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Infectious Diseases (all articles)

Review | Helicobacter pylori infection

2 May, 2023 | 13:37h | UTC

Helicobacter pylori infection – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Cohort Study | Infection-unrelated cancers are increasingly more common than infection-related cancers among individuals with HIV

2 May, 2023 | 13:32h | UTC

Age and Cancer Incidence in 5.2 Million People With Human Immunodeficiency Virus (HIV): The South African HIV Cancer Match Study – Clinical Infectious Diseases (free for a limited period)

Commentary: Infection-Unrelated Cancers Predominant Among Older Adults With HIV – Cancer Therapy Advisor

 

Commentary on Twitter

 

RCT | Molecular point-of-care testing for gastroenteritis reduced isolation time but increased antibiotic use

28 Apr, 2023 | 13:15h | UTC

Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial – The Lancet Infectious Diseases

Commentary: Molecular testing in suspected infectious diarrhoea—the value of negative results – The Lancet Infectious Diseases

 

M-A | Corticosteroids in community-acquired bacterial pneumonia

26 Apr, 2023 | 14:29h | UTC

Corticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis – Journal of General Internal Medicine (if the link is paywalled, try this one)

Related:

RCT | Hydrocortisone reduces mortality in severe community-acquired pneumonia

Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials – CHEST

Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review

ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia

 

M-A | Utility of differential time to positivity in diagnosing central line associated bloodstream infections

26 Apr, 2023 | 14:24h | UTC

Utility of Differential Time to Positivity in Diagnosing Central Line Associated Bloodstream Infections: A Systematic Review and Meta-Analysis – Clinical Infectious Diseases

 

Commentary on Twitter

 

Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people

26 Apr, 2023 | 14:11h | UTC

Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people – European Respiratory Review

 

M-A | Prevalence of atypical pathogens in patients with severe pneumonia

26 Apr, 2023 | 14:02h | UTC

Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis – BMJ Open

 

SR | Cranberries can prevent recurrent urinary tract infections in selected patients

25 Apr, 2023 | 14:41h | UTC

Cranberries for preventing urinary tract infections – Cochrane Library

Summary: Cranberries for preventing urinary tract infections – Cochrane Library

Commentaries:

Cranberry juice can prevent recurrent UTIs, but only for some people – The Conversation

Review confirms that cranberry products help prevent urinary tract infections – News Medical

 

Burden of typhoid and paratyphoid fever in India

25 Apr, 2023 | 14:32h | UTC

Burden of Typhoid and Paratyphoid Fever in India – New England Journal of Medicine

Related: The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Infectious Diseases

 

Commentary on Twitter

 

WHO releases first-ever Standard on universal access to rapid TB diagnostics

24 Apr, 2023 | 14:04h | UTC

News Release: WHO releases first-ever Standard on universal access to rapid TB diagnostics – World Health Organization

WHO Standard: Universal access to rapid tuberculosis diagnostics – World Health Organization

 

RCT | Oral fluvoxamine plus inhaled budesonide reduced hospitalizations in high-risk patients with early-onset COVID-19

24 Apr, 2023 | 13:51h | UTC

Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19: A Randomized Platform Trial – Annals of Internal Medicine

Commentary: Combination of fluvoxamine and inhaled budesonide reduces severe COVID-19 in high-risk outpatients – News Medical

 

Commentary on Twitter

 

RCT | Higher dose corticosteroids increase mortality in hypoxic COVID-19 patients on simple oxygen

24 Apr, 2023 | 13:55h | UTC

Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial – The Lancet

Editorial: Higher-dose dexamethasone for patients with COVID-19 and hypoxaemia? – The Lancet

Commentary: Higher-dose corticosteroids tied to 60% more deaths in low-oxygen COVID patients – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

RCT | Piperacillin-tazobactam better than cefoxitin in antimicrobial prophylaxis for open pancreatoduodenectomy

21 Apr, 2023 | 13:08h | UTC

Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Informing a Rational Approach to Antimicrobial Prophylaxis in Open Pancreatoduodenectomy – JAMA (free for a limited period)

 

Commentary on Twitter

 

M-A | Glucocorticoids may increase mortality for hospitalized Covid-19 patients not receiving oxygen

19 Apr, 2023 | 13:24h | UTC

Meta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen – NEJM Evidence

 

Commentary on Twitter (thread – click for more)

 

Opinion | Universal masking in health care settings: a pandemic strategy whose time has come and gone, for now

18 Apr, 2023 | 13:37h | UTC

Universal Masking in Health Care Settings: A Pandemic Strategy Whose Time Has Come and Gone, For Now – Annals of Internal Medicine

News Release: Healthcare epidemiologists and infectious diseases experts review changing context for masking in healthcare settings – Mass General Brigham

 

Opinion | In-person schooling is essential even during periods of high transmission of COVID-19

18 Apr, 2023 | 13:36h | UTC

In-person schooling is essential even during periods of high transmission of COVID-19 – BMJ Evidence-Based Medicine

 

Study shows approximately half of infectious diseases guideline authors have conflicts of interest with pharmaceutical companies

18 Apr, 2023 | 13:28h | UTC

Conflicts of Interest Among Infectious Diseases Clinical Practice Guideline Authors and the Pharmaceutical Industry – JAMA Network Open

 

Commonly encountered central nervous system infections in the intensive care unit

18 Apr, 2023 | 13:17h | UTC

Commonly encountered central nervous system infections in the intensive care unit – BJA Education

 

Podcast | Fungi fun! an in-depth look at tinea infections in children

18 Apr, 2023 | 13:14h | UTC

Fungi Fun! An In-Depth Look at Tinea Infections – The Cribsiders

 

Review | New antibiotics for Staphylococcus aureus infection

18 Apr, 2023 | 13:02h | UTC

New Antibiotics for Staphylococcus aureus Infection: An Update from the World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti-Infective Therapy (SITA) – Antibiotics

 

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

17 Apr, 2023 | 13:19h | UTC

Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)

Executive Summary: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)

 

Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals

17 Apr, 2023 | 13:17h | UTC

Strategies to prevent Clostridioides difficile infections in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

News Release: Updated guidance: Antimicrobial stewardship programs essential for preventing C. difficile in hospitals – Society for Healthcare Epidemiology of America

Commentary: New guidance deems antibiotic stewardship essential for preventing C diff infections – CIDRAP

 

Phase 2 RCT | High-dose VE303 reduces recurrent Clostridioides difficile infection rates

17 Apr, 2023 | 13:12h | UTC

VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

 

RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM

12 Apr, 2023 | 13:30h | UTC

Summary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.

Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline.  Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.

Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP

 

Commentary on Twitter

 

Perspective | Proposal of a model of care for outpatient antimicrobial therapy for infective endocarditis

12 Apr, 2023 | 13:08h | UTC

Outpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care – Antibiotics

 

Commentary on Twitter

 

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