Gastroenterology (all articles)
SR: Concomitant use of levothyroxine and proton pump inhibitors causes a significant increase in TSH concentration
18 Feb, 2021 | 02:48h | UTC
M-A: Role of diet in colorectal cancer incidence
17 Feb, 2021 | 01:12h | UTC
M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome
16 Feb, 2021 | 02:01h | UTC
Commentary on Twitter
Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis "The low-FODMAP diet reduces GI symptoms and improves quality of life in IBS subjects as compared to control diets"https://t.co/tTeRjKOV1O pic.twitter.com/raLdnlDQCJ
— Lukas Schwingshackl (@LSchwingshackl) February 15, 2021
FDA Drug Safety Communication: Initial safety trial results find Tofacitinib, used for arthritis and ulcerative colitis, may increase the risk of serious heart-related problems and cancer
9 Feb, 2021 | 01:00h | UTCCommentary: Arthritis, Colitis Drug Tied to Heart-Related Problems and Cancer – NEJM Journal Watch
RCT: In patients with cirrhosis treated with TIPS, prophylactic rifaximin reduced the risk for Hepatic Encephalopathy
7 Feb, 2021 | 21:10h | UTCThe Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Rifaximin prevents overt hepatic encephalopathy after TIPS – HealthDay
Commentary on Twitter
New findings published in @AnnalsofIM:
In patients with #cirrhosis treated with TIPS, rifaximin was well tolerated and reduced the risk for overt HE. #Rifaximin should therefore be considered for prophylaxis of post-TIPS HE https://t.co/d2p9dfcx3s. pic.twitter.com/M7zwmUxQA3
— Annals of Int Med (@AnnalsofIM) February 2, 2021
Meta-analysis: Risk of colorectal cancer and cancer related mortality after detection of low-risk or high-risk adenomas, compared with no adenoma, at index colonoscopy
3 Feb, 2021 | 01:20h | UTCRisk of Colorectal Cancer and Cancer Related Mortality After Detection of Low-risk or High-risk Adenomas, Compared With No Adenoma, at Index Colonoscopy: A Systematic Review And Meta-Analysis – Gastroenterology (link to abstract – $ for full-text)
Related studies: Colorectal Cancer Incidence and Mortality After Removal of Adenomas During Screening Colonoscopies – Gastroenterology AND Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population – Gastroenterology (link to abstract – $ for full-text) AND Baseline Colonoscopy Findings Associated with 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance – Gastroenterology (link to abstract – $ for full-text) AND Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA
Related guideline: Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology
Disorders of the enteric nervous system — a holistic view
2 Feb, 2021 | 01:04h | UTC
Pancreatic Cysts—An Overview and Summary of Society Guidelines, 2021
28 Jan, 2021 | 01:19h | UTCPancreatic Cysts—An Overview and Summary of Society Guidelines, 2021 – JAMA (free for a limited period)
Acute Pancreatitis: A Review
28 Jan, 2021 | 01:20h | UTCAcute Pancreatitis: A Review – JAMA (free for a limited period)
Podcast: Acute Pancreatitis Part 1 of 2: Diagnosis
Podcast: Acute Pancreatitis Part 2 of 2: Treatment
Cohort study: Aspirin linked to reduced risk of colon cancer if you start it before age 70
26 Jan, 2021 | 00:37h | UTCAspirin Use and Risk of Colorectal Cancer Among Older Adults – JAMA Oncology (free for a limited period)
Commentaries: Does aspirin lower colorectal cancer risk in older adults? It depends on when they start – Massachusetts General Hospital AND Aspirin Use Cuts CRC Risk in Those Initiating Use Before Age 70 – Physician’s Weekly
State of the art review: Management of non-alcoholic fatty liver disease
21 Jan, 2021 | 01:13h | UTCManagement of non-alcoholic fatty liver disease – The BMJ
Randomized trial: Pneumatic dilation does not work for persistent dysphagia after antireflux surgery
19 Jan, 2021 | 01:13h | UTCPneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomised sham-controlled clinical trial – Gut (link to abstract – $ for full-text)
Meta-analysis of observational studies: Proton pump inhibitors linked to increased risk for recurrent Clostridioides difficile infection
