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Internal Medicine

M-A of randomized trials | Association between intensity of LDL cholesterol reduction with statin-based therapies and secondary stroke prevention.

22 Feb, 2022 | 08:37h | UTC

Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention: A Meta-analysis of Randomized Clinical Trials – JAMA Neurology

Editorial: Low-Density Lipoprotein Cholesterol Level After a Stroke—Reducing It by Any Means (free for a limited period)

 


M-A: Diagnostic features, management and prognosis of type 2 myocardial infarction compared to type 1 myocardial infarction.

22 Feb, 2022 | 08:34h | UTC

Diagnostic features, management and prognosis of type 2 myocardial infarction compared to type 1 myocardial infarction: a systematic review and meta-analysis – BMJ Open

 


Early and late-onset syncope: insight into mechanisms.

22 Feb, 2022 | 08:29h | UTC

Early and late-onset syncope: insight into mechanisms – European Heart Journal

 

Commentary on Twitter

 


Expert Analysis | Asymptomatic ventricular preexcitation (Wolff-Parkinson-White Pattern): when to be concerned.

22 Feb, 2022 | 08:18h | UTC

Asymptomatic Ventricular Preexcitation (Wolff-Parkinson-White Pattern): When to Be Concerned – American College of Cardiology

 


Dietary carbohydrate and the risk of type 2 diabetes: an updated systematic review and dose–response meta-analysis of prospective cohort studies.

22 Feb, 2022 | 08:16h | UTC

Dietary carbohydrate and the risk of type 2 diabetes: an updated systematic review and dose–response meta-analysis of prospective cohort studies – Scientific Reports

 


ESCMID rapid guidelines for assessment and management of long COVID.

21 Feb, 2022 | 09:31h | UTC

ESCMID rapid guidelines for assessment and management of long COVID – Clinical Microbiology and Infection

Related:

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 


RCT: In patients with mild to moderate Covid-19 and comorbidities, treatment with Ivermectin did not reduce the risk of disease progression.

21 Feb, 2022 | 09:34h | UTC

Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial – JAMA Internal Medicine

Commentaries:

Ivermectin doesn’t prevent severe disease from Covid-19, new study finds – CNN

Ivermectin futile for mild to moderate COVID-19, study finds – CIDRAP

Related:

Case Series: Toxic effects from ivermectin use associated with prevention and treatment of Covid-19.

Long-term consequences of the misuse of ivermectin data.

Ivermectin: How false science created a Covid ‘miracle’ drug.

Fraudulent ivermectin studies open up new battleground between science and misinformation.

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.

Ivermectin: Cochrane’s most talked about review so far, ever. Why?

Flawed ivermectin preprint highlights challenges of COVID drug studies.

Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

Why was a major study on ivermectin for covid-19 just retracted?

RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.

Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”.

Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”.

Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials

RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

 


RCT: Advising overweight patients to increase sleep duration may reduce caloric intake.

21 Feb, 2022 | 09:27h | UTC

Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial – JAMA Internal Medicine

News Release: Getting more sleep reduces caloric intake, a game changer for weight loss programs – University of Chicago Medical Center

Commentaries:

Cut nearly 300 calories a day by doing something you already do – CNN

Individualized Sleep Counseling Can Aid Weight Loss in Overweight – HealthDay

 

Commentary on Twitter

 


Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

21 Feb, 2022 | 09:30h | UTC

Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus – European Heart Journal

News Release: Review highlights impact of Long COVID on cardiovascular system – University of Oxford

Related:

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

 


ERAS/SVS Consensus Statement on perioperative care in open aortic vascular surgery.

21 Feb, 2022 | 09:21h | UTC

Perioperative care in open aortic vascular surgery: A Consensus Statement by the Enhanced Recovery after Surgery (ERAS®) Society and Society for Vascular Surgery – Journal of Vascular Surgery

 


Review: Cancer-associated venous thromboembolism.

21 Feb, 2022 | 08:42h | UTC

Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Cancer-associated venous thromboembolism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Related:

NCCN Guideline: Cancer-Associated Venous Thromboembolic Disease.

ASH 2021 guidelines for prevention and treatment of venous thromboembolism in patients with cancer

Review: venous and arterial thromboembolism in patients with cancer.

Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?

