Endocrinology (all articles)

Summary: In a randomized, double-blind, placebo-controlled clinical trial involving 122 participants with plaque psoriasis, researchers investigated the effects of vitamin D supplementation on psoriasis severity during winter. Participants received either vitamin D (cholecalciferol, 100,000 IU loading dose followed by 20,000 IU/week) or a placebo for four months. The primary outcome was Psoriasis Area Severity Index (PASI) scores, with secondary outcomes including Physician Global Assessment, self-administered PASI, and Dermatology Life Quality Index scores.

The study found no significant difference in PASI scores or secondary outcomes between the two groups. The results suggest that vitamin D supplementation does not affect psoriasis severity. However, low baseline severity scores and a lower than expected increase in 25-hydroxyvitamin D levels in the intervention group may have influenced the findings, indicating that further research may be needed to account for these factors.

Article: Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels: A Randomized Clinical Trial – JAMA Dermatology (free for a limited period)

Commentary: Vitamin D Ineffective for Psoriasis Patients with Lower Serum 25-Hydroxyvitamin D Levels in Winter – HCP Live

Commentary on Twitter

This RCT, performed in North-Norway, found no measurable effect of vitamin D supplementation on psoriasis severity during winter. Low baseline severity, & lower-than-expected rise in 25(OH)D levels in intervention group, may have affected the results. https://t.co/ip17uFQsgM

— JAMA Dermatology (@JAMADerm) March 29, 2023

Cohort Study | Preoperative depression has minimal impact on 5-year bariatric surgery outcomes

4 Apr, 2023 | 13:23h | UTC

Preoperative Depression Status and 5 Year Metabolic and Bariatric Surgery Outcomes in the PCORnet Bariatric Study Cohort – Annals of Surgery

Single-arm study | Transcatheter arterialization of deep veins may help avoid amputation in chronic limb-threatening ischemia

3 Apr, 2023 | 14:03h | UTC

Transcatheter Arterialization of Deep Veins in Chronic Limb-Threatening Ischemia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

New procedure helps patients avoid leg amputation – Vanderbilt University

PROMISE II: Flow-Diverting Procedure May Save Limbs in CLTI – TCTMD

Transcatheter Arterialization Could Revolutionize Treatment of Limb-Threatening Ischemia – HCP Live

Transcatheter Arterialization for Limb Ischemia – American College of Cardiology

Commentary on Twitter

https://twitter.com/NEJM/status/1641192272539824128

M-A | Mediterranean & low-fat diets may reduce mortality and non-fatal MI in patients with high cardiovascular risk

3 Apr, 2023 | 13:59h | UTC

Summary: This systematic review and network meta-analysis aimed to determine the relative efficacy of different diets for preventing mortality and major cardiovascular events in patients at increased risk of cardiovascular disease. The study identified 40 randomized trials with 35,548 participants across seven dietary programs.

Moderate certainty evidence showed that Mediterranean and low-fat diets, with or without physical activity or other interventions, reduced all-cause mortality and non-fatal myocardial infarction in patients with increased cardiovascular risk. Mediterranean diet programs were also likely to reduce stroke risk.

Other dietary programs generally were not superior to minimal intervention. When compared with one another, no convincing evidence was found that the Mediterranean diet was superior to the low-fat diets in preventing mortality or non-fatal myocardial infarction.

Article: Comparison of seven popular structured dietary programmes and risk of mortality and major cardiovascular events in patients at increased cardiovascular risk: systematic review and network meta-analysis – The BMJ

News Release: Benefits of Mediterranean and low fat diet programmes in patients at risk of cardiovascular disease – BMJ Newsroom

Commentary: Mediterranean, Low-Fat Diets Both Good for Health: Network Meta-analysis – TCTMD

Assessment of childhood short stature: a GP guide

3 Apr, 2023 | 13:28h | UTC

Assessment of childhood short stature: a GP guide – British Journal of General Practice (free for a limited period)

Assessing heart failure risk: waist-to-height ratio outperforms BMI in HFrEF patients

31 Mar, 2023 | 13:49h | UTC

Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox – European Heart Journal

Editorial: Revisiting the obesity paradox in heart failure: what is the best anthropometric index to gauge obesity? – European Heart Journal

News Release: Study shows ‘obesity paradox’ does not exist: waist-to-height ratio is a better indicator of outcomes in patients with heart failure than BMI – European Society of Cardiology

Commentary: Study Debunks Obesity Paradox in HF, Encourages BMI Alternatives – TCTMD

M-A | Effects of statin therapy on glycemic control and insulin resistance

31 Mar, 2023 | 13:45h | UTC

Effects of statin therapy on glycemic control and insulin resistance: A systematic review and meta-analysis – European Journal of Pharmacology

Meta-Analysis: Medications that Reduce or Increase the Risk of New Onset Diabetes

Observational Study Points to an Increased Risk of Diabetes Among Patients Using Statins

Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus

Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes

Review | Management of immune related endocrinopathies following immune checkpoint inhibitor therapy for cancer

31 Mar, 2023 | 13:23h | UTC

Diagnostic criteria and management recommendations for immune related endocrinopathies following immune checkpoint inhibitor therapy for cancer – Endocrine Connections

The Diagnosis and Management of Endocrine Side Effects of Immune Checkpoint Inhibitors – Deutsches Ärzteblatt International

Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports – Clinical Diabetes and Endocrinology

