Infectious Diseases (all articles)
RCT | In patients with rheumatoid arthritis, Tofacitinib is associated with increased risk of infections compared to TNF inhibitors.
1 Sep, 2022 | 11:50h | UTC
Commentary on Twitter
Check out our latest paper on infections in #rheumatoid #arthritis patients from the ORAL Surveillance trial:
▶️ tofacitinib lead to higher infection rates (serious and non-serious) vs TNFi
▶️ increased rates more pronounced in patients aged > 65🔗 https://t.co/3pVrnzzFWD pic.twitter.com/Kf7p6D0jBD
— Annals of the Rheumatic Diseases (@eular_ARD) August 11, 2022
Study Commentary | Zinc for the prevention or treatment of respiratory tract infections: a new systematic review.
1 Sep, 2022 | 11:46h | UTC
Study shows dentists should give antibiotics to high-risk patients to help prevent infectious endocarditis.
1 Sep, 2022 | 11:43h | UTCOriginal Study: Antibiotic Prophylaxis Against Infective Endocarditis Before Invasive Dental Procedures – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: UK dentists should give antibiotics to patients at risk of heart infection – study – The Guardian
Meta-analysis of randomized trials | Antibiotic therapy vs. appendicectomy for uncomplicated acute appendicitis.
1 Sep, 2022 | 11:40h | UTCRelated:
Review: Diagnosis of uncomplicated and complicated appendicitis in adults.
A Randomized trial comparing antibiotics with appendectomy for appendicitis
Commentary on Twitter
👼 The reborn of surgery for uncomplicated acute appendicitis ?!
🧐 RCT comparing antibiotic 🤜🤛 appendicectomy: meta analysis of > 3000 patients
💊 No benefit on complications and LOS
🏥 Antibiotics 6X increase in hospital readmission!
🆓 full text https://t.co/VhL9u0Weua pic.twitter.com/SdyK0rKS3f
— Giovanni Marchegiani (@Gio_Marchegiani) August 17, 2022
RCT | Outpatient convalescent plasma therapy for high-risk patients with early COVID-19.
31 Aug, 2022 | 11:48h | UTC
Meta-analysis of randomized trials | Efficacy and safety of Plazomicin in the treatment of Enterobacterales infections.
31 Aug, 2022 | 11:39h | UTC
#ESCCongress | In critically ill patients with COVID-19, full-dose anticoagulation reduced thrombotic events but increased the risk of bleeding.
30 Aug, 2022 | 12:12h | UTCNews Release: Trial supports full-dose anticoagulation to prevent blood clots in COVID-19 patients – European Society of Cardiology
Related:
Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library
Commentary on Twitter
#OriginalResearch SimPub #ESCCongress: In the #COVID-PACT 2×2 factorial RCT, full-dose prophylactic anticoagulation, but not the addition of clopidogrel, reduced thrombotic complications but w/ increased bleeding among critically-ill patients w/ COVID-19 https://t.co/UNxFCIC5B9 pic.twitter.com/p5LGmpCGeL
— Circulation (@CircAHA) August 29, 2022
M-A | Adverse pregnancy and birth outcomes associated with Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum.
29 Aug, 2022 | 12:06h | UTC
M-A | Risk of hepatitis C virus infection associated with hospital-based invasive procedures.
29 Aug, 2022 | 12:00h | UTC
Perpetual Observational Studies | New strategies to support efficient implementation of observational studies and randomized trials in infectious diseases.
26 Aug, 2022 | 13:17h | UTC
Retrospective Cohort Study | Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge.
25 Aug, 2022 | 12:08h | UTC
Commentary on Twitter
During the clinical rollout of nirmatrelvir in Israel in early 2022, most patients (78%) had previous SARS-CoV-2 immunity. Benefit was seen among patients at highest risk for Covid-19 progression, such as those 65+. https://t.co/O6CxzDdIfH pic.twitter.com/ccCaCCh15i
— NEJM (@NEJM) August 24, 2022
Retrospective Cohort Study | Clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.
24 Aug, 2022 | 14:17h | UTC
Commentary on Twitter
Ambulatory #COVID19 was associated with a substantially increased risk of incident venous thromboembolism, but this risk was greatly reduced in fully vaccinated people with breakthrough infection. https://t.co/98zKNfEWaU #Research
— JAMA Internal Medicine (@JAMAInternalMed) August 18, 2022
Monkeypox: a clinical update for pediatricians.
24 Aug, 2022 | 14:19h | UTCMonkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health
Related:
CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.
Update on the Monkeypox Outbreak – JAMA
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Retrospective Cohort Study | Association of COVID-19 vs. Influenza with risk of arterial and venous thrombotic events among hospitalized patients.
