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Covid-19

Opinion: How we got herd immunity wrong.

28 Mar, 2022 | 09:50h | UTC

How we got herd immunity wrong – STAT

 

Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.

28 Mar, 2022 | 09:51h | UTC

Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes – JAMA

See also: Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes – JAMA

Editorial: COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy – JAMA

News Release: No increase in pregnancy complications after COVID-19 vaccination – Karolinska Institutet

 

[Preprint] Vaccine effectiveness of two and three doses of Pfizer and CoronaVac against COVID-19 in Hong Kong.

25 Mar, 2022 | 09:43h | UTC

Vaccine effectiveness of two and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong – medRxiv

 

Commentary on Twitter

 

[Preprint] Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study.

25 Mar, 2022 | 09:47h | UTC

Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study – medRxiv

 

Commentary on Twitter

 

[Preprint] RCT: Vitamin D supplements did not prevent Covid-19 or other acute respiratory infections.

25 Mar, 2022 | 09:49h | UTC

Vitamin D Supplements for Prevention of Covid-19 or other Acute Respiratory Infections: a Phase 3 Randomized Controlled Trial (CORONAVIT) – medRxiv

Related:

M-A: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19.

In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.

RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

 

Commentary on Twitter (thread – click for more)

https://twitter.com/KarlPfleger/status/1506871284214337543

 

Did the COVID lockdowns work? Here’s what we know two years on.

25 Mar, 2022 | 09:44h | UTC

Did the COVID lockdowns work? Here’s what we know two years on – The Conversation

Related:

M-A: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality.

Is the cure really worse than the disease? The health impacts of lockdowns during COVID-19 – “While there are certainly costs to be expected from intervening against COVID-19—every decision has a cost, after all—the counterfactual of an unmitigated epidemic makes these restrictions far less damaging than some have suggested”.

 

Test-negative, case-control study: effectiveness of the Pfizer vaccine against COVID-19 in adolescents.

24 Mar, 2022 | 09:44h | UTC

Effectiveness of BNT162b2 against COVID-19 in adolescents – The Lancet Infectious Diseases

 

Commentary on Twitter

 

RCT: Safety and efficacy of a third dose of the Pfizer Covid-19 vaccine during the Delta wave.

24 Mar, 2022 | 09:46h | UTC

Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine – New England Journal of Medicine

 

Commentary on Twitter

 

Systematic Review: Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19.

24 Mar, 2022 | 08:53h | UTC

Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19: a systematic review – The Lancet Digital Health

Commentaries:

Home blood oxygen monitoring can help COVID patients spot early warning signs – Imperial College London

Simple home oxygen monitors signal when to seek COVID care – CIDRAP

 

RCT: Awake prone positioning did not improve outcomes in patients with moderate hypoxemia due to covid-19.

24 Mar, 2022 | 09:48h | UTC

Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) – The BMJ

Editorial: Awake prone positioning for patients with covid-19

News Release: Lying prone long enough to improve outcomes is difficult for many covid-19 patients – BMJ

 

Oxford Covid jab gears up for final act: saving the rest of the world.

23 Mar, 2022 | 10:35h | UTC

Oxford Covid jab gears up for final act: saving the rest of the world – The Guardian

 

RCT: Among critically ill patients with Covid-19, treatment with an antiplatelet agent had a low likelihood of improving organ support–free days within 21 days.

23 Mar, 2022 | 10:38h | UTC

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status – JAMA

Commentary: Aspirin may improve 3-month survival for patients critically ill with COVID-19 – Imperial College London

 

Commentaries on Twitter

https://twitter.com/JAMA_current/status/1506188937852858369

 

Cohort Study: Perinatal complications in individuals in California with or without SARS-CoV-2 infection during pregnancy.

23 Mar, 2022 | 10:33h | UTC

Perinatal Complications in Individuals in California With or Without SARS-CoV-2 Infection During Pregnancy – JAMA Internal Medicine

News Release: Coronavirus may double severe complications in pregnancy – Kaiser Permanente

Commentary: COVID-19 in pregnancy tied to poor maternal outcomes, preterm birth, fetal death – CIDRAP

 

Cohort Study: Risks and burdens of incident diabetes in long COVID.

23 Mar, 2022 | 10:32h | UTC

Risks and burdens of incident diabetes in long COVID: a cohort study – The Lancet Diabetes & Endocrinology

 

Review: When to operate after SARS-CoV-2 infection?

