Evidence-based Medicine
Review: Understanding vaccine safety and the roles of the FDA and the CDC.
29 Apr, 2022 | 11:13h | UTCUnderstanding Vaccine Safety and the Roles of the FDA and the CDC – New England Journal of Medicine
Commentary on Twitter
Development and public acceptance of vaccines are crucial for disease control. Cody Meissner, M.D., reviews the process of evaluating vaccine safety and efficacy and factors that advisory bodies consider in making recommendations. https://t.co/ITqpGthoac pic.twitter.com/HTkyAaWvDO
— NEJM (@NEJM) April 28, 2022
Experts fear U.S. may default to annual Covid boosters without sufficient data.
28 Apr, 2022 | 10:51h | UTCExperts fear U.S. may default to annual Covid boosters without sufficient data – STAT
Commentary on Twitter
Vaccine experts are concerned the U.S. may be sleepwalking into a policy of recommending annual Covid-19 vaccine boosters — without having generated the evidence to show they are actually needed. https://t.co/3TiNZvP0HY
— STAT (@statnews) April 26, 2022
Cluster Randomized Trials: Concepts.
28 Apr, 2022 | 08:04h | UTCCluster Randomized Trials: Concepts – Students 4 Best Evidence
Commentary on Twitter
ICYMI… What is cluster randomization? This latest @Students4BE blog from @vinay_jaikumar summarizes the concepts of cluster randomization, and the logistical and statistical considerations while designing a cluster randomized controlled trial: https://t.co/nm3Mxc898v pic.twitter.com/248mtAmccT
— Students4BE (@Students4BE) April 9, 2022
Research Methods & Reporting | Searching clinical trials registers: guide for systematic reviewers.
27 Apr, 2022 | 07:56h | UTCSearching clinical trials registers: guide for systematic reviewers – The BMJ
Commentary on Twitter
Clinical trials registers are a key resource for identifying potentially eligible studies for systematic reviews, particularly those that are unpublished.
This paper provides step-by-step guidance on how to conduct systematic searches @KylieEHunterhttps://t.co/DKZwy8rBkx
— The BMJ (@bmj_latest) April 26, 2022
New horizons in evidence-based care for older people: individual participant data meta-analysis.
27 Apr, 2022 | 07:50h | UTC
PRISMA 2020 and PRISMA-S: common questions on tracking records and the flow diagram.
22 Apr, 2022 | 09:19h | UTC
Opinion | Low-grade prostate cancer (Gleason score 6): time to stop calling it cancer.
19 Apr, 2022 | 02:29h | UTCLow-Grade Prostate Cancer: Time to Stop Calling It Cancer – Journal of Clinical Oncology
Commentary: Doctors suggest new names for low-grade prostate cancer – Associated Press
EBM Analysis: Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomized studies.
18 Apr, 2022 | 10:48h | UTC
Commentary on Twitter
Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomised studies – by John P A Ioannidis#OpenAccess
▶️ https://t.co/ddc2xF4hdg pic.twitter.com/okUAdQwb85— BMJ Evidence-Based Medicine (@BMJ_EBM) April 15, 2022
Opinion | The big idea: should we get rid of the scientific paper? – “As a format it’s slow, encourages hype, and is difficult to correct. A radical overhaul of publishing could make science better”.
14 Apr, 2022 | 08:37h | UTCThe big idea: should we get rid of the scientific paper? – The Guardian
Review: Ethical considerations for Phase I trials in oncology.
14 Apr, 2022 | 08:14h | UTCEthical Considerations for Phase I Trials in Oncology – Journal of Clinical Oncology
Commentary on Twitter
? #JCO #CommentsAndControversies: Wondering or wanting to update your knowledge about #ethics & contemporary cancer #phase1 #ClinicalTrials? Check out this review by @RemNil10 @selin_bicer1 @EthicsdoctorP @KimmelmanJ ? https://t.co/yYVq0y3QdU pic.twitter.com/ciQlw1mxcj
— Journal of Clinical Oncology (@JCO_ASCO) April 11, 2022
Opinion | Time to rethink the scientific CV.
13 Apr, 2022 | 10:23h | UTCTime to rethink the scientific CV – Nature
Commentary on Twitter
As institutions and funders around the world reassess their approach to researcher evaluations, there’s a growing call to revamp the academic CVs used to support applications for jobs, funding, promotions and awards. Read the @NatureCareers feature. https://t.co/ZGxrJrA1ZG
— Nature Portfolio (@NaturePortfolio) April 12, 2022
Completeness of clinical evidence citation in trial protocols: A cross-sectional analysis.
12 Apr, 2022 | 08:33h | UTCCompleteness of clinical evidence citation in trial protocols: A cross-sectional analysis – Med
News Release: Clinical trials often fail to cite relevant past studies, researchers find – Cell Press
Twitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study.
11 Apr, 2022 | 01:48h | UTCTwitter promotion is associated with higher citation rates of cardiovascular articles: the ESC Journals Randomized Study – European Society of Cardiology (link to abstract – $ for full-text)
Related:
Randomized Trial: Twitter Promotion Increases Citation Rates of Cardiovascular Articles
Does Tweeting Improve Citations? One-Year Results from the TSSMN Prospective Randomized Trial
A critical review on altmetrics: can we measure the social impact factor?
