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Internal Medicine

M-A: Global percentage of asymptomatic SARS-CoV-2 infections around 40%.

15 Dec, 2021 | 08:47h | UTC

Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: ~40 Percent With Confirmed COVID-19 Are Asymptomatic – HealthDay

 

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

15 Dec, 2021 | 08:43h | UTC

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection – Nature Medicine

News release: COVID-19 infection, more likely than vaccines, to cause rare cardiovascular complications – University of Oxford

 

Commentaries on Twitter

 

[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.

15 Dec, 2021 | 08:46h | UTC

News release: Pfizer announces additional phase 2/3 study results confirming robust efficacy of novel Covid-19 oral antiviral treatment candidate in reducing risk of hospitalization or death

Commentaries:

Pfizer’s Covid pill remains 89% effective in final analysis, company says – STAT

Pfizer confirms COVID pill’s results, potency versus omicron – Associated Press

Related:

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

 

Commentary on Twitter (thread – click for more)

 

Rapidly spreading Omicron is now in 77 countries and WHO warns against assuming its effects are mild.

15 Dec, 2021 | 08:39h | UTC

Rapidly Spreading Omicron is Now in 77 Countries and WHO Warns Against Assuming its Effects are Mild – Health Policy Watch

 

Expert consensus and practical guidance: A global perspective on improving patient care in uncomplicated urinary tract infection.

15 Dec, 2021 | 08:33h | UTC

A global perspective on improving patient care in uncomplicated urinary tract infection: Expert consensus and practical guidance – Journal of Global Antimicrobial Resistance

 

[Not published yet] Initial data from South Africa showed vaccine protection vs. Omicron infection may drop to 30% but does cut severe disease.

15 Dec, 2021 | 08:38h | UTC

Vaccine protection vs. omicron infection may drop to 30% but does cut severe disease – NPR

See also: South Africa Omicron study finds drop in vaccine protection, fewer hospitalized – CIDRAP

 

Review: Diagnosis and management of acute appendicitis in adults.

15 Dec, 2021 | 08:28h | UTC

Diagnosis and Management of Acute Appendicitis in Adults: A Review – JAMA (free for a limited period)

Author Interview: Current Management of Acute Appendicitis: Antibiotics or Surgical Intervention

Commentary: Antibiotics can be first-line therapy for uncomplicated appendicitis cases – Duke University Medical Center

 

M-A: Pharmacotherapy for adults with overweight and obesity – “phentermine–topiramate and GLP-1 receptor agonists proved the best drugs in reducing weight”.

15 Dec, 2021 | 08:30h | UTC

Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Randomized crossover trial of metoprolol in patients with obstructive hypertrophic cardiomyopathy.

15 Dec, 2021 | 08:23h | UTC

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: The Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy – TEMPO – American College of Cardiology

 

Proposed subtypes of long-Covid and their respective potential therapies.

14 Dec, 2021 | 09:49h | UTC

Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies – Reviews in Medical Virology

Related:

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Infectious diseases learning pearls from inpatient ID consults.

15 Dec, 2021 | 08:22h | UTC

ID Learning Units from Inpatient ID Consults – HIV and ID Observations

 

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

14 Dec, 2021 | 08:44h | UTC

News release: Cannabis use could cause harmful drug interactions – Washington State University

Original Study: Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions – Drug Metabolism and Disposition

 

Short Review: Lymphogranuloma venereum.

14 Dec, 2021 | 08:42h | UTC

Lymphogranuloma venereum – Canadian Medical Association Journal

 

Podcast: No tension about inpatient hypertension.

14 Dec, 2021 | 08:39h | UTC

#310 No Tension About Inpatient Hypertension with Dr. Noble Maleque – The Curbsiders

 

UK Report on SARS-CoV-2 variants of concern finds significantly lower vaccine effectiveness (VE) against Omicron infection, but a moderate to high VE of 70 to 75% is seen after a third (booster) dose.

13 Dec, 2021 | 09:53h | UTC

Report: SARS-CoV-2 variants of concern and variants under investigation in England – UK Health Security Agency

Commentaries:

Omicron: Three vaccine doses key for protection against variant – BBC

Two jabs offer little protection against Omicron infection, UK data shows – The Guardian

UK Says Omicron to Become Its Dominant Variant Within Days – Associated Press

 

How to recognize and manage COVID-19-associated coagulopathy.

13 Dec, 2021 | 09:45h | UTC

How to recognize and manage COVID-19-associated coagulopathy – Hematology, ASH Education Program

 

COVID-19 and thrombosis: searching for evidence.

13 Dec, 2021 | 09:47h | UTC

COVID-19 and thrombosis: searching for evidence – Hematology, ASH Education Program

 

Pooled analysis of randomized trials on the effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction (EF) showed the effects were clinically meaningful and similar in patients with EF below 65% but were attenuated in patients with EF above 65%.

13 Dec, 2021 | 08:53h | UTC

Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction – European Heart Journal

 

Commentary on Twitter

 

SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact.

10 Dec, 2021 | 10:23h | UTC

SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact – Nature Reviews Immunology

 

Commentary on Twitter

 

Omicron spreads, but severe cases remain low in South Africa.

10 Dec, 2021 | 10:17h | UTC

Omicron spreads but severe cases remain low in South Africa – WHO Africa

 

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization.

10 Dec, 2021 | 10:11h | UTC

Guideline Hub: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization

Full Guideline: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Executive Summary: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization

News release: Coronary Revascularization the Focus of New ACC/AHA Clinical Guideline

ACC/AHA Slide Set: 2021 ACC/AHA/SCAI Guidelines for Coronary Artery Revascularization

Top Things to Know: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization

Key Perspectives: ACC/AHA/SCAI Coronary Revascularization Guideline

 

Commentary on Twitter

 

CDC chief says Omicron is ‘mild’ as early data comes in on US spread of variant.

10 Dec, 2021 | 10:14h | UTC

CDC chief says Omicron is ‘mild’ as early data comes in on US spread of variant – The Guardian

 

M-A: Performance of the European Society of Cardiology 0/1-hour, 0/2-hour, and 0/3-hour algorithms for rapid triage of acute myocardial infarction.

10 Dec, 2021 | 10:09h | UTC

Performance of the European Society of Cardiology 0/1-Hour, 0/2-Hour, and 0/3-Hour Algorithms for Rapid Triage of Acute Myocardial Infarction: An International Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Rapid ESC hs-cTn Algorithms Best 3-Hour Protocol for MI Rule-out: Meta-analysis – TCTMD

Performance of ESC 0/1-, 0/2-, 0/3-Hour Algorithms for AMI Compared – HealthDay

 

Commentary on Twitter

 

M-A: Intravenous diltiazem vs. metoprolol for atrial fibrillation with rapid ventricular rate.

10 Dec, 2021 | 10:05h | UTC

Intravenous diltiazem versus metoprolol for atrial fibrillation with rapid ventricular rate: A meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

 

Systematic Review: Antibiotics for adults and children with sore throats.

10 Dec, 2021 | 10:02h | UTC

Summary: Antibiotics for adults and children with sore throats – Cochrane Library

Original Research: Antibiotics for treatment of sore throat in children and adults – Cochrane Library

 

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