagnosis and management of acute kidney injury in patients with liver cirrhosis – United European Gastroenterology Journal

 

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Large observational study in Israel showed a third dose (booster) of the Pfizer–BioNTech vaccine had 90% effectiveness at preventing death due to Covid-19 compared to a two-dose regimen.

9 Dec, 2021 | 10:35h | UTC

BNT162b2 Vaccine Booster and Mortality Due to Covid-19 – New England Journal of Medicine

Editorial: Booster Doses and Prioritizing Lives Saved

 

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Review: Neuropsychiatric assessment and management of the ICU survivor.

10 Dec, 2021 | 10:01h | UTC

Neuropsychiatric assessment and management of the ICU survivor – Cleveland Clinic Journal of Medicine

 

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[Press release – not published yet] Lab study suggests a third dose (booster) of the Pfizer–BioNTech vaccine may be necessary to provide an adequate immune response to the Omicron variant.

9 Dec, 2021 | 10:29h | UTC

Press release: Pfizer and Biontech provide update on Omicron variant

Commentaries:

Omicron likely to weaken COVID vaccine protection – Nature

Pfizer-BioNTech says COVID booster should protect against Omicron – CIDRAP

Expert reaction to press release from Pfizer-BioNTech about omicron and neutralising antibody titres after two and three vaccine doses – Science Media Centre

Covid: Pfizer says booster shot promising against Omicron – BBC

Pfizer-BioNTech Covid-19 shot loses power against Omicron variant, but booster restores protection – STAT

 

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Large observational study in Israel showed a third dose (booster) of the Pfizer–BioNTech vaccine reduced the rates of confirmed Covid-19 and severe illness compared to a two-dose regimen.

9 Dec, 2021 | 10:32h | UTC

Protection against Covid-19 by BNT162b2 Booster across Age Groups – New England Journal of Medicine

Editorial: Booster Doses and Prioritizing Lives Saved

 

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As 57 countries report Omicron cases, Pfizer says its boosters offer protection – but WHO cautions more research is needed.

9 Dec, 2021 | 10:28h | UTC

As 57 Countries Report Omicron Cases, Pfizer Says its Boosters Offer Protection – But WHO Cautions More Research is Needed – Health Policy Watch

See also: Covid: Vaccines should work against Omicron variant, WHO says – BBC

 

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Multiple early studies find notable Omicron vaccine evasion.

9 Dec, 2021 | 10:26h | UTC

Multiple early studies find notable Omicron vaccine evasion – CIDRAP

Related: A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants.

 

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RCT: In critically ill adults undergoing tracheal intubation, use of a bougie did not significantly increase the incidence of successful first attempt intubation vs. with use of an endotracheal tube with stylet.

9 Dec, 2021 | 10:22h | UTC

Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

Related: Randomized Trial: Comparison of Intubation Techniques in Patients with Difficult Airways

 

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M-A: Effects of immediate or early oral feeding on acute pancreatitis.

9 Dec, 2021 | 10:14h | UTC

Effects of immediate or early oral feeding on acute pancreatitis: A systematic review and meta-analysis – Pancreatology

 

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Review: Current issues in the use of opioids for the management of postoperative pain.

9 Dec, 2021 | 10:18h | UTC

Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review – JAMA Surgery (free for a limited period)

 

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Systematic Review: Benefits and harms of annual, biennial, or triennial breast cancer mammography screening for women at average risk of breast cancer.

9 Dec, 2021 | 10:08h | UTC

Benefits and harms of annual, biennial, or triennial breast cancer mammography screening for women at average risk of breast cancer: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC) – British Journal of Cancer

 

Commentary on Twitter (thread – click for more)

https://twitter.com/ccaneloa/status/1464655542010494981

 

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Update in the diagnosis and management of acute pulmonary embolism for the non-respiratory physician.

9 Dec, 2021 | 10:00h | UTC

Update in the diagnosis and management of acute pulmonary embolism for the non-respiratory physician – Clinical Medicine Journal

 

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Modern day management of a unilateral pleural effusion.

9 Dec, 2021 | 09:58h | UTC

Modern day management of a unilateral pleural effusion – Clinical Medicine Journal

 

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Blood sugar targets in surgical intensive care: management and special considerations in patients with diabetes.