As scientists take to Twitter, study shows power of ‘visual abstract’ graphics
Perspective: How Twitter is Changing Medical Research
Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD
Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets
Rise of the Tweetorial – Precious Bodily Fluids
Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine
University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC
What’s your doctor reading? How social media is disrupting medical education – National Post
You must be joking: funny paper titles might lead to more citations.
11 Apr, 2022 | 00:51h | UTCYou must be joking: funny paper titles might lead to more citations – Nature
Original Study (preprint): If this title is funny, will you cite me? Citation impacts of humor and other features of article titles in ecology and evolution – bioRxiv
Viewpoint: Evaluating the effectiveness of diagnostic tests.
1 Apr, 2022 | 09:47h | UTCEvaluating the Effectiveness of Diagnostic Tests – JAMA (free for a limited period)
Strengthening systematic reviews in public health: guidance in the Cochrane Handbook for Systematic Reviews of Interventions, 2nd edition.
1 Apr, 2022 | 08:43h | UTC
Opinion: The illusion of evidence based medicine.
31 Mar, 2022 | 08:00h | UTCThe illusion of evidence based medicine – The BMJ
How to design high quality acupuncture trials—a consensus informed by evidence.
31 Mar, 2022 | 08:04h | UTCHow to design high quality acupuncture trials—a consensus informed by evidence – The BMJ
Commentary on Twitter
Despite over 14 000 published randomised controlled trials in acupuncture, shortcomings in the evidence persist.
This guidance covers the challenges particular to acupuncture trials and what researchers should consider when designing onehttps://t.co/eIKTov8pHT
— The BMJ (@bmj_latest) March 30, 2022
The RECOVERY Trial – two years on.
30 Mar, 2022 | 10:38h | UTCThe RECOVERY Trial – two years on – University of Oxford
Related:
[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
RECOVERY trial: Azithromycin not beneficial for patients admitted to hospital with COVID-19
RECOVERY trial: Effect of hydroxychloroquine in hospitalized patients with Covid-19
Randomized trial: Lopinavir–ritonavir not beneficial for patients admitted to hospital with COVID-19
Commentary on Twitter
"One trial. Over 47,000 participants. Nearly 200 hospital sites, across six countries. Ten results. Four effective COVID-19 treatments. And behind them all, an army of researchers, doctors, nurses, statisticians and supporting staff."https://t.co/cDlCUkG4cD
— Martin Landray (@MartinLandray) March 28, 2022
Methodological guidelines for the estimation of attributable mortality using a prevalence-based method: The STREAMS-P tool.
29 Mar, 2022 | 08:28h | UTC
Riding the Twitter wave: Enthusiasm for the social media platform changed science communication during the pandemic—but will it last?
28 Mar, 2022 | 09:56h | UTCRelated:
Perspective: How Twitter is Changing Medical Research
Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD
Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets
Rise of the Tweetorial – Precious Bodily Fluids
Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine
University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC
What’s your doctor reading? How social media is disrupting medical education – National Post
Commentary on Twitter
"[Twitter] has carried posts about a majority of the total COVID-19 literature—about 51% of journal articles on pandemic research had been mentioned in at least one tweet through May 2021" https://t.co/i4QEBE7F0m
— onisillos (@onisillos) March 25, 2022
Is there evidence of fabricated data in a Vitamin C trial published in CHEST?
28 Mar, 2022 | 09:58h | UTCEvidence of Fabricated Data in a Vitamin C trial by Paul E Marik et al in CHEST – This Scattrd Corn
Commentary on Twitter (thread – click for more)
Remember that Vitamin C cures sepsis paper that could never be replicated in 9 RCTs?
Turns out there is a good reason why: it’s very likely fraudulent.
More brilliant statistical sleuthing by @K_Sheldrick.https://t.co/eCayYZyeGo
1/— Nick Mark MD (@nickmmark) March 22, 2022
Prevalence of third-party tracking on medical journal websites.
23 Mar, 2022 | 09:56h | UTCPrevalence of Third-party Tracking on Medical Journal Websites – JAMA Health Forum
Commentary on Twitter
Interesting work in @JAMAHealthForum where the authors report that 99% of medical journals with an impact factor of 2.0 or higher expose visitors to third-party tracking by entities that work with pharmaceutical advertisers.https://t.co/ubvLQsuHeQ
— Chris Bennett, MD (@cleebennett) March 18, 2022
Future of clinical trial methodology.
21 Mar, 2022 | 09:59h | UTCFuture of Clinical Trial Methodology – Anesthesia & Analgesia
Commentary: Looking to the Future of Clinical Research Methodology – Anesthesia & Analgesia
Review: Challenging management dogma where evidence is non-existent, weak or outdated.
21 Mar, 2022 | 08:55h | UTCChallenging management dogma where evidence is non-existent, weak or outdated – Intensive Care Medicine (if the link is paywalled, try this one)