GI Surgery – Colorectal
Review | Lynch syndrome genetics and clinical implications
4 May, 2023 | 13:24h | UTCLynch syndrome genetics and clinical implications – Gastroenterology
RCT | Effect of multimodal prehabilitation in improving outcomes following colorectal cancer surgery
3 May, 2023 | 14:52h | UTCEffect of Multimodal Prehabilitation on Reducing Postoperative Complications and Enhancing Functional Capacity Following Colorectal Cancer Surgery: The PREHAB Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentary: Prehabilitation Prior to CRC Surgery Reduces Postoperative Complications – Cancer Therapy Advisor
Commentary on Twitter
Patients undergoing resection for nonmetastasized colorectal cancer may benefit from a 4-week multimodal prehabilitation program. https://t.co/e3TO1IdBPJ
— JAMA Surgery (@JAMASurgery) March 29, 2023
RCT | Recurrence outcomes following laparoscopic elective sigmoid resection vs. conservative treatment following diverticulitis
3 May, 2023 | 14:54h | UTCAuthor Interview: Outcomes Following Laparoscopic Elective Sigmoid Resection vs Conservative Treatment Following Diverticulitis – JAMA
Commentary on Twitter
In this study, elective sigmoid resection improved quality of life and decreased recurrence of diverticulitis in 2-year follow-up; these findings may help in decision-making regarding when to proceed to elective surgery for diverticulitis. https://t.co/fKkkQMu7T2
— JAMA Surgery (@JAMASurgery) April 19, 2023
RCT | Efficacy and safety of intraoperative hyperthermic intraperitoneal chemotherapy for locally advanced colon cancer
2 May, 2023 | 13:36h | UTCEfficacy and Safety of Intraoperative Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer: A Phase 3 Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Invited Commentary: Heated Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer–Restarting the Fire – JAMA Surgery (free for a limited period)
Commentary on Twitter
Hyperthermic intraperitoneal chemotherapy with mitomycin C along with complete cytoreduction improved locoregional control in patients with locally advanced colorectal cancer and should be considered for treatment of locally advanced colorectal cancer. https://t.co/hOM4TvgILB
— JAMA Surgery (@JAMASurgery) April 26, 2023
Cohort Study | Circulating tumor DNA methylation may enable early detection of recurrence in colorectal cancer
24 Apr, 2023 | 13:12h | UTCEarly Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation – JAMA Oncology (free for a limited period)
Editorial: Liquid Biopsy Assessment of Molecular Residual Disease in Localized Colorectal Cancer: Is It Ready for Prime Time? – JAMA Oncology (free for a limited period)
Commentary on Twitter
Cohort study of 299 pts w/stage I-III colorectal cancer, evaluating ctDNA evaluation w/methylation markers, showed ctDNA before & after surgery, after adjuvant chemo, & during longitudinal monitoring is highly associated w/recurrence. https://t.co/csHNz5kWz3 #CRCSM #GICSM
— JAMA Oncology (@JAMAOnc) April 21, 2023
Screening colonoscopy in seniors: common in patients with limited life expectancy and associated with higher complication risks
11 Apr, 2023 | 14:30h | UTCFrequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years – JAMA Internal Medicine (link to abstract – $ for full-text)
Related: Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
Commentary:
In older adults >75 years of age, most screening colonoscopies were in patients in patients with limited life expectancy (defined as <10 years) and associated with increased risk of adverse events. https://t.co/XOsy2UKNRx @Jessica_Halabi @MRothbergMD @burkegastrodoc
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2023
M-A | Irritable bowel syndrome is not associated with an increased risk of polyps and colorectal cancer
11 Apr, 2023 | 14:19h | UTC
RCT | Pelvic intraoperative neuromonitoring prevents dysfunction in patients with rectal cancer
4 Apr, 2023 | 13:43h | UTC
Perspective | Coping with anastomotic leaks: harder as one gets older?
