Gastroenterology (all articles)
ACG Guideline | Diagnosis and management of biliary strictures
3 Mar, 2023 | 14:13h | UTC
RCT | Effects of a vibrating capsule for chronic constipation
3 Mar, 2023 | 13:41h | UTCRandomized Placebo-Controlled Phase 3 Trial of Vibrating Capsule for Chronic Constipation – Gastroenterology (link to abstract – $ for full-text)
Commentary: Researchers reveal the impact of vibrating capsules in chronic constipation patients – News Medical
Review | Platelet aggregation inhibitors and anticoagulants in gastroenterological and visceral surgical procedures
1 Mar, 2023 | 14:03h | UTC
Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP
1 Mar, 2023 | 13:56h | UTC
Commentary on Twitter
Setting the standards ? of common bile duct and pancreatic duct
? CBD up to 8 mm < 65 y/o and up to 11 mm in ≥65 y/o
? PD diameters up to 3 mm in <65 y/o and up to 4 mm in ≥65 y/o
Landmark open access @Gut_BMJ paper ? kudos to authors ! ?https://t.co/hGEkfeVeRc pic.twitter.com/E4IXU50EZi
— Giovanni Marchegiani (@Gio_Marchegiani) February 28, 2023
RCT | Single CT colonography vs. three rounds of fecal immunochemical test for screening of colorectal cancer
1 Mar, 2023 | 13:43h | UTCSingle CT colonography versus three rounds of faecal immunochemical test for population-based screening of colorectal cancer (SAVE): a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary on Twitter
New research – Sali et al – Single CT colonography versus three rounds of faecal immunochemical test for population-based screening of #colorectalcancer (SAVE): a randomised controlled trialhttps://t.co/RBxgAm0xJA#gitwitter #crcsm #colorectalcancerscreening #colonography pic.twitter.com/XSeJHxuO7c
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) September 16, 2022
Study links proton pump inhibitor use to increased risk of acquiring drug-resistant bacteria in hospitalized patients
27 Feb, 2023 | 13:13h | UTCSummary: This case-control study investigated whether proton pump inhibitors (PPIs) are associated with an increased risk of acquiring extended-spectrum β-lactamase (ESBL) or carbapenemase-producing Enterobacterales among hospitalized patients. The study involved 2239 adult hospitalized patients. After controlling for confounding factors, patients who received PPIs within the previous 30 days had a nearly 50% increased risk (aIRR, 1.48) of acquiring ESBL- or carbapenemase-producing Enterobacterales compared with those who did not receive PPIs. The study has the limitations of an observational study but points to the need for judicious use of PPIs to mitigate the risk of acquiring drug-resistant Enterobacterales among hospitalized patients.
Commentaries:
Study links acid suppressants to colonization with multidrug-resistant bacteria – CIDRAP
Proton Pump Inhibitors Associated With Increased Risk of Drug-Resistant Infections – HCP Live
Cohort Study | Could regular laxative use be associated with an increased risk of dementia?
27 Feb, 2023 | 12:59h | UTCAssociation Between Regular Laxative Use and Incident Dementia in UK Biobank Participants – Neurology (link to abstract – $ for full-text)
News Release: Study: People Who Regularly Use Laxatives May Have an Increased Risk of Dementia – American Academy of Neurology
Commentary: Regular Use of Laxatives Linked to Risk for All-Cause Dementia – HealthDay
Guideline | Diagnosis and treatment of Helicobacter pylori
24 Feb, 2023 | 13:53h | UTCRelated:
M-A | Efficacy of elimination diets in eosinophilic esophagitis
24 Feb, 2023 | 13:47h | UTCSummary: This systematic review and meta-analysis evaluated the effectiveness of various dietary treatment regimens for eosinophilic esophagitis (EoE). After analyzing 34 studies with 1762 patients, it was concluded that dietary therapy is a viable and efficacious option for individuals with EoE of all ages, with an overall histological remission rate of 53.8% and a clinical response rate of 80.8%. The study also found that highly restrictive dietary regimes, such as a six-food elimination diet, may not be superior to less restrictive dietary regimens, such as a four-food elimination diet or one-food elimination diet, in achieving histological remission, supporting less restrictive dietary regimens as a treatment option. The study has several limitations, such as the observational nature of most studies included.
Commentary: Elimination diets effective for patients with eosinophilic esophagitis – ACP Gastroenterology
Commentary on Twitter
Efficacy of dietary therapy in eosinophilic esophagitis for (1) histologic remission & (2) clinical response
6⃣-food elimination diet: 61%, 93%
4⃣-food elimination diet: 49%, 74%
1⃣-food elimination diet: 51%, 87%
Targeted elimination diet: 46%, 69%#EoEhttps://t.co/VKXgCQO9O6 pic.twitter.com/KfpSburuwN— John Damianos, M.D. (@john_damianosMD) February 1, 2023
Article under a Creative Commons Attribution (CC BY 4.0) license
RCT | Electroacupuncture may improve opioid-induced constipation in patients with cancer
24 Feb, 2023 | 13:46h | UTCSummary: The study was a randomized clinical trial that evaluated the efficacy and safety of electroacupuncture (EA) for opioid-induced constipation (OIC) in adult patients with cancer pain. The trial included 100 patients with cancer and OIC who were randomly assigned to receive either EA or sham electroacupuncture (SA) for 24 sessions over 8 weeks. The study found that the proportion of overall responders was greater with EA (40,1%) than with SA (9,0%) at week 8, suggesting that EA treatment could be a safe and effective alternative for managing OIC in adult cancer patients. However, the trial’s limitations, such as the wide heterogeneity of cancer patients, the self-reported diary measurements, and the inability to blind acupuncturists, should be considered. Additionally, it’s worth noting that more patients in the EA group guessed that they received actual EA treatment compared to those who received SA (46 vs 22 patients).
