Family Medicine

Viewpoint: Another Nail in the Coffin for Fish Oil Supplements

20 Apr, 2018 | 01:36h | UTC

Another Nail in the Coffin for Fish Oil Supplements – JAMA (free for a limited period)

Systematic Review: First-line Drugs for Hypertension

20 Apr, 2018 | 01:34h | UTC

First-line drugs for hypertension – Cochrane Library (free)

Summary: Thiazides best first choice for hypertension – Cochrane Library (free)

“First-line low-dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension. First-line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality”.

Meta-Analysis: Baseline LDL Level and Total and Cardiovascular Mortality After LDL Lowering

20 Apr, 2018 | 01:31h | UTC

Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Patients With Highest LDL Levels Benefit Most From Lipid-Lowering Drugs – MedicalResearch.com (free) AND New Study Finds that Statins Prevent Cardiovascular Deaths – Science Based Medicine (free) AND Meta-Analysis: ‘Floor’ for Lipid-Lowering Mortality Benefits May Be Real – MedPage Today (free registration required)

“In meta-analyses of LDL-C lowering drug trials, we found that total and cardiovascular mortality were reduced only when the mean baseline LDL-C in the trial was >100 mg/dl” (from MedicalResearch.com)

Systematic Review: Exercise Interventions and Patient Beliefs for People with Hip, Knee or Hip and Knee Osteoarthritis

18 Apr, 2018 | 01:09h | UTC

Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review – Cochrane Library (free)

Perspective: Smoking Even One Cigarette a Day Raises Risk for Coronary Heart Disease

18 Apr, 2018 | 01:11h | UTC

Smoking even one cigarette a day raises risk for coronary heart disease – The Washington Post (a few articles per month are free) (via @DrFrieden see Tweet)

See original article: Meta-Analysis: Just One Cigarette a Day Seriously Elevates Cardiovascular Risk (free article and commentaries)

Perspective: Incremental Benefits and Harms of the 2017 ACC/AHA High Blood Pressure Guideline

18 Apr, 2018 | 01:03h | UTC

Incremental Benefits and Harms of the 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: New blood pressure guidelines may make millions anxious that they’re at risk of heart disease – The Conversation (free) AND New blood pressure guidelines could put lives at risk – The University of Sydney (free)

Cohort Study: Nut Consumption and Incidence of Seven Cardiovascular Diseases

18 Apr, 2018 | 01:04h | UTC

Nut consumption and incidence of seven cardiovascular diseases – Heart (free)

Commentaries: Nuts May Be Good for the Heart, but Are Hardly a Miracle Food – The New York Times (10 articles per month are free)

Meta-Analysis: Association Between Newer Antidiabetic Drug Classes and Mortality

18 Apr, 2018 | 00:56h | UTC

Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients With Type 2 Diabetes – JAMA (free)

Multimedia (2 minute video): Association Between Newer Antidiabetic Drug Classes and Mortality in Patients With Type 2 Diabetes (free)

Commentary: Diabetes drug may not reduce risk of death – Imperial College London (free)

Position Statement: Pain Management at the End of Life

17 Apr, 2018 | 20:01h | UTC

Pain Management at the End of Life – American Society for Pain Management Nursing and Hospice and Palliative Nurses Association Position Statement (free)

Source: Medscape (free registration required)

USPSTF Statement: Interventions to Prevent Falls in Community-Dwelling Older Adults

17 Apr, 2018 | 15:19h | UTC

Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Preventing Fractures and Falls: A Limited Role for Calcium and Vitamin D Supplements? (free) AND New Prevention Guidelines for Falls and Fractures—Looking Beyond the Letters (free)

Preconception Health – New Series from The Lancet Journals

17 Apr, 2018 | 01:13h | UTC

New Series from The Lancet Journals: Preconception health (free registration required)

Commentaries: Obese couples could be risking health of future children, studies say – The Guardian (free) AND Parents’ Preconception Well-Being Affects Child’s Future Health – Medscape (free registration required)

