Endocrinology (all articles) | Page 43 of 92 | Links Medicus Content Curation & Alerts in Medicine

#AHA20 – Randomized trial: In patients with refractory hypercholesterolemia, the use of Evinacumab significantly reduced the LDL levels. Larger studies with patient-relevant outcomes are needed.

16 Nov, 2020 | 01:59h | UTC

Evinacumab in Patients with Refractory Hypercholesterolemia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Evinacumab in Patients With Refractory Hypercholesterolemia – Evinacumab for Refractory Hypercholesterolemia – American College of Cardiology

Commentary on Twitter

In patients with hypercholesterolemia that is refractory to statin and PCSK9 inhibitor therapy, the use of evinacumab reduced plasma lipid levels by 50%. #AHA20

— NEJM (@NEJM) November 15, 2020

#AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo

16 Nov, 2020 | 01:57h | UTC

Side effects often attributed to statins were the same for those taking a placebo – American Heart Association

Commentary: ‘Nocebo effect’ cause of most statin side-effects, study suggests – The Guardian

Original study: N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects – New England Journal of Medicine ($ – no abstract available)

Commentary on Twitter

Patients who had discontinued statins because of side effects received four bottles of a statin, four bottles of placebo, and four empty bottles. Each used for 1 month, in random sequence. The symptom burden with placebo was 90% of the symptom burden with the statin. #AHA20

— NEJM (@NEJM) November 15, 2020

#AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk

16 Nov, 2020 | 01:51h | UTC

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial – JAMA

Editorial 1: Effects of Omega-3 Fatty Acids on Major Adverse Cardiovascular Events: What Matters Most: the Drug, the Dose, or the Placebo?

Editorial 2: Do Omega-3 Fatty Acids Benefit Health?

Commentary: STRENGTH trial finds new fish oil medication did not reduce the risk of cardiac events – American Heart Association

Commentary on Twitter

In this RCT, omega-3 fatty acids (EPA/DHA) did not reduce major adverse CV events vs corn oil in statin-treated patients at high CV risk
(Compare w Vascepa in REDUCE-IT) https://t.co/7BIs1Rr8YZ #STRENGTHTrial #AHA20 #SteveNissen @ProfSNicholls @Dmozaffarian @ClevelandClinic

— JAMA (@JAMA_current) November 15, 2020

[Not Published Yet] #AHA20 – Randomized trial: Fish oil and vitamin D supplements not effective for preventing atrial fibrillation

16 Nov, 2020 | 01:49h | UTC

Fish oil and vitamin D supplements not effective for preventing atrial fibrillation – American Heart Association

Commentary: Fish Oil, Vitamin D Don’t Prevent A-fib: VITAL Rhythm – TCTMD

World Diabetes Day 2020 (14 November 2020): Introducing the Global Diabetes Compact

16 Nov, 2020 | 01:43h | UTC

World Diabetes Day 2020: Introducing the Global Diabetes Compact – World Health Organization

KDIGO Guideline Synopsis: Diabetes management in chronic kidney disease. Use of ACE inhibitors or ARBs, glycemic monitoring and targets, and choice of antihyperglycemic drugs are covered

11 Nov, 2020 | 09:09h | UTC

Diabetes Management in Chronic Kidney Disease: Synopsis of the 2020 KDIGO Clinical Practice Guideline – Annals of Internal Medicine

Original guideline: Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease

Perioperative evaluation and management of patients with diabetes, thyroid disease, and adrenal insufficiency. Use of insulin and noninsulin diabetic medications, management of hyper and hypothyroidism, and use of stress-dose corticosteroids are some of the subjects reviewed

10 Nov, 2020 | 09:24h | UTC

Perioperative Evaluation and Management of Endocrine Disorders – Mayo Clinic Proceedings

Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes

4 Nov, 2020 | 09:38h | UTC

Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years – BMJ Nutrition, Prevention & Health

Commentary on Twitter

PUBLISHED! We wanted to showcase what a low-carb approach could achieve for people with #T2D in UK NHS general practice Our @BMJNutrition paper published today. Open access PLEASE read it https://t.co/zxj2XESBaO HUGE thanks to patients and staff @nnedpro Hurrah! pic.twitter.com/BLML1vSA6i

— Dr David Unwin (@lowcarbGP) November 3, 2020

Social determinants of health and diabetes: A scientific review

3 Nov, 2020 | 03:07h | UTC

Social Determinants of Health and Diabetes: A Scientific Review – Diabetes Care

Cohort study: Dietary inflammatory potential and risk of cardiovascular disease among men and women in the U.S.