Commentary on Twitter
RCT: Electroacupuncture (EA) could alleviate opioid-induced constipation in adult cancer patients with a good safety profile. EA may be considered as an alternative treatment for opioid-induced constipation. https://t.co/zywl2A14ij pic.twitter.com/9RhSVaZVSJ
— JAMA Network Open (@JAMANetworkOpen) February 22, 2023
Review | Constipation in children and adolescents
23 Feb, 2023 | 13:06h | UTCConstipation in Children and Adolescents – Deutsches Ärzteblatt international
AGA Guideline | Role of biomarkers for the management of ulcerative colitis
22 Feb, 2023 | 12:38h | UTC
AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease
22 Feb, 2023 | 12:37h | UTCRelated:
Management of NAFLD in primary care settings – Liver International
Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports
RCT | Cold snare polypectomy reduces bleeding compared to hot snare polypectomy
22 Feb, 2023 | 12:34h | UTCCold Versus Hot Snare Polypectomy for Small Colorectal Polyps: A Pragmatic Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Cold snare polypectomy significantly reduces bleeding risk compared to hot snare polypectomy – Science News Net
SR | Probiotics for management of functional abdominal pain disorders in children
22 Feb, 2023 | 12:20h | UTCProbiotics for management of functional abdominal pain disorders in children – Cochrane Library
RCT | Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease
20 Feb, 2023 | 12:27h | UTCSummary: The article reports on a randomized trial that compared the effects of alternate-day fasting (ADF) combined with exercise, fasting alone, or exercise alone in adults with obesity and non-alcoholic fatty liver disease (NAFLD). After three months, the combination of ADF and exercise significantly reduced intrahepatic triglyceride content, body weight, fat mass, waist circumference, and alanine transaminase levels compared to the control group. The intervention seems promising for patients with fatty liver disease who want to improve their health without using medications.
Article: Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial – Cell Metabolism (link to abstract – $ for full-text)
News Release: Alternate-day fasting could be a good option for patients with fatty liver disease – University of Illinois Chicago
M-A | Efficacy and safety of drugs for gastroparesis
17 Feb, 2023 | 13:05h | UTCCommentaries:
Review finds only two efficacious medications to treat gastroparesis – ACP Gastroenterology
Two drug classes appear effective for gastroparesis treatment – MDedge
Commentary from the author on Twitter (thread – click for more)
Our latest (and definitely last!) paper of 2022 is now published online in @AGA_Gastro and is a network meta-analysis of drugs in gastroparesis:https://t.co/kpz8nH6ekT
— Alexander Ford (@alex_ford12399) December 26, 2022
Review | Perioperative optimization of Crohn’s disease
17 Feb, 2023 | 12:39h | UTCPerioperative optimization of Crohn’s disease – Annals of Gastroenterological Surgery
Current status of liver transplantation for non-B non-C liver cirrhosis and hepatocellular carcinoma
17 Feb, 2023 | 12:36h | UTC
Rare, overlooked, or underappreciated causes of recurrent abdominal pain: a primer for gastroenterologists
16 Feb, 2023 | 15:12h | UTC
Commentary from the author on Twitter
Our paper in @AGA_CGH looking at Rare, Overlooked, or Underappreciated Causes of Recurrent Abdominal Pain: A Primer for Gastroenterologists
Thanks to @umfoodoc @dbrennerGIMD and my mentor #DrBrandt @MonteGastro for including me in this important work https://t.co/91MKLqvgLy pic.twitter.com/HcHiRehhNI
— Marc Fenster (@Marcfenster1) September 28, 2022
RCT | Orlistat and a low-carb diet show promising results for the treatment of Metabolic-Associated Fatty Liver Disease
16 Feb, 2023 | 15:07h | UTCSummary: The study aimed to compare the effects of orlistat or a high-protein/lower-carbohydrate diet with a control diet in Asian patients with obesity and metabolic-associated fatty liver disease (MAFLD) over 24 weeks. The primary endpoint was the relative change in liver fat content (LFC) assessed by MRI-PDFF. A total of 118 patients were randomly assigned to the control group, orlistat group, or experimental diet group. All three groups demonstrated improvement in liver steatosis at week 24, with the orlistat group and the experimental diet group both showing a significant decrease in LFC compared to the control group.*
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
Cohort Study | Antibiotics, hormonal therapies, oral contraceptives, and NSAIDS linked to increased risk of inflammatory bowel disease
16 Feb, 2023 | 14:59h | UTCAssociations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)
Position Paper | Medical Management of pediatric inflammatory bowel disease
15 Feb, 2023 | 16:03h | UTC
Single-arm study | Effects of SER-109 as an investigational microbiome therapeutic in recurrent C. difficile infection
14 Feb, 2023 | 10:47h | UTCSummary: This was a phase 3, open-label, single-arm trial of 263 adults with recurrent Clostridioides difficile Infection (CDI). The trial aimed to evaluate the safety and rate of CDI recurrence after administration of the investigational microbiome therapeutic SER-109. The trial found that SER-109 was well tolerated and the overall rate of recurrent CDI was low, regardless of the number of prior recurrences, demographics, or diagnostic approach.
(By ChatGPT, reviewed and edited)
Commentary: Phase 3 trial provides more positive data for recurrent C diff microbiome drug – CIDRAP
Related:
Guideline | Barrett’s esophagus and stage 1 esophageal adenocarcinoma: monitoring and management
13 Feb, 2023 | 12:49h | UTC