Hematology (all articles)
Sickle Cell Disease: A Primary Care Update
30 Jan, 2020 | 07:32h | UTCSickle cell disease: A primary care update – Cleveland Clinic Journal of Medicine (free)
ASH Guidelines for Sickle Cell Disease: Transfusion Support
29 Jan, 2020 | 08:27h | UTC
Meta-Analysis of Direct Oral Anticoagulants Randomized Trials: Double vs. Triple Antithrombotic Therapy in Patients with Atrial Fibrillation Following Percutaneous Coronary Intervention
22 Jan, 2020 | 09:28h | UTCRelated: Meta-analysis: Double Anti-thrombotic Therapy Safer than Triple Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease (studies on the subject)
[Abstract Only] Randomized Trial: Effects of Addition of Anti-thymocyte Globulin to Standard Graft-versus-host Disease Prophylaxis in Patients with Hematological Malignancies Undergoing Transplantation from Unrelated Donor
22 Jan, 2020 | 09:16h | UTCAddition of anti-thymocyte globulin to standard graft-versus-host disease prophylaxis versus standard treatment alone in patients with haematological malignancies undergoing transplantation from unrelated donors: final analysis of a randomised, open-label, multicentre, phase 3 trial – The Lancet Haematology (link to abstract – $ for full-text)
Recommendations for Therapeutic Apheresis
21 Jan, 2020 | 01:10h | UTC
Addendum to BSH Guidelines on Investigation and Management of Antiphospholipid Syndrome: Use of Direct Acting Oral Anticoagulants
19 Jan, 2020 | 20:55h | UTCRelated: Randomized Trial: DOAC Not as Good as Vitamin K Antagonist for Anticoagulation in Antiphospholipid Syndrome (link to abstract and commentaries)
Cohort Study: Incidental Lymphopenia and Mortality
19 Jan, 2020 | 20:45h | UTCCommentaries: Lymphopenia may hint a higher risk of future illness, death – News Medical (free) AND Incidental Low Lymphocyte Count Linked to Increased Mortality – MedicalResearch.com (free)
Randomized Trial: Effect of Dasatinib vs. Imatinib in the Treatment of Pediatric Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
19 Jan, 2020 | 20:38h | UTCEffect of Dasatinib vs Imatinib in the Treatment of Pediatric Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Commentary: Dasatinib Superior to Imatinib in Pediatric ALL – MedPage Today (free)
Randomized Trial: Twice-daily vs. Alternate-day Oral Iron Therapy in the Treatment of Iron-deficiency Anemia
16 Jan, 2020 | 03:23h | UTC
Review: Surveillance in Patients with Diffuse Large B Cell Lymphoma
15 Jan, 2020 | 01:07h | UTCSurveillance in Patients with Diffuse Large B Cell Lymphoma – Mayo Clinic Proceedings (free)
Meta-Analysis: Multiple Drug Combinations of Bortezomib, Lenalidomide, and Thalidomide for First‐line Treatment in Adults with Transplant‐Ineligible Multiple Myeloma
15 Jan, 2020 | 00:54h | UTCMultiple drug combinations of bortezomib, lenalidomide, and thalidomide for first‐line treatment in adults with transplant‐ineligible multiple myeloma: a network meta‐analysis – Cochrane Library (free)
Commentary: Featured Review: Reducing uncertainties in choosing first-line treatment in newly diagnosed multiple myeloma – Cochrane Library (free)
ESMO Guideline: Marginal Zone Lymphomas
14 Jan, 2020 | 00:26h | UTC
[Abstract Only] Randomized Trial: Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
14 Jan, 2020 | 00:03h | UTCLuspatercept in Patients with Lower-Risk Myelodysplastic Syndromes – New England Journal of Medicine (link to abstract – $ for full-text)
Systematic Review and Economic Evaluation: Different Strategies for Pharmacological Thromboprophylaxis for Lower-limb Immobilization after Injury
12 Jan, 2020 | 21:14h | UTCSource: EvidenceAlerts
New Guideline on the Management of Epistaxis
10 Jan, 2020 | 08:30h | UTCClinical Practice Guideline: Nosebleed (Epistaxis) – Otolaryngology–Head and Neck Surgery (free)
Executive Summary: Clinical Practice Guideline: Nosebleed (Epistaxis) – Otolaryngology–Head and Neck Surgery (free)
News Release: Nosebleed (epistaxis): New clinical practice guideline – American Academy of Otolaryngology-Head and Neck Surgery (free)
