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Endocrinology (all articles)

RCT | Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity.

9 Aug, 2022 | 12:59h | UTC

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial – JAMA Internal Medicine

Author Interview: Effectiveness of Early Time-Restricted Eating for Weight Loss and Fat Loss in Adults With Obesity – JAMA

Commentaries:

Time-Restricted Eating to Improve Health—A Promising Idea in Need of Stronger Clinical Trial Evidence – JAMA Internal Medicine (free for a limited period)

Expert reaction to study looking at early time-restricted eating and weight loss in obese adults – Science Media Centre

Related:

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials – Frontiers in Nutrition

Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition

Calorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine (link to abstract – $ for full-text)

Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials – JAMA Network Open

 

RCT | Effect of a comprehensive telehealth intervention vs. telemonitoring and care coordination in patients with persistently poor type 2 diabetes control.

9 Aug, 2022 | 12:44h | UTC

Effect of a Comprehensive Telehealth Intervention vs Telemonitoring and Care Coordination in Patients With Persistently Poor Type 2 Diabetes Control: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Comprehensive telehealth intervention effective for reducing HbA1c in poorly controlled diabetes – Physician’s Weekly

 

Commentary on Twitter

 

Systematic Review | Diabetes mellitus and perioperative outcomes.

9 Aug, 2022 | 12:28h | UTC

Diabetes mellitus and perioperative outcomes: a scoping review of the literature – British Journal of Anaesthesia

 

RCT | Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes.

8 Aug, 2022 | 11:56h | UTC

Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): A randomized, open-label, multinational, phase 3b trial – Diabetes, Obesity and Metabolism

 

M-A | Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards.

8 Aug, 2022 | 11:37h | UTC

Effectiveness and safety of new oral and injectable agents for in-hospital management of type 2 diabetes in general wards: systematic review and meta-analysis – Diabetes Research and Clinical Practice

 

Cohort Study | Age at menopause and risk of heart failure and atrial fibrillation.

5 Aug, 2022 | 14:38h | UTC

Age at menopause and risk of heart failure and atrial fibrillation: a nationwide cohort study – European Heart Journal (link to abstract – $ for full-text)

Editorial: Premature menopause and cardiovascular disease: can we blame estrogen? – European Heart Journal

News Release: Premature menopause is associated with increased risk of heart problems – European Society of Cardiology

 

Cohort study | Adults with Type 2 Diabetes and nonalcoholic fatty liver disease are at increased risk of severe hypoglycemia.

5 Aug, 2022 | 14:30h | UTC

Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease – JAMA Network Open

Commentary: Consider Fatty Liver Disease for Hypoglycemia Risk in Diabetes – JAMA Network Open (free registration required)

 

Commentary on Twitter

 

In a cohort study with a median follow‐up of 23.2 years, both very low and very high LDL‐C levels are associated with increased risk of cardiovascular mortality in the general population.

4 Aug, 2022 | 14:25h | UTC

Association of Low‐Density Lipoprotein Cholesterol Levels with More than 20‐Year Risk of Cardiovascular and All‐Cause Mortality in the General Population – Journal of the American Heart Association

 

Cohort Study | Bariatric surgery linked to doubling chance of marriage or divorce.

4 Aug, 2022 | 14:16h | UTC

News Release: Bariatric Surgery Linked to Doubling Chance of Marriage or Divorce – University of Pittsburgh

Original Study: Changes in Marital Status Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A US Multicenter Prospective Cohort Study – Annals of Surgery Open

Commentary: Spouse Getting Weight Loss Surgery? Your Marriage Might Be in Trouble – HealthDay

 

Network M-A | Evidence synthesis evaluating body weight gain among people treating HIV with antiretroviral therapy.

4 Aug, 2022 | 13:30h | UTC

Evidence synthesis evaluating body weight gain among people treating HIV with antiretroviral therapy – a systematic literature review and network meta-analysis – eClinicalMedicine

 

Commentary on Twitter

 

Guideline | Preventing obesity in midlife women.

3 Aug, 2022 | 14:37h | UTC

Preventing Obesity in Midlife Women: A Recommendation From the Women’s Preventive Services Initiative – Annals of Internal Medicine

News Release: Women’s Preventive Services Initiative issues guidelines for preventing obesity in midlife women – American College of Physicians

Commentary: Counseling Can Prevent Obesity in Normal, Overweight Women – HealthDay

 

Commentary on Twitter

 

Study shows the incidence of obesity among US children is increasing.

