Evidence-based Medicine
Discordant and inappropriate discordant recommendations in consensus and evidence based guidelines: empirical analysis.
5 Dec, 2021 | 23:14h | UTCEditorial: A moratorium on strong recommendations is needed – The BMJ
Commentary: Can we trust strong recommendations based on low quality evidence? – The BMJ
Commentary on Twitter
NEW research finds that consensus based guidelines produce more recommendations violating the evidence based medicine principles than evidence based guidelines https://t.co/8eCGZfiNZ3
— The BMJ (@bmj_latest) November 28, 2021
Practical recommendations on quantifying and interpreting treatment effects in the presence of terminal competing risks.
3 Dec, 2021 | 10:07h | UTCPractical Recommendations on Quantifying and Interpreting Treatment Effects in the Presence of Terminal Competing Risks: A Review – JAMA Cardiology (free for a limited period)
Commentary on Twitter
Our paper on how to analyze and interpret terminal competing risks in cardiovascular clinical trials just out in JAMA Cardiology. Always a pleasure to collaborate with LJ Wei, Marc Pfeffer and Scott Solomon and their great teams. https://t.co/9hk6wru7yU pic.twitter.com/64sgoOjldQ
— Otavio Berwanger (@OtavioBerwanger) December 1, 2021
Randomized clinical trials in critical care: past, present and future.
3 Dec, 2021 | 10:10h | UTCRandomised clinical trials in critical care: past, present and future – Intensive Care Medicine
Commentary on Twitter
RCTs in critical care, history, major challenges & limitations, recent developments trying to solve some of these
📊conventional & novel RCTs
📊rationale for choosing methodological approach (advantages/potential disadvantages – pros/cons)@CritCareReviewshttps://t.co/kjCw7dFuou pic.twitter.com/xS9lHK4cuY— Intensive Care Medicine (@yourICM) December 2, 2021
Perspective | Harms versus benefits in medicine: not just a decision for experts.
3 Dec, 2021 | 10:05h | UTCHarms versus benefits in medicine: not just a decision for experts – The Conversation
Guidelines developed under pressure. The case of the COVID-19 low-quality “rapid” guidelines and potential solutions.
1 Dec, 2021 | 08:54h | UTC
Omicron Variant: Videos with opinions on the subject.
28 Nov, 2021 | 21:33h | UTC- Omicron: What we know so far about the new COVID-19 variant | DW News
- OMG Omicron? | A Doctor Explains, LIVE – ZDoggMD
Brief review: The clinician’s guide to p values, confidence intervals, and magnitude of effects.
28 Nov, 2021 | 21:06h | UTCThe clinician’s guide to p values, confidence intervals, and magnitude of effects – Eye (if the link is paywalled, try this one)
Related:
Bayesian interpretation of p values in clinical trials.
Scientists Rise Up Against Statistical Significance
.050 shades of grey in p-value cutoffs
What a nerdy debate about p-values shows about science — and how to fix it – VOX
Big names in statistics want to shake up much-maligned P value – Nature News
‘One-size-fits-all’ threshold for P values under fire – Nature News
Statisticians issue warning over misuse of P values – Nature News
Understanding common misconceptions about p-values – The 20% Statistician
Review: Studies for the evaluation of diagnostic tests.
28 Nov, 2021 | 20:59h | UTCStudies for the Evaluation of Diagnostic Tests – Deutsches Ärzteblatt International
Opinion: The misuse and abuse of meta-analyses.
26 Nov, 2021 | 09:52h | UTCThe misuse and abuse of meta-analyses – Science-Based Medicine
Visual transformation for guidelines presentation of the strength of recommendations and the certainty of evidence.
26 Nov, 2021 | 09:43h | UTC
Review: The value of systematic reviews and meta-analyses in surgery.
25 Nov, 2021 | 10:11h | UTCThe Value of Systematic Reviews and Meta-Analyses in Surgery – European Surgical Research
GRADE Guidance 24. Optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelines.
23 Nov, 2021 | 08:38h | UTC
Commentary on Twitter
🆕#gradeguidance how & when to appropriately integrate non-randomized |observational studies in your #evidencesynthesis of intervention effects & some of the implications for @GRADE_WG approach @CharlieNeck @schunemann_mac @RMorganPhD @Elie__Akl +@JClinEpi https://t.co/2pAdQShX9q
— GRADE Working Group (@GRADE_WG) November 19, 2021
Overdiagnosis: it’s official – the term is now included in the medical subject headings (MeSH) vocabulary.
21 Nov, 2021 | 22:53h | UTCOverdiagnosis: it’s official – The BMJ
Related:
Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine
Overdiagnosis across medical disciplines: a scoping review – The BMJ Open
Too much medical care: bad for you, bad for health care systems – STAT News
Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review
Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician
Five warning signs of overdiagnosis – The Conversation
What is overdiagnosed cancer? And why does it matter? – Croakey
Blame rising cancer overdiagnosis on ‘irrational exuberance’ for early detection – STAT
A food allergy epidemic… or just another case of overdiagnosis?
An epidemic of overdiagnosis: Melanoma diagnoses sky rocket
Optimizing the use of Twitter for research dissemination: The “Three Facts and a Story” randomized-controlled trial.