Study Commentary: Herpes Zoster Vaccine Reduces Chances of Shingles after Stem Cell Transplants
9 Jan, 2020 | 23:22h | UTCHerpes zoster vaccine reduces chances of shingles after stem cell transplants – NIHR Signal (free)
Original Study: Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Study Commentary: Continuing an Anticoagulant at Home After Abdominal Surgery Cuts Thrombosis Risk
9 Jan, 2020 | 23:21h | UTCContinuing an anticoagulant at home after abdominal surgery cuts thrombosis risk – NIHR Signal (free)
Original Study: Systematic Review: Prolonged Thromboprophylaxis with Low Molecular Weight Heparin for Abdominal or Pelvic Surgery – Cochrane Library (link to study and summary)
[Abstract Only] Randomized Trial: Four Cycles of R-CHOP Non-inferior to Six Cycles of R-CHOP in Patients with Aggressive B-cell non-Hodgkin Lymphoma and Favorable Prognosis
8 Jan, 2020 | 21:49h | UTCFour versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Commentary on Twitter
Four cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): The new standard of care for limited DLBCL with favorable prognosis https://t.co/oAH9dJJGZA
— Georgios Pongas, MD (@pongasg) December 24, 2019
[Abstract Only] Randomized Trial: Overall Survival with Daratumumab, Bortezomib, Melphalan, and Prednisone in Newly Diagnosed Multiple Myeloma
8 Jan, 2020 | 21:47h | UTCOverall survival with daratumumab, bortezomib, melphalan, and prednisone in newly diagnosed multiple myeloma (ALCYONE): a randomised, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Overall Survival With the Addition of Daratumumab to VMP in Newly Diagnosed, Transplant-Ineligible Multiple Myeloma -The ASCO Post (free)
Guideline: Transfusion Strategies in Non-bleeding Critically Ill Adults
8 Jan, 2020 | 08:50h | UTCEditorial: Transfusion thresholds: the dangers of guidelines based on randomized controlled trials (free)
[Abstract Only] Randomized Trial: Direct Oral Anticoagulant Similarly Effective as Standard Anticoagulants for the Treatment of Acute Venous Thromboembolism in Children
8 Jan, 2020 | 01:02h | UTCRivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial – The Lancet Haematology (link to abstract – $ for full-text)
Commentary: Thrombosis: Anticoagulant Rivaroxaban soon also available for children – Medical University of Vienna (free)
[Abstract Only] Study: Long-term Follow Up of Gene Therapy for Hemophilia A
8 Jan, 2020 | 00:52h | UTCMultiyear Follow-up of AAV5-hFVIII-SQ Gene Therapy for Hemophilia A – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Study shows safety, long-term beneficial impact of gene therapy for patients with Hemophilia A – Queen Mary University of London (free)
Consensus: Diagnosis and Treatment of Autoimmune Hemolytic Anemia in Adults
7 Jan, 2020 | 01:41h | UTCRelated: Autoimmune hemolytic anemia – Hematology (free) AND Guidelines on the management of drug‐induced immune and secondary autoimmune, haemolytic anaemia – British Journal of Haematology (free)
Position Statement: Diagnosis, Grading, and Treatment Recommendations for Children, Adolescents, and Young Adults with Sinusoidal Obstructive Syndrome
6 Jan, 2020 | 23:03h | UTCDiagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement – The Lancet Haematology (free registration required)
Commentary: MD Anderson-convened consortium provides first universal recommendations for pediatric patients with sinusoidal obstructive syndrome (free)
Randomized Trial: Fresh Red Blood Cell Transfusions Not Better Than Standard-issue Red Blood Cell Transfusions in Critically Ill Pediatric Patients
13 Dec, 2019 | 10:20h | UTCEffect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Age of Red Blood Cells for Transfusion in Critically Ill Pediatric Patients (free for a limited period)
Commentaries: Fresh red blood cell transfusions do not help critically ill children more than older cells – NIH News Releases (free) AND Blood transfusions: Fresh red blood cells no better than older ones – University of Montreal (free)