Family Medicine
Cohort Study: Metformin Safe for Many Patients with Chronic Kidney Disease
7 Jun, 2018 | 02:49h | UTCAssociation of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study Supports Metformin Use at eGFRs as Low as 30 – NEJM Physician’s First Watch (free) AND Metformin safe for most diabetics with kidney disease – UPI (free) AND Evidence Growing Metformin Safe in Many With Diabetes and CKD – Medscape (free registration required)
Related Studies: Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease (link to abstract and commentaries) AND Metformin is linked to reduced mortality in type 2 diabetes with comorbid CKD and CHF – ACP Diabetes Monthly (free)
Short Review: Stimulants for ADHD in children
7 Jun, 2018 | 02:50h | UTCStimulants for ADHD in children: Revisited – Therapeutics Initiative (via @AllenFrancesMD)
“There is convincing evidence that a proportion of boys and girls treated with stimulants in BC and around the world are simply the youngest in their class”
Review: Pulmonary Function Tests for the Generalist
7 Jun, 2018 | 02:45h | UTCPulmonary Function Tests for the Generalist: A Brief Review – Mayo Clinic Proceedings (free)
Research: New Risk Calculator Estimates Millions are Being Overtreated with Statins
7 Jun, 2018 | 02:42h | UTCClinical Implications of Revised Pooled Cohort Equations for Estimating Atherosclerotic Cardiovascular Disease Risk – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: New risk calculator could change the aspirin, statins, and blood pressure medications some people take – STAT (free) AND Statin recommendations may change, especially for African-Americans – CNN (free) AND Millions could have incorrect statin, aspirin and blood pressure prescriptions – Stanford Medicine, via ScienceDaily (free) AND Current models overestimate CVD risk of 11.8M US adults – Cardiovascular Business (free)
Highlights from the New GOLD COPD Guidelines
7 Jun, 2018 | 02:44h | UTCCatch up on new COPD guidelines – ACP Internist (free)
Original Guideline: 2018 Global Strategy for Prevention, Diagnosis and Management of COPD – Global Initiative for Chronic Obstructive Lung Disease (GOLD) (free PDF)
Pocket Guide: COPD Diagnosis, Management and Prevention (free PDF)
Systematic Review: Exercise for Cognitive Brain Health in Aging
7 Jun, 2018 | 02:43h | UTCExercise for cognitive brain health in aging: A systematic review for an evaluation of dose – Neurology Clinical Practice (link to abstract – $ for full-text)
Commentary: How Much Exercise Is Needed to Help Improve Thinking Skills? – American Academy of Neurology, via NewsWise (free) AND Exercise regimen can maintain cognition in older adults, researchers say – UPI (free) AND 1-Hour Exercise, 3 Times a Week Boosts Cognition in Older Adults – MedPage Today (free registration required)
Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders
7 Jun, 2018 | 02:37h | UTCCurrent Concepts in Diagnosis and Treatment of Functional Neurological Disorders – JAMA Neurology (free for a limited period)
Canadian Guideline: Management of Chronic Hepatitis C
7 Jun, 2018 | 02:36h | UTCCommentaries: Hepatitis C guideline recommends screening for all people born 1945-1975 – CMAJ, via EurekAlert (free) AND Canadian Group Offers New Guidelines on Hepatitis C Screening, Management – NEJM Physician’s First Watch (free)
Related Guidelines: HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C – American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) (free) AND EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)
Richard Lehman’s journal review – 4 June 2018
7 Jun, 2018 | 02:35h | UTCRichard Lehman’s journal review, 4 June 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Case-Control Study: Possible Association of Hydrochlorothiazide Use and Risk of Melanoma
6 Jun, 2018 | 21:53h | UTCAssociation of Hydrochlorothiazide Use and Risk of Malignant Melanoma – JAMA Internal Medicine (free)
Commentaries: Hydrochlorothiazide Associated with Melanoma Risk – NEJM Physician’s First Watch (free) AND Hydrochlorothiazide Tied to Increased Melanoma Risk – MedPage Today (free registration required)
This observational data suggests a possible association. Needs to be confirmed by other studies.
Opinion: Rush to Treat Non-alcoholic Fatty Liver Disease Causing More Harm than Good
6 Jun, 2018 | 21:45h | UTCRush to treat liver patients causing more harm than good – The University of Leeds (free) (via @PaulGlasziou)
Original article: Too much medicine: overdiagnosis and overtreatment of non-alcoholic fatty liver disease- The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Perspective: For Patients with Type 2 Diabetes, What’s the Best Target Hemoglobin A1C?
