Internal Medicine | Page 127 of 487 | Links Medicus Content Curation & Alerts in Medicine

M-A: Evaluating the association between LDL Cholesterol reduction and relative and absolute effects of statin treatment.

15 Mar, 2022 | 10:04h | UTC

Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentary from the author: Benefits of statins may have been overstated – new study – The Conversation

Commentary on Twitter

Our study in @JAMAInternalMed asked 2 questions 1. Is reducing one’s ‘bad’ cholesterol was associated with a proportional reduction in death, heart attack and stroke? 2. What's the absolute reduction in risk from taking statins? https://t.co/Zwh7LmUD0e

— Dr Paula Byrne (@pbyrne82) March 14, 2022

Review | Resistance exercise as a treatment for sarcopenia: prescription and delivery.

15 Mar, 2022 | 09:55h | UTC

Resistance exercise as a treatment for sarcopenia: prescription and delivery – Age and Ageing

Caring for older adults during the COVID-19 pandemic.

15 Mar, 2022 | 09:48h | UTC

Caring for older adults during the COVID-19 pandemic – Clinical Microbiology and Infection

Clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit.

15 Mar, 2022 | 08:45h | UTC

2021 KSCCM clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit – Acute and Critical Care

Single-center RCT: Accessible Hepatitis C care for people who inject drugs.

15 Mar, 2022 | 08:36h | UTC

Accessible Hepatitis C Care for People Who Inject Drugs: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentary on Twitter

This randomized clinical trial found that the accessible care model provides a framework for developing treatment programs geared toward engaging, treating, and curing hepatitis C virus infection in people who inject drugs. https://t.co/zauS1gtPgO

— JAMA Internal Medicine (@JAMAInternalMed) March 14, 2022

Cohort Study: Evaluating rates of recurrent ischemic stroke among young adults with embolic stroke of undetermined source.

15 Mar, 2022 | 08:33h | UTC

Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source: The Young ESUS Longitudinal Cohort Study – JAMA Neurology (free for a limited period)

Commentary: Embolic Stroke of Undetermined Source in the Young: Low Recurrence, but Few Answers — Growing evidence that role of atrial fibrillation is less important than originally believed – MedPage Today (free registration required)

Commentary on Twitter

Study found relatively low rate of subsequent ischemic stroke and new onset #AF in young patients with ESUS compared to older patients. History of stroke/TIA, diabetes, and coronary artery disease were predictive of recurrence. https://t.co/mzTgMkVFGN @PereraKanjana

— JAMA Neurology (@JAMANeuro) March 14, 2022

Review: Diagnosis and management of postural orthostatic tachycardia syndrome.

15 Mar, 2022 | 08:26h | UTC

Diagnosis and management of postural orthostatic tachycardia syndrome – Canadian Medical Association Journal

Cohort studies show an independent association of Lipoprotein(a) and coronary artery calcification with atherosclerotic cardiovascular risk.

15 Mar, 2022 | 08:28h | UTC

Independent Association of Lipoprotein(a) and Coronary Artery Calcification With Atherosclerotic Cardiovascular Risk – Journal of the American College of Cardiology (link to abstract – $ for full-text)

M-A: Similar outcomes with Beta-lactam monotherapy vs. combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa.

15 Mar, 2022 | 08:29h | UTC

Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa: a meta-analysis – International Journal of Antimicrobial Agents (link to abstract – $ for full-text)

Podcast: Cardiorenal Syndrome Pearls.

15 Mar, 2022 | 08:23h | UTC

#326 NephMadness 2022: Cardiorenal Syndrome – The Curbsiders

Cohort Study: History of neurological or psychiatric conditions increases the likelihood of developing more.

15 Mar, 2022 | 08:08h | UTC

News Release: History of neurological or psychiatric conditions increases the likelihood of developing more – University of Waterloo

Original Study: Incidence of neurological and psychiatric comorbidity over time: a population-based cohort study in Ontario, Canada – Age and Ageing (link to abstract – $ for full-text)

Systematic Review: Long-term outcomes among patients with advanced kidney disease who forgo maintenance dialysis.

