Covid-19
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
29 Oct, 2021 | 10:20h | UTCRelated:
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
The effectiveness of the AstraZeneca vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo was 77.9% against symptomatic Covid-19, 87.6% against hospitalization, and 93.6% against death.
29 Oct, 2021 | 10:25h | UTC
Commentary on Twitter (thread – click for more)
Effectiveness of Oxford-AstraZeneca COVID-19 vaccine by dose in over 60s in São Paulo state, published today in @NatureComms with @juliocroda @otavio_ranzani @datcummings as part of the VEBRA COVID-19 group 1/8https://t.co/zIbPb45nEJ
— Matt Hitchings (@MHitchingsEpi) October 28, 2021
Under-reporting of deaths limits our understanding of true burden of covid-19.
29 Oct, 2021 | 10:18h | UTCUnder-reporting of deaths limits our understanding of true burden of covid-19 – The BMJ
Related:
Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.
Just how do deaths due to COVID-19 stack up?
Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter
Mortality data have been essential in understanding the spread of covid-19 and navigating the trade-offs that underlie political decision making, yet under-reporting in official death records has greatly obscured this understanding.
What should be done?https://t.co/pI8aVpa3NR
— The BMJ (@bmj_latest) October 14, 2021
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
29 Oct, 2021 | 10:16h | UTCmRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern – Science
Commentary from the author on Twitter (thread – click for more)
Antibodies come and go, but memory cells are forever (maybe not forever, but at least 6 months). Our latest in @ScienceMagazine: https://t.co/YHHBMrMsTA
How long does immune memory last after #mRNA vax? Is it effective vs. variants? What about “boosted” responses?
Full ?⬇️… pic.twitter.com/oZ5BxLuVdw
— Rishi Goel (@rishirajgoel) October 14, 2021
Nine Pandemic Words That Almost No One Gets Right.
29 Oct, 2021 | 10:12h | UTCNine Pandemic Words That Almost No One Gets Right – The Atlantic
RCT: Early treatment of Covid-19 with SARS-CoV-2 neutralizing antibody Sotrovimab is associated with reduced risk of hospitalization.
28 Oct, 2021 | 10:20h | UTC
Commentary on Twitter
In this phase 3 trial, sotrovimab or placebo was administered to outpatients within 5 days after the onset of #COVID19 symptoms. Patients receiving sotrovimab had a lower incidence of hospitalization for any reason. #IDTwitter https://t.co/4VcgoK3xac pic.twitter.com/W82v3jNRmB
— NEJM (@NEJM) October 27, 2021
Merck to allow other nations to produce new COVID-19 antiviral.
28 Oct, 2021 | 10:18h | UTCMerck to allow other nations to produce new COVID-19 antiviral – CIDRAP
See also:
Merck will allow drugmakers in other countries to make its COVID-19 pill – NPR
Related:
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.
28 Oct, 2021 | 10:22h | UTCCommentaries:
The TOGETHER Trial: COVID-19 and Fluvoxamine Take Two – REBEL EM
The antidepressant fluvoxamine can keep COVID-19 patients out of the hospital – ScienceNews
Related:
Commentary on Twitter
NEW in @LancetGH: Using SSRI #fluvoxamine to treat high-risk outpatients with early-diagnosed #COVID19 reduced the need for prolonged observation in an emergency setting or hospitalisation: largest trial to date. https://t.co/BVtMju74lp @TogetherTrial pic.twitter.com/F1FnZuyqdY
— The Lancet (@TheLancet) October 27, 2021
Two observational studies cast doubt on the effects of school closures to reduce the spread of Covid-19.
28 Oct, 2021 | 10:17h | UTCStudy 2: The impact of school opening model on SARS-CoV-2 community incidence and mortality – Nature Medicine
Commentaries on Twitter
Results from a study in the US published in @NatureMedicine indicate that schools can reopen for in-person learning without substantially increasing community case rates of SARS-CoV-2. However, the impacts are variable and more study is needed. https://t.co/NFt1vNNb76 pic.twitter.com/fNgsJn6WLg
— Nature Portfolio (@NaturePortfolio) October 27, 2021
(thread – click for more)
2 new @NatureMedicine papers
First from half of US public school data
"Schools can open for in-person learning during the pandemic with minimal contribution to sustained community incidence of infections, provided other public safety measures are adopted."https://t.co/gn8MzrYVxE pic.twitter.com/qGfQLMzDEW— Eric Topol (@EricTopol) October 27, 2021
Brain fog can persist for months after COVID diagnosis.
28 Oct, 2021 | 10:13h | UTCAssessment of Cognitive Function in Patients After COVID-19 Infection – JAMA Network Open
Commentaries:
Brain fog can persist 8 months after COVID diagnosis – CIDRAP
What COVID vaccines for young kids could mean for the pandemic.
28 Oct, 2021 | 10:15h | UTCWhat COVID vaccines for young kids could mean for the pandemic – Nature
Related: FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
Breakthrough infections occur in those with lower antibody levels.
27 Oct, 2021 | 01:45h | UTCOriginal study: Covid-19 Breakthrough Infections in Vaccinated Health Care Workers – New England Journal of Medicine
FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
27 Oct, 2021 | 01:48h | UTCFDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children – STAT
See also:
Tracking the FDA advisory panel meeting on Covid-19 vaccines for kids – STAT
FDA advisory panel recommends Pfizer vaccine for kids ages 5 to 11 – NPR
Mix-and-match COVID vaccines ace the effectiveness test – “No need for brand loyalty”.
