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Covid-19

Germany offers booster shots to everyone amid ‘very worrying’ surge in cases.

7 Nov, 2021 | 20:22h | UTC

Germany offers booster shots to everyone amid ‘very worrying’ surge in cases – CNN

 

Study compares the decline in effectiveness for Moderna, Pfizer, and Janssen vaccines and consequences for mortality.

5 Nov, 2021 | 09:59h | UTC

Original study: SARS-CoV-2 vaccine protection and deaths among US veterans during 2021 – Science

News release: Breakthrough Infection Study Compares Decline in Vaccine Effectiveness and Consequences for Mortality – Public Health Institute

 

Commentary on Twitter

 

Review: SARS-CoV-2 indoor air transmission is a threat that can be addressed with science.

5 Nov, 2021 | 09:55h | UTC

SARS-CoV-2 indoor air transmission is a threat that can be addressed with science – Proceedings of the National Academies of Sciences

Related:

Ten scientific reasons in support of airborne transmission of SARS-CoV-2

Editorial: Covid-19 has redefined airborne transmission

Covid-19: What do we know about airborne transmission of SARS-CoV-2?

Real-world data show that filters clean COVID-causing virus from air.

Perspective | The plan to stop every respiratory virus at once – “The benefits of ventilation reach far beyond the coronavirus. What if we stop taking colds and flus for granted, too?”

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.

Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers.

WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19

CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk

Guidance: Using Ventilation and filtration to reduce aerosol transmission of COVID-19 in long-term care homes

It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols.

 

Commentary on Twitter

 

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

5 Nov, 2021 | 09:56h | UTC

Effects of covid-19 pandemic on life expectancy and premature mortality in 2020: time series analysis in 37 countries – The BMJ

Related:

Global Covid-19 deaths surpass five million.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary from the author on Twitter (thread – click for more)

 

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

5 Nov, 2021 | 09:51h | UTC

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first – NPR

Related:

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

Debate: Are vaccine passports and covid passes a valid alternative to lockdown?

5 Nov, 2021 | 09:53h | UTC

Are vaccine passports and covid passes a valid alternative to lockdown? – The BMJ

News Release: Covid passes: the best way of preventing another lockdown or a threat to civil freedoms and rights? – BMJ

 

Observational study showed J&J single shot vaccine had an effectiveness of 74% against symptomatic Covid-19.

4 Nov, 2021 | 10:08h | UTC

Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19 – JAMA Network Open

Commentaries:

Single-Dose Ad26.COV2.S Vaccine—Room for Improvement – JAMA Network Open

Real-world study shows J&J COVID-19 vaccine 74% effective – CIDRAP

Related:

J&J COVID-19 Vaccine: FDA recommends booster shot for all adults aged 18 and older at least two months following initial vaccination with the single-shot vaccine.

[Press release – not published yet] J&J says booster shot at two months provided 75% protection against moderate to severe COVID-19 globally and 94% of such cases in the U.S.

CDC Report: Moderna’s vaccine associated with greater effectiveness (93%) against Covid-19 hospitalization compared to Pfizer (88%) and J&J (71%) vaccines.

[Preprint] Observational study finds single-dose Johnson & Johnson vaccine is 76.7% effective in preventing SARS-CoV-2 infection

RCT: Single-Dose Johnson & Johnson Vaccine has 85% efficacy against severe/critical Covid-19 and maintains efficacy against variant B.1.351

 

WHO issues emergency use approval for India’s Covaxin.

4 Nov, 2021 | 10:11h | UTC

WHO issues emergency use listing for eighth COVID-19 vaccine – World Health Organization

Commentaries:

WHO Gives India’s Covaxin Approval, Opening the Door to COVAX distribution – Health Policy Watch

WHO green-lights India’s COVID vaccine as global cases rise – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

CDC Guidance: Immunocompromised may need a fourth Covid-19 shot.

4 Nov, 2021 | 10:06h | UTC

Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States – Centers for Disease Control and Prevention

Commentaries:

Immunocompromised may need a fourth Covid-19 shot, CDC says – CNN

Some immunocompromised people can receive a 4th Covid shot, CDC says – NBC News

 

Ten Things to Know About Multisystem Inflammatory Syndrome in Children (MIS-C).

4 Nov, 2021 | 10:00h | UTC

Ten Things to Know About MIS-C – American College of Cardiology

Related:

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

 

ASH Guideline issued a conditional recommendation against routine use of outpatient anticoagulant prophylaxis in patients with COVID-19 being discharged from the hospital.

4 Nov, 2021 | 10:03h | UTC

American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: July 2021 update on post-discharge thromboprophylaxis – Blood Advances

 

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.

3 Nov, 2021 | 10:09h | UTC

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm – The Lancet Infectious Diseases

Related:

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

CDC advisers endorse Pfizer’s Covid-19 vaccine for kids 5-11.

