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[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.

15 Dec, 2021 | 08:46h | UTC

News release: Pfizer announces additional phase 2/3 study results confirming robust efficacy of novel Covid-19 oral antiviral treatment candidate in reducing risk of hospitalization or death

Commentaries:

Pfizer’s Covid pill remains 89% effective in final analysis, company says – STAT

Pfizer confirms COVID pill’s results, potency versus omicron – Associated Press

Related:

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

 

Commentary on Twitter (thread – click for more)

 

Rapidly spreading Omicron is now in 77 countries and WHO warns against assuming its effects are mild.

15 Dec, 2021 | 08:39h | UTC

Rapidly Spreading Omicron is Now in 77 Countries and WHO Warns Against Assuming its Effects are Mild – Health Policy Watch

 

Expert consensus and practical guidance: A global perspective on improving patient care in uncomplicated urinary tract infection.

15 Dec, 2021 | 08:33h | UTC

A global perspective on improving patient care in uncomplicated urinary tract infection: Expert consensus and practical guidance – Journal of Global Antimicrobial Resistance

 

M-A: Pharmacotherapy for adults with overweight and obesity – “phentermine–topiramate and GLP-1 receptor agonists proved the best drugs in reducing weight”.

15 Dec, 2021 | 08:30h | UTC

Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Proposed subtypes of long-Covid and their respective potential therapies.

14 Dec, 2021 | 09:49h | UTC

Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies – Reviews in Medical Virology

Related:

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

14 Dec, 2021 | 08:44h | UTC

News release: Cannabis use could cause harmful drug interactions – Washington State University

Original Study: Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions – Drug Metabolism and Disposition

 

Short Review: Lymphogranuloma venereum.

14 Dec, 2021 | 08:42h | UTC

Lymphogranuloma venereum – Canadian Medical Association Journal

 

Perspective: Alcohol-related harm is a public health issue, not a lifestyle choice.

14 Dec, 2021 | 08:41h | UTC

Alcohol-related harm is a public health issue, not a lifestyle choice – Health Policy Watch

Related:

COVID-19 pandemic and alcohol consumption: Impacts and interconnections – Toxicology Reports

National, Regional, and Global Burdens of Disease Attributable to Alcohol Use

Study: Alcohol Use and Burden for 195 Countries and Territories

Study: The Global Burden of Disease Attributable to Alcohol and Drug Use

Study: Global Alcohol Exposure Between 1990 and 2017 and Forecasts Until 2030

Analysis: Prioritizing Action on Alcohol for Health and Development

5000 alcohol-related cancer deaths could be prevented every year by doubling alcohol taxes in the European Region, says WHO/Europe.

Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.

Research: Contribution of alcohol use disorders to the burden of dementia

 

UK Report on SARS-CoV-2 variants of concern finds significantly lower vaccine effectiveness (VE) against Omicron infection, but a moderate to high VE of 70 to 75% is seen after a third (booster) dose.

13 Dec, 2021 | 09:53h | UTC

Report: SARS-CoV-2 variants of concern and variants under investigation in England – UK Health Security Agency

Commentaries:

Omicron: Three vaccine doses key for protection against variant – BBC

Two jabs offer little protection against Omicron infection, UK data shows – The Guardian

UK Says Omicron to Become Its Dominant Variant Within Days – Associated Press

 

NICE Guideline | Ectopic pregnancy and miscarriage: diagnosis and initial management.

13 Dec, 2021 | 09:42h | UTC

Ectopic pregnancy and miscarriage: diagnosis and initial management – National Institute for Health and Care Excellence

 

NICE Guideline | Pelvic floor dysfunction: prevention and non-surgical management.

13 Dec, 2021 | 09:43h | UTC

Pelvic floor dysfunction: prevention and non-surgical management – National Institute for Health and Care Excellence

 

NICE Guideline | Inducing labor.

13 Dec, 2021 | 08:55h | UTC

Inducing labour – National Institute for Health and Care Excellence

Related: NICE recommends offering women induced labor earlier in new draft guidance – “women with uncomplicated singleton pregnancies should be offered induction at 41 weeks and the induction should take place as soon as possible. Previous guidelines advised induction between 41 and 42 weeks”.

 

Colorectal cancer incidence, mortality, tumor characteristics, and treatment before and after the introduction of the fecal immunochemical testing-based screening program in the Netherlands: a population-based study.

