Covid-19
Cohort Study: Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia – “Bacterial superinfection within 48 hours of intubation was detected in 21 percent of patients”.
26 Oct, 2021 | 01:59h | UTC
Commentary on Twitter
Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia
🔓 Open Access
🔗 https://t.co/MaCZkKrQdQ pic.twitter.com/sscICvqYjS— ATS Blue Journal (@ATSBlueEditor) October 19, 2021
COVID: how worried should we be about the new AY.4.2 lineage of the coronavirus?
26 Oct, 2021 | 02:01h | UTCCOVID: how worried should we be about the new AY.4.2 lineage of the coronavirus? – The Conversation
What It Means To Be Fully Vaccinated.
26 Oct, 2021 | 01:57h | UTCWhat It Means To Be Fully Vaccinated – Think Global Health
Opinion | COVID STEROID-2: Double the steroid, double the fun? – “Dexamethasone 6 mg/day alone is likely suboptimal for most patients with severe COVID pneumonia. Dexamethasone 12 mg/day may provide a reasonable intensity of immunomodulation”.
25 Oct, 2021 | 00:01h | UTCCOVID STEROID-2: Double the steroid, double the fun? – PulmCrit
Commentary on Twitter
COVID-STEROID 2
🥈5% lower mortality with 12 mg dexamethasone (vs 6 mg) – which is *huge* – but p=0.09 😩
🥈RCTs with toci/bari show that 6 mg dex alone is suboptimal.
🥈If using dex monotherapy, 12 mg is now a sensible dose for sicker pts.
Fresh blog: https://t.co/oPz7vAYHGN pic.twitter.com/diDqqUxSTC— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) October 23, 2021
Review: Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?
25 Oct, 2021 | 00:03h | UTC
Commentary on Twitter
New on our #COVID19 resource centre—Personal View: Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?
Read in @LancetRespirMed: https://t.co/ZOTgVQYd6w pic.twitter.com/7BwRPLzsib
— The Lancet (@TheLancet) October 23, 2021
Half doses, third doses, kids’ doses: Covid vaccine delivery goes next-level difficult.
24 Oct, 2021 | 23:52h | UTCHalf doses, third doses, kids’ doses: Covid vaccine delivery goes next-level difficult – STAT
Review: Cardiac involvement in the long-term implications of COVID-19.
24 Oct, 2021 | 23:59h | UTCCardiac involvement in the long-term implications of COVID-19 – Nature Reviews Cardiology
How you’ll know when Covid-19 has gone from “pandemic” to “endemic”.
24 Oct, 2021 | 23:53h | UTCHow you’ll know when Covid-19 has gone from “pandemic” to “endemic” – Vox
AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.
24 Oct, 2021 | 23:58h | UTCFertility rates and birth outcomes after ChAdOx1 nCoV-19 (AZD1222) vaccination – The Lancet
Related:
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter
New research letter: Fertility rates and birth outcomes after ChAdOx1 nCoV-19 (AZD1222) vaccination. Authors analysed pregnancies occurring in four ongoing clinical trials in the UK, Brazil, and South Africa. https://t.co/hDM1olKts9@OxfordVacGroup | #COVID19 #AstraZeneca pic.twitter.com/m5qvWhPcph
— The Lancet (@TheLancet) October 23, 2021
Coronavirus: Chinese residents start receiving vaccine boosters.
24 Oct, 2021 | 23:51h | UTCCoronavirus: Chinese residents start receiving vaccine boosters – South China Morning Post
2021 Interim Guidance to Health Care Providers for Basic and Advanced Cardiac Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19.
24 Oct, 2021 | 23:49h | UTCCommentary: CPR on a COVID Patient: Not a Moment to Waste Looking for PPE: Updated AHA guidance says resuscitation should not be delayed by mask availability – MedPage Today (free registration required)
Commentary on Twitter (thread – click for more)
(1/2) NEW! The AHA has published its 2021 interim CPR guidance for #HCPs who treat cardiac arrest patients with suspected or confirmed #COVID19. The paper in @CircOutcomes is an update to the 2020 Interim CPR Guidance: https://t.co/tuTwWkE0dL. pic.twitter.com/B1el7dCKJM
— AHA CPR & First Aid (@HeartCPR) October 13, 2021
Perspective | The flawed science of antibody testing for SARS-CoV-2 immunity.
22 Oct, 2021 | 10:30h | UTCThe Flawed Science of Antibody Testing for SARS-CoV-2 Immunity – JAMA
[Press release – not published yet] A phase 3 trial with more than 10,000 participants showed a booster dose of the Pfizer/BioNTech vaccine had an efficacy of 95.6% against disease; there were 5 cases in the booster group and 109 cases in the non-boosted group, not classified according to severity.