3 Nov, 2021 | 10:11h | UTC

ACIP Presentation Slides: November 2-3, 2021 Meeting – Centers for Disease Control and Prevention

Commentaries:

CDC advisors give go-ahead to COVID-19 vaccines for young kids – CIDRAP

CDC advisers endorse Pfizer’s Covid-19 vaccine for kids 5-11 – STAT

American Academy of Pediatrics Applauds CDC Advisory Committee’s Approval of Safe, Effective COVID-19 Vaccine for Children Ages 5-11

 

Adolescents’ recreational screen time doubled during pandemic, affecting mental health.

3 Nov, 2021 | 10:06h | UTC

News release: Adolescents’ recreational screen time doubled during pandemic, affecting mental health – University of California, San Francisco

Original Study: Screen Time Use Among US Adolescents During the COVID-19 Pandemic: Findings From the Adolescent Brain Cognitive Development (ABCD) Study – JAMA Pediatrics

Commentary: Kids nearly doubled screen time during the pandemic, but there is something you can do about it – CNN

 

Commentary from the author on Twitter

 

Short Review: Cardiac injury in Covid-19.

3 Nov, 2021 | 10:04h | UTC

Cardiac injury in COVID-19 – Intensive Care Medicine

 

Commentary on Twitter

 

Review: The role of chest imaging in the diagnosis, management, and monitoring of Covid-19.

3 Nov, 2021 | 10:05h | UTC

The role of chest imaging in the diagnosis, management, and monitoring of coronavirus disease 2019 (COVID-19) – Insights into Imaging

 

Global Covid-19 deaths surpass five million.

2 Nov, 2021 | 02:59h | UTC

Global Covid-19 deaths surpass five million – CNN

See also:

The COVID-19 pandemic has now killed 5 million people around the world – NPR

G20 leaders back COVID measures as deaths top 5 million – CIDRAP

Covid-19 deaths pass five million worldwide – BBC

Related:

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary on Twitter

 

In Covid-19 vaccinated people, those with prior infection are likely to have more antibodies.

2 Nov, 2021 | 03:03h | UTC

News release: In Covid-19 Vaccinated People, Those with Prior Infection Likely to Have More Antibodies – Johns Hopkins Medicine

Original Article: Durability of Antibody Levels After Vaccination With mRNA SARS-CoV-2 Vaccine in Individuals With or Without Prior Infection – JAMA

 

J&J Covid-19 vaccination is associated with increased risk of cerebral venous sinus thrombosis.

2 Nov, 2021 | 03:02h | UTC

Age- and Sex-Specific Incidence of Cerebral Venous Sinus Thrombosis Associated With Ad26.COV2.S COVID-19 Vaccination – JAMA

Commentary: Cerebral Venous Sinus Thrombosis Rate Up After Ad26.COV2.S Shot – HealthDay

 

Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States.

2 Nov, 2021 | 02:58h | UTC

Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States – Pediatrics

Related:

Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience – “Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza”.

Deaths from COVID ‘incredibly rare’ among children.

[Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.

 

Observational study suggests a third dose of the Pfizer COVID-19 vaccine can prevent severe COVID-19-related outcomes, compared with only two doses received at least 5 months before.

31 Oct, 2021 | 20:14h | UTC

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study – The Lancet

Invited Commentary: Boosters appear effective, but are they always needed? – The Lancet

 

Commentaries on Twitter

 

Study shows fully vaccinated individuals can still catch SARS-CoV-2 delta variant and efficiently transmit infection in household settings, including to fully vaccinated contacts.

31 Oct, 2021 | 20:16h | UTC

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study – The Lancet Infectious Diseases

Commentaries:

COVID vaccines effective but household transmission of delta a risk for 1 in 4 – Imperial College London

What is the vaccine effect on reducing transmission in the context of the SARS-CoV-2 delta variant? – The Lancet Infectious Diseases

CoVID-19 vaccines lower risk of infection with delta variant, but infection can still be passed on in household settings – the Lancet

COVID vaccines protect against Delta but don’t fully stop disease spread – CIDRAP

Covid: Double vaccinated can still spread virus at home – BBC

 

Commentary on Twitter

 

Editorial: Safety and efficacy of antivirals against SARS-CoV-2 – “we need evidence not optimism”.

31 Oct, 2021 | 20:11h | UTC

Safety and efficacy of antivirals against SARS-CoV-2 – The BMJ

 

Commentary on Twitter

 

CDC Study: COVID-19 vaccine associated with 5 times the protection of ‘natural immunity’.

31 Oct, 2021 | 20:09h | UTC

Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

COVID-19 vaccine gives 5 times the protection of ‘natural immunity,’ data show – CIDRAP

COVID shots more protective than past infection, study shows – Associated Press

 

Commentary on Twitter

 

Cohort Study: Among patients with ST-segment elevation myocardial infarction, a concomitant Covid-19 diagnosis is associated with increased in-hospital mortality.

31 Oct, 2021 | 20:10h | UTC

Association Between COVID-19 Diagnosis and In-Hospital Mortality in Patients Hospitalized With ST-Segment Elevation Myocardial Infarction – JAMA

Editorial: Myocardial Infarction During the COVID-19 Pandemic – JAMA

Commentary: STEMI and COVID-19 Often a Lethal Combo, Affirms Largest Study Yet – TCTMD

 

Commentary from the author on Twitter (thread – click for more)

 

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