4 Apr, 2023 | 13:34h | UTCCoping with anastomotic leaks: harder as one gets older? – British Journal of Surgery
Two FITs better than one: enhancing diagnostic performance for colorectal cancer in symptomatic populations
4 Apr, 2023 | 13:32h | UTC
Brief Review | What every gastroenterologist should know about gastrointestinal neuroendocrine tumors
4 Apr, 2023 | 13:29h | UTC
RCT | Vedolizumab for the treatment of chronic pouchitis
3 Apr, 2023 | 13:49h | UTCVedolizumab for the Treatment of Chronic Pouchitis – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: New hope for patients after vedolizumab found effective to treat Chronic Pouchitis – University of Oxford
Commentary on Twitter
In a phase 4, double-blind, randomized trial, vedolizumab therapy was more effective than placebo in inducing remission in patients with chronic pouchitis after ileal pouch–anal anastomosis for ulcerative colitis. Full results of EARNEST trial: https://t.co/5OnC72j2Ik pic.twitter.com/RcH1uAB1AI
— NEJM (@NEJM) March 29, 2023
Cohort Study | Long-term quality of life and functional outcome of patients with rectal cancer following a watch-and-wait approach
3 Apr, 2023 | 13:31h | UTCLong-term Quality of Life and Functional Outcome of Patients With Rectal Cancer Following a Watch-and-Wait Approach – JAMA Surgery (free for a limited period)
Invited Commentary: Guiding Patients Through a “Watch-and-Wait” Approach for Rectal Cancer—Understanding the Functional Outcomes – JAMA Surgery (free for a limited period)
Related:
Commentary on Twitter
Results of this study suggest that patients with rectal cancer who were observed by a watch-and-wait approach had good quality of life, with some patients reporting bowel and sexual dysfunction. https://t.co/zaK3bjJA8n
— JAMA Surgery (@JAMASurgery) March 31, 2023
RCT | No reduction in parastomal hernia rate 3 years after stoma construction with prophylactic Mesh
27 Mar, 2023 | 13:07h | UTC
RCT | Topical lidocaine or lidocaine/diltiazem ointment following rubber band ligation of hemorrhoids
27 Mar, 2023 | 13:05h | UTCTopical Lidocaine or Lidocaine/Diltiazem Ointment Following Rubber Band Ligation of Hemorrhoids: A Prospective Three-Armed Randomized Controlled Trial – Diseases of the Colon & Rectum (link to abstract – $ for full-text)
Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
23 Mar, 2023 | 13:11h | UTCSummary: This study investigated the association between estimated life expectancy, surveillance colonoscopy findings, and follow-up recommendations among older adults. The study utilized data from the New Hampshire Colonoscopy Registry and included adults over 65 who underwent colonoscopy for surveillance after prior polyps.
Life expectancy was estimated using a validated prediction model and categorized into three groups: less than 5 years, 5 to less than 10 years, and 10 or more years.
Out of the 9,831 adults included in the study, 8% had advanced polyps or CRC. Among the 5,281 patients with available recommendations, 86.9% were advised to return for a future colonoscopy. Surprisingly, 58.1% of older adults with less than 5 years of life expectancy were also recommended to return for future surveillance colonoscopy.
The study concluded that many older adults with limited life expectancy are still recommended for future surveillance colonoscopy. This data could help refine decision-making about pursuing or stopping surveillance colonoscopy in older adults with a history of polyps.
Article: Association of Life Expectancy With Surveillance Colonoscopy Findings and Follow-up Recommendations in Older Adults – JAMA Internal Medicine (link to abstract – $ for full-text)
JAMA Patient Page: What Should I Know About Stopping Routine Cancer Screening?
