General Hematology | Page 9 of 18 | Links Medicus Content Curation & Alerts in Medicine

Guideline Synopsis: Antithrombotic therapy for venous thromboembolism.

17 May, 2022 | 11:12h | UTC

Antithrombotic Therapy for Venous Thromboembolism – JAMA (free for a limited period)

Original Guideline: Antithrombotic Therapy for VTE Disease

Second Update of the CHEST Guideline and Expert Panel Report

Cohort Study: Venous or arterial thrombosis and deaths among COVID-19 cases.

17 May, 2022 | 11:02h | UTC

Venous or arterial thrombosis and deaths among COVID-19 cases: a European network cohort study – The Lancet Infectious Diseases

Invited Commentary: Risk of arterial and venous thromboses after COVID-19 – The Lancet Infectious Diseases

News Release: COVID-19’s high blood clot risk – University of Oxford

Commentary on Twitter

Clots with Covid: Multi-national report of over 900,000 people indicates propensity of risk for arterial and venous thrombi is in men, with increasing age, and association with fatalities (4-fold in non-hospitalized) https://t.co/muGnDld4Um pic.twitter.com/6bLiHPLInm

— Eric Topol (@EricTopol) May 13, 2022

Under a Creative Commons Attribution (CC BY 4.0) license

Cohort Study: Sustainability of a clinical decision support intervention for outpatient care for emergency department patients with acute pulmonary embolism.

17 May, 2022 | 10:44h | UTC

Sustainability of a Clinical Decision Support Intervention for Outpatient Care for Emergency Department Patients With Acute Pulmonary Embolism – JAMA Network Open

Commentary on Twitter

This multicenter cohort study of ED patients with acute pulmonary embolism found the initial increase in outpatient management from a physician champion-led, EHR-embedded clinical decision support intervention was sustained 4 years later. https://t.co/UPf8pAOTry

— JAMA Network Open (@JAMANetworkOpen) May 16, 2022

M-A: Direct oral anticoagulants not as effective as vitamin K antagonists in patients with antiphospholipid syndrome.

13 May, 2022 | 10:43h | UTC

Direct oral anticoagulants versus vitamin K antagonists in patients with antiphospholipid syndrome: systematic review and meta-analysis – RMD Open

Review: Hemophagocytic Lymphohistiocytosis in patients with HIV.

11 May, 2022 | 10:47h | UTC

A Review of Hemophagocytic Lymphohistiocytosis in Patients With HIV – Open Forum Infectious Diseases

Point/Counterpoint: Should therapeutic heparin be administered to acutely ill hospitalized patients with COVID-19?

3 May, 2022 | 11:04h | UTC

POINT: Should Therapeutic Heparin Be Administered to Acutely Ill Hospitalized Patients With COVID-19? Yes – CHEST

COUNTERPOINT: Should Therapeutic Heparin Be Administered to Acutely Ill Hospitalized Patients With COVID-19? No – CHEST

Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week – Journal of the American College of Cardiology

National, regional, and global estimates of anemia by severity in women and children for 2000–19.

20 Apr, 2022 | 09:25h | UTC

National, regional, and global estimates of anaemia by severity in women and children for 2000–19: a pooled analysis of population-representative data – The Lancet Global Health

Invited Commentary: Sustainable Development Goals for anaemia: 20 years later, where are we now? – The Lancet Global Health

Phase 1–2 clinical trial: Rilzabrutinib, an oral BTK inhibitor, in immune thrombocytopenia.

19 Apr, 2022 | 01:35h | UTC

Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Rilzabrutinib for blood disorder shows promise in phase 1–2 clinical trial – Massachusetts General Hospital

Commentary on Twitter

Rilzabrutinib had rapid and durable clinical activity in adults with immune thrombocytopenia, with low-level toxic effects. https://t.co/boWT4LpQkk pic.twitter.com/ZpNXHYL2Gv

— NEJM (@NEJM) April 18, 2022

RCT: Mitapivat vs. placebo for Pyruvate Kinase Deficiency.

18 Apr, 2022 | 10:13h | UTC

Mitapivat versus Placebo for Pyruvate Kinase Deficiency – New England Journal of Medicine

Cohort Study: Non-O blood type is associated with increased risk of venous thromboembolism in patients with cancer.

