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Perspective | Here’s a new data point for cancer patients to consider: ‘time toxicity’

19 Apr, 2023 | 13:18h | UTC

Here’s a new data point for cancer patients to consider: ‘time toxicity’ – STAT

 


Opinion | Universal masking in health care settings: a pandemic strategy whose time has come and gone, for now

18 Apr, 2023 | 13:37h | UTC

Universal Masking in Health Care Settings: A Pandemic Strategy Whose Time Has Come and Gone, For Now – Annals of Internal Medicine

News Release: Healthcare epidemiologists and infectious diseases experts review changing context for masking in healthcare settings – Mass General Brigham

 


Study shows approximately half of infectious diseases guideline authors have conflicts of interest with pharmaceutical companies

18 Apr, 2023 | 13:28h | UTC

Conflicts of Interest Among Infectious Diseases Clinical Practice Guideline Authors and the Pharmaceutical Industry – JAMA Network Open

 


Report | The implications of defining obesity as a disease

18 Apr, 2023 | 12:55h | UTC

The implications of defining obesity as a disease: a report from the Association for the Study of Obesity 2021 annual conference – eClinicalMedicine

 

Commentary on Twitter

 


SR | Experiences and perceptions of cash transfers for health

12 Apr, 2023 | 13:23h | UTC

Experiences of conditional and unconditional cash transfers intended for improving health outcomes and health service use: a qualitative evidence synthesis – Cochrane Library

Summary: Experiences and perceptions of cash transfers for health – Cochrane Library

 


ChatGPT et al? Not so fast, say journal editors

11 Apr, 2023 | 14:36h | UTC

ChatGPT et al? Not So Fast, Say Journal Editors – TCTMD

Related:

AI-Generated Medical Advice—GPT and Beyond – JAMA (free for a limited period)

Chat GPT will change Medicine – Vinay Prasad’s Observations and Thoughts

The use of ChatGPT and other large language models in surgical science – BJS Open

ChatGPT vs. NCI: analyzing the quality of cancer information on myths and misconceptions

ChatGPT has many uses. Experts explore what this means for healthcare and medical research – The Conversation

Artificial Intelligence in Medicine & ChatGPT: De-Tether the Physician – Journal of Medical Systems (if the link is paywalled, try this one)

Can artificial intelligence help for scientific writing? – Critical Care

Artificial intelligence in academic writing: a paradigm-shifting technological advance

Performance of ChatGPT on USMLE: potential for AI-assisted medical education using large language models

Perspective | ChatGPT-assisted diagnosis: is the future suddenly here?

Perspective | Generating scholarly content with ChatGPT: ethical challenges for medical publishing

ChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine

ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)

ChatGPT: five priorities for research – Nature

The path forward for ChatGPT in academia – Lumo’s Newsletter

Nonhuman “Authors” and Implications for the Integrity of Scientific Publication and Medical Knowledge – JAMA

ChatGPT is fun, but not an author – Science

Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature

ChatGPT listed as author on research papers: many scientists disapprove – Nature

Abstracts written by ChatGPT fool scientists

 


Umbrella review unveils benefits of cutting free sugars to 6 teaspoons/day

10 Apr, 2023 | 14:00h | UTC

Dietary sugar consumption and health: umbrella review – The BMJ

News Release: Limit added sugar to six teaspoons a day to improve health, urge experts – BMJ Newsroom

 


WHO Report | 1 in 6 people globally affected by infertility

5 Apr, 2023 | 13:47h | UTC

News Release: 1 in 6 people globally affected by infertility – World Health Organization

Report: Infertility Prevalence Estimates, 1990–2021 – World Health Organization

Key facts: Infertility – World Health Organization

Commentaries:

Infertility affects a ‘staggering’ 1 in 6 people worldwide, WHO says – CNN

One in six people worldwide affected by infertility, WHO reports – The Guardian

 

Commentary on Twitter (thread – click for more)

 


RCT | Mindfulness therapy proves more effective and affordable than cognitive behavioral therapy for depression

4 Apr, 2023 | 14:04h | UTC

Summary: The LIGHTMind Randomized Clinical Trial studied 410 adults with mild to moderate depression, comparing the clinical effectiveness and cost-effectiveness of practitioner-supported mindfulness-based cognitive therapy self-help (MBCT-SH) to practitioner-supported cognitive behavioral therapy self-help (CBT-SH). The trial provided participants with either an MBCT-SH or CBT-SH workbook and six support sessions with a trained practitioner. Depressive symptom severity was measured using the Patient Health Questionnaire (PHQ-9) score at 16 weeks after randomization.

