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Antibiotic Stewardship

Study: More than half of antibiotics prescribed in US hospitals were not consistent with recommended prescribing practices

21 Mar, 2021 | 21:44h | UTC

Assessment of the Appropriateness of Antimicrobial Use in US Hospitals

Commentary: New findings spur call to reduce improper antibiotic use in hospitals – CIDRAP

 

Commentary on Twitter

 

Systematic review: Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease

23 Mar, 2021 | 02:09h | UTC

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease – Cochrane Library

 

M-A: Most patients with allergy to Penicillin can be given Cefazolin

21 Mar, 2021 | 21:41h | UTC

Assessment of the Frequency of Dual Allergy to Penicillins and Cefazolin: A Systematic Review and Meta-analysis – JAMA Surgery

Commentary: Common antibiotic can safely be given to most surgery patients despite penicillin allergy – Massachusetts General Hospital

 

Commentary on Twitter (thread – click for more)

 

RCT: No benefit from probiotic therapy in critical illness

16 Mar, 2021 | 01:30h | UTC

Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT) – Intensive Care Medicine

 

Commentary on Twitter

 

RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

9 Mar, 2021 | 02:29h | UTC

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Rightsizing Treatment for Pneumonia in Children

Commentary: Five days of antibiotics fine for children with pneumonia – McMaster University

 

Commentary on Twitter (thread – click for more)

 

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases

7 Mar, 2021 | 18:58h | UTC

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases – International Journal of Infectious Diseases

 

Systematic Review: Different classes of antibiotics given to women routinely for preventing infection at cesarean section

5 Mar, 2021 | 08:27h | UTC

Different classes of antibiotics given to women routinely for preventing infection at caesarean section – Cochrane Library

Summary: Comparing different types of antibiotics given routinely to women at caesarean section to reduce infections – Cochrane Library

 

Respiratory microbiome in mechanically ventilated patients: a narrative review

5 Mar, 2021 | 08:14h | UTC

Respiratory microbiome in mechanically ventilated patients: a narrative review – Intensive Care Medicine

 

Commentary on Twitter

 

WHO Action Framework: Leveraging vaccines to reduce antibiotic use and prevent antimicrobial resistance

5 Mar, 2021 | 08:08h | UTC

Leveraging Vaccines to Reduce Antibiotic Use and Prevent Antimicrobial Resistance: a WHO Action Framework – Clinical Infectious Diseases

 

Addressing Antibiotic Overuse in the Outpatient Setting: Lessons From Behavioral Economics

4 Mar, 2021 | 08:27h | UTC

Addressing Antibiotic Overuse in the Outpatient Setting: Lessons From Behavioral Economics – Mayo Clinic Proceedings

 

Chronic suppurative otitis media: Cochrane evidence on treatment options

3 Mar, 2021 | 08:26h | UTC

Chronic suppurative otitis media (infection and inflammation of the middle ear): Cochrane evidence on treatment options – Evidently Cochrane

 

Studies: Secondary infections in patients with severe COVID-19

2 Mar, 2021 | 02:05h | UTC

Secondary Infections in Patients with Severe COVID-19 – NEJM Journal Watch

Study 1: Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome – Intensive Care Medicine

Study 2: COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA network – Intensive Care Medicine

 

Guideline: Treatment of methicillin-resistant Staphylococcus aureus (MRSA)

2 Mar, 2021 | 01:50h | UTC

Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK – JAC-Antimicrobial Resistance

 

Commentary on Twitter

 

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

2 Mar, 2021 | 01:46h | UTC

Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge: a systematic review – JAC-Antimicrobial Resistance

 

Commentary on Twitter

 

PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?

28 Feb, 2021 | 20:43h | UTC

PRO: Carbapenems should be used for ALL infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

Editorial: Navigating treatment approaches for presumed ESBL-producing infections

 

Commentary on Twitter (thread – click for more)

 

Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone

24 Feb, 2021 | 02:25h | UTC

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter

Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)

 

Commentary on Twitter

 

Diverticulitis: Observational study in outpatients suggests amoxicillin-clavulanate is a safe and effective option compared with metronidazole-fluoroquinolone

24 Feb, 2021 | 02:16h | UTC

Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis: Two Nationwide Cohort Studies – Annals of Internal Medicine

Commentaries: Amoxicillin-clavulanate safe and effective compared with metronidazole-with-fluoroquinolone for diverticulitis – American College of Physicians AND Study supports fluoroquinolone-sparing treatment for diverticulitis – CIDRAP

 

Global guideline for the diagnosis and management of rare mold infections

19 Feb, 2021 | 02:18h | UTC

Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology – The Lancet Infectious Diseases (free for a limited period)

 

Commentary on Twitter

 

Serology anno 2021 – fungal infections: from invasive to chronic

17 Feb, 2021 | 01:19h | UTC

Serology anno 2021 – fungal infections: from invasive to chronic – Clinical Microbiology and Infection

 

Commentary on Twitter

 

Study: Obesity and risk of catheter-related infections in the ICU

16 Feb, 2021 | 01:46h | UTC

Obesity and risk of catheter-related infections in the ICU. A post hoc analysis of four large randomized controlled trials – Intensive Care Medicine

 

Commentary on Twitter

 

Corticosteroids for community acquired pneumonia, influenza and COVID-19: when, how and benefits or harm?

15 Feb, 2021 | 00:47h | UTC

Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm? – European Respiratory Review

 

Randomized trial: Procalcitonin to reduce long-term infection-associated adverse events in sepsis

15 Feb, 2021 | 00:43h | UTC

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial – American Journal of Respiratory and Critical Care Medicine

 

RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

 

Cohort study: The use of macrolide antibiotics in pregnancy is not associated with an increased risk of major congenital malformations

12 Feb, 2021 | 02:04h | UTC

Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study – The BMJ

 

Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis

11 Feb, 2021 | 01:50h | UTC

Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis – Journal of Antimicrobial Chemotherapy

Related: Risk of acute kidney injury and Clostridioides difficile infection with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin – Clinical Infectious Diseases AND Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text) AND Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text) AND Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients – Critical Care

 

Commentary on Twitter

 

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