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Antibiotic Stewardship

Ventilator associated tracheobronchitis and pneumonia: one infection with two faces

23 May, 2023 | 12:49h | UTC

Ventilator associated tracheobronchitis and pneumonia: one infection with two faces – Intensive Care Medicine

 

Editorial | Selective digestive decontamination – Pro

22 May, 2023 | 13:34h | UTC

Selective digestive decontamination – Pro – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 

Stenotrophomonas Maltophilia: review and meta-analysis of treatment options

22 May, 2023 | 13:25h | UTC

Stenotrophomonas maltophilia Infections: A Systematic Review and Meta-Analysis of Comparative Efficacy of Available Treatments, with Critical Assessment of Novel Therapeutic Options – Antibiotics

 

Consensus Paper | Diagnosis and antimicrobial treatment for infections post-ACL reconstruction

16 May, 2023 | 14:46h | UTC

Recommendations on diagnosis and antimicrobial treatment of infections after anterior cruciate ligament reconstruction (ACL-R) endorsed by ESSKA and EBJIS – Journal of Infection

 

Development of evidence-based guidelines for the treatment and management of periprosthetic hip infection

15 May, 2023 | 12:39h | UTC

Development of evidence-based guidelines for the treatment and management of periprosthetic hip infection – Bone & Joint Open

 

Review | Early switch to oral antimicrobials in brain abscess

10 May, 2023 | 15:55h | UTC

Early switch to oral antimicrobials in brain abscess: A narrative review – Clinical Microbiology and Infection

 

Consensus Paper | Strategies to prevent surgical site infections in acute-care hospitals

8 May, 2023 | 13:21h | UTC

Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

News Release: New guidance: antibiotics should be halted upon closure of incisions – Society for Healthcare Epidemiology of America

Commentary: New guidance calls for stopping antibiotic prophylaxis immediately after surgery – CIDRAP

Related: Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals

 

AACC Guidance document on the clinical use of procalcitonin

8 May, 2023 | 13:12h | UTC

AACC Guidance Document on the Clinical Use of Procalcitonin – The Journal of Applied Laboratory Medicine (free for a limited period)

 

Commentary on Twitter

 

Brief review | What’s new in therapeutic drug monitoring of antimicrobials?

8 May, 2023 | 13:08h | UTC

What’s new in therapeutic drug monitoring of antimicrobials? – Intensive Care Medicine

 

Commentary on Twitter

 

Diagnostic Stewardship | A continuum of antibiotic stewardship in combating antimicrobial resistance

4 May, 2023 | 13:58h | UTC

Diagnostic stewardship in infectious diseases: a continuum of antimicrobial stewardship in the fight against antimicrobial resistance – International Journal of Antimicrobial Agents

 

SR | Fecal microbiota transplantation effective in recurrent C. difficile treatment

3 May, 2023 | 15:29h | UTC

Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile) – Cochrane Library

Summary: Stool transplantation for treatment of repeated Clostridioides difficile infection – Cochrane Library

Commentaries:

Cochrane study finds stool transplants more effective than antibiotics for treating recurring, life-threatening gut infections – Cochrane Library

Expert reaction to two Cochrane reviews looking at stool transplants for recurrent Clostridium difficile infection, and for inflammatory bowel disease – Science Media Centre

Fecal microbiota transplant: Effective solution for recurrent C. difficile infections – News Medical

Related:

RCT | Fecal microbiota transplantation better than standard of care for first or second Clostridioides difficile infection.

Long-term safety of fecal microbiota transplantation for recurrent Clostridioides difficile infection

 

Commentary on Twitter

 

Review | Helicobacter pylori infection

2 May, 2023 | 13:37h | UTC

Helicobacter pylori infection – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Commentary on Twitter

 

RCT | Molecular point-of-care testing for gastroenteritis reduced isolation time but increased antibiotic use

28 Apr, 2023 | 13:15h | UTC

Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial – The Lancet Infectious Diseases

Commentary: Molecular testing in suspected infectious diarrhoea—the value of negative results – The Lancet Infectious Diseases

 

M-A | Utility of differential time to positivity in diagnosing central line associated bloodstream infections

26 Apr, 2023 | 14:24h | UTC

Utility of Differential Time to Positivity in Diagnosing Central Line Associated Bloodstream Infections: A Systematic Review and Meta-Analysis – Clinical Infectious Diseases

 

Commentary on Twitter

https://twitter.com/CIDJournal/status/1648807186443673600

 

M-A | Prevalence of atypical pathogens in patients with severe pneumonia

26 Apr, 2023 | 14:02h | UTC

Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis – BMJ Open

 

RCT | Piperacillin-tazobactam better than cefoxitin in antimicrobial prophylaxis for open pancreatoduodenectomy

21 Apr, 2023 | 13:08h | UTC

Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Informing a Rational Approach to Antimicrobial Prophylaxis in Open Pancreatoduodenectomy – JAMA (free for a limited period)

 

Commentary on Twitter

 

Review | New antibiotics for Staphylococcus aureus infection

18 Apr, 2023 | 13:02h | UTC

New Antibiotics for Staphylococcus aureus Infection: An Update from the World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti-Infective Therapy (SITA) – Antibiotics

 

Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals

17 Apr, 2023 | 13:17h | UTC

Strategies to prevent Clostridioides difficile infections in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

News Release: Updated guidance: Antimicrobial stewardship programs essential for preventing C. difficile in hospitals – Society for Healthcare Epidemiology of America

Commentary: New guidance deems antibiotic stewardship essential for preventing C diff infections – CIDRAP

 

Phase 2 RCT | High-dose VE303 reduces recurrent Clostridioides difficile infection rates

17 Apr, 2023 | 13:12h | UTC

VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

 

RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM

12 Apr, 2023 | 13:30h | UTC

Summary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.

Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline.  Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.

Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP

 

Commentary on Twitter

 

Perspective | Proposal of a model of care for outpatient antimicrobial therapy for infective endocarditis

12 Apr, 2023 | 13:08h | UTC

Outpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care – Antibiotics

 

Commentary on Twitter

 

Brief Review | Ten tips on fever in the ICU

10 Apr, 2023 | 14:02h | UTC

Ten tips on fever – Intensive Care Medicine

 

Consensus Paper | Best management of patients with an acute sore throat

6 Apr, 2023 | 13:32h | UTC

Best management of patients with an acute sore throat – a critical analysis of current evidence and a consensus of experts from different countries and traditions – Infectious Diseases

 

M-A | Comparison of the diagnostic accuracies of monocyte distribution width, procalcitonin, and C-reactive protein for sepsis

6 Apr, 2023 | 13:00h | UTC

Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Systematic Review and Meta-Analysis – Critical Care Medicine

 

ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia

5 Apr, 2023 | 13:45h | UTC

ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia – Intensive Care Medicine

 

Commentary on Twitter

 

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