Results showed that MBCT-SH led to significantly greater reductions in depressive symptoms and was more cost-effective than CBT-SH. The between-group difference was 1.5 PHQ-9 points, and MBCT-SH cost health services £526 ($631) less per participant over a 42-week follow-up period. A substantial portion of this cost difference was due to additional face-to-face individual psychological therapy accessed by CBT-SH participants outside of the study intervention.

The trial concluded that offering practitioner-supported MBCT-SH for mild to moderate depression could improve outcomes and save money compared to CBT-SH. To translate these findings into practice, proper training and supervision for practitioners delivering MBCT-SH are necessary. Future research should focus on corroborating and extending these findings, exploring factors contributing to MBCT-SH’s relative effectiveness, and examining potential barriers and facilitators for successful implementation in routine clinical practice.

Article: Clinical Effectiveness and Cost-Effectiveness of Supported Mindfulness-Based Cognitive Therapy Self-help Compared With Supported Cognitive Behavioral Therapy Self-help for Adults Experiencing Depression: The Low-Intensity Guided Help Through Mindfulness (LIGHTMind) Randomized Clinical Trial – JAMA Psychiatry

Commentary:

Mindfulness better than CBT for treating depression, study finds – The Guardian

Practitioner-Supported Mindfulness-Based Cognitive Therapy Aids Depression – HealthDay

 

Commentary on Twitter

 


Opinion | AI-generated medical advice—GPT and beyond

4 Apr, 2023 | 14:00h | UTC

AI-Generated Medical Advice—GPT and Beyond – JAMA (free for a limited period)

Related:

Chat GPT will change Medicine – Vinay Prasad’s Observations and Thoughts

The use of ChatGPT and other large language models in surgical science – BJS Open

ChatGPT vs. NCI: analyzing the quality of cancer information on myths and misconceptions

ChatGPT has many uses. Experts explore what this means for healthcare and medical research – The Conversation

Artificial Intelligence in Medicine & ChatGPT: De-Tether the Physician – Journal of Medical Systems (if the link is paywalled, try this one)

Can artificial intelligence help for scientific writing? – Critical Care

Artificial intelligence in academic writing: a paradigm-shifting technological advance

Performance of ChatGPT on USMLE: potential for AI-assisted medical education using large language models

Perspective | ChatGPT-assisted diagnosis: is the future suddenly here?

Perspective | Generating scholarly content with ChatGPT: ethical challenges for medical publishing

ChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine

ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)

ChatGPT: five priorities for research – Nature

The path forward for ChatGPT in academia – Lumo’s Newsletter

Nonhuman “Authors” and Implications for the Integrity of Scientific Publication and Medical Knowledge – JAMA

ChatGPT is fun, but not an author – Science

Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature

ChatGPT listed as author on research papers: many scientists disapprove – Nature

Abstracts written by ChatGPT fool scientists

 


RCT | No significant fracture reduction from monthly 60,000 IU vitamin D3 supplementation

4 Apr, 2023 | 13:58h | UTC

The effect of monthly vitamin D supplementation on fractures: a tertiary outcome from the population-based, double-blind, randomised, placebo-controlled D-Health trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related:

SR | Calcium and vitamin D supplements do not increase bone mineral density or prevent fractures in premenopausal women

RCT | Supplemental Vitamin D does not reduce incident fractures in midlife and older adults.

Comparison of fracture risk using different supplemental doses of vitamin D, calcium or their combination: a network meta-analysis of randomised controlled trials – BMJ Open

Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA

 


M-A | No significant health benefits found for low-volume alcohol intake

4 Apr, 2023 | 13:48h | UTC

Summary: This systematic review and meta-analysis aimed to investigate the association between alcohol use and all-cause mortality, taking into account potential sources of bias. The study analyzed data from 107 cohort studies published between January 1980 and July 2021, which included 4,838,825 participants and 425,564 deaths.

The study found no significant reductions in all-cause mortality risk for drinkers who consumed less than 25 grams of ethanol per day compared to lifetime nondrinkers. However, there was a significantly increased risk of all-cause mortality among female drinkers who drank 25 or more grams per day and male drinkers who drank 45 or more grams per day.

