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Mammographic features are associated with cardiometabolic disease risk and mortality.

6 Aug, 2021 | 09:04h | UTC

Mammographic features are associated with cardiometabolic disease risk and mortality – European Heart Journal

 

Viewpoint: Aligning payments, services, and quality in primary care.

6 Aug, 2021 | 09:08h | UTC

Aligning Payments, Services, and Quality in Primary Care – JAMA (free for a limited period)

 

Researchers tell doctors to avoid routine urinary tests for older patients with delirium.

6 Aug, 2021 | 09:01h | UTC

Researchers tell doctors to avoid routine urinary tests for older patients with delirium – Johns Hopkins University School of Medicine

Original article: Things We Do for No Reason™: Obtaining Urine Testing in Older Adults With Delirium Without Signs or Symptoms of Urinary Tract Infection – Journal of Hospital Medicine ($)

 

Commentary on Twitter (thread – click for more)

 

RCT: Subcutaneous REGEN-COV antibody combination prevented symptomatic Covid-19 infection in previously uninfected household contacts of infected persons.

5 Aug, 2021 | 09:01h | UTC

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 – New England Journal of Medicine

Related:

RCT: Bamlanivimab plus Etesevimab reduce mortality and hospitalization in ambulatory patients with early Covid-19 (within 3 days of a positive test) who are at risk for clinical deterioration (i.e., older people, obese, diabetics, immunocompromised, with CV disease).

[Preprint] RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalized COVID-19 patients who have not mounted their own immune response.

 

Commentary on Twitter

 

Myocarditis and pericarditis after vaccination for COVID-19.

5 Aug, 2021 | 08:57h | UTC

Myocarditis and Pericarditis After Vaccination for COVID-19 – JAMA

Related:

Analysis finds benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis.

CDC: Use of mRNA COVID-19 vaccine after reports of myocarditis among vaccine recipients – “Continued use of mRNA COVID-19 vaccines in all recommended age groups will prevent morbidity and mortality from COVID-19 that far exceed the number of cases of myocarditis expected”.

Case Series: Myocarditis following immunization with mRNA COVID-19 vaccines.

CDC: mRNA vaccines are likely linked to cases of myocarditis and pericarditis – 1,226 cases of myocarditis or pericarditis have been reported mostly in people under 30.

 

Commentary on the Latest AAP Guidelines for the Febrile Neonate.

5 Aug, 2021 | 08:36h | UTC

Small Talk – Hot Off The Presses: The Latest AAP Guidelines for the Febrile Neonate – emDocs

Original guideline:

AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.

Related:

M-A: Low prevalence of bacterial meningitis among well-appearing febrile infants aged 29-60 days with positive urinalysis results – “These results suggest that for these infants, the decision to use lumbar puncture should not be guided by urinalysis results alone”.

Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis

[Abstract Only] Observational Study Suggests Testing for Meningitis May Not be Necessary for Febrile Well-Appearing Young Infants with Positive Urinalysis

Study: Clinical Prediction Rule to Identify Febrile Infants at Low Risk for Serious Bacterial Infections

Cohort Study: Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections

 

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

4 Aug, 2021 | 10:06h | UTC

Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2 – The Lancet Child & Adolescent Health

Invited commentary: Citizen science and biomedical research (free registration required)

Commentaries:

Expert reaction to study looking at long-lasting symptoms from COVID-19 in children – Science Media Centre

Long Covid uncommon in children, analysis finds – King’s College London

Study finds long-term Covid symptoms rare in school-age children – The Guardian

Most children with Covid-19 recover within a week, but a small percentage have long-term symptoms, a study says. – The New York Times

Related:

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Cohort study: Risk factors for long covid in previously hospitalized children.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Commentary on Twitter

 

AAP Interim guidance on supporting the emotional and behavioral health needs of children, adolescents, and families during the COVID-19 pandemic.

4 Aug, 2021 | 10:03h | UTC

Interim Guidance on Supporting the Emotional and Behavioral Health Needs of Children, Adolescents, and Families During the COVID-19 Pandemic – American Academy of Pediatrics

 

Opinion (video): “The Delta Surge May Collapse Faster Than You Think.”

4 Aug, 2021 | 09:53h | UTC

The Delta Surge May Collapse Faster Than You Think – ZDoggMD

Related:

The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.

How the coronavirus infects cells — and why Delta is so dangerous.

COVID vaccines slash viral spread, but Delta is an unknown – “Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty”.

CDC changes mask guidance in response to threat of Delta variant of Covid-19.

 

Position statement: Perioperative management of post-COVID-19 surgical patients.

4 Aug, 2021 | 10:00h | UTC

Perioperative management of post-COVID-19 surgical patients: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement – Indian Journal of Anaesthesia

Related:

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

WSES Position Paper: The management of surgical patients in the emergency setting during COVID-19 pandemic

Preparing previously COVID-19-positive patients for elective surgery: A framework for preoperative evaluation

 

Commentary on Twitter

 

AAP Guidance: Post-COVID-19 conditions in children and adolescents.