27 Oct, 2021 | 01:42h | UTCMix-and-match COVID vaccines ace the effectiveness test – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Heterologous AstraZeneca/Pfizer vaccination seems to be associated with increased effectiveness against Covid-19 compared to homologous Pfizer/Pfizer vaccination.
27 Oct, 2021 | 01:44h | UTCImmunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
A dose of the AstraZeneca COVID-19 vaccine followed by a dose of the Pfizer/BioNTech vaccine confers better protection against SARS-CoV-2 infection than two doses of the Pfizer vaccine, according to a study in healthcare workers published in @Nature. https://t.co/6hIVkiOLQ1 pic.twitter.com/AmsyVUMpoj
— Nature Portfolio (@NaturePortfolio) October 26, 2021
What game theory can teach us about controlling pandemics.
27 Oct, 2021 | 01:39h | UTCWhat game theory can teach us about controlling pandemics – The BMJ Opinion
Commentary on Twitter
Sorry but panvax is just covax with money and better/early contracts – What game theory can teach us about controlling pandemics – The BMJ https://t.co/bZyhfxCkP3
— Amanda Glassman (@glassmanamanda) October 22, 2021
COVID super-immunity: one of the pandemic’s great puzzles – “People who have previously recovered from COVID-19 have a stronger immune response after being vaccinated than those who have never been infected. Scientists are trying to find out why”.
27 Oct, 2021 | 01:41h | UTCCOVID super-immunity: one of the pandemic’s great puzzles – Nature
Systematic Review: Antibiotics for the treatment of COVID‐19 – “We are certain that risk of death in hospitalized COVID‐19 patients is not reduced by treatment with azithromycin after 28 days”.
26 Oct, 2021 | 02:07h | UTCAntibiotics for the treatment of COVID‐19 – Cochrane Library
Commentary on Twitter
JUST PUBLISHED – Are #antibiotics an effective treatment for #COVID19 & do they cause unwanted effects? https://t.co/EVHduxmtdD New Cochrane Review looked at evidence from 11 studies: ❌ antibiotic azithromycin is not an effective treatment, ?not enough research on other types.
— The Cochrane Library (@CochraneLibrary) October 22, 2021
[Press release – not published yet] Moderna says its COVID vaccine produced a strong antibody response for kids 6 to 11.
26 Oct, 2021 | 02:06h | UTCPress release: Moderna Announces Positive Top Line Data from Phase 2/3 Study of COVID-19 Vaccine in Children 6 to 11 Years of Age
Commentary: Moderna says new data supports its COVID vaccine for kids 6 to 11 – NPR
Case Series: Toxic effects from ivermectin use associated with prevention and treatment of Covid-19.
26 Oct, 2021 | 02:02h | UTC
Infection with Covid-19 carries a much higher risk of developing neurological complications than Covid-19 vaccines.
26 Oct, 2021 | 02:04h | UTCOriginal Study: Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection – Nature Medicine
Commentaries:
Covid: Vaccine study links virus to rare neurological illness – BBC
Commentary on Twitter
A study in @NatureMedicine finds there is an increased risk of neurological complications in those who received COVID-19 vaccines, but the risk of these complications is greater following a positive SARS-CoV-2 test. https://t.co/WKnFa9InbL pic.twitter.com/xir6U3JhL8
— Nature Portfolio (@NaturePortfolio) October 25, 2021
Cohort Study: Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia – “Bacterial superinfection within 48 hours of intubation was detected in 21 percent of patients”.
26 Oct, 2021 | 01:59h | UTC
Commentary on Twitter
Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia
? Open Access
? https://t.co/MaCZkKrQdQ pic.twitter.com/sscICvqYjS— ATS Blue Journal (@ATSBlueEditor) October 19, 2021
COVID: how worried should we be about the new AY.4.2 lineage of the coronavirus?
26 Oct, 2021 | 02:01h | UTCCOVID: how worried should we be about the new AY.4.2 lineage of the coronavirus? – The Conversation
What It Means To Be Fully Vaccinated.
26 Oct, 2021 | 01:57h | UTCWhat It Means To Be Fully Vaccinated – Think Global Health
Opinion | COVID STEROID-2: Double the steroid, double the fun? – “Dexamethasone 6 mg/day alone is likely suboptimal for most patients with severe COVID pneumonia. Dexamethasone 12 mg/day may provide a reasonable intensity of immunomodulation”.
25 Oct, 2021 | 00:01h | UTCCOVID STEROID-2: Double the steroid, double the fun? – PulmCrit
Commentary on Twitter
COVID-STEROID 2
?5% lower mortality with 12 mg dexamethasone (vs 6 mg) – which is *huge* – but p=0.09 ?
?RCTs with toci/bari show that 6 mg dex alone is suboptimal.
?If using dex monotherapy, 12 mg is now a sensible dose for sicker pts.
Fresh blog: https://t.co/oPz7vAYHGN pic.twitter.com/diDqqUxSTC— ???? ?????? ? (@PulmCrit) October 23, 2021