Family Medicine
RCT | Chlortalidone and Hydrochlorothiazide resulted in similar reductions of CVD in older patients with hypertension.
7 Nov, 2022 | 12:50h | UTCNews Release (not published yet): No difference in heart outcomes found in use of two diuretics to treat blood pressure – American Heart Association
Commentaries:
In High BP, Chlorthalidone and Hydrochlorothiazide Have Similar Impact on MACE – TCTMD
Diuretic Comparison Project – DCP – American College of Cardiology
RCT | Intravenous iron did not significantly reduce hospital admissions in patients with heart failure and iron deficiency.
7 Nov, 2022 | 12:48h | UTCCommentaries:
IRONMAN Misses but Lends Support to IV Iron Repletion in HF – TCTMD
Updated systematic review on cannabis and other plant-based treatments for chronic pain.
7 Nov, 2022 | 12:39h | UTCRelated:
Systematic Review: Cannabis-based products for chronic pain.
Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders
M-A: Birth outcomes of neonates exposed to marijuana in utero.
Cannabis-related allergies: an international overview and consensus recommendations.
Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
Review: Considerations for cannabinoids in perioperative care by anesthesiologists.
Review: Cannabis-based Medicines and the Perioperative Physician
Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know
RCT | Efficacy of a digital behavioral therapeutic application to improve glycemic control in adults with Type 2 DM.
7 Nov, 2022 | 12:33h | UTCCommentary: Smartphone-delivered CBT improves glycemic control in people with type 2 diabetes – medwire News
RCT | Efficacy of prune juice containing sorbitol, pectin, and polyphenol in chronic constipation.
7 Nov, 2022 | 12:34h | UTCPrune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial – American Journal of Gastroenterology (free for a limited period)
Commentary on Twitter
In the 📕#RedJournal — Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial
Koyama, et al.👉 https://t.co/IFnZTfnw8I@AmCollegeGastro pic.twitter.com/C244dAWNIa
— AJG – The American Journal of Gastroenterology (@AmJGastro) October 19, 2022
Crossover RCT | Efficacy of low-dose Empagliflozin as an adjunct to hybrid closed-loop insulin therapy in adults with Type 1 DM.
7 Nov, 2022 | 12:24h | UTCLow-Dose Empagliflozin as Adjunct to Hybrid Closed-Loop Insulin Therapy in Adults With Suboptimally Controlled Type 1 Diabetes: A Randomized Crossover Controlled Trial – Diabetes Care (link to abstract – $ for full-text)
RCT | Once-weekly Semaglutide effective for weight loss in adolescents with obesity.
4 Nov, 2022 | 13:59h | UTCOnce-Weekly Semaglutide in Adolescents with Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
STEP TEENS: High-dose semaglutide weight loss benefits shown in adolescents – medwire News
Trial Shows Weight-Loss Drug Works in Teens – HealthDay
Commentary on Twitter
In this trial, adolescents with obesity assigned to weekly subcutaneous semaglutide plus lifestyle intervention had a greater reduction in BMI than those who received lifestyle intervention alone. https://t.co/yiFseP38xa pic.twitter.com/uRqkFfon1s
— NEJM (@NEJM) November 2, 2022
RCT | Discontinuing RAS inhibitors in patients with advanced CKD did not result in a slower decline in eGFR.
4 Nov, 2022 | 13:55h | UTCRenin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR. #KidneyWk https://t.co/81EIwG5FQ0 pic.twitter.com/nHNmzlPbHV
— NEJM (@NEJM) November 3, 2022
M-A | Blood pressure lowering and prevention of dementia.
4 Nov, 2022 | 13:46h | UTCNews Release: Best evidence yet that lowering blood pressure can prevent dementia – George Institute for Global Health
Commentary: Meta-Analysis Shows Decrease in Dementia Risk With HTN Treatment – HealthDay
Guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice.
4 Nov, 2022 | 13:42h | UTCExecutive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice – Rheumatology
Guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids.
4 Nov, 2022 | 13:44h | UTCExecutive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids – Rheumatology
Cohort Study | Moderate to heavy drinking is linked to an increased risk of hemorrhagic stroke in young adults.
4 Nov, 2022 | 13:36h | UTCCumulative Alcohol Consumption Burden and the Risk of Stroke in Young Adults: A Nationwide Population-Based Study – Neurology (link to abstract – $ for full-text)
Commentaries:
Moderate-to-Heavy Drinking Linked to Stroke Risk in Young Adults – HealthDay
Moderate to heavy drinking could increase the risk of stroke in young adults – News Medical
M-A | Risk of major adverse events associated with gabapentinoid and opioid combination therapy.