14 Apr, 2022 | 08:29h | UTC

ABO blood group type and risk of venous thromboembolism in patients with cancer – Blood Advances (link to abstract – $ for full-text)

Review: Cutaneous manifestations of monoclonal gammopathy.

14 Apr, 2022 | 08:21h | UTC

Cutaneous manifestations of monoclonal gammopathy – Blood Cancer Journal

M-A: Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia.

8 Apr, 2022 | 10:50h | UTC

Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis – International Journal of Infectious Diseases

Case series of Thrombosis with Thrombocytopenia Syndrome after Covid-19 vaccination in the US.

Review: Vaccine-induced immune thrombotic thrombocytopenia.

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

Study finds increased risk of pulmonary embolism up to 110 days after COVID-19.

7 Apr, 2022 | 10:06h | UTC

Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study – The BMJ

News Release: Study finds increased risk of serious blood clots up to six months after COVID-19 – BMJ

Editorial: Thromboembolism and bleeding after covid-19

Commentary: Covid: Blood clot risk higher for six months after having virus – BBC

M-A: Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives.

6 Apr, 2022 | 10:55h | UTC

Risk of recurrence in women with venous thromboembolism related to estrogen-containing contraceptives: Systematic review and meta-analysis – Journal of Thrombosis and Haemostasis

RCT: Erythropoietin not beneficial for patients with acute kidney injury.

6 Apr, 2022 | 10:02h | UTC

Erythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial – BMC Nephrology

Practice review: Evidence-based and effective management of anemia in palliative care patients.

1 Apr, 2022 | 08:21h | UTC

Practice review: Evidence-based and effective management of anaemia in palliative care patients – Palliative Medicine

RCT: Early outpatient treatment with convalescent plasma reduces the risk of hospitalization in patients with Covid-19.

31 Mar, 2022 | 08:39h | UTC

Early Outpatient Treatment for Covid-19 with Convalescent Plasma – New England Journal of Medicine

Commentaries:

Study finds convalescent plasma can be effective early COVID-19 therapy – Johns Hopkins University School of Medicine

Early Use of High-Titer Plasma Reduced COVID Hospitalizations— Randomized trial that influenced indication shows benefits in a mostly unvaccinated population – MedPage Today (free registration required)

Commentary on Twitter

https://twitter.com/NEJM/status/1509278140433981444

Retrospective Cohort Study: Risks for anaphylaxis with intravenous iron formulations.

30 Mar, 2022 | 10:16h | UTC

Risks for Anaphylaxis With Intravenous Iron Formulations: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Risk of Severe Allergic Reaction Higher with Two Intravenous Iron-Boosting Products – Rutgers University

Commentary: Risks for Anaphylaxis Compared Among IV Iron Products – HealthDay

Multidisciplinary consensus for the management of pulmonary thromboembolism.

29 Mar, 2022 | 09:54h | UTC

Multidisciplinary consensus for the management of pulmonary thromboembolism – Archivos de Bronconeumología

Consensus Recommendations: Management of immune thrombocytopenia.

29 Mar, 2022 | 09:50h | UTC

Management of immune thrombocytopenia: 2022 update of Korean experts recommendations – Blood Research

RCT: Effects of freshly irradiated vs. irradiated and stored red blood cell transfusion on cerebral oxygenation in preterm infants.

29 Mar, 2022 | 08:44h | UTC

Effects of Freshly Irradiated vs Irradiated and Stored Red Blood Cell Transfusion on Cerebral Oxygenation in Preterm Infants: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Use of Irradiated Red Blood Cell Transfusions in Newborns to Improve Intracerebral Saturation – JAMA Pediatrics (free for a limited period)

Commentary on Twitter

In a proof-of-concept randomized trial, transfusion of freshly irradiated red blood cells resulted in favorable cerebral oxygenation kinetics in preterm infants compared with transfusion of irradiated and stored red blood cells. https://t.co/IqpyhKuv9z pic.twitter.com/BzTNnkgzm7

— JAMA Pediatrics (@JAMAPediatrics) March 28, 2022