Evidence-based Medicine
Guide to statistics and methods: estimands, estimators, and estimates.
24 Aug, 2021 | 08:52h | UTCEstimands, Estimators, and Estimates – JAMA (free for a limited period)
Health researchers report funder pressure to suppress results – “Small study hints that interference from bodies funding research into public-health issues such as nutrition and exercise might be more common than realized”.
22 Aug, 2021 | 22:41h | UTCHealth researchers report funder pressure to suppress results – Nature
Original study: “He who pays the piper calls the tune”: Researcher experiences of funder suppression of health behaviour intervention trial findings – PLOS One
Prescription medications for use in pregnancy – perspective from the US Food and Drug Administration.
20 Aug, 2021 | 08:55h | UTC
Commentary on Twitter
"There are only 9 [NINE!] drugs that have ever been approved and marketed in the United States for obstetrical indications."
Pregnant individuals deserve data to help them make informed decisions. #ResearchPregnancy https://t.co/sj7dWUzKNZ
— All Source Pregnancy (@PregnancyAll) July 17, 2021
The animal origin of SARS-CoV-2 – “Trading of animals susceptible to bat coronaviruses is the likely cause of the COVID-19 pandemic”.
18 Aug, 2021 | 08:53h | UTCThe animal origin of SARS-CoV-2 – Science
Video: Evolutionary Origins of SARS-CoV-2
Related: Fauci says natural origins theory of coronavirus is still the most likely.
Commentary on Twitter (thread – click for more)
Big news! Our perspective on the origins of SARS-CoV-2 is now out at @ScienceMagazine❗❗ https://t.co/lrCQHgARdB
— Spyros Lytras (@SpyrosLytras) August 17, 2021
The use of Twitter by medical journals: systematic review of the literature.
18 Aug, 2021 | 08:31h | UTC
Commentary on Twitter
The Use of #Twitter by Medical Journals: #SystematicReview of the Literature by Erskine & Hendricks https://t.co/3M8UgqmghI
"4 key strategies implemented by #medjournals: tweeting the title & link of the article, infographics, podcasts, & hosting monthly … journal clubs."
— Carrie Price (@carrieprice78) August 16, 2021
Scientific medical conferences can be easily modified to improve female inclusion: a prospective study.
17 Aug, 2021 | 08:53h | UTCAuthor Interview: Victoria Salem on improving female inclusion in conferences
Commentaries:
Women participate less at conferences, even with gender-balanced delegates – Imperial College London
Women participate less at conferences, even if gender-balanced – study – The Guardian
Commentaries on Twitter
?conference organisers take note: female chairs and picking first questions from females are easy modifications for scientific medical conferences to improve female inclusion https://t.co/pt722RB6E8
— Dr Sharleen O’Reilly (@OReillySharleen) August 5, 2021
"If women are not visible at conferences, they cannot act as role models…creating a self-perpetuating cycle."
How scientific medical conferences can be easily modified to improve female inclusion. Read in @TheLancetEndo—https://t.co/3vK5KCdqco #GenerationEquality pic.twitter.com/YPaqnlcCZo
— The Lancet (@TheLancet) July 30, 2021
Excellent study @Soc_Endo – a female session chair and the first question asked by a woman significantly increases active female participation at a scientific conference – read @TheLancetEndo and listen to first author Victoria Salem, highly recommended! @MDSEquality @500womensci https://t.co/PWECJ7TLFU
— Wiebke Arlt ? ? Birmingham, Yes Birmingham (@WiebkeArlt) July 30, 2021
Study shows clinicians significantly overestimate the benefits of treatment to individual patients.
13 Aug, 2021 | 08:58h | UTC
Commentary on Twitter
All clinicians & trainees should read this study by @dr_dmorgan et al: in this survey N=542 “Clinicians consistently overestimated the chance that treatments would benefit an individual patient.”
Not by a few %age points, but overestimations of >10-20x!https://t.co/o5SSTnztgi
— Awais Aftab (@awaisaftab) August 10, 2021
WHO’s Solidarity clinical trial enters a new phase with three new candidate drugs.
12 Aug, 2021 | 09:02h | UTCCommentary:
WHO-led Trial Will Test Malaria and Cancer Medicines Against COVID-19 – Health Policy Watch
Related:
WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
Commentary on Twitter (thread – click for more)
WHO’s #COVID19 Solidarity clinical trial enters a new phase – Solidarity PLUS – with three new candidate drugs:
-artesunate
-imatinib
-infliximab— World Health Organization (WHO) (@WHO) August 11, 2021
Vaccination: Effectiveness versus Efficacy.
12 Aug, 2021 | 09:01h | UTCVaccination: Effectiveness versus Efficacy – by Luis Correa, MD
A giant trial of COVID-19 treatments organized by the WHO is restarting. Here are the drugs it’s betting on.