13 Dec, 2021 | 08:50h | UTC

Colorectal cancer incidence, mortality, tumour characteristics, and treatment before and after introduction of the faecal immunochemical testing-based screening programme in the Netherlands: a population-based study – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Pooled analysis of randomized trials on the effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction (EF) showed the effects were clinically meaningful and similar in patients with EF below 65% but were attenuated in patients with EF above 65%.

13 Dec, 2021 | 08:53h | UTC

Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction – European Heart Journal

 

Commentary on Twitter

 

Cohort Study: Association of bilateral salpingo-oophorectomy with all cause and cause specific mortality.

13 Dec, 2021 | 08:42h | UTC

Association of bilateral salpingo-oophorectomy with all cause and cause specific mortality: population based cohort study – The BMJ

Commentary: Bilateral salpingo-oophorectomy may have risks for younger women, but safe for post-menopausal patients – News Medical

 

Commentary on Twitter

 

Omicron spreads, but severe cases remain low in South Africa.

10 Dec, 2021 | 10:17h | UTC

Omicron spreads but severe cases remain low in South Africa – WHO Africa

 

Systematic Review: Antibiotics for adults and children with sore throats.

10 Dec, 2021 | 10:02h | UTC

Summary: Antibiotics for adults and children with sore throats – Cochrane Library

Original Research: Antibiotics for treatment of sore throat in children and adults – Cochrane Library

 

Large observational study in Israel showed a third dose (booster) of the Pfizer–BioNTech vaccine had 90% effectiveness at preventing death due to Covid-19 compared to a two-dose regimen.

9 Dec, 2021 | 10:35h | UTC

BNT162b2 Vaccine Booster and Mortality Due to Covid-19 – New England Journal of Medicine

Editorial: Booster Doses and Prioritizing Lives Saved

 

Large observational study in Israel showed a third dose (booster) of the Pfizer–BioNTech vaccine reduced the rates of confirmed Covid-19 and severe illness compared to a two-dose regimen.

9 Dec, 2021 | 10:32h | UTC

Protection against Covid-19 by BNT162b2 Booster across Age Groups – New England Journal of Medicine

Editorial: Booster Doses and Prioritizing Lives Saved

 

As 57 countries report Omicron cases, Pfizer says its boosters offer protection – but WHO cautions more research is needed.

9 Dec, 2021 | 10:28h | UTC

As 57 Countries Report Omicron Cases, Pfizer Says its Boosters Offer Protection – But WHO Cautions More Research is Needed – Health Policy Watch

See also: Covid: Vaccines should work against Omicron variant, WHO says – BBC

 

RCT: Among children between the ages of 6 and 11 years with uncontrolled moderate-to-severe asthma, add-on Dupilumab reduced exacerbations and improved lung function.

9 Dec, 2021 | 10:21h | UTC

Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma – New England Journal of Medicine

Commentary: International study supports dupilumab for treatment of moderate-to-severe asthma in children – Vanderbilt University Medical Center

 

Systematic Review: Benefits and harms of annual, biennial, or triennial breast cancer mammography screening for women at average risk of breast cancer.

9 Dec, 2021 | 10:08h | UTC

Benefits and harms of annual, biennial, or triennial breast cancer mammography screening for women at average risk of breast cancer: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC) – British Journal of Cancer

 

Commentary on Twitter (thread – click for more)

https://twitter.com/ccaneloa/status/1464655542010494981

 

[Preprint] Risk of Hospitalization, severe disease, and mortality due to COVID-19 in children with SARS-CoV-2 infection in Germany – “overall hospitalization rate associated with SARS-CoV-2 infection was 35.9 per 10,000 children, ICU admission rate was 1.7 per 10,000 and case fatality was 0.09 per 10,000”.

8 Dec, 2021 | 10:18h | UTC

Risk of Hospitalization, severe disease, and mortality due to COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany – medRxiv

Related:

Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.

Review: Should children under 12 years of age be vaccinated against COVID-19?

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

 

Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors.

8 Dec, 2021 | 09:58h | UTC

Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors – Canadian Medical Association Journal

 

ESC Position Paper: Optimal follow-up after acute pulmonary embolism.

8 Dec, 2021 | 10:02h | UTC

Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society – European Heart Journal

 

Commentary on Twitter

 

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