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Obesity

Cohort Study | Preoperative depression has minimal impact on 5-year bariatric surgery outcomes

4 Apr, 2023 | 13:23h | UTC

Preoperative Depression Status and 5 Year Metabolic and Bariatric Surgery Outcomes in the PCORnet Bariatric Study Cohort – Annals of Surgery

 


Assessing heart failure risk: waist-to-height ratio outperforms BMI in HFrEF patients

31 Mar, 2023 | 13:49h | UTC

Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox – European Heart Journal

Editorial: Revisiting the obesity paradox in heart failure: what is the best anthropometric index to gauge obesity? – European Heart Journal

News Release: Study shows ‘obesity paradox’ does not exist: waist-to-height ratio is a better indicator of outcomes in patients with heart failure than BMI – European Society of Cardiology

Commentary: Study Debunks Obesity Paradox in HF, Encourages BMI Alternatives – TCTMD

 


M-A | The effect of curcumin supplementation on weight loss and anthropometric indices

27 Mar, 2023 | 13:04h | UTC

The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials – American Journal of Clinical Nutrition

 


Phase 2 RCT | Semaglutide did not improve fibrosis in NASH-related cirrhosis

27 Mar, 2023 | 13:01h | UTC

Semaglutide 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial – The Lancet Gastroenterology & Hepatology

Commentary: Semaglutide Well-Tolerated, But Shows Lack of Improvement in Liver Fibrosis – HCP Live

 

Commentary on Twitter

 


RCT | Effect of various dosing schedules on the pharmacokinetics of oral semaglutide

22 Mar, 2023 | 13:07h | UTC

Effect of Various Dosing Schedules on the Pharmacokinetics of Oral Semaglutide: A Randomised Trial in Healthy Subjects – Clinical Pharmacokinetics

 


RCT | Time-restricted eating not more effective than daily calorie restriction for managing nonalcoholic fatty liver disease

21 Mar, 2023 | 13:38h | UTC

Summary: The TREATY-FLD randomized clinical trial investigated the effects of time-restricted eating (TRE) versus daily calorie restriction (DCR) on intrahepatic triglyceride (IHTG) content and metabolic risk factors in patients with obesity and nonalcoholic fatty liver disease (NAFLD).

Participants were randomly assigned to either TRE (eating only between 8:00 am and 4:00 pm) or DCR (habitual meal timing) and instructed to maintain a diet of 1500 to 1800 kcal/d for men and 1200 to 1500 kcal/d for women for 12 months.

The study found that the IHTG content was reduced by 6.9% in the TRE group and 7.9% in the DCR group after 12 months, a difference that was not statistically significant. Furthermore, TRE did not produce additional benefits for reducing body weight, liver stiffness, or metabolic risk factors compared with DCR.

The study supports that the main focus of a diet for managing NAFLD is caloric restriction, which can be achieved both with a TRE strategy or without a TRE strategy with similar results.

Article: Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease: The TREATY-FLD Randomized Clinical Trial – JAMA Network Open

Commentary: Time-Restricted Eating Not More Beneficial Than Calorie Restriction For Patients With NAFLD, Obesity – HCP Live

 

Commentary on Twitter

 


Review | Choosing the best endoscopic approach for post-bariatric surgical leaks and fistulas

20 Mar, 2023 | 13:23h | UTC

Choosing the best endoscopic approach for post-bariatric surgical leaks and fistulas: Basic principles and recommendations – World Journal of Gastroenterology

Related: Curriculum for bariatric endoscopy and endoscopic treatment of the complications of bariatric surgery: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement – Endoscopy

 


Associations of relative fat mass, a new index of adiposity, with type-2 diabetes in the general population

17 Mar, 2023 | 13:04h | UTC

Associations of relative fat mass, a new index of adiposity, with type-2 diabetes in the general population – European Journal of Internal Medicine

 


M-A | Health effects of the time-restricted eating in adults with obesity

17 Mar, 2023 | 12:54h | UTC

Health effects of the time-restricted eating in adults with obesity: A systematic review and meta-analysis – Frontiers in Nutrition

Related:

Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial – Cell Metabolism

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial – JAMA Internal Medicine

