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Just the Facts: What Drugs are Safe and Effective for COVID-19?

27 May, 2020 | 02:31h | UTC

Just the Facts: What drugs are safe and effective for COVID-19? – Canadian Journal of Emergency Medicine

Related Guidelines: NIH Coronavirus Disease 2019 (COVID-19) Treatment Guidelines – National Institutes of Health AND Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection

“Apart from supportive care, there are no current effective therapeutics for COVID-19”

 


Short Review: Using Insulin to Treat Poorly Controlled Type 2 Diabetes in 2020

27 May, 2020 | 02:18h | UTC

Using Insulin to Treat Poorly Controlled Type 2 Diabetes in 2020 – JAMA (free for a limited period)

 


Randomized Trial: Antihypertensive Medication Reduction vs. Usual Care Among Older Adults Taking Multiple Antihypertensive Medications

27 May, 2020 | 02:16h | UTC

Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: The OPTIMISE Randomized Clinical Trial – JAMA

Editorial: Deprescribing Antihypertensive Medications for Patients Aged 80 Years or Older: Is Doing Less Doing No Harm?

Commentary: Less is more? Deprescribing blood pressure lowering medications is safe in the short-term in older people with frailty and multiple long-term conditions – University of Oxford

 

Related Commentary on Twitter

 


Study Shows Abnormalities in Placentas from COVID-19-positive Pregnant Women

26 May, 2020 | 10:00h | UTC

Placental Pathology in COVID-19 – American Journal of Clinical Pathology

Commentaries: Placentas from COVID-19-positive pregnant women show injury – Northwestern University AND Expert reaction to study looking at placentas from COVID19-positive pregnant women – Science Media Centre AND Covid-19 appears to attack placenta during pregnancy, study says – CNN AND Placenta Injury Observed in Pregnant Women Who Test Positive For Coronavirus – Forbes

 


Review: COVID-19 and Cardiovascular Disease

26 May, 2020 | 10:05h | UTC

COVID-19 and Cardiovascular Disease – Circulation

Related Guidelines: COVID-19 rapid guideline: acute myocardial injury – National Institute for Health and Care Excellence AND ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic – European Society of Cardiology AND Management of Acute Myocardial Infarction During the COVID-19 Pandemic – Journal of the American Academy of Cardiology

 


Perspective: In Pandemic, Many Seeing Upsides to Telemedicine

26 May, 2020 | 09:52h | UTC

Part I: In pandemic, many seeing upsides to telemedicine – CIDRAP

Part II: COVID-19 reveals telehealth barriers, solutions – CIDRAP

 


Study: Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients

26 May, 2020 | 09:43h | UTC

Androgenetic Alopecia Present in the Majority of Hospitalized COVID-19 Patients – the “Gabrin sign” – Journal of the American Academy of Dermatology

 


Perspective: “Here’s What Needs to Happen Before We Can All Get Vaccinated for COVID-19”

26 May, 2020 | 09:45h | UTC

Here’s what needs to happen before we can all get vaccinated for COVID-19 – CBC

 


WHO Pauses Hydroxychloroquine Arm Of COVID-19 Clinical Trial Due to Safety Concerns

26 May, 2020 | 09:35h | UTC

WHO Pauses Hydroxychloroquine Arm Of COVID-19 Clinical Trial – After Lancet Study Finds Higher Mortality Rate Among Patients Getting The Drug – Health Policy Watch

See also: WHO halts hydroxychloroquine trial for coronavirus amid safety fears – The Guardian AND WHO Halts Hydroxychloroquine Trial Over Safety Concerns – NPR

 


Opinion: The ‘Just Stay Home’ Message Will Backfire

26 May, 2020 | 09:33h | UTC

The ‘Just Stay Home’ Message Will Backfire – The Atlantic

“We need less extreme and more nuanced recommendations for navigating life during the pandemic.”

