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Family Medicine

Bronchiolitis: evidence and guidance for practice.

8 Dec, 2021 | 09:55h | UTC

Bronchiolitis: evidence and guidance for practice – Evidently Cochrane

 


Review: Perioperative pain management issues unique to older adults undergoing surgery.

8 Dec, 2021 | 09:52h | UTC

Perioperative Pain Management Issues Unique to Older Adults Undergoing Surgery: A Narrative Review – Annals of Surgery Open

 


Evaluation and management of pelvic organ prolapse.

8 Dec, 2021 | 09:50h | UTC

Evaluation and Management of Pelvic Organ Prolapse – Mayo Clinic Proceedings

 


Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

7 Dec, 2021 | 10:19h | UTC

Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults – Circulation

News Release: Young people recover quickly from rare myocarditis side effect of COVID-19 vaccine – American Heart Association

 


The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.

7 Dec, 2021 | 10:23h | UTC

The Risk of Postoperative Complications following Major Elective Surgery in Active or Resolved COVID-19 in the United States – Annals of Surgery

Related:

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

 


Review of 4,470 cases of Multisystem Inflammatory Syndrome in Children in the US.

7 Dec, 2021 | 10:08h | UTC

Multisystem Inflammatory Syndrome in Children—United States, February 2020–July 2021 – Clinical Infectious Diseases

Related:

WHO issues guidelines on the treatment of children with multisystem inflammatory syndrome associated with COVID-19.

An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2.

Ten Things to Know About Multisystem Inflammatory Syndrome in Children (MIS-C).

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Cohort study: Six month follow-up of Multisystem Inflammatory Syndrome in Children.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, there was no evidence that recovery differed after primary treatment with intravenous immune globulin (IVIG) alone, IVIG plus glucocorticoids, or glucocorticoids alone.

Cohort study: Among children with Multisystem Inflammatory Syndrome (MIS-C) associated with Covid-19, initial treatment with intravenous immune globulin (IVIG) plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone.

Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

Neurologic involvement in children and adolescents with COVID-19 or Multisystem Inflammatory Syndrome

Clinical Update: Acute covid-19 and multisystem inflammatory syndrome in children

Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19

Cutaneous findings in SARS-CoV-2-associated Multisystem Inflammatory Disease in Children (MIS-C)

SR: Multisystem inflammatory syndrome in children related to COVID-19

Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children

ACR Guidance for pediatric patients with multisystem inflammatory syndrome in children associated with SARS‐CoV‐2

New systematic review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 infection summarizes the clinical features, management, and outcomes of the disease, showing favorable outcomes for the majority of children

 


A qualitative study identified a wide variation of expected impacts of the 626 low-value services spotted by the US Choosing Wisely recommendations.

7 Dec, 2021 | 08:39h | UTC

Longitudinal Content Analysis of the Characteristics and Expected Impact of Low-Value Services Identified in US Choosing Wisely Recommendations – JAMA Internal Medicine (free for a limited period)

Editorial: The Next Frontier of Less Is More—From Description to Implementation – JAMA Internal Medicine (free for a limited period)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 


Systematic Review: Current practices of management of maternal and congenital Cytomegalovirus infection during pregnancy after a maternal primary infection occurring in first trimester of pregnancy.

7 Dec, 2021 | 08:35h | UTC

Current practices of management of maternal and congenital Cytomegalovirus infection during pregnancy after a maternal primary infection occurring in first trimester of pregnancy: Systematic review – PLOS One

 


Six different COVID-19 boosters are safe and increase immunity when given after two doses of AstraZeneca or Pfizer-BioNTech, with significant variations in immune responses, UK trial shows.

5 Dec, 2021 | 23:57h | UTC

News Release: Six different COVID-19 boosters are safe and increase immunity when given after two doses of AstraZeneca or Pfizer-BioNTech, with large variations in immune responses, UK trial shows – The Lancet

Original Study: Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial – The Lancet

Commentaries:

Six different COVID-19 boosters induce variable immune response – CIDRAP

Covid booster shots significantly strengthen immunity, trial finds – The Guardian

Expert reaction to COV-BOOST study investigating safety and immunogenicity of seven COVID-19 vaccines as a third dose following two doses of either Oxford-AstraZeneca or Pfizer – Science Media Centre

 

Commentary on Twitter

 


European data on Omicron: Out of 109 cases confirmed so far, all cases for which there is available information on severity were either asymptomatic or mild.

5 Dec, 2021 | 23:50h | UTC

Epidemiological update: Omicron variant of concern (VOC) – data as of 3 December 2021 (12.00) – European Centre for Disease Prevention and Control

 

Commentary on Twitter:

 


Early data from South Africa hints Omicron variant may cause less severe Covid, but more research is needed.

5 Dec, 2021 | 23:51h | UTC

Early data from South Africa hints Omicron variant may cause less severe Covid, but more research is needed – STAT

Original report: Tshwane District Omicron Variant Patient Profile – Early Features

 


Fauci says early reports encouraging about omicron variant – “Thus far, it does not look like there’s a great degree of severity to it”.

5 Dec, 2021 | 23:47h | UTC

Fauci says Omicron variant doesn’t look severe, but ‘got to be careful’ – Associated Press

 


WHO has no reports yet of Omicron Covid deaths.