Social Determinants of Health: An American College of Physicians Position Paper

16 Apr, 2018 | 21:37h | UTC

Addressing Social Determinants to Improve Patient Care and Promote Health Equity: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

Richard Lehman’s journal review – 16 April 2018

16 Apr, 2018 | 17:51h | UTC

Richard Lehman’s journal review, 16 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

Guidelines for the Investigation of Chronic Diarrhoea in Adults: British Society of Gastroenterology

16 Apr, 2018 | 16:58h | UTC

Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition – Gut (free)

Source: Hospital Medicine Virtual Journal Club

AHA Position Statement: Moving Beyond Atrial Fibrillation as a Binary Entity

16 Apr, 2018 | 17:45h | UTC

Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Atrial Fibrillation beyond “All or None”: The Missing Piece in Understanding Atrial Fibrillation? (free)

Top Ten Things to Know: Atrial Fibrillation Burden—Moving Beyond AF as a Binary Entity (free PDF)

Meta-Analysis of Observational Studies: Proton Pump Inhibitors are Associated with Increased Risk of Kidney Disease

16 Apr, 2018 | 16:54h | UTC

Acid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis – Journal of Gastroenterology and Hepatology (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

Proton pump inhibitors were associated with higher risks of acute interstitial nephritis (HR, 2.78; 95% CI, 1.25‐6.17), acute kidney injury (HR, 1.85; 95% CI, 1.33‐2.59), chronic kidney disease (HR, 1.47; 95% CI, 1.03‐2.09), and end‐stage renal disease (HR, 1.61; 95% CI, 1.26‐2.04) than non‐PPI therapy. Similar risks were not identified for H₂RA therapy.

Registry Analysis: Safety of Low-Dose Glucocorticoid Exposure Was Assessed

15 Apr, 2018 | 23:48h | UTC

Association Between Glucocorticoid Exposure and Healthcare Expenditures for Potential Glucocorticoid-related Adverse Events in Patients with Rheumatoid Arthritis – The Journal of Rheumatology (link to abstract – $ for full-text)

Commentary: How Safe Are Low-Dose Steroids in Patients with Rheumatoid Arthritis? – NEJM Journal Watch (free for a limited period)

Cohort Study: β-Blockers Linked with Increased Mortality in Diabetic Patients

14 Apr, 2018 | 20:21h | UTC

Risk of All-Cause Mortality in Diabetic Patients Taking β-Blockers – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentary: Beta-blockers associated with mortality risk in patients with diabetes, study finds – ACP Diabetes (free)

Meta-analysis: Risk Thresholds for Alcohol Consumption

14 Apr, 2018 | 19:51h | UTC

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies – The Lancet (free)

Editorial: Thresholds for safer alcohol use might need lowering (free)

Commentaries: Drinking a pint of beer may lower your life expectancy by the same amount as smoking a cigarette – new research – The Conversation (free) AND Expert reaction to study looking at drinking alcohol, life expectancy and alcohol limits – Science Media Centre (free) AND More than six weekly glasses of wine could curb life expectancy by up to five years – OnMedica (free) AND Consuming more than five drinks a week could shorten your life – University of Cambridge, via ScienceDaily (free) AND How much alcohol is too much? A new study says it’s found the number – PBS News Hour (free)

Randomized Controlled Trial: Fish Oil Supplements No Better Than Placebo for Dry Eye

14 Apr, 2018 | 20:01h | UTC

n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease – New England Journal of Medicine (free for a limited period)

Commentaries: Omega-3s From Fish Oil Supplements No Better Than Placebo for Dry Eye – NIH, National Eye Institute (NEI), via NewsWise (free) AND Fish oil capsules don’t help dry eye symptoms, study finds – STAT (free) AND Fish oil supplements ineffective against dry eye – Reuters (free)

Guideline: Primary Care of Adults with Intellectual and Developmental Disabilities

14 Apr, 2018 | 19:44h | UTC

Primary care of adults with intellectual and developmental disabilities: 2018 Canadian consensus guidelines – Canadian Family Physician (free)