 

Related Commentary on Twitter

 


[Abstract Only] Meta-Analysis: Helicobacter Pylori Eradication Therapy to Prevent Gastric Cancer

26 May, 2020 | 09:21h | UTC

Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis – Gut (abstract only – $ for full-text)

 


Systematic Review Shows Evidence is Inconclusive on the Use of Non‐nutritive Sweeteners for Diabetes Mellitus

26 May, 2020 | 09:27h | UTC

Non‐nutritive sweeteners for diabetes mellitus – Cochrane Library

Summary: Non-nutritive sweeteners for diabetes mellitus – Cochrane Library

 


Perspective: The World May Be Overestimating the Power of Vaccines

25 May, 2020 | 01:55h | UTC

The world needs Covid-19 vaccines. It may also be overestimating their power – STAT

 


Hydroxychloroquine and Chloroquine for Covid-19: Large Observational Analysis Finds No Benefit and Possible Harm

25 May, 2020 | 02:03h | UTC

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – The Lancet

Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch

 


Opinion: Why Countries Should Stop Using Anti-malarial Drugs for COVID-19

25 May, 2020 | 02:02h | UTC

Why countries should stop using anti-malarial drugs for COVID-19 – The Conversation

 


[Preprint] Meta-Analysis: Susceptibility to and Transmission of COVID-19 Amongst Children and Adolescents Compared with Adults

25 May, 2020 | 01:52h | UTC

Susceptibility to and transmission of COVID-19 amongst children and adolescents compared with adults: a systematic review and meta-analysis – medRxiv

Commentaries: Children appear half as likely to catch COVID-19 as adults – London School of Hygiene & Tropical Medicine AND Expert reaction to systematic review preprint looking at susceptibility to SARS-CoV-2 infection in children and adolescents compared with adults – Science Media Centre

 


Promising Early Results with New Vaccine from China in Phase I Trial

25 May, 2020 | 01:57h | UTC

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – The Lancet

Commentaries: First human trial of COVID-19 vaccine finds it is safe and induces rapid immune response – The Lancet AND Early Study Of Covid-19 Vaccine Developed In China Sees Mixed Results – Forbes AND Coronavirus Vaccine Shows Promising Early Results in China – The New York Times AND A Chinese biotech just published the first human data for its coronavirus vaccine candidate, supporting further trials – Business Insider AND Experts skeptical after researchers report positive vaccine results – CNN AND Two COVID-19 Vaccine Candidates Induce Immune Response In Healthy Volunteers – Health Policy Watch

 


Study: 10 of 60 Patients Treated for COVID-19 Persisted with Positive RT-PCR Results from 4 to 24 Days After Hospital Discharge

25 May, 2020 | 01:50h | UTC

Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China – JAMA Network Open

Commentaries: Expert reaction to study on PCR testing results from 60 people after clinical recovery from COVID-19 – Science Media Centre AND 16% of recovered patients test positive for COVID-19 weeks after discharge: study – UPI

 


Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach

25 May, 2020 | 01:42h | UTC

Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach – Annals of Internal Medicine

 


Cohort Study: Fluconazole Use in the First Trimester of Pregnancy Linked to Increased Risk of Musculoskeletal Malformations

25 May, 2020 | 01:31h | UTC

Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study – The BMJ

Commentary: Musculoskeletal Malformations Up With Fluconazole in Pregnancy – Physician’s Weekly

 


How Coronavirus Lockdowns Stopped Flu in its Tracks

22 May, 2020 | 04:53h | UTC

How coronavirus lockdowns stopped flu in its tracks – Nature

“Reported rates of influenza and other infections have fallen sharply, but some communicable diseases may see a rise.”

 


Olfactory Dysfunction in COVID-19: Diagnosis and Management

21 May, 2020 | 09:24h | UTC

Olfactory Dysfunction in COVID-19: Diagnosis and Management – JAMA

Related: Loss of smell and taste as symptoms of COVID-19: what does the evidence say? – CEBM Oxford

 


COVID-19 in Children: Clinical Approach and Management

21 May, 2020 | 09:19h | UTC

COVID-19 in Children: Clinical Approach and Management – The Indian Journal of Pediatrics

Related Systematic Reviews: SARS-CoV-2 Infection in Children and Adolescents (study and commentaries) AND SARS-CoV-2 (COVID-19): What do we know about children? A systematic review – Clinical Infectious Diseases

 


Systematic Review: Safety and Adverse Effects of 80 Antidepressants, Antipsychotics, Anti‐attention‐deficit/hyperactivity Medications and Mood Stabilizers in Children and Adolescents

21 May, 2020 | 09:10h | UTC

Safety of 80 antidepressants, antipsychotics, anti‐attention‐deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta‐review of 78 adverse effects – World Psychiatry

 


[No Publication Available] Covid-19 Patients Testing Positive After Recovery Aren’t Infectious

20 May, 2020 | 10:00h | UTC

Covid Patients Testing Positive After Recovery Aren’t Infectious, Study Shows – Bloomberg

See also: People who recover from coronavirus and test positive again are NOT contagious: Korean CDC finds ‘re-positive’ patients did not infect any of their 790 contacts – Daily Mail

 


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