Internal Medicine
M-A: Intermittent Fasting and Obesity-Related Health Outcomes.
13 Jan, 2022 | 08:22h | UTC
Systematic Review: In patients who are about to undergo noncardiac surgery, biomarkers (BNP/NT‐proBNP, troponin or their combination) may provide added prognostic value to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all‐cause mortality. The results cannot be interpreted as conclusive due to the high risks of bias in most papers.
13 Jan, 2022 | 08:15h | UTC
The COVID-19 Treatment Guidelines Panel’s Statement on Anticoagulation in Hospitalized Patients With COVID-19 – in the absence of contraindications, use therapeutic-dose anticoagulation with low molecular weight heparin for hospitalized patients not in the ICU who have a D-dimer above the upper limit of normal.
12 Jan, 2022 | 09:11h | UTC
Statement on therapies for high-risk, nonhospitalized patients with mild to moderate Covid-19.
12 Jan, 2022 | 09:14h | UTCSee also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines
Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.
12 Jan, 2022 | 09:09h | UTCCommentaries:
Pfizer antiviral pills may be risky with other medications – NBC News
See also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines
Podcast: Long COVID Pearls.
12 Jan, 2022 | 09:04h | UTC#315 Long COVID with Dr. Monica Verduzco-Gutierrez – The Curbsiders
Perspective | Covid-19: Is it safe to reduce the self-isolation period?
12 Jan, 2022 | 09:00h | UTCCovid-19: Is it safe to reduce the self-isolation period? – The BMJ
RCT: High-dose weekly Semaglutide (2.4 mg) resulted in increased weight loss compared to daily Liraglutide (3.0 mg).
12 Jan, 2022 | 08:55h | UTCEffect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this randomized clinical trial of 338 participants, mean body weight change from baseline to 68 weeks was –15.8% with semaglutide vs –6.4% with liraglutide, a statistically significant difference. https://t.co/8tktjqw4mE pic.twitter.com/BxrL1XPpKv
— JAMA (@JAMA_current) January 11, 2022
German Guideline: Oxygen therapy in the acute care of adult patients.
12 Jan, 2022 | 08:57h | UTCGerman S3 Guideline: Oxygen Therapy in the Acute Care of Adult Patients – Respiration
Clinical Review: Diagnostic reasoning in cardiovascular medicine.
12 Jan, 2022 | 08:49h | UTCDiagnostic reasoning in cardiovascular medicine – The BMJ
RCT: Endoscopic sinus surgery with medical therapy vs. medical therapy alone for chronic rhinosinusitis with nasal polyps.
12 Jan, 2022 | 08:51h | UTCEndoscopic sinus surgery with medical therapy versus medical therapy for chronic rhinosinusitis with nasal polyps: a multicentre, randomised, controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Endoscopic sinus surgery + medical therapy > medical therapy alone in pts w/ chronic rhinosinusitis w/ nasal polyps (although minimal clinically important difference was not met)
From Wytske Fokkens & colleagues https://t.co/VKxCQZ97Am pic.twitter.com/IzXq712lNL
— The Lancet Respiratory Medicine (@LancetRespirMed) January 8, 2022
RCT: Among patients younger than 21 years of age with provoked thromboembolism, anticoagulation for 6 weeks was non-inferior vs. 12 weeks on the risk of recurrence and bleeding events.
12 Jan, 2022 | 08:53h | UTCEffect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism: The Kids-DOTT Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Duration of Anticoagulant Treatment for Acute Provoked Venous Thromboembolism in Pediatric Patients – JAMA (free for a limited period)
Cohort Study: Higher consumption of olive oil linked to lower risk of cardiovascular, cancer, and all-cause mortality.
12 Jan, 2022 | 08:41h | UTCConsumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries:
Higher olive oil intake associated with lower risk of CVD mortality – American College of Cardiology
Consequences of a diagnostic label: A systematic scoping review and thematic framework.
12 Jan, 2022 | 08:37h | UTC
Clinical Guideline: Acute-on-chronic liver failure.
11 Jan, 2022 | 02:43h | UTCAcute-on-Chronic Liver Failure Clinical Guidelines – American Journal of Gastroenterology
Related: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU
Commentary on Twitter
📣NEW ACG Guidelines Acute-on-Chronic #Liver Failure by @JasmohanBajaj et al.
