Hematology (all articles)
Guideline: Diagnosis and Management of Sepsis‐induced Coagulopathy and Disseminated Intravascular Coagulation
20 Aug, 2019 | 08:53h | UTCRelated Reviews: Diagnosis of sepsis‐induced disseminated intravascular coagulation and coagulopathy – Acute Medicine & Surgery (free) AND Sepsis-associated disseminated intravascular coagulation and its differential diagnoses – Journal of Intensive Care (free) AND Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation – Journal of Clinical Medicine (free)
Source: Critical Care Reviews Newsletter
Prevention and Treatment of Pregnancy-Associated Venous Thromboembolism: Critical Appraisal of International Guidelines
18 Aug, 2019 | 21:35h | UTC
Consensus Statement: Utilization of Hematopoietic Stem Cell Transplantation for the Treatment of Multiple Myeloma
11 Aug, 2019 | 21:13h | UTC
Randomized Trial: Longer-term Efficiency and Safety of Increasing the Frequency of Whole Blood Donation
9 Aug, 2019 | 07:00h | UTCInvited Commentary: Ironing out frequent blood donation (free)
Original Study: Efficiency and safety of varying the frequency of whole blood donation (free)
Dysproteinemia and the Kidney: Core Curriculum 2019
8 Aug, 2019 | 08:00h | UTCDysproteinemia and the Kidney: Core Curriculum 2019 – American Journal of Kidney Diseases (free)
Related Reviews: Dysproteinemias and Glomerular Disease – Clinical Journal of the American Society of Nephrology (free) AND Paraprotein–Related Kidney Disease: Kidney Injury from Paraproteins—What Determines the Site of Injury? – Clinical Journal of the American Society of Nephrology (free) AND Paraprotein–Related Kidney Disease: Glomerular Diseases Associated with Paraproteinemias – Clinical Journal of the American Society of Nephrology (free)
Randomized Trial: Transfusion Volume for Children with Severe Anemia
7 Aug, 2019 | 08:18h | UTCTransfusion Volume for Children with Severe Anemia in Africa – New England Journal of Medicine (free)
Commentary: Larger blood transfusions could halve deaths of children with severe anaemia – Imperial College London (free)
Related Study: Immediate Transfusion in African Children with Uncomplicated Severe Anemia – New England Journal of Medicine (free)
ASCO Guideline: Venous Thromboembolism Prophylaxis and Treatment in Patients with Cancer
7 Aug, 2019 | 08:34h | UTCSee also: Summary of Recommendations (free PDF) AND Visual Abstract (free PDF)
Cohort Study: Perioperative Management of Patients with Atrial Fibrillation Receiving a Direct Oral Anticoagulant
6 Aug, 2019 | 08:10h | UTCPerioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)
Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)
“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”
Related Commentary on Twitter
PAUSE is the largest trial to date that addresses perioperative DOAC timing and demonstrates safe management with the ability to influence guidelines https://t.co/WDM3yWt9nA
— JAMA Internal Medicine (@JAMAInternalMed) August 5, 2019
[Abstract Only] Ibrutinib–Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia
5 Aug, 2019 | 01:40h | UTCIbrutinib–Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Survival increased in chronic lymphocytic leukemia patients treated with ibrutinib and rituximab – 2 Minute Medicine (free)
Expert Consensus: Management of Hypersensitivity Reactions to Intravenous Iron in Adults
2 Aug, 2019 | 00:05h | UTC
Meta-Analysis: Liberal vs. Restrictive Red Blood Cell Transfusion Strategy in Sepsis or Septic Shock
31 Jul, 2019 | 01:44h | UTCRelated Systematic Review: Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion – Cochrane Library (free)
Related Guideline: Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients – British Committee for Standards in Haematology (free)
Consensus Paper: Management of Severe Bleeding in Patients Treated with Oral Anticoagulants
30 Jul, 2019 | 01:39h | UTCRelated: 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants (free guideline and summary)
Brazilian Guidelines on Myeloproliferative Neoplasms
27 Jul, 2019 | 16:55h | UTCRelated Study: Classification and Personalized Prognosis in Myeloproliferative Neoplasms – New England Journal of Medicine (free)
Related Guideline: NCCN Guidelines Insights: Myeloproliferative Neoplasms, Version 2.2018 (free)
[Abstracts Only] Randomized Trials: Evaluation of New Treatment for Anemia of Chronic Kidney