4 Nov, 2022 | 13:13h | UTC
2022 ACC/AHA Guideline for the diagnosis and management of aortic disease.
3 Nov, 2022 | 14:21h | UTCNews Release: ACC, AHA Issue Aortic Disease Guideline – American Heart Association
USPSTF Statement | Hormone therapy is not recommended for the prevention of chronic conditions in postmenopausal women.
3 Nov, 2022 | 14:19h | UTCEditorial: Menopausal Hormone Therapy for Prevention of Chronic Conditions: When Is Enough, Enough? – JAMA
JAMA Patient Page: Menopausal Hormone Therapy for Prevention of Chronic Conditions
Author Interview: USPSTF Recommendation: Hormone Therapy for Prevention of Postmenopausal Chronic Conditions – JAMA
Commentary: USPSTF: Hormone Therapy Not Advised for Primary Prevention of Chronic Conditions – HealthDay
M-A | Effect of pulmonary rehabilitation in dyspnea, exercise capacity, fatigue, and quality of life in patients with COVID-19.
3 Nov, 2022 | 14:09h | UTC
Cross-Sectional Study | Prevalence of and factors associated with high blood pressure among adolescents in India.
3 Nov, 2022 | 13:57h | UTCInvited Commentary: Prevalence of High Blood Pressure Among Youth in India and Association With Future Cardiovascular Disease – JAMA Network Open
Commentary on Twitter
1 in 3 adolescents in India have high BP, which is is associated with the trifecta of overweight/obesity, high blood sugar, high blood lipids, and can be prevented. #OAResearch https://t.co/i2Cth5ol2T
— JAMA Network Open (@JAMANetworkOpen) October 31, 2022
Cohort Study | Mental health morbidities and time to cancer diagnosis among adults with colon cancer in England.
3 Nov, 2022 | 13:55h | UTCInvited Commentary: The Interface Between Colon Cancer and Mental Health Morbidities – JAMA Network Open
Cohort Study | Association of maternal caffeine consumption during pregnancy with child growth.
3 Nov, 2022 | 13:51h | UTCAssociation of Maternal Caffeine Consumption During Pregnancy With Child Growth – JAMA Network Open
Commentaries:
Expert reaction to study looking at caffeine in pregnancy and child height – Science Media Centre
Even a Little Coffee in Pregnancy Might Stunt a Child’s Growth – HealthDay
Related:
Cohort Study: Associations of Maternal Caffeine Intake with Birth Outcomes
Study suggests a personalized frequency of urinary albumin screening may be best for patients with Type 1 Diabetes.
3 Nov, 2022 | 13:46h | UTCOptimal Frequency of Urinary Albumin Screening in Type 1 Diabetes – Diabetes Care (link to abstract – $ for full-text)
Development, validation and clinical utility of a risk prediction model for adverse pregnancy outcomes in gestational diabetes.
3 Nov, 2022 | 13:45h | UTC
Commentary on Twitter (thread – click for more)
🧵PeRSonal GDM is a modelling tool that predicts if women with gestational diabetes could have ⬆️ risk of adverse pregnancy outcomes. It's being tested in other groups & developed as an online clinical calculator. New work by @DrShamilCooray @HelenaTeede & team in @eClinicalMed pic.twitter.com/tIyM4KHlre
— MCHRI (@MCHRImonash) September 5, 2022
Observational study suggests Apixaban for AF is associated with a lower risk of GI bleeding vs. other DOACs.
3 Nov, 2022 | 13:32h | UTCComparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation: A Multinational Population-Based Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Best blood thinner for minimizing bleeding risk identified – University College London
Commentary: GI Bleeding Lower With Apixaban Versus Other DOACs in A-Fib – HealthDay
NICE Guideline | Osteoarthritis in over 16s: diagnosis and management.
2 Nov, 2022 | 14:29h | UTC
ACCP Guideline | Perioperative management of antithrombotic therapy.
1 Nov, 2022 | 12:18h | UTCExecutive Summary: Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline – CHEST
Commentary on Twitter
2022 guideline for perioperative management of VKAs, heparin bridging, DOACs & antiplatelets
Pts requiring elective surgery, in general,🛑💊 before surgery
👉VKAs 3-5d
👉DOACS 1-2d
👉P2Y12 receptor inhibitors 3-7d✅drug specificshttps://t.co/RYNrEOovRe @SCCM_Surgery @SCCM_CPP— Lauren R. Sorce, PhD, RN, CPNP-AC/PC, FAAN, FCCM (@SCCMPresident) August 26, 2022
Sarcopenia definition, diagnosis and treatment: consensus is growing.
1 Nov, 2022 | 12:01h | UTCSarcopenia definition, diagnosis and treatment: consensus is growing – Age and Ageing
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