📕https://t.co/T3CqvOAMrj#Cirrhosis #GItwitter #LiverTwitter #MostReadinRed pic.twitter.com/LHwIkUtGZt
— AJG – The American Journal of Gastroenterology (@AmJGastro) January 10, 2022
AHA Scientific Statement: Comprehensive management of cardiovascular risk factors for adults with Type 2 Diabetes.
11 Jan, 2022 | 02:40h | UTC
Medical Decisions: Some are Easy and Some Not So Much.
11 Jan, 2022 | 02:31h | UTCMedical Decisions: Some are Easy and Some Not So Much – Stop and Think blog, by John Mandrola
Commentary on Twitter
https://twitter.com/drjohnm/status/1480289256518176770
Review: New aspects in the management of hypertension in patients with chronic kidney disease not on renal replacement therapy.
11 Jan, 2022 | 02:22h | UTC
The ‘Ten Commandments’ of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.
11 Jan, 2022 | 02:20h | UTCRelated:
NICE Guideline | Acute heart failure: diagnosis and management.
The ‘ten commandments’ for the 2021 ESC Guidelines on CVD prevention.
M-A: Fecal immunochemical test to triage patients with possible colorectal cancer symptoms.
11 Jan, 2022 | 02:18h | UTC
Commentary on Twitter
🆕#CuttingEdgeBlog Plain English summary📰
"Worried about symptoms of bowel cancer? A simple stool test may help."@ian_bissett @SawKS88 @ChenLiu_NZ @williamxu_98 @chrisvarghese98
Blog🔗: https://t.co/Pb7zfsfWT3
Based on the paper 🔗: https://t.co/20proTApNd pic.twitter.com/IAUsHIqUrn
— BJS (@BJSurgery) January 10, 2022
Cohort study: Among health care workers previously vaccinated with 2 doses of the Pfizer-BioNTech vaccine, receiving a third dose was associated with reduced risk of SARS-CoV-2 infection.
11 Jan, 2022 | 01:35h | UTCEditorial: Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection – JAMA
Review: Rapid diagnostic testing for SARS-CoV-2.
11 Jan, 2022 | 01:34h | UTCRapid Diagnostic Testing for SARS-CoV-2 – New England Journal of Medicine
Clinical Practice Guideline Summary: Recommended Drugs and Biologics in Adult Patients with COVID-19.
11 Jan, 2022 | 01:26h | UTC
Commentary on Twitter
Fantastic outpatient treatment approach from Ontario #COVID19 Clinical Practice Guidelines
Risk level:high mod low
Eg:high:Sotrovimab is recommended if NA Remdesivir if NA Fluvoxamine or Budesonide
Paxlovid/Molnupiravir not added coz not yet approved CA https://t.co/dDhj6vA0uv pic.twitter.com/4ucrKIcMn8— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) January 8, 2022
M-A: Fatigue and cognitive impairment in Post-COVID-19 Syndrome.
11 Jan, 2022 | 01:28h | UTC
New CDC Guidance shortens isolation and quarantine period for Covid-19; patients that tested positive should isolate for 5 days and, if asymptomatic after this period, can leave isolation if they can continue to mask for 5 days to minimize the risk of infecting others.
9 Jan, 2022 | 01:13h | UTCSee also: Quarantine and Isolation – Centers for Disease Control and Prevention
Commentaries:
Facing criticism, CDC updates Covid-19 isolation recommendations with guidance on testing – CNN
CDC posts rationale for shorter isolation, quarantine – Associated Press
Covid-19: CDC shortens isolation period as US cases hit record high – The BMJ
Shortened CDC COVID isolation guide draws sharply mixed reviews – CIDRAP
New CDC isolation guidelines raise concerns among health experts – NPR
CDC Reduces Recommended Isolation Time for People With COVID-19 – HealthDay
COVID isolation and quarantine period for general population shortened by CDC – News Medical
CDC shortens recommended Covid-19 isolation and quarantine time – CNN
CDC cuts the recommended isolation and quarantine periods for coronavirus infections – NPR
US officials recommend shorter COVID isolation, quarantine – Associated Press
See new recommendations from other countries:
Covid: Self-isolation cut from 10 days to seven with negative tests – BBC