M-A: Extended thromboprophylaxis after hospital discharge for medically ill patients with cancer – Extended thromboprophylaxis is not associated with a reduced rate of venous thromboembolic events and is associated with increased risk of hemorrhage

Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

 


RCT: Sub dissociative dose of ketamine with haloperidol vs. fentanyl on pain reduction in patients with acute pain in the emergency department.

21 Feb, 2022 | 08:37h | UTC

Sub dissociative dose of ketamine with haloperidol versus fentanyl on pain reduction in patients with acute pain in the emergency department; a randomized clinical trial – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

 


Review | Acute traumatic brain injury in frail patients: the next pandemic.

21 Feb, 2022 | 08:31h | UTC

Acute traumatic brain injury in frail patients: the next pandemic – Current Opinion in Critical Care

 


Overview of Allergy and Anaphylaxis.

21 Feb, 2022 | 08:28h | UTC

Overview of Allergy and Anaphylaxis – Emergency Clinics of North America

 


Pro-Con Debate: Anesthesiologist- versus hospitalist- run preoperative clinics and perioperative care.

21 Feb, 2022 | 08:17h | UTC

Pro-Con Debate: Anesthesiologist- Versus Hospitalist- Run Preoperative Clinics and Perioperative Care – Anesthesia & Analgesia

 


New U.S. adult immunization schedule released by ACIP.

18 Feb, 2022 | 10:07h | UTC

Recommended Adult Immunization Schedule, United States, 2022 – Annals of Internal Medicine

News release: New adult immunization schedule recommends changes to zoster, pneumococcal, and hep B vaccines – American College of Physicians

See also: Adult Immunization Schedule: Recommendations for Ages 19 Years or Older, United States, 2022 – Centers for Disease Control and Prevention

 


Cohort Study: Risks of mental health outcomes in people with covid-19.

18 Feb, 2022 | 10:02h | UTC

Risks of mental health outcomes in people with covid-19: cohort study – The BMJ

Editorial: Mental health after covid-19 – The BMJ

News release: Study suggests increased risk of mental health disorders after COVID-19 infection – BMJ

Commentaries:

Mental health in people with covid-19 – The BMJ

Large study reveals clearer links between COVID-19, mental health risks – CIDRAP

 


Another study suggests a lower risk of hospitalization and death from infection with SARS-CoV-2 Omicron variant vs. Delta.

18 Feb, 2022 | 10:01h | UTC

Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada – JAMA

 


The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

18 Feb, 2022 | 09:56h | UTC

The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review – JACC: Basic to Translational Science

Related: COVID-19 infections increase risk of heart conditions up to a year later, study finds.

 


WHO Interim Guidance: Contact tracing and quarantine in the context of the Omicron SARS-CoV-2 variant.

18 Feb, 2022 | 09:59h | UTC

Contact tracing and quarantine in the context of the Omicron SARS-CoV-2 variant: interim guidance – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


NICE Updated Guidance: Management of Type 2 Diabetes.

18 Feb, 2022 | 08:41h | UTC

Type 2 diabetes in adults: management – National Institute for Health and Care Excellence

Related: Guideline: ADA 2022 Standards of Medical Care in Diabetes.

 


Guideline: Dietary changes to alleviate gastrointestinal symptoms.

18 Feb, 2022 | 08:38h | UTC

World Gastroenterology Organisation Global Guidelines: Diet and the Gut – Journal of Clinical Gastroenterology

 


Viewpoint: Achieving diagnostic excellence for older patients.

18 Feb, 2022 | 08:37h | UTC

Achieving Diagnostic Excellence for Older Patients – JAMA (free for a limited period)

 


Arrhythmias in female patients: incidence, presentation and management.

18 Feb, 2022 | 08:31h | UTC

Arrhythmias in Female Patients: Incidence, Presentation and Management – Circulation Research (free for a limited period)

 


M-A: In patients with transient ischemic attack (TIA), referral to a TIA clinic that can provide urgent investigation and initiation of preventive measures may be as effective for preventing stroke compared to impatient care.

18 Feb, 2022 | 08:29h | UTC

Risk of Subsequent Stroke Among Patients Receiving Outpatient vs Inpatient Care for Transient Ischemic Attack: A Systematic Review and Meta-analysis – JAMA Network Open

 


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