24 Aug, 2022 | 14:16h | UTCCommentary: Higher risk of vein blood clots in COVID vs flu patients – CIDRAP
News Release: People with Severe COVID-19 Face Increased Risk of Life-Threatening Blood Clots – Penn Medicine News
Commentary on Twitter
The risk of blood clots in hospitalized patients with Covid vs influenza was increased 60-90% within 90 days, for venous but not arterial thrombosishttps://t.co/wPHf18NYYB @JAMA_current
Retrospective, much smaller influenza cohort from 2018-2019 pic.twitter.com/sClYHF0J6U— Eric Topol (@EricTopol) August 16, 2022
Cluster RCT | Effect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients.
24 Aug, 2022 | 14:02h | UTCEffect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients: a cluster-randomized controlled trial – Clinical Microbiology and Infection (link to abstract – $ for full-text)
Commentary on Twitter
Antiseptic bathing for CLABSI prevention:
SW-RCT incl 72 ICUs with 76,815 showed no significant differences between daily bathing with a) 2% chlorhexidine-impregnated cloths vs b) 0.08% octenidine vs c) water & soap in CLAPSI
Thanks to @CritCareReviews https://t.co/Ou3g3ptMLp— Peter Nydahl (@NydahlPeter) May 30, 2022
Cluster RCT | Effect of biannual mass azithromycin distributions to preschool-aged children on trachoma prevalence.
24 Aug, 2022 | 13:55h | UTC
Commentary on Twitter
Cluster-randomized trial in trachoma-hypoendemic region of Niger mass azithromycin distributions targeted to pre-school children did not reduce trachoma. #OAResearch https://t.co/G7rfZShdz7 pic.twitter.com/UGUlc0x8G8
— JAMA Network Open (@JAMANetworkOpen) August 23, 2022
Long-term follow up of a RCT | Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine.
24 Aug, 2022 | 13:53h | UTCPrecancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
Virological replacement & clinical unmasking are two phenomena of interest following #HPVvaccination. We show that clinical unmasking might attenuate long-term reductions in cervical precancer following successful implementation of HPV vax programs in highly screened populations https://t.co/Z7dGQNG1kG
— Monica Sierra (@MonicaSSierra) June 14, 2022
Updated systematic review and critical appraisal: prediction models for diagnosis and prognosis of covid-19.
23 Aug, 2022 | 13:31h | UTCCommentary: Update to living systematic review on prediction models for diagnosis and prognosis of covid-19 – The BMJ
Commentary on Twitter
NEW update in @bmj_latest
606 prognostic models for #COVID19 identified – 29 had low risk of bias, 32 had unclear risk of bias, AND 545 HAD HIGH RISK OF BIAS!
+Poorly reported – use TRIPOD please https://t.co/tVA0xHXdRu#epitwitter #statstwitter pic.twitter.com/n71vdgY8wM
— Gary Collins 🇪🇺 (@GSCollins) August 22, 2022
Study Commentary | Non-sterile gloves for suturing traumatic lacerations?
23 Aug, 2022 | 13:29h | UTCNon-Sterile Gloves for Suturing Traumatic Lacerations? – RebelEM
Original Study: Non-sterile gloves and dressing versus sterile gloves, dressings and drapes for suturing of traumatic wounds in the emergency department: a non-inferiority multicentre randomised controlled trial – Emergency Medicine Journal (link to abstract – $ for full-text)
Risk of myocarditis after sequential doses of COVID-19 vaccine vs. after SARS-CoV-2 infection by age and sex.
23 Aug, 2022 | 13:25h | UTCNews Release: Myocarditis risk significantly higher after COVID-19 infection vs. after a COVID-19 vaccine – Circulation
M-A | Incidence and mortality of non-AIDS-defining cancers among people living with HIV.
23 Aug, 2022 | 13:26h | UTCRelated: Study: Cancer Patients with HIV Infection Have Worse Outcomes
M-A | Incubation period of COVID-19 caused by unique SARS-CoV-2 strains.
23 Aug, 2022 | 13:24h | UTC
Review | The role of abdominal drain cultures in managing abdominal infections.
23 Aug, 2022 | 12:48h | UTCThe Role of Abdominal Drain Cultures in Managing Abdominal Infections – Antibiotics
Review | Drug regimens of novel antibiotics in critically ill patients with varying renal functions.
23 Aug, 2022 | 12:49h | UTC
WHO makes new recommendations for Ebola treatments, calls for improved access.
22 Aug, 2022 | 12:26h | UTCNews Release: WHO makes new recommendations for Ebola treatments, calls for improved access – World Health Organization
Guideline: Therapeutics for Ebola virus disease – World Health Organization
Commentary on Twitter (thread – click for more)
WHO publishes its first guideline for #Ebola virus disease therapeutics: recommends the use of two monoclonal antibodies.
WHO calls on the global community to increase access to these lifesaving medicines.
📌 https://t.co/tstO3pBYlf pic.twitter.com/ZrDg43TyL2
— World Health Organization (WHO) (@WHO) August 19, 2022