Antibiotic Stewardship
Consensus Paper | Implementing strategies to prevent infections in acute-care settings
14 Jul, 2023 | 13:03h | UTCNews Release: New guidance for infection prevention in acute care settings – Society for Healthcare Epidemiology of America
Related:
Practice Recommendation | Strategies to prevent MRSA transmission and infection in hospitals
Consensus Paper | Strategies to prevent surgical site infections in acute-care hospitals
Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals
Quality Improvement Study | Improved asymptomatic bacteriuria management by reduction of unnecessary urine culture requests
14 Jul, 2023 | 12:54h | UTCRelated:
Study: Hospital Intervention Resulted in a 45% Reduction in the Urine Cultures Ordered
USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults
IDSA Guideline for the Management of Asymptomatic Bacteriuria
Commentary on Twitter
🔥🔥🔥Powerful message from our new study in @JAMAInternalMed: diagnostic stewardship (better use of diagnostic tests) was responsible for ALL the⬇️in unnecessary antibiotic use for ASB. ➕results🟰💪nudge to action. Time to👀👀upstream to improve care! https://t.co/yO4UpA6ZKK pic.twitter.com/hXZGvNmVJP
— Valerie Vaughn (@ValerieVaughnMD) July 11, 2023
Intervention Study | Pharmacist review may reduce antibiotic overuse at discharge
12 Jul, 2023 | 13:37h | UTCCommentary: Pharmacist review identifies improper antibiotic prescriptions – CIDRAP
Practice Recommendation | Strategies to prevent MRSA transmission and infection in hospitals
10 Jul, 2023 | 14:02h | UTCCommentary: New guidelines recommend antibiotic stewardship for preventing MRSA – CIDRAP
Podcast | Untangling catheter associated UTIs
10 Jul, 2023 | 13:21h | UTC#402 Don’t Get Caught with a CAUTI – The Curbsiders
Consensus Paper | The place of new antibiotics for Gram-negative bacterial infections in intensive care
7 Jul, 2023 | 16:15h | UTC
RCT | Lower rates of treatment failure with standard-course vs. short-course therapy in pediatric UTIs
5 Jul, 2023 | 01:09h | UTCShort-Course Therapy for Urinary Tract Infections in Children: The SCOUT Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
See also: Visual Abstract
Commentary: Treatment Failure Down With Standard-Course Therapy in Pediatric UTI – HealthDay
SR | Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
5 Jul, 2023 | 01:04h | UTC
Global incidence in hospital-associated infections resistant to antibiotics: an analysis of point prevalence surveys from 99 countries
30 Jun, 2023 | 14:33h | UTC
WHO outlines 40 research priorities on antimicrobial resistance
26 Jun, 2023 | 00:50h | UTCNews release: WHO outlines 40 research priorities on antimicrobial resistance – World Health Organization
Report: Global research agenda for antimicrobial resistance in human health – World Health Organization
Commentary on Twitter
🔥WHO published its 1st global research agenda for the world’s scientists to address the most urgent human health priorities to combat antimicrobial resistance
It outlines 40 research topics on drug-resistant bacteria,fungi& Mycobacterium TB
H/t @paimadhuhttps://t.co/AOVObnJK5Q pic.twitter.com/owZJwMIDXK— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 22, 2023
RCT | High-dose dual-antibiotic cement doesn’t lower infection rates in hip hemiarthroplasty
26 Jun, 2023 | 00:47h | UTCSummary: This randomized superiority trial studied the effect of high-dose dual-antibiotic loaded cement versus standard care single-antibiotic loaded cement on deep surgical site infection (SSI) rates in hip hemiarthroplasty patients. This large-scale study, conducted in 26 UK hospitals, included people aged 60 and older with a hip fracture.
The trial randomly allocated 4936 participants to either treatment group. The primary outcome was deep SSI at 90 days post-randomisation. Notably, no significant difference was found between the groups. About 1.7% of participants in the single-antibiotic group and 1.2% in the dual-antibiotic group experienced a deep SSI (adjusted odds ratio 1.43; 95% CI 0.87–2.35; p=0.16). This result contradicts previous findings suggesting that high-dose dual-antibiotic cement could reduce infection rates.