9 Dec, 2021 | 10:06h | UTC

Blood Sugar Targets in Surgical Intensive Care – Deutsches Ärzteblatt International

 

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Interstitial lung disease on the acute take for the non-respiratory physician.

9 Dec, 2021 | 09:57h | UTC

Interstitial lung disease on the acute take for the non-respiratory physician – Clinical Medicine Journal

 

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Review: Diagnosis and management of non-cystic fibrosis bronchiectasis.

9 Dec, 2021 | 09:53h | UTC

Diagnosis and management of non-cystic fibrosis bronchiectasis – Clinical Medicine Journal

 

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Review: Lung cancer for the non-respiratory physician.

9 Dec, 2021 | 09:54h | UTC

Lung cancer for the non-respiratory physician – Clinical Medicine Journal

 

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WHO recommends against the use of convalescent plasma to treat COVID-19.

8 Dec, 2021 | 10:24h | UTC

News Release: WHO recommends against the use of convalescent plasma to treat COVID-19 – World Health Organization

See Guidance: WHO’s living guidelines on COVID-19 therapeutics

Infographic: A living WHO guideline on drugs for covid-19 – The BMJ

 

Commentary on Twitter (thread – click for more)

Convalescent plasma is a transfusion of blood plasma from someone who has recovered from #COVID19, and is used as a treatment for COVID19 https://t.co/Bobq7OTDGq pic.twitter.com/pfO1sFvUpJ

— World Health Organization (WHO) (@WHO) December 7, 2021

 

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A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants.

8 Dec, 2021 | 10:22h | UTC

A first, small study suggests Omicron is a larger threat to Covid-19 immunity than other variants – STAT

Original Study: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection – medRxiv

 

Commentary from the author on Twitter (thread – click for more)

We have completed our first experiments on neutralization of Omicron by Pfizer BNT162b2 vaccination elicited immunity

Manuscript available at https://t.co/rGaEB9GdmS

and should be available on medRxiv in the coming days

— Alex Sigal (@sigallab) December 7, 2021

See also (thread – click for more)

New work from AHRI's @sigallab strongly suggests that the SARS-CoV-2 #Omicron variant escapes antibody immunity induced by the Pfizer vaccine, but that considerable immunity is retained in people who were both vaccinated & previously infected. https://t.co/AZWi3qexin pic.twitter.com/3phPFyKEPh

— Africa Health Research Institute (@AHRI_News) December 7, 2021

 

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RCT: In patients with severe Covid-19, high-flow oxygen therapy reduced the likelihood of invasive mechanical ventilation and decreased the time to clinical recovery compared to conventional oxygen therapy.

8 Dec, 2021 | 10:15h | UTC

Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial – JAMA

Related:

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research – “The two randomized controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation”.

[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

 

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Video | COVID-19 Update: Omicron Variant.

8 Dec, 2021 | 10:09h | UTC

COVID-19 Update: Omicron Variant – JAMA

 

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Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors.

8 Dec, 2021 | 09:58h | UTC

Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors – Canadian Medical Association Journal

 

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ESC Position Paper: Optimal follow-up after acute pulmonary embolism.

8 Dec, 2021 | 10:02h | UTC

Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society – European Heart Journal

 

Commentary on Twitter

Do you routinely discuss how/when to resume sporting activities and traveling with your PE patients? Or future cardiovascular risk? Check this recent ESC/ERS position paper on optimal follow-up of acute PE for these and other key aspects of counselling: https://t.co/KEQ7FnFwXX

— Erik Klok (@Erik_Klok_MD) December 7, 2021

 

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Review: Perioperative pain management issues unique to older adults undergoing surgery.

8 Dec, 2021 | 09:52h | UTC

Perioperative Pain Management Issues Unique to Older Adults Undergoing Surgery: A Narrative Review – Annals of Surgery Open

 

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Raising awareness for time-limited trial discussion upon ICU triage and admission.

8 Dec, 2021 | 09:57h | UTC

Raising awareness for time-limited trial discussion upon ICU triage and admission – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

Enhancing situational awareness/prompt time-limited trial discussion vs burden/harm of inappropriate #ICU admission
F functional impairment
R recurrent hospitalisations
A advanced malignancy/chronic diseases
I irreversible organ failure
L long 🏥 stayhttps://t.co/C3aR2lbZtt pic.twitter.com/IB0xjSGVup

— Intensive Care Medicine (@yourICM) December 6, 2021

 

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