4 Aug, 2021 | 10:01h | UTC

Post-COVID-19 Conditions in Children and Adolescents – American Academy of Pediatrics

 

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

4 Aug, 2021 | 09:55h | UTC

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset – eLlife

Related:

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary on Twitter (thread – click for more)

 

RCT: Text-message reminders can increase COVID-19 vaccinations.

4 Aug, 2021 | 09:12h | UTC

Behavioral Nudges Increase COVID-19 Vaccinations – Nature

Commentaries:

Text-message ‘nudges’ can encourage holdouts to get COVID vaccination, study finds – UCLA

Text reminders boost vaccine appointments – Carnegie Mellon University

 

Commentary on Twitter

 

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

4 Aug, 2021 | 09:07h | UTC

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia position statement – Pain

See also:

Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials – Pain

General risks of harm with cannabinoids, cannabis, and cannabis-based medicine possibly relevant to patients receiving these for pain management: an overview of systematic reviews – Pain

Commentary:

More evidence needed to back cannabis as pain treatment, says review – Imperial College London

Medicinal cannabis to manage chronic pain? We don’t have evidence it works – The Conversation

Related:

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

 

RCT: Routine treatment with fluoxetine does not reduce the incidence of depression after stroke.

4 Aug, 2021 | 08:56h | UTC

Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Editorial: Poststroke Selective Serotonin Reuptake Inhibitors—Do They Work for Anything? (free for a limited period)

Related:

[Abstract Only] Randomized trial: Fluoxetine does not improve functional recovery after acute stroke

Randomized Trial: Effects of Fluoxetine on Functional Outcomes After Acute Stroke

 

Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks – “Given often-temporary improvements, unfavorable effects on dietary intake, and inadequate data demonstrating long-term safety, for most individuals, the risks of ketogenic diets may outweigh the benefits.”

4 Aug, 2021 | 08:53h | UTC

Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks – Frontiers in Nutrition

Commentary: Keto diets review finds heart risks, cancer risk, dangers to pregnant women and kidney patients – Physicians Committee for Responsible Medicine

 

RCT: Midodrine can reduce the recurrence of vasovagal syncope.

4 Aug, 2021 | 08:54h | UTC

Midodrine for the Prevention of Vasovagal Syncope: A Randomized Clinical Trial – Annals of Internal Medicine

Commentary: Midodrine Cuts Recurrent Syncope in Young, Healthy Patients – HealthDay

Summary for patients: Summary for Patients: Midodrine to Prevent Fainting – Annals of Internal Medicine

 

Commentary on Twitter

 

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

3 Aug, 2021 | 09:05h | UTC

Six Month Follow-up of Patients With Multisystem Inflammatory Syndrome in Children – Pediatrics (PDF)

 

Cohort study: Risk factors for long covid in previously hospitalized children.

3 Aug, 2021 | 09:06h | UTC

Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study – European Respiratory Review

Commentaries:

Study investigates long-term sequelae of COVID-19 in hospitalized children – News Medical

 

Commentary on Twitter

 

A blood marker predicts who gets ‘breakthrough’ COVID (neutralizing antibodies).

3 Aug, 2021 | 09:01h | UTC

A blood marker predicts who gets ‘breakthrough’ COVID – Nature

Related:

A correlate of protection for SARS-CoV-2 vaccines is urgently needed – “Recent studies suggest that neutralizing antibodies could serve as a correlate of protection for vaccines against SARS-CoV-2 in humans”.

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.

Covid-19 breakthrough infections in vaccinated health care workers.

 

Covid: Pulse oxygen monitors work less well on darker skin, experts say.

3 Aug, 2021 | 09:00h | UTC

Covid: Pulse oxygen monitors work less well on darker skin, experts say – BBC

Related:

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias

“Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients

 

WHO Advocacy Brief: Scale, impact, and harms of social isolation and loneliness among older people.

3 Aug, 2021 | 02:29h | UTC

Social Isolation and Loneliness – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Prevalence, costs, and consequences of low-value preprocedural urinalyses in the US.

3 Aug, 2021 | 02:13h | UTC

Prevalence, Costs, and Consequences of Low-Value Preprocedural Urinalyses in the US – JAMA Internal Medicine

Editorial: Moving Beyond Guidelines—Use of Value-Based Preoperative Testing (free for a limited period)

Commentary: Preoperative screening urinalysis is widely used—but usually unnecessary, study finds – MedicalXpress

 

M-A: Association between adiposity and cardiovascular outcomes.

3 Aug, 2021 | 02:11h | UTC

Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies – European Heart Journal

 

Commentary on Twitter

 

Opinion | Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective.

2 Aug, 2021 | 00:28h | UTC

Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective – The Conversation

 

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