5 Dec, 2021 | 23:48h | UTC

WHO has no reports yet of Omicron Covid deaths – MedicalXpress

 

Commentary on Twitter

 


Cohort Study: Among asymptomatic individuals that have undergone treadmill testing, high-grade premature ventricular contractions occurring during recovery were associated with increased risk of cardiovascular mortality.

5 Dec, 2021 | 23:42h | UTC

Exercise-Induced Ventricular Ectopy and Cardiovascular Mortality in Asymptomatic Individuals – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Exercise-Induced Ventricular Ectopy and Cardiovascular Mortality – American College of Cardiology

 


[Preprint] Preliminary data points to increased risk of SARS-CoV-2 reinfection associated with the emergence of Omicron variant in South Africa.

3 Dec, 2021 | 10:29h | UTC

Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa – medRxiv

Commentaries:

Global Omicron COVID cases rise as evidence for immune escape grows – CIDRAP

Omicron seems to carry higher Covid reinfection risk, says South Africa – The Guardian

Reinfections three times more likely with Omicron: S. African research – MedicalXpress

 

Commentary from the author on Twitter (thread – click for more)

 


Podcast: The Omicron Variant of SARS-CoV-2.

3 Dec, 2021 | 10:21h | UTC

The Omicron Variant of SARS-CoV-2 – New England Journal of Medicine

 


Interactive Infographic: Visualizing SARS-CoV-2 transmission routes and mitigations.

3 Dec, 2021 | 10:26h | UTC

Visualising SARS-CoV-2 transmission routes and mitigations – The BMJ

Commentary: New interactive graphic tool illustrates SARS-CoV-2 transmission routes and mitigations – News Medical

 

Commentary on Twitter

 


How bad is Omicron? What scientists know so far.

3 Dec, 2021 | 10:18h | UTC

How bad is Omicron? What scientists know so far – Nature

 


The Omicron Variant Is a Mystery. Here’s How Science Will Solve It – “So far, panic about the new Covid variant has outpaced actual information. Here’s what scientists around the world are trying to uncover”.

2 Dec, 2021 | 10:08h | UTC

The Omicron Variant Is a Mystery. Here’s How Science Will Solve It – Wired

See also the latest articles on the subject:

Where did ‘weird’ Omicron come from? – Science

We can prevail over Omicron. We just need to use the tools we have – The Guardian

How South African Researchers Identified the Omicron Variant of COVID – The New Yorker

The omicron variant has been found in 23 countries – NPR

These countries have found cases of the Omicron Covid-19 variant so far – CNN

Scientists say it will take weeks to tell how dangerous Omicron really is. Here’s why – CNN

Coronavirus variants: Here’s what we know – CNN

To catch variants like omicron, the world needs to sequence way more virus genes – Vox

Omicron’s Best- and Worst-Case Scenarios – The Atlantic

Africa: tackle HIV and COVID-19 together – Nature

Omicron Travel Bans Violate International Health Rules and Decimate Southern Africa’s Fragile Tourism Industry – Health Policy Watch

The mystery of where omicron came from — and why it matters – NPR

A reason for optimism on Omicron: Our immune systems are not blank slates – STAT

Omicron – Science-Based Medicine

Covid: Omicron may require ‘very stringent response’, say Sage scientists – BBC

WHO warns against Omicron travel bans as nations shut borders – MedicalXpress

Israeli doctor believes he caught Omicron variant of Covid in London – The Guardian

First case of Omicron coronavirus variant identified in the U.S. – STAT

 


AAP Clinical Report | Tuberculosis Infection in Children and Adolescents.

2 Dec, 2021 | 09:58h | UTC

Tuberculosis Infection in Children and Adolescents: Testing and Treatment – Pediatrics

 


Systematic Review: Models of COVID-19 vaccine prioritization – “for countries seeking to minimize deaths, prioritizing vaccination of senior adults was the optimal strategy and for countries seeking to minimize cases the young were prioritized”.

2 Dec, 2021 | 10:02h | UTC

Models of COVID-19 vaccine prioritisation: a systematic literature search and narrative review – BMC Medicine

 


ERS guideline on non-CPAP therapies for obstructive sleep apnea.

2 Dec, 2021 | 09:56h | UTC

European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea – European Respiratory Review

 


AHA Scientific Statement: Supporting physical activity in patients and populations during life events and transitions.

2 Dec, 2021 | 09:53h | UTC

Supporting Physical Activity in Patients and Populations During Life Events and Transitions: A Scientific Statement From the American Heart Association – Circulation

News Release: Major life events influence level of physical activity, may negatively impact heart health – American Heart Association

 


The ‘ten commandments’ for the 2021 ESC Guidelines on CVD prevention.

2 Dec, 2021 | 09:45h | UTC

The ‘ten commandments’ for the 2021 ESC Guidelines on CVD prevention – European Heart Journal

Original Article: #ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.

 


Guideline: Management of ureteral calculi.

2 Dec, 2021 | 09:54h | UTC

Canadian Urological Association guideline: Management of ureteral calculi – Abridged version – Canadian Urological Association Journal

Related Guidelines:

Renal and ureteric stones: assessment and management – National Institute for Health and Care Excellence

Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clinical Practice Guideline From the American College of Physicians

Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement – Journal of Nephrology

The Urological Association of Asia clinical guideline for urinary stone disease – International Journal of Urology

 


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