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Family Medicine

Systematic Review: Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis.

4 Mar, 2022 | 08:46h | UTC

Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis – Cochrane Library

Summary: What are the benefits and risks of topical medications for treating epidemic keratoconjunctivitis? – Cochrane Library

 

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.

4 Mar, 2022 | 08:45h | UTC

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts – The Lancet Public Health

Commentaries:

Meta-analysis of 15 studies reports new findings on how many daily walking steps needed for longevity benefit – University of Massachusetts Amherst

Living a long life is a multi-step process – The Lancet Public Health

 

Podcast: Obesity medicine pearls.

4 Mar, 2022 | 08:43h | UTC

#324: Obesity Medicine FAQ with Dr. Fatima Cody Stanford – The Curbsiders

 

WHO: COVID-19 pandemic triggers a 25% increase in the prevalence of anxiety and depression worldwide.

3 Mar, 2022 | 09:44h | UTC

News Release: COVID-19 pandemic triggers 25% increase in prevalence of anxiety and depression worldwide – World Health Organization

Scientific Brief: Mental health and COVID-19: Early evidence of the pandemic’s impact – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

RCT: Nirsevimab for prevention of RSV in healthy late-preterm and term infants.

3 Mar, 2022 | 09:42h | UTC

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants – New England Journal of Medicine

Commentaries:

Nirsevimab Protects Late-Preterm, Term Infants from RSV-Related Lower RTI, Study Finds – AJMC

Nirsevimab Prophylaxis Wards Off RSV Infections in Healthy Infants— Monoclonal antibody showed 74.5% efficacy against RSV infections requiring medical care – MedPage Today (free registration required)

Related: Randomized trial: Single-dose nirsevimab for prevention of RSV in preterm infants

 

National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis.

3 Mar, 2022 | 08:51h | UTC

National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis – The Lancet Global Health

Invited commentary: Child and adolescent deaths: a call for strengthening mortality surveillance systems – The Lancet Global Health

 

[News release – not published yet] Study finds blood pressure cuff size matters, affects blood pressure readings.

3 Mar, 2022 | 08:47h | UTC

Study finds blood pressure cuff size matters, affects blood pressure readings – AHA Newsroom

 

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

3 Mar, 2022 | 08:43h | UTC

Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong – JAMA Pediatrics

Commentary: Study: Dosing change could reduce COVID-19 vaccine heart side effect in teens – UPI

Related:

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

A low-energy diet shows promise for reducing the symptoms of fibromyalgia.

3 Mar, 2022 | 08:23h | UTC

Early Relationships of a Low-Energy Diet With Symptoms of Fibromyalgia ACR Open Rheumatology

Commentary: Fibromyalgia Patients See Rapid Benefit From Low-Cal Diet — With marked symptom reduction in just 3 weeks, weight loss not a factor – MedPage Today (free registration required)

 

The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials.

3 Mar, 2022 | 08:22h | UTC

The effects of foods on LDL cholesterol levels: A systematic review of the accumulated evidence from systematic reviews and meta-analyses of randomized controlled trials – Nutrition, Metabolism & Cardiovascular Diseases

 

Meta-analysis showed a 2.4-fold increased risk of cancer in patients with pediatric-onset inflammatory bowel disease.

3 Mar, 2022 | 08:06h | UTC

Development of Cancer Among Patients With Pediatric-Onset Inflammatory Bowel Disease: A Meta-analysis of Population-Based Studies – JAMA Network Open

Commentary: Kids With IBD Need Close Monitoring as They Grow Up — Meta-analysis confirms: substantially increased cancer risk in adulthood – MedPage Today (free registration required)

 

Concise Review: A Practical 5-step approach to nausea and vomiting.

3 Mar, 2022 | 08:04h | UTC

A Practical 5-Step Approach to Nausea and Vomiting – Mayo Clinic Proceedings

 

M-A: Evaluation of budesonide-formoterol for maintenance and reliever therapy among patients with poorly controlled asthma.

3 Mar, 2022 | 07:59h | UTC

Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis – JAMA Network Open

 

Erosive hand osteoarthritis: latest findings and outlook.

3 Mar, 2022 | 08:01h | UTC

Erosive hand osteoarthritis: latest findings and outlook – Nature Reviews Rheumatology (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Prescribing Nirmatrelvir–Ritonavir for Covid-19: How to recognize and manage drug–drug interactions.