The analysis highlighted the importance of controlling for former drinker bias and misclassification errors and found sex differences in the risk of all-cause mortality.

In conclusion, the updated meta-analysis found no significantly reduced risk of all-cause mortality associated with low-volume alcohol consumption after adjusting for potential confounding factors. The study recommends that future longitudinal studies in this field should attempt to minimize lifetime selection biases by not including former and occasional drinkers in the reference group and by using younger cohorts at baseline.

Article: Association Between Daily Alcohol Intake and Risk of All-Cause Mortality: A Systematic Review and Meta-analyses – JAMA Network Open

Commentary: Drinking Alcohol Brings No Health Benefits, Study Finds – HealthDay

Related:

Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020 – The Lancet

National, regional, and global burdens of disease from 2000 to 2016 attributable to alcohol use: a comparative risk assessment study – The Lancet Public Health

Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet

The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Psychiatry

Prioritising action on alcohol for health and development – The BMJ

Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study – The Lancet Oncology

 


Opinion | ChatGPT will change Medicine

30 Mar, 2023 | 14:22h | UTC

Chat GPT will change Medicine – Vinay Prasad’s Observations and Thoughts

Related:

The use of ChatGPT and other large language models in surgical science – BJS Open

ChatGPT vs. NCI: analyzing the quality of cancer information on myths and misconceptions

ChatGPT has many uses. Experts explore what this means for healthcare and medical research – The Conversation

Artificial Intelligence in Medicine & ChatGPT: De-Tether the Physician – Journal of Medical Systems (if the link is paywalled, try this one)

Can artificial intelligence help for scientific writing? – Critical Care

Artificial intelligence in academic writing: a paradigm-shifting technological advance

Performance of ChatGPT on USMLE: potential for AI-assisted medical education using large language models

Perspective | ChatGPT-assisted diagnosis: is the future suddenly here?

Perspective | Generating scholarly content with ChatGPT: ethical challenges for medical publishing

ChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine

ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)

ChatGPT: five priorities for research – Nature

The path forward for ChatGPT in academia – Lumo’s Newsletter

Nonhuman “Authors” and Implications for the Integrity of Scientific Publication and Medical Knowledge – JAMA

ChatGPT is fun, but not an author – Science

Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature

ChatGPT listed as author on research papers: many scientists disapprove – Nature

Abstracts written by ChatGPT fool scientists

 


Alcohol minimum unit pricing in Scotland led to substantial decrease in alcohol-attributable deaths and hospitalizations

29 Mar, 2023 | 13:28h | UTC

Evaluating the impact of alcohol minimum unit pricing on deaths and hospitalisations in Scotland: a controlled interrupted time series study – The Lancet

News Release: Minimum unit pricing for alcohol associated with a 13% decrease in deaths from alcohol consumption in Scotland – Lancet

Commentaries:

Expert reaction to study looking at alcohol-related deaths and hospitalisations in Scotland since the minimum unit pricing for alcohol policy was introduced – Science Media Centre

Minimum pricing averts alcohol deaths, study claims – BBC

Scotland’s minimum pricing linked to 13% drop in alcohol-related deaths, study finds – The Guardian

 

Commentary on Twitter (thread – click for more)

 


Perspective | The use of ChatGPT and other large language models in surgical science

28 Mar, 2023 | 15:01h | UTC

The use of ChatGPT and other large language models in surgical science – BJS Open

 


ChatGPT vs. NCI: analyzing the quality of cancer information on myths and misconceptions

28 Mar, 2023 | 15:00h | UTC

Using ChatGPT to evaluate cancer myths and misconceptions: artificial intelligence and cancer information – JNCI Cancer Spectrum

News Release: Looking for cancer information: Can ChatGPT be counted on? – Huntsman Cancer Institute

Commentary: Report Examines Accuracy of ChatGPT in Providing Information on Common Cancer Myths and Misconceptions – The ASCO Post

 


Survey | Perspectives of patients about immediate access to test results through an online patient portal

23 Mar, 2023 | 13:02h | UTC

Summary: This study aimed to assess patient and caregiver attitudes and preferences related to receiving immediately released test results through an online patient portal.

In a survey of 8,139 respondents across 4 US academic medical centers, 95,7% of patients preferred to receive immediately released test results through an online patient portal, even if their healthcare practitioner had not yet reviewed the result. However, 7.5% of respondents reported that reviewing results before being contacted by a healthcare practitioner increased worry. This worry was more common among respondents who received abnormal results (16.5%) compared to those whose results were normal (5%).