News release: Antibiotic bone cement found not to reduce infection after hip replacement – University of Oxford
Review | Differentiating infection, colonization, and sterile inflammation in critical illness
26 Jun, 2023 | 00:41h | UTCDifferentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling – Intensive Care Medicine (free for a limited period)
Commentary on Twitter
Infection, colonisation, sterile inflammation in critical illness?
🧫 current approaches to distinguishing
🧫 host–pathogen interactions
🧫 techniques to characterise host response
🧫 challenges/limitations of host‑response diagnostics
#FOAMcc @yourICM
🖇️https://t.co/d3vhgrt3ZE pic.twitter.com/eDFiinMvSp— Intensive Care Medicine (@yourICM) June 22, 2023
Review | The antibiotic bead pouch – A useful technique for infection prevention and therapy in trauma surgery
26 Jun, 2023 | 00:35h | UTC
Review | Therapeutic drug monitoring of antimicrobials in critically ill obese patients
26 Jun, 2023 | 00:29h | UTCTherapeutic Drug Monitoring of Antimicrobials in Critically Ill Obese Patients – Antibiotics
Commentary on Twitter
🆕️⚡️Narrative Review @antibioticsmdpi
with @fabio_taccone
Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Obese Patients #IDTwitter #CCTwitter https://t.co/s8dvWjtIwt pic.twitter.com/WWyflkblVY— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 24, 2023
Retrospective study | Increasing prevalence and severity of carbapenem-resistant Klebsiella Pneumoniae in ICUs
23 Jun, 2023 | 13:25h | UTC
Consensus Paper | Primary prophylaxis of invasive fungal diseases in patients with hematological malignancies
23 Jun, 2023 | 13:23h | UTC
Review | Early lead extraction for infected implanted cardiac electronic devices
22 Jun, 2023 | 15:03h | UTC
Review | Antifungal dosing in critically ill patients on extracorporeal membrane oxygenation
21 Jun, 2023 | 13:31h | UTC
The foot in diabetes – a reminder of an ever-present risk
21 Jun, 2023 | 13:10h | UTCThe foot in diabetes – a reminder of an ever-present risk – Clinical Medicine Journal
Related: Guideline Series | Prevention and management of diabetes-related foot disease
RCT | Continuous vs. intermittent meropenem administration shows similar mortality and drug-resistance in sepsis patients
19 Jun, 2023 | 14:11h | UTCContinuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis? – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Trial finds no difference between continuous, intermittent meropenem for sepsis patients – CIDRAP
Commentary on Twitter
Continuous administration of meropenem, compared with intermittent administration, does not improve clinically relevant outcomes in critically ill patients with #sepsis. https://t.co/eJ9zdGI4k2 #CCR23 pic.twitter.com/8n2eR9qBPe
— JAMA (@JAMA_current) June 16, 2023
Review | Necessity of antigen testing for Legionella in hospitalized patients with community-acquired pneumonia
19 Jun, 2023 | 13:56h | UTC
Review | Bloodstream infection and gram-negative resistance: the role for newer antibiotics
16 Jun, 2023 | 13:57h | UTCBloodstream Infection and Gram-Negative Resistance: The Role for Newer Antibiotics – Antibiotics
Review | Aminoglycosides for the treatment of severe infection due to resistant gram-negative pathogens
16 Jun, 2023 | 13:56h | UTC
Review | Antifungal stewardship interventions in patients with hematologic malignancies
16 Jun, 2023 | 13:47h | UTCAntifungal Stewardship Interventions in Patients with Hematologic Malignancies
Review | Contribution of wastewater to antimicrobial resistance
15 Jun, 2023 | 14:49h | UTCRelated studies on surveillance of wastewater:
Use of Wastewater for Mpox Outbreak Surveillance in California – New England Journal of Medicine
Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly.
CDC unveils its latest weapon in Covid-19 detection: wastewater.
[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.
Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT
The myriad ways sewage surveillance is helping fight COVID around the world – Nature
It’s time to begin a national wastewater testing program for Covid-19 – STAT
Coronavirus: Testing sewage an ‘easy win’ – BBC