3 Nov, 2020 | 03:05h | UTC

Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S. – Journal of the American College of Cardiology

Editorial: Ideal Dietary Patterns and Foods to Prevent Cardiovascular Disease: Beware of Their Anti-Inflammatory Potential

Commentary: High Intake of Proinflammatory Foods Linked to CVD Risk – NEJM Journal Watch^∗

[Abstract Only] Cohort study: Sodium–Glucose Cotransporter-2 Inhibitors and the risk for diabetic ketoacidosis

3 Nov, 2020 | 03:01h | UTC

Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Diabetic Ketoacidosis: A Multicenter Cohort Study – Annals of Internal Medicine

Commentarios: Can You Spot Euglycemic DKA From SGLT-2 Inhibitors? – Journal Feed AND Sodium glucose cotransporter-2 inhibitor use associated with increased risk of diabetic ketoacidosis – 2 Minute Medicine

Study provides new estimates of breast cancer risks associated with different hormone replacement therapy preparations

30 Oct, 2020 | 01:04h | UTC

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases – The BMJ

Commentaries: Study provides new estimates of breast cancer risks associated with HRT – University of Oxford AND New estimates of breast cancer risks associated with HRT – The BMJ AND HRT: Breast Ca Risk Tied to Hormone Type, Duration of Tx – Physician’s Weekly

Systematic review: PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease

29 Oct, 2020 | 08:57h | UTC

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease – Cochrane Library

Summary: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library

[Abstract Only] Randomized trial: Effect of Finerenone on chronic kidney disease outcomes in Type 2 diabetes

25 Oct, 2020 | 23:34h | UTC

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Finerenone Linked to Reduced Cardiorenal Events for Chronic Kidney Disease – HCPLive

Commentary on Twitter (thread – click for more)

‼️Effect of Finerenone on CKD outcomes in T2DM

⚡️Finerenone decreased risk of CKD progression by 18%

⚡️Finerenone decreased CV morbidity & mortality by 14%

Published in @NEJM today https://t.co/XvshpZZCK4 @ASNKidney #Kidneywk pic.twitter.com/FOkxnG1enz

— Aisha Shaikh (@aishaikh) October 23, 2020

KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease

20 Oct, 2020 | 01:33h | UTC

KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease – Kidney International

Executive summary: 2020 KDIGO Diabetes Management in CKD Guideline: evidence-based advances in monitoring and treatment – Kidney International

Commentary on Twitter

2020 #KDIGO Diabetes Management in #CKD Guidelinehttps://t.co/G127PgO1fe @deboerih @P_Rossing @goKDIGO pic.twitter.com/3kVNDpAoub

— Kidney International (@Kidney_Int) October 4, 2020

Life expectancy after bariatric surgery in the Swedish Obese Subjects Study

16 Oct, 2020 | 09:29h | UTC

Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study – New England Journal of Medicine

Commentary: Higher average life expectancy after obesity surgery – University of Gothenburg

Commentary on Twitter

https://twitter.com/NEJM/status/1316816109279084545

Review: Evaluation and treatment of patients with hypercortisolism

16 Oct, 2020 | 09:24h | UTC

Evaluation and Treatment of Patients With Hypercortisolism: A Review – JAMA Surgery

Meta-analysis: Nonpharmacologic interventions for reducing blood pressure in adults with prehypertension to established hypertension

14 Oct, 2020 | 09:20h | UTC

Nonpharmacologic Interventions for Reducing Blood Pressure in Adults With Prehypertension to Established Hypertension – Journal of the American Heart Association

Commentary on Twitter

Which lifestyle intervention works best for hypertension? #Bayesian meta-analysis suggests the #DASH diet https://t.co/1CgLVwN4LB #AHAJournals @tinauchojo pic.twitter.com/wzJ87OPT0m

— JAHA (@JAHA_AHA) October 5, 2020