17 Jan, 2021 | 22:00h | UTC
Review: Gastroesophageal reflux disease
17 Jan, 2021 | 21:52h | UTCGastroesophageal Reflux Disease: A Review – JAMA (free for a limited period)
Long-term safety of fecal microbiota transplantation for recurrent Clostridioides difficile infection
17 Jan, 2021 | 21:50h | UTCLong-term Safety of Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection – Gastroenterology (link to abstract – $ for full-text)
Commentary: Fecal Transplants Safe Long Term for Recurrent C. Diff — But new-onset conditions post-fecal microbiota transplantation need further study – MedPage Today (free registration required)
Antibiotics alone for uncomplicated appendicitis: Oral Moxifloxacin almost as good as intravenous Ertapenem + oral Levofloxacin
14 Jan, 2021 | 01:57h | UTCEditorial: Evolving Issues in the Use of Antibiotics for the Treatment of Uncomplicated Appendicitis
Commentary: More Support for Single-Drug Antibiotics for Uncomplicated Appendicitis – Physician’s Weekly
Commentary on Twitter
In this RCT comparing 7d oral moxifloxacin vs 2d IV ertapenam 5d oral levofloxacin metronidazole for adults w uncomplicated #appendicitis, Tx success was >65% for both, but oral #antibiotics did not meet noninferiority criteria vs IV PO https://t.co/SwcopsGZTm #VisualAbstract
— JAMA (@JAMA_current) January 12, 2021
Randomized trial: First-line treatment with infliximab vs. conventional treatment in children with newly diagnosed moderate-to-severe Crohn’s disease
14 Jan, 2021 | 01:27h | UTC
USPSTF recommends screening for Hepatitis B Virus infection in adolescents and adults
13 Jan, 2021 | 01:43h | UTCAuthor Interview: USPSTF Recommendation: Screening for Hepatitis B Virus Infection in Adolescents and Adults
Patient Page: Screening for Hepatitis B in Nonpregnant Adolescents and Adults – JAMA
Randomized trial: Proton pump inhibitors do not benefit patients with persistent throat symptoms
10 Jan, 2021 | 20:32h | UTC
Commentary on Twitter
Medicating random throat symptoms with proton pump inhibitors (for months) has, somehow, become routine care despite no gd evidence it actually helps.
So guess what happens if you compare 16 wk of double dose PPI with placebo in a proper trial?
…Yeah.https://t.co/mrnq4tcEUk pic.twitter.com/uZo630Sg9j
— Jussi Mustonen (@JusiMD) January 8, 2021
Review: Management of Crohn Disease
10 Jan, 2021 | 20:20h | UTCManagement of Crohn Disease: A Review – JAMA (free for a limited period)
Podcast: Crohn Disease Management – JAMA
ACG Clinical Guideline: Management of irritable bowel syndrome
16 Dec, 2020 | 10:09h | UTC
Randomized trial: Budesonide orodispersible tablets maintain remission in patients with eosinophilic esophagitis
13 Dec, 2020 | 23:12h | UTCEditorial: Maintenance Topical Steroid Therapy in Eosinophilic Esophagitis: Not So Hard to Swallow Any More?
Commentary: Budesonide for Maintaining EoE Remission – gutsandgrowth
Commentary on Twitter
In a phase 3 trial, up to 48 weeks of treatment with BOT was superior to placebo in maintaining remission of #EoE https://t.co/vewrFYgIG9 pic.twitter.com/P1DzdWb2vH
— Gastroenterology (@AGA_Gastro) November 25, 2020
British HIV Association guidelines on the management of gastrointestinal opportunistic infections in people living with HIV
11 Dec, 2020 | 09:16h | UTC
Systematic Review: Probiotics probably make little or no difference for patients with acute infectious diarrhea
10 Dec, 2020 | 08:53h | UTCProbiotics for treating acute infectious diarrhoea – Cochrane Library
Summary: Do probiotics help to treat acute infectious diarrhoea? – Cochrane Library
Randomized trial: In patients with recurrent, complicated, or persistent painful diverticulitis, sigmoid resection improved quality of life but was associated with a small but significant risk of major complications
10 Dec, 2020 | 08:51h | UTCAuthor Interview: Laparoscopic Sigmoid Resection vs Conservative Treatment in Improving Quality of Life in Diverticulitis
Commentary on Twitter
https://twitter.com/drferzli/status/1330948905941557248