The authors concluded that balancing patients’ expectations of immediate access to their information with the need to manage increased worry and healthcare practitioner burden is important as healthcare systems navigate this new era of health information transparency.

Article: Perspectives of Patients About Immediate Access to Test Results Through an Online Patient Portal – JAMA Network Open

News Release: Patients prefer immediate access to medical test results online, even if it’s bad news – UT Southwestern Medical Center

 

Commentary from one of the authors on Twitter

 


RCT | Impact of sleep deprivation on health-related quality of life in healthy children

23 Mar, 2023 | 12:57h | UTC

Effect of Sleep Changes on Health-Related Quality of Life in Healthy Children: A Secondary Analysis of the DREAM Crossover Trial – JAMA Network Open

Commentaries:

Sleep Disruption Linked to Lower HRQOL in Children – HealthDay

How just 39 minutes of sleep can make or break your child’s health, happiness and school day – CNN

 


Opinion | The rapid growth of mega-journals: threats and opportunities

22 Mar, 2023 | 13:40h | UTC

The Rapid Growth of Mega-Journals: Threats and Opportunities – JAMA (free for a limited period)

 


Cohort study | Professional soccer players are at increased risk of Alzheimer’s disease and other dementias

21 Mar, 2023 | 13:46h | UTC

Summary: The article reports on a cohort study conducted in Sweden to investigate whether male soccer players in the top division are at increased risk of neurodegenerative disease compared to matched controls from the general population. This is a topic of concern as there is a hypothesis that the repetitive mild head trauma sustained through heading the ball and concussions might cause neurodegenerative disease.

The study included 6007 football players and 56,168 controls and used nationwide registers to identify diagnoses of neurodegenerative disease. The study revealed that male professional soccer players in Sweden had a higher risk of neurodegenerative disease, particularly Alzheimer’s disease and other dementias, and outfield players had a higher risk than goalkeepers.

Article: Neurodegenerative disease among male elite football (soccer) players in Sweden: a cohort study – The Lancet Public Health

News Release: Elite football players are more likely to develop dementia, suggests Swedish study – Lancet

Commentaries:

Dementia risk higher for outfield players than goalkeepers – study – BBC

Neurodegenerative Diseases Are the Cost of Sports – Health Policy Watch

Related:

Dementia risk in former professional footballers is related to player position and career length.

Study: Neurodegenerative Disease Mortality Increased Among Former Professional Soccer Players

 


Comparative study highlights women’s lower susceptibility to sudden cardiac arrest during sports

21 Mar, 2023 | 13:44h | UTC

Summary: This study assessed the incidence, characteristics, and outcomes of sports-related sudden cardiac arrest (Sr-SCA) in women. Data from three European registries were analyzed, identifying 34,826 SCA cases between 2006 and 2017, with 760 cases (2.2%) being Sr-SCA, including 54 in women.

The average annual incidence of Sr-SCA in women was 0.19 per million, over 10 times lower than in men (2.63 per million). When extrapolated to the European population, this translates to 98 cases per year in women and 1,350 cases in men.

Characteristics, bystander response, time to defibrillation, and survival rates did not significantly differ between women and men. The findings highlight the considerably lower risk of Sr-SCA in women compared to men and should be considered when designing preparticipation screening strategies in the future.

Article: Incidence of Cardiac Arrest During Sports Among Women in the European Union – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Incidence of Cardiac Arrest During Sports Among Women – American College of Cardiology

 

Commentary on Twitter

 


The paradox of endurance training: higher coronary plaque prevalence found in lifelong athletes

21 Mar, 2023 | 13:42h | UTC

Summary: The Master@Heart study aimed to investigate the relationship between lifelong endurance exercise and coronary atherosclerosis measured by computed tomography coronary angiography (CTCA) in a cohort of 191 lifelong master endurance athletes, 191 late-onset athletes, and 176 healthy non-athletes. All participants were male with a low cardiovascular risk profile.

The study found that lifelong endurance sport participation was not associated with a more favorable coronary plaque composition compared to maintaining a healthy lifestyle. In fact, lifelong endurance athletes exhibited a higher prevalence of coronary plaques, including more non-calcified plaques in proximal segments, than fit and healthy individuals with a similarly low cardiovascular risk profile.