2 Mar, 2022 | 09:01h | UTC

Prescribing Nirmatrelvir–Ritonavir: How to Recognize and Manage Drug–Drug Interactions – Annals of Internal Medicine

Related:

Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.

Pfizer antiviral pills may be risky with other medications – NBC News

The New COVID-19 Pill, Paxlovid, Interacts with Many Medications: Cardiac Patients Take Note – The Skeptical Cardiologist

 

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

2 Mar, 2022 | 09:03h | UTC

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week – Journal of the American College of Cardiology

Commentary: Review of Anticoagulation in Patients With COVID-19: Key Points – American College of Cardiology

 

RCT: Arthroscopic hip surgery compared with personalized hip therapy in people over 16 years old with femoroacetabular impingement syndrome.

2 Mar, 2022 | 09:04h | UTC

Abstract: Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT – Health Technology Assessment

Download Full Report

Related: Randomized Trial: Arthroscopic Hip Surgery vs. Physiotherapy and Activity Modification for the Treatment of Femoroacetabular Impingement

 

NICE Guideline: Mental wellbeing at work.

2 Mar, 2022 | 08:57h | UTC

Mental wellbeing at work – National Institute for Health and Care Excellence

 

Systematic Review: Postcholecystectomy diarrhea rate and predictive factors.

2 Mar, 2022 | 08:48h | UTC

Postcholecystectomy diarrhoea rate and predictive factors: a systematic review of the literature – BMJ Open

 

Guideline Update: Timing of elective surgery and risk assessment after SARS-CoV-2 infection – “The guidance remains that patients should avoid elective surgery within 7 weeks of infection, unless the benefits of doing so exceed the risk of waiting”.

1 Mar, 2022 | 08:58h | UTC

Timing of elective surgery and risk assessment after SARS-CoV-2 infection: an update – Anaesthesia

Related:

Perioperative cardiovascular considerations prior to elective noncardiac surgery in patients with a history of Covid-19.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

BJS commission on surgery and perioperative care post-COVID-19.

The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

 

Systematic review on inappropriate use of clinical practices in Canada identified 144 underused practices, 109 overused practices, and 25 practices that were both under- and overused.

1 Mar, 2022 | 08:52h | UTC

Inappropriate use of clinical practices in Canada: a systematic review – Canadian Medical Association Journal

Commentary: What problems in health care quality should we target as the world burns around us? – Canadian Medical Association Journal

News Release: Inappropriate use of 228 clinical practices in Canada – Canadian Medical Association Journal

 

[Preprint] Study shows significantly reduced effectiveness of the Pfizer vaccine in children 5 to 11 after the emergency of the Omicron variant.

1 Mar, 2022 | 08:54h | UTC

Effectiveness of the BNT162b2 vaccine among children 5-11 and 12-17 years in New York after the Emergence of the Omicron Variant – medRxiv

Commentaries:

Pfizer Covid vaccine is less effective in kids 5 to 11, study finds – STAT

Pfizer Covid-19 vaccine effectiveness fell quickly for kids during Omicron surge but still offered some protection against severe disease – CNN

More mask mandates fall as poor COVID vaccine protection noted in young kids – CIDRAP

 

RCT: A mindfulness-oriented intervention may reduce opioid misuse and chronic pain in primary care.

1 Mar, 2022 | 08:32h | UTC

Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Mindfulness-Based Intervention Found to Reduce Chronic Pain and Opioid Misuse – Psychiatric News Alert

 

Commentary on Twitter

 

Review: New generation psychological treatments in chronic pain.

1 Mar, 2022 | 08:41h | UTC

New generation psychological treatments in chronic pain – The BMJ (free for a limited period)

 

New CDC interim guidance recommends a 4-month Rifapentine-Moxifloxacin regimen to treat drug-susceptible pulmonary tuberculosis.

27 Feb, 2022 | 22:49h | UTC

Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis — United States, 2022 – CDC Morbidity and Mortality Weekly Report

Related:

Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

WHO Guideline: Screening for Tuberculosis Disease

New WHO Recommendations to Prevent Tuberculosis

CDC Guidelines for the Treatment of Latent Tuberculosis Infection

Guideline: Treatment of Drug-Resistant Tuberculosis

NICE Guideline: Tuberculosis

The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis

Regimens to Treat Multidrug-resistant Tuberculosis: Past, Present and Future Perspectives

Guidelines for the Management of TB in Adults Living with HIV

 

Commentary on Twitter

 

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