Internal Medicine
M-A: No difference in outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to P. aeruginosa.
21 Jan, 2022 | 09:37h | UTCBeta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to P. aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)
Cluster Randomized Trial: A multifactorial falls prevention program in UK care homes reduced fall rates among older people and was cost effective.
21 Jan, 2022 | 09:21h | UTCNews Release: Falls in care homes can be significantly reduced with intervention, says new study – University of Nottingham
Commentary on Twitter
NEW RESEARCH: A falls prevention programme for older people in care homes, co-designed with care home staff & residents, that involved awareness raising, education, screening, decision & implementation support was associated with a reduction in falls rate https://t.co/wupI0LeAxj
— The BMJ (@bmj_latest) December 11, 2021
Booster longevity: Data reveals how long a third shot protects.
20 Jan, 2022 | 09:33h | UTCBooster longevity: Data reveals how long a third shot protects – NPR
Original Report: SARS-CoV-2 variants of concern and variants under investigation in England – U.K. Health Security Agency
A populational-based retrospective cohort study in Qatar showed a reduced risk of Covid-19 breakthrough infections with the Moderna vs. the Pfizer–BioNTech vaccine.
20 Jan, 2022 | 09:30h | UTCEffectiveness of mRNA-1273 and BNT162b2 Vaccines in Qatar – New England Journal of Medicine
Commentary on Twitter
In two matched retrospective cohort studies comparing BNT162b2 and mRNA-1273, both were highly effective at preventing hospitalization & death. Breakthrough infections were lower among those who received mRNA-1273 than those who received BNT162b2. https://t.co/wgkrzfLNHz pic.twitter.com/E8hXIDFqWW
— NEJM (@NEJM) January 19, 2022
Short Review: Fluvoxamine for symptomatic outpatients with COVID-19.
20 Jan, 2022 | 09:25h | UTCFluvoxamine for symptomatic outpatients with COVID-19 – Canadian Medical Association Journal
Related:
Fluvoxamine for Covid-19: What Prescribers and Pharmacists Need to Know.
Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.
Milder disease with Omicron: is it the virus or the pre-existing immunity?
20 Jan, 2022 | 09:28h | UTC
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
20 Jan, 2022 | 09:17h | UTCGlobal burden of bacterial antimicrobial resistance in 2019: a systematic analysis – The Lancet
Editorial: Antimicrobial resistance: time to repurpose the Global Fund – The Lancet
Commentary: Antimicrobial resistance now a leading cause of death worldwide, study finds – The Guardian
Commentary on Twitter
NEW—An estimated 1.2 million people died in 2019 from antibiotic-resistant bacterial infections, more deaths than HIV/AIDS or malaria.#GRAMPaper reveals the scale of antimicrobial resistance (#AMR), now a leading cause of death worldwide: https://t.co/2h5UEKemEq #AMRSOS pic.twitter.com/aWLhmdirJ8
— The Lancet (@TheLancet) January 20, 2022
RCT: Among patients with recurrent Clostridioides difficile infection, the use of SER-109, an oral microbiome therapy, reduced recurrence rate compared to placebo (12% vs. 40%).
20 Jan, 2022 | 09:11h | UTCSER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection – New England Journal of Medicine (link to abstract – $ for full-text)
M-A: the accuracy of serological tests to support the diagnosis of celiac disease.
20 Jan, 2022 | 09:02h | UTC
Meta-analysis of randomized controlled trials: Drug treatment for panic disorder with or without agoraphobia.
20 Jan, 2022 | 09:06h | UTC
Study shows that the retinal age gap might be a potential biomarker of aging linked to increased mortality risk.
20 Jan, 2022 | 09:04h | UTCRetinal age gap as a predictive biomarker for mortality risk – British Journal of Ophthalmology (link to abstract – $ for full-text)
News Release: Difference between retina’s biological age and person’s real age linked to heightened death risk – BMJ
Commentary on Twitter
Difference between retina’s biological age and person’s real age linked to heightened death risk finds @BMJ_Ophth study https://t.co/TNveo5E77D
— BMJ Group (@bmj_company) January 19, 2022
Systematic Review: Prevalence, incidence and survival of heart failure.