10 Aug, 2021 | 09:52h | UTCA giant trial of COVID-19 treatments is restarting. Here are the drugs it’s betting on – Science
Related: WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
Giving and taking: ethical treatment assignment in controlled trials.
10 Aug, 2021 | 08:52h | UTCGiving and taking: ethical treatment assignment in controlled trials. – The James Lindt Library
Commentary on Twitter
It was a pleasure and an honour to collaborate with @iainchalmersTTi in writing this piece https://t.co/TP66e4FAOd on ethical issue in treatment assignment in clinical trials. #clinicaltrials
— Stephen John Senn (@stephensenn) August 9, 2021
Adapting interventions to new contexts—the ADAPT guidance – “Use of interventions with a previous evidence base in new contexts might be more efficient than developing new interventions”.
8 Aug, 2021 | 23:46h | UTCAdapting interventions to new contexts—the ADAPT guidance – The BMJ
Commentary on Twitter
"Although some interventions transfer well, effectiveness and implementation often depend on the context."
This paper presents new evidence and consensus informed guidance for adapting and transferring interventions to new contextshttps://t.co/of1ojFR6VD
— The BMJ (@bmj_latest) August 8, 2021
Flawed ivermectin preprint highlights challenges of COVID drug studies.
6 Aug, 2021 | 10:07h | UTCFlawed ivermectin preprint highlights challenges of COVID drug studies – Nature
Related:
Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.
Why was a major study on ivermectin for covid-19 just retracted?
Establishment of an international collaborative network for N-of-1 trials and single-case designs.
6 Aug, 2021 | 09:02h | UTC
Methodology over metrics: current scientific standards are a disservice to patients and society.
5 Aug, 2021 | 08:42h | UTC
The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018.
5 Aug, 2021 | 08:37h | UTCRelated:
Review: Medical Reversals in Family Practice
Sham Surgeries: A Tale of Medical Reversals & the Role of the Media
Opinion (video): “The Delta Surge May Collapse Faster Than You Think.”
4 Aug, 2021 | 09:53h | UTCThe Delta Surge May Collapse Faster Than You Think – ZDoggMD
Related:
The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.
How the coronavirus infects cells — and why Delta is so dangerous.
CDC changes mask guidance in response to threat of Delta variant of Covid-19.
Interpreting the results of intention-to-treat, per-protocol, and as-treated analyses of clinical trials.
4 Aug, 2021 | 08:57h | UTC
AHA Scientific Statement: Considerations for cardiovascular genetic and genomic research with marginalized racial and ethnic groups and indigenous peoples.
3 Aug, 2021 | 02:24h | UTCNews release: New statement provides path to include ethnicity, ancestry, race in genomic research – American Heart Association
M-A: Effects of experimental interventions to improve the peer‐review process – “Modifications of the traditional peer‐review process at reviewer‐level are associated with improved quality, at the price of longer duration.”
3 Aug, 2021 | 02:09h | UTCEditorial: Reviewing Peer Review
Investigation: FDA allows drugs without proven clinical benefit to languish for years on accelerated pathway.
2 Aug, 2021 | 00:09h | UTCNews release: Investigation finds nearly half of drugs granted FDA ‘fast track’ approval lack proven clinical benefit – The BMJ
Commentary: Over 100 Drugs Given Speedy Approvals Still Lack Proof of Clinical Efficacy – MedPage Today (free registration required)
Olympic Pseudoscience – Tokyo Edition.
29 Jul, 2021 | 11:08h | UTCOlympic Pseudoscience – Tokyo Edition – Science Based Medicine
Systematic review and meta-analysis of depression, anxiety, and suicidal ideation among Ph.D. students.
28 Jul, 2021 | 09:54h | UTC
Commentaries on Twitter
A study in @SciReports concludes that depression and anxiety are highly prevalent among PhD students and programs to monitor and promote mental health are urgently needed. https://t.co/zTWxGC4Rs0 pic.twitter.com/tINXMmeJWj
— Nature Portfolio (@NaturePortfolio) July 27, 2021
*New* meta-analysis of >15K PhD students finds that 24% have clinical symptoms of depression & 17% of anxiety.
As a baseline: The prevalence of major depression among young adults in the US is ~13% & anxiety disorder is 4%.
Ht @wormmaps https://t.co/QPxHj0tgTc
— Amy Maxmen, PhD (@amymaxmen) July 13, 2021
Using Updated PubMed: New features and functions to enhance literature searches.
27 Jul, 2021 | 03:32h | UTCUsing Updated PubMed: New Features and Functions to Enhance Literature Searches – JAMA (free for a limited period)
Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence.
27 Jul, 2021 | 03:23h | UTC