22 Mar, 2022 | 09:44h | UTC

When to operate after SARS-CoV-2 infection? A review on the recent consensus recommendation of the DGC/BDC and the DGAI/BDA – Langenbeck’s Archives of Surgery

Related:

Guideline Update: Timing of elective surgery and risk assessment after SARS-CoV-2 infection – “The guidance remains that patients should avoid elective surgery within 7 weeks of infection, unless the benefits of doing so exceed the risk of waiting”.

Perioperative cardiovascular considerations prior to elective noncardiac surgery in patients with a history of Covid-19.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

BJS commission on surgery and perioperative care post-COVID-19.

The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

 

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity.

21 Mar, 2022 | 09:47h | UTC

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity – Nature Reviews Microbiology

 

Commentary on Twitter

 

Infographic: IDSA COVID-19 outpatient treatment guidelines roadmap.

21 Mar, 2022 | 09:51h | UTC

COVID-19 Outpatient Treatment Guidelines Roadmap – Infectious Diseases Society of America

 

Commentary on Twitter

 

CDC Report: Effectiveness of mRNA vaccination in preventing COVID-19–associated invasive mechanical ventilation and death in the US.

21 Mar, 2022 | 09:38h | UTC

Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Related Study: COVID-19–Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status — COVID-NET, 14 States, July 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Commentary: Studies show vaccines protect against serious Omicron illness – CIDRAP

 

Commentary on Twitter

 

Effectiveness of the Johnson & Johnson vaccine in health-care workers in South Africa in a period when the beta and then the delta SARS-CoV-2 variants of concerns were dominant.

21 Mar, 2022 | 09:43h | UTC

Effectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study – The Lancet

Invited Commentary: Sisonke: reaching several goals together – The Lancet

 

Commentary on Twitter (thread – click for more)

 

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

21 Mar, 2022 | 09:37h | UTC

Myocarditis Following a Third BNT162b2 Vaccination Dose in Military Recruits in Israel – JAMA

Related:

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

M-A: Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxemic respiratory failure.

18 Mar, 2022 | 09:32h | UTC

Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis – The Lancet Respiratory Medicine

Invited Commentary: The pandemic and the great awakening in the management of acute hypoxaemic respiratory failure – The Lancet Respiratory Medicine

Related:

[Preprint] RCT: In hypoxic but not critically ill patients with COVID-19, an intervention to increase prone positioning did not improve outcomes.

RCT: Awake prone positioning reduces the need for intubation in patients with COVID-19.

RCT: Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19 – no difference in intubation rates compared to standard care.

M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required

 

Study finds no increased risk of rare neurological events after covid vaccination.

18 Mar, 2022 | 09:31h | UTC

News Release: Study finds no increased risk of rare neurological events after covid vaccination – BMJ Newsroom

Original Study: Association between covid-19 vaccination, SARS-CoV-2 infection, and risk of immune mediated neurological events: population based cohort and self-controlled case series analysis – The BMJ

Editorial: The neurological safety of covid-19 vaccines

 

Using absolute risk reduction to guide the equitable distribution of COVID-19 vaccines.

18 Mar, 2022 | 09:28h | UTC

Using absolute risk reduction to guide the equitable distribution of COVID-19 vaccines – BMJ Evidence-Based Medicine

News Release: Researchers find equitable COVID-19 vaccine distribution can target risks in different geographical areas – University of New Mexico

 

Commentary on Twitter

 

2022 ACC expert consensus decision pathway on cardiovascular sequelae of COVID-19 in adults: myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play.

17 Mar, 2022 | 09:26h | UTC

2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis and Other Myocardial Involvement, Post-Acute Sequelae of SARS-CoV-2 Infection, and Return to Play: A Report of the American College of Cardiology Solution Set Oversight Committee – Journal of the American College of Cardiology

Commentaries:

ACC Issues Clinical Guidance on CV Consequences of COVID-19 – American College of Cardiology

ACC Releases Guidance on CV Issues With COVID-19 – TCTMD

Key Points: 2022 ACC Decision Pathway on Cardiovascular Sequelae of COVID-19

Related:

Review | Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus.

The pathogenesis and long-term consequences of Covid-19 cardiac injury: state-of-the-art review.

COVID-19 infections increase risk of heart conditions up to a year later, study finds.

 

Commentary on Twitter (thread – click for more)

 

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

17 Mar, 2022 | 09:12h | UTC

Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron – New England Journal of Medicine

Related: [Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

 

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