3 Aug, 2022 | 14:00h | UTC

Changes in the Incidence of Childhood Obesity – Pediatrics

Original Study: Childhood Obesity Rate in the U.S. Higher Now Than 12 Years Prior – HealthDay

 

M-A | GLP1 receptor agonists are associated with increased risk of progression of retinopathy in patients with type 2 diabetes.

2 Aug, 2022 | 12:32h | UTC

Progression of retinopathy with glucagon-like peptide-1 receptor agonists with cardiovascular benefits in type 2 diabetes – A systematic review and meta-analysis – Journal of Diabetes and its Complications (link to abstract – $ for full-text)

Commentary: GLP1 RA use tied to increased risk of rapidly worsening retinopathy in type 2 diabetes – Medical Dialogues

 

RCT | Safety and efficacy of Tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan.

2 Aug, 2022 | 12:05h | UTC

Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

See also (note: the dulaglutide dosage used in this trial was probably suboptimal): Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Related:

Tirzepatide Once Weekly for the Treatment of Obesity – New England Journal of Medicine

Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis – Diabetologia

Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis – Nature Medicine

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity.

1 Aug, 2022 | 12:35h | UTC

Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity (MERIT): a prospective, multicentre, randomised trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Cohort Study | Long-term leisure-time physical activity intensity and all-cause and cause-specific mortality.

1 Aug, 2022 | 12:26h | UTC

Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults – Circulation (free for a limited period)

News Release: New study finds lowest risk of death was among adults who exercised 150-600 minutes/week – American Heart Association

 

Perspective | Aspirin for the primary prevention of atherosclerotic cardiovascular disease in women.

1 Aug, 2022 | 12:25h | UTC

Aspirin for the Primary Prevention of Atherosclerotic Cardiovascular Disease in Women – JAMA (free for a limited period)

 

Cohort Study | Association of assisted reproductive technology with offspring growth and adiposity from infancy to early adulthood.

1 Aug, 2022 | 11:54h | UTC

Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood – JAMA Network Open

News Release: Concerns about effects of fertility treatment on children’s development are unwarranted, large study suggest – University of Bristol

 

Commentary on Twitter

 

M-A | Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes.

29 Jul, 2022 | 12:37h | UTC

Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis – The Lancet Diabetes & Endocrinology

Commentaries:

No justification for bespoke antihypertensive intervention in type 2 diabetes – medwire News

Blood pressure control according to type 2 diabetes status – The Lancet Diabetes & Endocrinology (free registration required)

 

Commentary on Twitter

 

Position Paper | Red yeast rice for dyslipidemias and cardiovascular risk reduction.

29 Jul, 2022 | 12:35h | UTC

Red yeast rice for dyslipidaemias and cardiovascular risk reduction: A Position Paper of the International Lipid Expert Panel – Pharmacological Research

 

RCT | Supplemental Vitamin D does not reduce incident fractures in midlife and older adults.

28 Jul, 2022 | 13:31h | UTC

Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Daily Vitamin D supplements don’t lower risk of bone fractures, study finds – STAT

Related:

Comparison of fracture risk using different supplemental doses of vitamin D, calcium or their combination: a network meta-analysis of randomised controlled trials – BMJ Open

Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA

 

Commentary on Twitter

 

Guideline | Management of diabetic macular edema.

28 Jul, 2022 | 13:18h | UTC

Management of Diabetic Macular Edema: Guidelines from the Emirates Society of Ophthalmology – Ophthalmology and Therapy

 

Consensus statement on the management of familial hypercholesterolemia.

28 Jul, 2022 | 13:16h | UTC

2022 Consensus statement on the management of familial hypercholesterolemia in Korea – The Korean Journal of Internal Medicine

 

M-A | Effectiveness of wearable activity trackers to increase physical activity and improve health.

26 Jul, 2022 | 13:27h | UTC

Effectiveness of wearable activity trackers to increase physical activity and improve health: a systematic review of systematic reviews and meta-analyses – The Lancet Digital Health

Commentary: Wearable activity trackers encourage us to walk up to 40 minutes more each day – University of South Australia

 

Commentary on Twitter

Under a CC BY-NC-ND 4.0 license

 

RCT | Safety and efficacy of Liraglutide vs. Colesevelam for treating bile acid diarrhea.

26 Jul, 2022 | 12:29h | UTC

Safety and efficacy of liraglutide versus colesevelam for the treatment of bile acid diarrhoea: a randomised, double-blind, active-comparator, non-inferiority clinical trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Diabetes Drug for Bile Acid Diarrhea Bests Standard of Care in Small Trial — Liraglutide proves superior to colesevelam for cutting daily stool frequency in Danish trial – MedPage Today (free registration required)

 

Commentary on Twitter

 

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