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Hematology (all articles)

RCT: Ivosidenib and Azacitidine in IDH1-Mutated Acute Myeloid Leukemia.

21 Apr, 2022 | 09:56h | UTC

Ivosidenib and Azacitidine in IDH1-Mutated Acute Myeloid Leukemia – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

National, regional, and global estimates of anemia by severity in women and children for 2000–19.

20 Apr, 2022 | 09:25h | UTC

National, regional, and global estimates of anaemia by severity in women and children for 2000–19: a pooled analysis of population-representative data – The Lancet Global Health

Invited Commentary: Sustainable Development Goals for anaemia: 20 years later, where are we now? – The Lancet Global Health

 

Pre-transplant EASIX (endothelial activation and stress index) may predict the hazard of sepsis after allogeneic stem cell transplantation.

19 Apr, 2022 | 02:04h | UTC

Pre-transplant EASIX and sepsis after allogeneic stem cell transplantation – Intensive Care Medicine

 

Commentary on Twitter

 

Phase 1–2 clinical trial: Rilzabrutinib, an oral BTK inhibitor, in immune thrombocytopenia.

19 Apr, 2022 | 01:35h | UTC

Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Rilzabrutinib for blood disorder shows promise in phase 1–2 clinical trial – Massachusetts General Hospital

 

Commentary on Twitter

 

RCT: Mitapivat vs. placebo for Pyruvate Kinase Deficiency.

18 Apr, 2022 | 10:13h | UTC

Mitapivat versus Placebo for Pyruvate Kinase Deficiency – New England Journal of Medicine

 

Cohort Study: Non-O blood type is associated with increased risk of venous thromboembolism in patients with cancer.

14 Apr, 2022 | 08:29h | UTC

ABO blood group type and risk of venous thromboembolism in patients with cancer – Blood Advances (link to abstract – $ for full-text)

 

Review: Cutaneous manifestations of monoclonal gammopathy.

14 Apr, 2022 | 08:21h | UTC

Cutaneous manifestations of monoclonal gammopathy – Blood Cancer Journal

 

Review | Induction therapy prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma.

14 Apr, 2022 | 08:03h | UTC

Induction therapy prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma: an update – Blood Cancer Journal

 

NCCN Guidelines: CAR T-cell–related toxicities in patients with cancer.

11 Apr, 2022 | 01:32h | UTC

Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network

Related:

Reviews: CAR T-Cell Therapy Toxicities and Side Effects

Reviews: CAR T-Cell Therapy Toxicities and Side Effects

Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared

Reviews: CAR T-Cell Therapy Toxicities and Side Effects

 

M-A: Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia.

8 Apr, 2022 | 10:50h | UTC

Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis – International Journal of Infectious Diseases

Related:

Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.

Review: Vaccine-induced immune thrombotic thrombocytopenia.

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 

Study finds increased risk of pulmonary embolism up to 110 days after COVID-19.

7 Apr, 2022 | 10:06h | UTC

Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study – The BMJ

News Release: Study finds increased risk of serious blood clots up to six months after COVID-19 – BMJ

Editorial: Thromboembolism and bleeding after covid-19

Commentary: Covid: Blood clot risk higher for six months after having virus – BBC

 

M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.

6 Apr, 2022 | 10:55h | UTC

Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives: Systematic review and meta-analysis – Journal of Thrombosis and Haemostasis

 

RCT: Erythropoietin not beneficial for patients with acute kidney injury.

6 Apr, 2022 | 10:02h | UTC

Erythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial – BMC Nephrology

 

Before-and-after study: Antimicrobial stewardship in high-risk febrile neutropenia patients reduced carbapenem and glycopeptide use and was associated with improved clinical outcomes.

4 Apr, 2022 | 00:49h | UTC

Antimicrobial stewardship in high-risk febrile neutropenia patients – Antimicrobial Resistance & Infection Control

Related:

Safety and efficacy of antibiotic de-escalation and discontinuation in high-risk hematological patients with febrile neutropenia: a single-center experience.

Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology

 

Commentary from the author on Twitter (thread – click for more)

https://twitter.com/AdrienContejean/status/1508792991917432838

 

Practice review: Evidence-based and effective management of anemia in palliative care patients.

1 Apr, 2022 | 08:21h | UTC

Practice review: Evidence-based and effective management of anaemia in palliative care patients – Palliative Medicine

 

Practice review: Evidence-based and effective management of fatigue in patients with advanced cancer.

1 Apr, 2022 | 08:26h | UTC

Practice review: Evidence-based and effective management of fatigue in patients with advanced cancer – Palliative Medicine

 

Review: The use of virtual care in patients with hematologic malignancies.

1 Apr, 2022 | 08:18h | UTC

The Use of Virtual Care in Patients with Hematologic Malignancies: A Scoping Review – Current Oncology

 

RCT: Early outpatient treatment with convalescent plasma reduces the risk of hospitalization in patients with Covid-19.

31 Mar, 2022 | 08:39h | UTC

Early Outpatient Treatment for Covid-19 with Convalescent Plasma – New England Journal of Medicine

Commentaries:

Study finds convalescent plasma can be effective early COVID-19 therapy – Johns Hopkins University School of Medicine

Early Use of High-Titer Plasma Reduced COVID Hospitalizations— Randomized trial that influenced indication shows benefits in a mostly unvaccinated population – MedPage Today (free registration required)

 

Commentary on Twitter

https://twitter.com/NEJM/status/1509278140433981444

 

Guidance on the need for contraception related to use of pharmaceuticals: providing information on the proper use of pharmaceuticals in patients with reproductive potential.

31 Mar, 2022 | 07:49h | UTC

Guidance on the need for contraception related to use of pharmaceuticals: the Japan Agency for Medical Research and Development Study Group for providing information on the proper use of pharmaceuticals in patients with reproductive potential

 

Retrospective Cohort Study: Risks for anaphylaxis with intravenous iron formulations.

30 Mar, 2022 | 10:16h | UTC

Risks for Anaphylaxis With Intravenous Iron Formulations: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Risk of Severe Allergic Reaction Higher with Two Intravenous Iron-Boosting Products – Rutgers University

Commentary: Risks for Anaphylaxis Compared Among IV Iron Products – HealthDay

 

Multidisciplinary consensus for the management of pulmonary thromboembolism.

29 Mar, 2022 | 09:54h | UTC

Multidisciplinary consensus for the management of pulmonary thromboembolism – Archivos de Bronconeumología

 

Consensus Recommendations: Management of immune thrombocytopenia.

29 Mar, 2022 | 09:50h | UTC

Management of immune thrombocytopenia: 2022 update of Korean experts recommendations – Blood Research

 

RCT: Effects of freshly irradiated vs. irradiated and stored red blood cell transfusion on cerebral oxygenation in preterm infants.

29 Mar, 2022 | 08:44h | UTC

Effects of Freshly Irradiated vs Irradiated and Stored Red Blood Cell Transfusion on Cerebral Oxygenation in Preterm Infants: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Use of Irradiated Red Blood Cell Transfusions in Newborns to Improve Intracerebral Saturation – JAMA Pediatrics (free for a limited period)

 

Commentary on Twitter

 

Review | Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion.

28 Mar, 2022 | 08:47h | UTC

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Cohort study: Long-term treatment with clozapine is associated with increased risk of hematological malignancies.

28 Mar, 2022 | 08:43h | UTC

Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

 

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