Commentary on Twitter
Findings suggest that recommending against future surveillance colonoscopy in older adults with low-risk colonoscopy findings and/or limited life expectancy should be considered more frequently than is currently practiced. https://t.co/7jKpYyuZON
— JAMA Internal Medicine (@JAMAInternalMed) March 13, 2023
Guidelines for post polypectomy colonoscopic surveillance
22 Mar, 2023 | 13:31h | UTCRelated:
USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.
ACG Clinical Guidelines: Start colorectal cancer screening at 45
Review | Surveillance strategies following curative resection and non-operative approach of rectal cancer: how and how long?
15 Mar, 2023 | 14:59h | UTC
RCT | Transanal vs. laparoscopic total mesorectal excision for mid and low rectal cancer
10 Mar, 2023 | 14:03h | UTCTransanal versus laparoscopic total mesorectal excision for mid and low rectal cancer (Ta-LaTME study): multicentre, randomized, open-label trial – British Journal of Surgery (link to abstract – $ for full-text)
Ileal pouch-anal anastomosis in the older adult: a review of postoperative outcomes and pouchitis treatment
9 Mar, 2023 | 14:00h | UTC
Cohort Study | Endoscopic biopsy with normal mucosa associated with elevated risk of inflammatory bowel disease for at least 30 years
8 Mar, 2023 | 14:10h | UTCSummary:
This study explored the long-term risk of inflammatory bowel disease (IBD) after an endoscopic biopsy with normal mucosa. The researchers identified individuals in Sweden with a lower or upper gastrointestinal (GI) biopsy of normal mucosa, their matched population references, and unexposed full siblings.
They found that individuals with a previous lower or upper GI biopsy showing normal mucosa were at persistently higher risk of overall IBD, ulcerative colitis, and Crohn’s disease compared to their matched population references and unexposed full siblings, and the increased risk persisted at least 30 years after the biopsy with normal findings.
The findings suggest a substantial symptomatic period before IBD diagnosis, and clinicians should be aware of the long-term increased risk of IBD in those with symptoms requiring GI investigation but with a finding of histologically normal mucosa.
Commentary: Risk for IBD Remains High After Endoscopic Biopsy With Normal Mucosa – HealthDay
Colorectal cancer statistics in the US, 2023
6 Mar, 2023 | 14:02h | UTCColorectal cancer statistics, 2023 – CA: A Cancer Journal for Clinicians
Severity and impact of accidental bowel leakage two decades after no, one, or two obstetrical sphincter injuries
3 Mar, 2023 | 13:56h | UTCSummary: This study investigated the long-term severity and subjective impact of anal incontinence among women who had experienced 1 or 2 consecutive obstetrical anal sphincter injuries compared with those without injuries. The study used prospectively registered data and a questionnaire to analyze outcomes, including the frequency of fecal and gas incontinence, the impact on daily life, and the effect on other pelvic floor disorders. The results showed that the severity and impact of anal incontinence doubled and quadrupled in women with 1 or 2 consecutive sphincter injuries, respectively, compared with those without injury. The second sphincter injury had an equally large additive effect compared to the first injury. However, the study found that 1 or 2 sphincter injuries did not affect other pelvic floor disorders or lower urinary tract symptoms compared to women without injury.
News Release: Decades-long suffering from obstetric injuries – University of Gothenburg
Review | Platelet aggregation inhibitors and anticoagulants in gastroenterological and visceral surgical procedures
1 Mar, 2023 | 14:03h | UTC
RCT | Single CT colonography vs. three rounds of fecal immunochemical test for screening of colorectal cancer
1 Mar, 2023 | 13:43h | UTCSingle CT colonography versus three rounds of faecal immunochemical test for population-based screening of colorectal cancer (SAVE): a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary on Twitter
New research – Sali et al – Single CT colonography versus three rounds of faecal immunochemical test for population-based screening of #colorectalcancer (SAVE): a randomised controlled trialhttps://t.co/RBxgAm0xJA#gitwitter #crcsm #colorectalcancerscreening #colonography pic.twitter.com/XSeJHxuO7c
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) September 16, 2022