22 Oct, 2021 | 10:34h | UTC
Commentaries on Twitter
This will presumably mean everyone gets boosters early next year. That’s great, because they do work. Except it’s likely to be boosters for rich countries at the expense of primary vaccination for poorer countries. You won’t stop the pandemic when half the world is unvaccinated https://t.co/F31DMSI2zf
— Niall Conroy (@NICU_doc_salone) October 21, 2021
The 1st randomized trial of a booster (3rd) shot in 10,000 people, placebo-controlled, shows 95.6% efficacy, with 5 cases (Pfizer vaccine) vs 109 in placebo group, Delta variant, broad benefit across age groups https://t.co/TQpF35d8Jk pic.twitter.com/3RkqvXNfsU
— Eric Topol (@EricTopol) October 21, 2021
WHO estimates that between 80 000 to 180 000 health and care workers could have died from Covid-19.
22 Oct, 2021 | 10:29h | UTCNews release: WHO and partners call for action to better protect health and care workers from COVID-19 – World Health Organization
WHO Statement: joint statement on WHO’s estimates of health and care worker deaths due to covid-19
Commentaries:
WHO calls for health worker protection against COVID-19 – CIDRAP
Covid may have killed up to 180,000 health workers globally, WHO says – The Guardian
Commentary on Twitter
.@WHO estimates 115,000 health workers have died from #Covid19. Huge, tragic loss.
And while some health workers in the US are QUITTING jobs because they don't want to be vaccinated, many HCWs around the world are still waiting for vaccine. Unconscionable. https://t.co/z4u9XSX2Wj— Helen Branswell 🇨🇦 (@HelenBranswell) October 21, 2021
Vaccine apartheid: This is not the way to end the pandemic.
22 Oct, 2021 | 10:26h | UTCVaccine apartheid: This is not the way to end the pandemic – Journal of Paediatrics and Child Health
Commentary on Twitter
Vaccine apartheid is devastating, especially for children@VSLanziotti @yoncabulutmd @surf4children @sgdambrauskas call for everyone to advocate for vaccine equity https://t.co/jzJd9kwcCi pic.twitter.com/0hEPk8B4xv
— Madhu Pai, MD, PhD (@paimadhu) October 21, 2021
RCT: In adults with Covid-19 and severe hypoxemia, 12 mg vs. 6 mg of Dexamethasone did not result in a statistically significant difference in the number of days alive without life support.
22 Oct, 2021 | 10:32h | UTCEditorial: Glucocorticoid Dose in COVID-19: Lessons for Clinical Trials During a Pandemic – JAMA
Commentary on Twitter
In a randomized trial of patients with #COVID19 and severe hypoxemia, compared with 6 mg of dexamethasone, 12 mg of dexamethasone did not statistically significantly reduce the number of days alive without life support at 28 days https://t.co/BMgLTel4aU pic.twitter.com/WKwI8xCUYO
— JAMA (@JAMA_current) October 21, 2021
Opinion | Politics is derailing a crucial debate over the immunity you get from recovering from Covid-19.
22 Oct, 2021 | 10:22h | UTC
M-A: Risk factors for poor prognosis in children and adolescents with COVID-19.
22 Oct, 2021 | 10:24h | UTC
An analysis of Scotland’s mortality in 114,000 SARS-CoV2–infected people revealed that the vaccine effectiveness against death from the Delta variant was 90% for the Pfizer vaccine and 91% for AstraZeneca.
21 Oct, 2021 | 10:15h | UTC
Pfizer vaccine showed estimated effectiveness of 93% against symptomatic SARS-CoV-2 Delta variant infection in adolescents.
21 Oct, 2021 | 10:17h | UTC
Commentary on Twitter
The remarkably high effectiveness (VE) of vaccination for teens vs the Delta variant in over 94,000 vaccinees and 94,000 matched controls: 93% VE vs symptomatic infection (95% CI 88,97) https://t.co/wwoXlw7PH9@NEJM pic.twitter.com/8m3fJ7avc5
— Eric Topol (@EricTopol) October 20, 2021
A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.
21 Oct, 2021 | 10:14h | UTCRelated:
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
FDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK.
21 Oct, 2021 | 10:09h | UTCFDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK – CNN
See also:
FDA OKs mixing COVID vaccines; backs Moderna, J&J boosters – Associated Press
FDA OKs Moderna, J&J boosters, along with ‘mix and match’ approach – NBC News
COVID-19 pneumonia: pathophysiology and management.
21 Oct, 2021 | 10:12h | UTCCOVID-19 pneumonia: pathophysiology and management – European Respiratory Review
Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay.
21 Oct, 2021 | 10:08h | UTCInstead of quarantine for Covid-exposed students, some schools are trying test-to-stay – CNN
Related:
Opinion | Data from routine Covid testing can help schools stay open this year.
CDC Study: Pfizer vaccine showed 93% effectiveness against Covid-19 hospitalization among children aged 12-18 years.
20 Oct, 2021 | 10:31h | UTC
Commentary on Twitter (thread – click for more)
Vaccination reduced the risk of hospitalization among 12–18-year-olds by 93%, according to a new CDC study. No vaccinated adolescents died or were admitted to the ICU.
— Dr. Tom Frieden (@DrTomFrieden) October 19, 2021