Further research is needed to understand how these findings on CTCA might translate into clinical events in endurance athletes.

Article: Lifelong endurance exercise and its relation with coronary atherosclerosis – European Heart Journal

Commentaries:

Lifelong Endurance Exercise and Coronary Atherosclerosis – American College of Cardiology

MASTER@HEART: Long-term Endurance Athletes Not Immune to Atherosclerosis – TCTMD

 


M-A | Comparison of mental health symptoms before and during the covid-19 pandemic

21 Mar, 2023 | 13:40h | UTC

Comparison of mental health symptoms before and during the covid-19 pandemic: evidence from a systematic review and meta-analysis of 134 cohorts – The BMJ

Editorial: Mental health and the covid-19 pandemic – The BMJ

News Release: Study suggests little deterioration in mental health linked to the pandemic – BMJ Newsroom

Commentaries:

A patient’s perspective on mental health and the pandemic – The BMJ

Expert reaction to systematic review and meta-analysis on mental health before and during the COVID-19 pandemic – Science Media Centre

World’s most comprehensive study on COVID-19 mental health – McGill University

 


M-A | The efficacy of Kangaroo-Mother care to the clinical outcomes of LBW and premature infants

21 Mar, 2023 | 13:35h | UTC

Summary: Kangaroo-Mother Care (KMC) is a method that involves skin-to-skin contact between the mother and newborn, frequent exclusive or almost exclusive breastfeeding, and early discharge. KMC is an alternative to traditional care interventions for low birthweight (LBW) infants, and the World Health Organization has recommended its use for LBW infants for over a decade.

The authors conducted a meta-analysis including 17 randomized clinical trials involving 17,668 participants. They found that KMC can significantly reduce neonatal mortality, lower hypothermia and sepsis rates, and reduce the duration of hospital stay. The authors suggest that KMC should be promoted, popularized, and standardized in clinical practice.

Article: The efficacy of Kangaroo-Mother care to the clinical outcomes of LBW and premature infants in the first 28 days: A meta-analysis of randomized clinical trials – Frontiers in Pediatrics

Related:

Immediate “Kangaroo Mother Care” and Survival of Infants with Low Birth Weight – New England Journal of Medicine

Effect of community-initiated kangaroo mother care on survival of infants with low birthweight: a randomised controlled trial – The Lancet

Effect of Community-Initiated Kangaroo Mother Care on Postpartum Depressive Symptoms and Stress Among Mothers of Low-Birth-Weight Infants: A Randomized Clinical Trial – JAMA Network Open

Kangaroo mother care to reduce morbidity and mortality in low birthweight infants – Cochrane Library

Preterm care during the COVID-19 pandemic: A comparative risk analysis of neonatal deaths averted by kangaroo mother care versus mortality due to SARS-CoV-2 infection – EclinicalMedicine

 


COVID-19 pandemic measures may have caused reduced cognitive abilities among German students, study shows

20 Mar, 2023 | 13:50h | UTC

Summary: This study investigated the impact of the COVID-19 pandemic on the cognitive abilities of secondary school students in Germany. The study compared the intelligence test performance of 424 students in Grades 7 to 9, tested after the first six months of the pandemic, to the results of two highly comparable student samples tested in 2002 and 2012.

The study found that the 2020 sample had substantially lower intelligence test scores than both the 2002 and 2012 samples. The study also retested the 2020 sample after another full school year of COVID-19-affected schooling in 2021 and found no signs of catching up to previous cohorts or further declines in cognitive performance.

It can be inferred from the article that the lower intelligence test scores of the 2020 sample may have been caused by the prolonged disruption of regular schooling due to the COVID-19 pandemic, including lockdowns and school closures.

The study highlights the potential negative impact of the COVID-19 pandemic on the cognitive abilities of secondary school students and suggests that these consequences should be taken into account when conducting intelligence assessments in the post-pandemic era. It also recommends that appropriate compensatory measures be implemented to address any learning loss or cognitive deficits that may have resulted from the disruption of regular schooling during the pandemic.

Article: Students’ intelligence test results after six and sixteen months of irregular schooling due to the COVID-19 pandemic – PLOS One

News Release: After 6 months of disrupted schooling during COVID-19, German students scored substantially lower on intelligence tests than comparative earlier cohorts, with the gap persisting after 16 months – PLOS

 


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