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials – Frontiers in Nutrition

Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition

Calorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine

Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials – JAMA Network Open

 


Cohort Study | Higher ultra-processed food consumption linked to increased cancer incidence and mortality

15 Mar, 2023 | 14:48h | UTC

Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank – eClinicalMedicine

News Release: Ultra-processed foods may be linked to increased risk of cancer – Imperial College London

Commentary: Expert reaction to study looking at ultra-processed foods and risk of different cancers – Science Media Centre

Related:

Association of ultra-processed food consumption with colorectal cancer risk among men and women: results from three prospective US cohort studies – The BMJ

Joint association of food nutritional profile by Nutri-Score front-of-pack label and ultra-processed food intake with mortality: Moli-sani prospective cohort study – The BMJ

Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study – The BMJ

Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé) – The BMJ

 


Report | Economic impact of overweight and obesity to surpass $4 trillion by 2035

6 Mar, 2023 | 14:32h | UTC

Summary:

A recent report from the World Obesity Federation has issued a warning that the number of people worldwide suffering from overweight or obesity could increase significantly by 2035, surpassing the 50% mark. The report, called the World Obesity Atlas 2023, also highlights the significant economic impact of this trend, estimating that the cost of overweight and obesity could reach $4.32tn annually by 2035, equivalent to almost 3% of the global GDP.

The report also identifies two groups that are particularly at risk: children and individuals from lower-income countries. Childhood obesity is a growing concern, as the report predicts it could double by 2035. Additionally, lower-income countries face a rapid increase in obesity prevalence, with nine out of 10 countries with the greatest expected increases in obesity coming from low or lower-middle income countries.

 

Report: World Obesity Atlas 2023

News release: Economic impact of overweight and obesity to surpass $4 trillion by 2035

Commentary: Report: Obesity could cost the world over $4 trillion a year by 2035 – STAT

Related:

Report: Tenfold increase in childhood and adolescent obesity in four decades

Global cost of obesity-related illness to hit $1.2tn a year from 2025

Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019 – eClinicalMedicine

Global inequalities in the double burden of malnutrition and associations with globalization: a multilevel analysis of Demographic and Healthy Surveys from 55 low-income and middle-income countries, 1992–2018.

The Lancet Series: The Double Burden of Malnutrition

 


M-A | Sugar-sweetened beverage consumption and weight gain in children and adults

6 Mar, 2023 | 14:04h | UTC

Article: Sugar-sweetened beverage consumption and weight gain in children and adults: a systematic review and meta-analysis of prospective cohort studies and randomized controlled trials – The American Journal of Clinical Nutrition

News Release: More evidence that sugary drinks cause weight gain – University of Toronto

 


M-A | Metabolic side effects in persons with schizophrenia during mid- to long-term treatment with antipsychotics

23 Feb, 2023 | 13:26h | UTC

Summary: This study aimed to evaluate the mid- to long-term metabolic side effects of 31 antipsychotics in persons with schizophrenia by analyzing 137 eligible randomized controlled trials with 35,007 participants. The primary outcome was weight gain, with secondary outcomes including fasting glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. The study found that antipsychotic drugs differ in their propensity to induce metabolic side effects. Chlorpromazine, clozapine, olanzapine, and zotepine produced the most weight gain. The confidence in the evidence ranged from low to moderate. The study suggests that differences in weight gain were more pronounced than previously published short-term data and that weight gain is most pronounced at the beginning of treatment and then remains stable.

Article: Metabolic side effects in persons with schizophrenia during mid- to long-term treatment with antipsychotics: a network meta-analysis of randomized controlled trials – World Psychiatry (free for a limited period)

 


M-A | Sugar-sweetened beverage consumption and weight gain in children and adults

22 Feb, 2023 | 12:26h | UTC

Sugar-sweetened beverage consumption and weight gain in children and adults: a systematic review and meta-analysis of prospective cohort studies and randomized controlled trials – American Journal of Clinical Nutrition

 


Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019

22 Feb, 2023 | 12:17h | UTC

Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019 – eClinicalMedicine

 


RCT | Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease

20 Feb, 2023 | 12:27h | UTC

Summary: The article reports on a randomized trial that compared the effects of alternate-day fasting (ADF) combined with exercise, fasting alone, or exercise alone in adults with obesity and non-alcoholic fatty liver disease (NAFLD). After three months, the combination of ADF and exercise significantly reduced intrahepatic triglyceride content, body weight, fat mass, waist circumference, and alanine transaminase levels compared to the control group. The intervention seems promising for patients with fatty liver disease who want to improve their health without using medications.