20 Jan, 2022 | 09:00h | UTCPrevalence, incidence and survival of heart failure: a systematic review – Heart
Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis.
20 Jan, 2022 | 08:52h | UTC
Review: Evaluating the patient with a pulmonary nodule.
20 Jan, 2022 | 08:56h | UTCEvaluating the Patient With a Pulmonary Nodule: A Review – JAMA (free for a limited period)
Author Interview: Evaluation and Management of Patients With Pulmonary Nodules
Consensus Statement: Exercise/physical activity in individuals with Type 2 Diabetes.
20 Jan, 2022 | 08:51h | UTC
Commentary from the author on Twitter
Exercise/Physical Activity in Individuals with
Type 2 Diabetes: A Consensus Statement from
the American College of Sports Medicine
Honored to contribute w/several esteemed colleagues to this report now out on #exercise & #diabetes @MSSEonline @ACSMNews https://t.co/UNmoU2BgLR— Juleen R. Zierath (@JuleenRZierath) January 14, 2022
Review: Diagnosis and treatment of polycystic ovary syndrome.
20 Jan, 2022 | 08:54h | UTCDiagnosis and Treatment of Polycystic Ovary Syndrome – JAMA (free for a limited period)
Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.
20 Jan, 2022 | 08:39h | UTCCannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain – CNS Drugs
Related:
Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
M-A: Association of Sodium-Glucose Cotransporter 2 Inhibitors with cardiovascular outcomes in patients with Type 2 Diabetes and other risk factors for cardiovascular disease.
20 Jan, 2022 | 08:42h | UTC
Commentary on Twitter
This meta-analysis found that use of SGLT2-Is was associated with lower occurrence of cardiovascular death or hospitalization for heart failure by 33% in high-risk patients. @mukul_bhattarai @AkcharAl @AbhiKulk82 @mominsiddique01 @Mohsin_Salih19 https://t.co/omPP6Qwofg
— JAMA Network Open (@JAMANetworkOpen) January 5, 2022
COVID-19 testing infographics.
19 Jan, 2022 | 08:59h | UTCCOVID-19 testing infographics – British Society for Immunology
Commentary on Twitter
It’s important to understand #COVID19 testing so everyone can make informed decisions about their health ℹ🦠
Our infographics & blog have been updated with the latest information & guidance so you can find out what different tests mean for you 👉https://t.co/7a5Ul6tEZn pic.twitter.com/mUzdZc13aa
— British Society for Immunology (@britsocimm) January 17, 2022
RCT: In non–critically ill hospitalized patients with COVID-19, the use of a P2Y12 Inhibitor (ticagrelor in 63% of patients and clopidogrel in 37%) in addition to a therapeutic dose of heparin did not improve survival free of organ support compared to therapeutic heparin alone.
19 Jan, 2022 | 08:56h | UTCEditorial: Antiplatelet Therapy in Patients With COVID-19—More Is Less? – JAMA
Commentary: Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19 – HealthDay
RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.
19 Jan, 2022 | 08:41h | UTCBalanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)
Related:
Commentary on Twitter
https://twitter.com/NEJM/status/1483540959518281730
Fact check: The theory that SARS-CoV-2 is becoming milder.
19 Jan, 2022 | 08:44h | UTCFact check: The theory that SARS-CoV-2 is becoming milder – NPR
Clinical practice guidelines for therapeutic drug monitoring of teicoplanin.
19 Jan, 2022 | 08:27h | UTC
Systematic Review: Intermittent prophylactic antibiotics for bronchiectasis.
19 Jan, 2022 | 08:33h | UTCIntermittent prophylactic antibiotics for bronchiectasis – Cochrane Library
Summary: Long term antibiotics taken at regular intervals by people with bronchiectasis – Cochrane Library
Practical guide to cardiopulmonary exercise testing in adults.
19 Jan, 2022 | 08:26h | UTCPractical guide to cardiopulmonary exercise testing in adults – Respiratory Research