27 Jul, 2019 | 13:55h | UTCRoxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis- New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Roxadustat Effective in Correcting Anemia in Nondialysis CKD and Dialysis – Renal & Urology News (free) AND New Oral Agent for Anemia in CKD Encouraging but Questions Remain – Medscape (free registration required)
ACG Clinical Guideline: Hereditary Hemochromatosis
26 Jul, 2019 | 01:13h | UTCACG Clinical Guideline: Hereditary Hemochromatosis – The American Journal of Gastroenterology (free PDF)
Related Guidelines: Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases (free) AND Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype – Hepatology International (free)
Clinical Guide and Update on Porphyrias
26 Jul, 2019 | 01:11h | UTCClinical Guide and Update on Porphyrias – Gastroenterology (free)
Related Reviews: Update review of the acute porphyrias – British Journal of Haematology (free) AND Acute Hepatic Porphyrias: Review and Recent Progress – Hepatology Communications (free) AND Acute hepatic porphyrias: Recommendations for evaluation and long‐term management – Hepatology (free) AND An overview of the cutaneous porphyrias – F1000 Research (free)
Meta-Analysis: Risk of Recurrent Thromboembolism after Discontinuation of Anticoagulant Treatment for First Unprovoked Venous Thromboembolism Event
26 Jul, 2019 | 01:06h | UTCCommentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)
“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”
Related Commentary on Twitter
Excited to share my first study published today in @bmj_latest on recurrence risk after stopping #anticoagulation for unprovoked #VTE. Big thanks to the MARVELOUS collaborators, @CIHR_IRSC for funding/support & @RodgerMarc for continued mentorship https://t.co/jnT86dRzHK#phdlife pic.twitter.com/SSVTYwkXth
— Faizan Khan, PhD (@FaizanK91) July 25, 2019
Cohort Study: Association of Immune Marker Changes With Progression of MGUS to Multiple Myeloma
23 Jul, 2019 | 01:27h | UTCAssociation of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma – JAMA Oncology (free for a limited period)
Commentaries: Monoclonal Gammopathy May Be of Unpredictable Significance – JAMA Oncology (free for a limited period) AND Study Supports Annual Monitoring for Patients with Monoclonal Gammopathy of Undetermined Significance – NEJM Journal Watch (free)
Perspective: The Promise and Price of Cellular Therapies
19 Jul, 2019 | 09:43h | UTCThe Promise and Price of Cellular Therapies – The New Yorker (a few articles per month are free)
“New “living drugs”—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?”
Review: Anticoagulation in the Cirrhotic Patient
19 Jul, 2019 | 09:38h | UTCAnticoagulation in the cirrhotic patient – JHEP Reports (free)
Related: The Complex Role of Anticoagulation in Cirrhosis: An Updated Review of Where We Are and Where We Are Going – Digestion (free) AND Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations – Canadian Journal of Gastroenterology and Hepatology (free) AND Anticoagulation in cirrhosis: a new paradigm? – Clinical and Molecular Hepatology (free)
[Abstract Only] Meta-Analysis: Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease
16 Jul, 2019 | 09:43h | UTCBenefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-vitamin K oral anticoagulants appear superior to vitamin K antagonists in early-stage CKD – ACP Internist (free) AND Evidence Favors NOACs for Anticoagulation in Early Chronic Kidney Disease – NEJM Journal Watch (free)
Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared
14 Jul, 2019 | 19:41h | UTCRelated reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free) AND Managing the toxicities of CAR T‐cell therapy – Hematological Oncology (free)
Source: Critical Care Reviews Newsletter
Pediatric Transfusion Algorithms: Coming to a Cardiac Operating Room Near You
14 Jul, 2019 | 19:05h | UTC
NCCN Guideline: Acute Myeloid Leukemia
2 Jul, 2019 | 01:16h | UTC
[Abstract Only] Randomized Trial: Treatments for Patients with Multiple Myeloma Eligible for Transplantation Compared
30 Jun, 2019 | 17:20h | UTCBortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study – The Lancet (link to abstract – $ for full-text)
Commentary: EHA 2019: CASSIOPEIA Trial Examines Addition of Daratumumab to Standard Treatment Before and After ASCT in Multiple Myeloma – The ASCO Post (free)