Article: Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial – Cell Metabolism (link to abstract – $ for full-text)

News Release: Alternate-day fasting could be a good option for patients with fatty liver disease – University of Illinois Chicago

 


Research shows ad libitum meal energy intake is influenced by energy density, eating rate and hyper-palatable foods

8 Feb, 2023 | 12:36h | UTC

Ad libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns – Nature Food (free for a limited period)

News Release: Research shows impact of ‘hyper-palatable’ foods across four diets – University of Kansas

 

Commentary from one of the authors on Twitter (thread – click for more)

 


RCT | Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity

7 Feb, 2023 | 13:54h | UTC

Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial – Cell Metabolism

News Release: Combination of time-restricted eating and high-intensity interval training can help reduce belly fat – The Norwegian University of Science and Technology/News Medical

 

Commentary on Twitter

Under a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) license

 


The introduction of sugary drinks tax in the UK was followed by a drop in obesity cases among children

1 Feb, 2023 | 13:32h | UTC

Associations between trajectories of obesity prevalence in English primary school children and the UK soft drinks industry levy: An interrupted time series analysis of surveillance data – PLOS Medicine

News Releases:

UK soft drink taxes associated with decreased obesity in girls – PLOS

Sugary drinks tax may have prevented over 5,000 cases of obesity a year in year six girls alone – University of Cambridge

Commentaries:

Expert reaction to study looking at the UK sugary drinks tax and obesity in children – Science Media Centre

UK sugar tax ‘prevents 5,000 cases of obesity in year 6 girls annually’ – The Guardian

Related:

WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.

M-A: Outcomes following taxation of sugar-sweetened beverages.

Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics

Cutting back on sugar-sweetened beverages: What works? – Cochrane Library

Association of a Beverage Tax on Sugar-Sweetened and Artificially Sweetened Beverages With Changes in Beverage Prices and Sales at Chain Retailers in a Large Urban Setting – JAMA

Impact of sugar‐sweetened beverage taxes on purchases and dietary intake: Systematic review and meta‐analysis – Obesity Reviews

Association between tax on sugar sweetened beverages and soft drink consumption in adults in Mexico: open cohort longitudinal analysis of Health Workers Cohort Study – The BMJ

Potential impact on prevalence of obesity in the UK of a 20% price increase in high sugar snacks: modelling study – The BMJ

Changes in food purchases after the Chilean policies on food labelling, marketing, and sales in schools: a before and after study – The Lancet Planetary Health

Association of a Sweetened Beverage Tax With Soda Consumption in High School Students – JAMA Pediatrics

Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine

Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation

Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian

 

Commentary from the author on Twitter (thread – click for more)

 


M-A | Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults

26 Jan, 2023 | 12:52h | UTC

Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials – British Journal of Sports Medicine

 

Commentary on Twitter

 


Health and economic outcomes associated with musculoskeletal disorders attributable to high BMI in 192 countries

23 Jan, 2023 | 13:16h | UTC

Health and Economic Outcomes Associated With Musculoskeletal Disorders Attributable to High Body Mass Index in 192 Countries and Territories in 2019 – JAMA Network Open

 


AAP Guideline | Evaluation and treatment of children and adolescents with obesity

10 Jan, 2023 | 14:54h | UTC

Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity – Pediatrics

Executive Summary: Clinical Practice Guideline for the Evaluation and Treatment of Children and Adolescents With Obesity – Pediatrics

News Release: American Academy of Pediatrics Issues Its First Comprehensive Guideline on Evaluating, Treating Children and Adolescents With Obesity – American Academy of Pediatrics

Commentaries:

Childhood obesity requires early, aggressive treatment, new guidelines say – NPR

New guidance: Use drugs, surgery early for obesity in kids – Associated Press

 


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