1 Jun, 2018 | 04:36h | UTCFor Patients With Type 2 Diabetes, What’s the Best Target Hemoglobin A1C? – JAMA (free for a limited period)
Related: A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks – Diabetes Care (free) AND Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)
Richard Lehman’s journal review, 29 May 2018
1 Jun, 2018 | 04:03h | UTCRichard Lehman’s journal review, 29 May 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Meta-Analysis: Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality
1 Jun, 2018 | 03:51h | UTCEditorial: Prenatal Vitamin D Supplementation to Improve Health in Offspring (free)
Commentary: Vitamin D Supplementation of Moms Linked to Better Outcomes for Newborns – Physician’s First Watch (free)
Guideline: Type 2 Diabetes Mellitus in Older People
1 Jun, 2018 | 03:48h | UTCCommentary: New guidance on treating diabetes in elderly and frail adults – University of Exeter, via EurekAlert (free)
Perspective: Incidental Anarchy
29 May, 2018 | 20:14h | UTCIncidental anarchy – The BMJ Opinion (free)
“Giles Maskell writes on over diagnosis and underdiagnosis, the complexities of incidental findings and urges clinicians to “Think before you scan because you can” (via @bmj_latest see Tweet)
Review: Supplements Not Effective for CVD Prevention and Treatment
29 May, 2018 | 20:15h | UTCSupplemental Vitamins and Minerals for CVD Prevention and Treatment – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Most vitamin, mineral supplements not shown to lower heart disease risk – American College of Cardiology, via ScienceDaily (free) AND Aside From Folate, Vitamins Appear Largely Ineffective For Prevention, Study Finds – Forbes (free) AND Most popular vitamin and mineral supplements provide no health benefit, study finds – St. Michael’s Hospital, via EurekAlert (free)
Meta-Analysis: Concomitant Fibromyalgia Common in Patients with Inflammatory Arthritis
29 May, 2018 | 20:09h | UTCCommentary: Comorbid fibromyalgia common in patients with inflammatory arthritis – MedwireNews (free)
ACP Position Paper: Women’s Health Policy in the United States
29 May, 2018 | 20:10h | UTCCommentary: U.S. doctors call for health policies that support women – Reuters (free)
Research: Aspirin Effect on Adverse Pregnancy Outcomes Associated with Stage 1 Hypertension
29 May, 2018 | 18:28h | UTCAspirin Effect on Adverse Pregnancy Outcomes Associated With Stage 1 Hypertension in a High-Risk Cohort – Hypertension (link to abstract – $ for full-text)
Commentary: Low-dose aspirin could help pregnant women with high blood pressure avoid a dangerous condition – AHA News (free)
Related Study: Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia (free article and commentaries)
“These findings emphasize the importance of recognition of stage 1 hypertension as an additive risk factor in women at high risk for preeclampsia and the benefit of aspirin”.
Randomized Trial: Acupuncture Not Effective for Improving the Likelihood of In Vitro Fertilization
29 May, 2018 | 18:29h | UTC
Effect of Acupuncture vs Sham Acupuncture on Live Births Among Women Undergoing In Vitro Fertilization: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Fertility study finds acupuncture ineffective for IVF birth rates – NICM, Western Sydney University, via ScienceDaily (free) AND Acupuncture during IVF doesn’t increase chances of having a baby – The Conversation (free) AND Acupuncture doesn’t improve likelihood of IVF success, study finds – The Guardian (free) AND Does Acupuncture Increase Live Births For Women Undergoing IVF? – MedicalResearch.com (free)
Editorial: A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks
28 May, 2018 | 12:54h | UTCA1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks – Diabetes Care (free) (via @Abraham_RMI)
Related guideline: Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)
“Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes” (from ACP Guideline, prompting the Editorial)
Cohort Study: Weight Gain with Antidepressant Utilization
28 May, 2018 | 12:38h | UTCEditorial: Antidepressant induced weight gain (free)
Commentaries: Antidepressant therapy and risk of weight gain – The BMJ Opinion (free) AND Taking antidepressants could be linked to weight gain, according to a new study — and some drugs heighten the risk more than others – Business Insider (free) AND Antidepressants linked to risk of weight gain, study shows – OnMedica (free) AND Antidepressant use linked with weight gain – NHS Choices (free)
Cohort Study: Pre-pregnancy Maternal BMI and Optimal Weight Gain During Pregnancy
28 May, 2018 | 12:17h | UTCCommentaries: Very obese women should lose weight during pregnancy for a healthy baby – Elsevier, via ScienceDaily (free) AND Very Obese Women: Lose Weight in Pregnancy for Healthy Baby – Medscape (free registration required)
Cohort Study: Incidence and Cost of Medication Harm in Older Adults Following Hospital Discharge
24 May, 2018 | 23:35h | UTCCommentaries: Medication-related harm is common in older adults after hospital discharge – OnMedica (free) AND Medication-related harm found to be common among older adults, but preventable – News Medical (free)