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

30 Mar, 2023 | 14:14h | UTC

Vitamin D supplementation and cognition—Results from analyses of the D-Health trial – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Original Study: RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

Research: Circulating vitamin D concentration and risk of seven cancers

Research: Vitamin D and risk of total and site specific cancers

Phase 2 RCT | Safety and efficacy of once-weekly basal insulin Fc in people with type 2 diabetes

30 Mar, 2023 | 14:08h | UTC

Safety and efficacy of once-weekly basal insulin Fc in people with type 2 diabetes previously treated with basal insulin: a multicentre, open-label, randomised, phase 2 study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

SR | Anti‐vascular endothelial growth factor for proliferative diabetic retinopathy

29 Mar, 2023 | 13:15h | UTC

Anti‐vascular endothelial growth factor for proliferative diabetic retinopathy – Cochrane Library

Summary: Injections of anti-vascular endothelial growth factor for advanced diabetic retinopathy – Cochrane Library

Podcast | Diabetes updates

29 Mar, 2023 | 13:09h | UTC

#387: Diabetes Updates with Dr. Marie McDonnell: New Tools for the New Rules – The Curbsiders

A syndrome-specific antibiotic stewardship intervention reduced antipseudomonal antibiotic use in diabetic foot infections

29 Mar, 2023 | 13:10h | UTC

Impact of a syndrome-specific antibiotic stewardship intervention on antipseudomonal antibiotic use in inpatient diabetic foot infection management – Antimicrobial Stewardship & Healthcare Epidemiology

Practical guide to glucocorticoid induced hyperglycemia and diabetes

28 Mar, 2023 | 14:35h | UTC

Practical Guide to Glucocorticoid Induced Hyperglycaemia and Diabetes – Diabetes Therapy

Coffee consumption vs. caffeine avoidance: cardiac ectopy, daily steps, and sleep impacts

27 Mar, 2023 | 13:32h | UTC

Summary: A prospective, randomized, case-crossover trial studied the acute health effects of caffeinated coffee consumption in 100 ambulatory adults.

Participants were monitored using continuous electrocardiogram devices, wrist-mounted accelerometers, and ongoing glucose monitoring systems for 14 days. They received daily text messages instructing them to either consume caffeinated coffee or abstain from caffeine.

The primary outcome was the mean number of daily premature atrial contractions. Results indicated that caffeinated coffee consumption didn’t lead to significantly more daily premature atrial contractions compared to caffeine avoidance. However, it was associated with a higher number of daily premature ventricular contractions, increased daily steps, and reduced nightly sleep.

Article: Acute Effects of Coffee Consumption on Health among Ambulatory Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

What to know about new research on coffee and heart risks – Associated Press

CRAVE Trials Offers Most Comprehensive Overview Yet of Impact of Coffee, Caffeine Intake – HCP Live

Acute Effects of Coffee Consumption on Health – American College of Cardiology

Commentary: Semaglutide Well-Tolerated, But Shows Lack of Improvement in Liver Fibrosis – HCP Live

Commentary on Twitter

New research – Loomba et al – Semaglutide 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trialhttps://t.co/qkydKMpVfO #NASH #NAFLD #cirrhosis #gitwitter #livertwitter #medtwitter @DrLoomba pic.twitter.com/2A1dylSiq3

— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) March 17, 2023

M-A | Benefits and harms of drug treatment for type 2 diabetes

Umbrella review unveils benefits of cutting free sugars to 6 teaspoons/day

Swiss recommendations for the treatment of type 2 diabetes mellitus

Cohort Study | Pregnancy glucose intolerance, even below diabetes criteria, linked to increased risk of type 2 diabetes

Pharmacotherapy of obesity: an update on the available medications and drugs under investigation

M-A | Efficacy of flash glucose monitoring in type 1 and type 2 diabetes

RCT | No significant fracture reduction from monthly 60,000 IU vitamin D3 supplementation

RCT | Vitamin D supplementation shows no significant impact on psoriasis severity

Cohort Study | Preoperative depression has minimal impact on 5-year bariatric surgery outcomes

Single-arm study | Transcatheter arterialization of deep veins may help avoid amputation in chronic limb-threatening ischemia

M-A | Mediterranean & low-fat diets may reduce mortality and non-fatal MI in patients with high cardiovascular risk

Assessment of childhood short stature: a GP guide

Assessing heart failure risk: waist-to-height ratio outperforms BMI in HFrEF patients

M-A | Effects of statin therapy on glycemic control and insulin resistance

Review | Management of immune related endocrinopathies following immune checkpoint inhibitor therapy for cancer

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

Phase 2 RCT | Safety and efficacy of once-weekly basal insulin Fc in people with type 2 diabetes

SR | Anti‐vascular endothelial growth factor for proliferative diabetic retinopathy

Podcast | Diabetes updates

A syndrome-specific antibiotic stewardship intervention reduced antipseudomonal antibiotic use in diabetic foot infections

Practical guide to glucocorticoid induced hyperglycemia and diabetes

Coffee consumption vs. caffeine avoidance: cardiac ectopy, daily steps, and sleep impacts

Dissecting coffee’s impact: high consumption lowers blood pressure, raises LDL-cholesterol

M-A | The effect of curcumin supplementation on weight loss and anthropometric indices

Phase 2 RCT | Semaglutide did not improve fibrosis in NASH-related cirrhosis

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