15 Mar, 2022 | 08:11h | UTC

Long-term Outcomes Among Patients With Advanced Kidney Disease Who Forgo Maintenance Dialysis: A Systematic Review – JAMA Network Open

Commentaries:

Conservative Care for Kidney Failure—The Other Side of the Coin – JAMA Network Open

Study: Advanced kidney disease patients can survive, with quality life, without dialysis – UPI

Meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies.

14 Mar, 2022 | 01:47h | UTC

A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies – Annals of Surgery

Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

Meta-Analysis: Effects of Restrictive vs. Liberal Transfusion Strategies on Longer-term Outcomes After Cardiac Surgery

Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury

Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care

Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA

Review: Post-acute COVID-19 syndrome.

14 Mar, 2022 | 01:34h | UTC

Post-acute COVID-19 syndrome – European Respiratory Journal

ESCMID rapid guidelines for assessment and management of long COVID.

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

Practical, evidence-based approaches to nutritional modifications to reduce atherosclerotic cardiovascular disease.

14 Mar, 2022 | 01:25h | UTC

Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement – American Journal of Preventive Cardiology

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

14 Mar, 2022 | 01:31h | UTC

Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Long-Term Cannabis Use Associated With Cognitive Deficits in Midlife – Psychiatric News Alert

Systematic Review: Systemic interventions for treatment of Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.

14 Mar, 2022 | 01:20h | UTC

Systemic interventions for treatment of Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome – Cochrane Library

Summary: Which treatments that affect the whole body work best to treat severe skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis)? – Cochrane Library

Systematic Review: Point‐of‐care viral load tests to detect high HIV viral load in people living with HIV/AIDS attending health facilities.

14 Mar, 2022 | 01:19h | UTC

Point‐of‐care viral load tests to detect high HIV viral load in people living with HIV/AIDS attending health facilities – Cochrane Library

Summary: Point-of-care tests for detecting high viral load in people living with HIV attending healthcare facilities – Cochrane Library

Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.

14 Mar, 2022 | 01:04h | UTC

Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies – Intensive and Critical Care Nursing

RCT: Vortioxetine 5, 10, and 20 mg significantly reduces the risk of relapse compared with placebo in patients with remitted major depressive disorder.

14 Mar, 2022 | 01:03h | UTC

Vortioxetine 5, 10, and 20 mg significantly reduces the risk of relapse compared with placebo in patients with remitted major depressive disorder: The RESET study – Journal of Affective Disorders

Commentary on Twitter

RCT: In patients with remitted MDD with 10 mg/day of vortioxetine, time to relapse was longer and cumulative relapse rates were lower for vortioxetine 5 mg (19.3%), 10 mg (17.9%), and 20 mg (17.4%) versus placebo (32.5%) over 28 weeks (p<0.05 for all) https://t.co/LzwFaxVt4d pic.twitter.com/Gq3lLTtVcS

— P𝘧OL (@psychopharmacol) March 11, 2022

Review: Mycobacterial skin infection.

14 Mar, 2022 | 00:59h | UTC

Mycobacterial skin infection – Current Opinion in Infectious Diseases

Diagnostic test interpretation: cardiopulmonary exercise testing.

14 Mar, 2022 | 01:01h | UTC

Cardiopulmonary Exercise Testing – JAMA (free for a limited period)

RCT: Effectiveness of Fosfomycin for treating multidrug-resistant Escherichia coli bacteremic urinary tract infections.

14 Mar, 2022 | 00:53h | UTC

Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

The Role of Intravenous Fosfomycin: Finding Our Way Out of Dante’s Forest Dark – JAMA Network Open

Fosfomycin Not Noninferior to Comparators for Bacteremic UTI – HealthDay

‘Forgotten’ antibiotic recovered for resistant bacterial infections – University of Seville

Commentary on Twitter

In this RCT, fosfomycin did not demonstrate noninferiority in MDR-E coli bacteremic UTI, mostly due to adverse event-related withdrawals in mITT, but showed efficacy in per protocol analysis. #FORESTtrial @jesusrbano https://t.co/oiPtiQo2XA pic.twitter.com/Q44QQb18cN

— JAMA Network Open (@JAMANetworkOpen) January 13, 2022