21 Nov, 2021 | 22:48h | UTCRelated:
Perspective: How Twitter is Changing Medical Research
Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD
Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets
Rise of the Tweetorial – Precious Bodily Fluids
Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine
University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC
What’s your doctor reading? How social media is disrupting medical education – National Post
Commentary from the author on Twitter (thread – click for more)
We wanted to⬆️engagement with @JHepatology research
🤔Hypothesis: people are ⬆️ likely to connect with the people behind the research than the research itself
🧐Plan: Randomize papers to personal story tweets or graphical abstracts
🧐Primary Outcome: paper downloads#livertwitter pic.twitter.com/rxvbGrANRp— Elliot Tapper (@ebtapper) June 1, 2021
A billion-dollar donation: estimating the cost of researchers’ time spent on peer review.
17 Nov, 2021 | 08:16h | UTCRelated:
The $450 question: Should journals pay peer reviewers?
Opinion: Peer reviewers—time for mass rebellion?
5 things we learned about peer review in 2020
Editorial: Evaluation and Peer Review During a Pandemic
Commentary on Twitter
Peer reviewers worked over 100 million hours in 2020, estimated value $1.5 billion https://t.co/tY9klsLedU Feat @ceptional pic.twitter.com/kNn1Blovxg
— Neuroskeptic 🇺🇦 (@Neuro_Skeptic) November 16, 2021
#AHA21 – Among patients with intermittent atrial fibrillation, n-of-1 trials with 466 patients found alcohol, but not caffeine, increased the risk of atrial fibrillation events.
16 Nov, 2021 | 08:29h | UTCIndividualized Studies of Triggers of Paroxysmal Atrial Fibrillation: The I-STOP-AFib Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
Commentary: Avoiding AF Triggers Doesn’t Improve Quality of Life: I-STOP-AFib – TCTMD
Commentary on Twitter
Study found randomization to N-of-1 trial #Afib trigger testing fails to improve QOL but reduces number of Afib episodes. Testing alcohol associated with more Afib, but caffeine is not https://t.co/LElYEBUEcs
— JAMA Cardiology (@JAMACardio) November 14, 2021
Editorial: COVID is disrupting scientific careers around the world.
14 Nov, 2021 | 20:08h | UTCCOVID is disrupting scientific careers around the world – Nature
See also:
Scientists count the career costs of COVID – Nature
Potentially long-lasting effects of the pandemic on scientists – Nature
The COVID pandemic has harmed researcher productivity – and mental health – “Surveys show that women, parents of young children and people of color are most affected by pandemic-related disruptions and need more support”.
12 Nov, 2021 | 10:35h | UTCThe COVID pandemic has harmed researcher productivity – and mental health – Nature
Series: Diversity, equity, and inclusion in medical research.
12 Nov, 2021 | 10:23h | UTCHomepage: DEI in medical research – Nature Medicine
Editorial: Diversity, equity and inclusion: we are in it for the long run
Opinion articles:
Role of funders in addressing the continued lack of diversity in science and medicine
The US National Institutes of Health approach to inclusive excellence
Promoting diversity and inclusion in STEMM starts at the top
A commitment to scientific equity from a philanthropic funder
Commentary on Twitter (thread – click for more)
Today we publish 4 comments and an editorial that launch a new series: #DEI in medical research.
Diversity, equity and inclusion are critically important if medical research is to deliver on its goal to improve human health.
A thread…
(1 of 6)https://t.co/khtyXipNOY pic.twitter.com/5EG0wXBKSt— Nature Medicine (@NatureMedicine) November 11, 2021
A New Dementia Test Raises More Questions Than Answers – “A 5-minute assessment on an iPad could transform how we screen for dementia—or overwhelm the health care system with worried test-takers”.
11 Nov, 2021 | 08:29h | UTCA New Dementia Test Raises More Questions Than Answers – Wired
Perspective | Why scientific journal authorship practices make no sense “et al”.
9 Nov, 2021 | 01:07h | UTCWhy scientific journal authorship practices make no sense et al. – Science
Related:
Editorial: Authorship and Publication Matters: Credit and Credibility.
Opinion: No More First Authors, no More Last Authors
The authorship rows that sour scientific collaborations.
Mapping conflict of interests: scoping review.
7 Nov, 2021 | 20:10h | UTCMapping conflict of interests: scoping review – The BMJ
Press release: Study reveals “extensive network” of industry ties with healthcare – BMJ
Editorial: Safety and efficacy of antivirals against SARS-CoV-2 – “we need evidence not optimism”.
31 Oct, 2021 | 20:11h | UTCSafety and efficacy of antivirals against SARS-CoV-2 – The BMJ
Commentary on Twitter
"Effective antivirals have an obvious appeal, but this must not cloud objective and transparent decision making." @dpsg108 and colleagues on the government's stockpiling of molnupiravir and PF-07321332+ritonavir for covid-19https://t.co/JUj1Y9op3P
— The BMJ (@bmj_latest) October 28, 2021
Cardiovascular clinical examination: the need for an evidence-based approach.
31 Oct, 2021 | 19:57h | UTC
Commentary on Twitter
Which role for cardiac clinical examination today?
According to new cardiopulse, cardiac physical diagnosis shold be regarded as a science that can be learnt, rather than an art that can only be aspired to.https://t.co/oG1NJusXrS#cardiotwitter, @ESC_Journals, @escardio. pic.twitter.com/B9iUSv0gnj— EHJ Editor-in-Chief (@ehj_ed) October 30, 2021
Predatory publishers’ latest scam: bootlegged and rebranded papers.
29 Oct, 2021 | 09:45h | UTCPredatory publishers’ latest scam: bootlegged and rebranded papers – Nature
Related: Predatory Journals: No Definition, No Defense