Editor's Choice
Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19.
29 Mar, 2022 | 10:05h | UTC
Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers.
29 Mar, 2022 | 09:58h | UTCCumulative burden of psychiatric disorders and self-harm across 26 adult cancers – Nature Medicine
See also: Suicide risk and mortality among patients with cancer – Nature Medicine (if the link is paywalled, try this one)
Invited Commentary: Shining a light on the psychological burden of cancer – Nature Medicine
Commentary on Twitter
Patients with cancer who are diagnosed with a psychiatric disorder had a higher incidence of mortality and are at greater risk of self-harm compared with other patients with cancer, according to a paper published in @NatureMedicine. https://t.co/U5b7ODKSNd pic.twitter.com/816N6ZCfms
— Nature Portfolio (@NaturePortfolio) March 28, 2022
Multidisciplinary consensus for the management of pulmonary thromboembolism.
29 Mar, 2022 | 09:54h | UTC
Scientists find that the impact of social media on wellbeing varies across adolescence.
29 Mar, 2022 | 09:56h | UTCNews Release: Scientists find that the impact of social media on wellbeing varies across adolescence – University of Cambridge
Original Study: Windows of developmental sensitivity to social media – Nature Communications
Commentaries:
Teenage social media use linked to less life-satisfaction for some – BBC
Social media may affect girls’ mental health earlier than boys’, study finds – The Guardian
Expert reaction to study on social media use and wellbeing over adolescence – Science Media Centre
Review Series: Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2022.
28 Mar, 2022 | 10:06h | UTCVasopressor choice and timing in vasodilatory shock
Brain injury biomarkers for predicting outcome after cardiac arrest
The importance of neuromonitoring in non-brain injured patients
Artificial intelligence in critical care medicine
Artificial intelligence in infection management in the ICU
Sepsis performance improvement programs: from evidence towards clinical implementation
How to prolong filter life during continuous renal replacement therapy?
Immunomodulation by tetracyclines in the critically ill: an emerging treatment option?
The role of mitochondria in the immune response in critical illness
AGA clinical practice update on the role of diet in irritable bowel syndrome.
28 Mar, 2022 | 10:04h | UTCRelated:
10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.
Supplement: Irritable bowel syndrome and related conditions.
RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Guidelines for the treatment of irritable bowel syndrome
ACG Clinical Guideline: Management of irritable bowel syndrome
M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome
Study challenges the theory that light alcohol consumption benefits heart health.
28 Mar, 2022 | 10:09h | UTCNews Release: Large study challenges the theory that light alcohol consumption benefits heart health – Massachusetts General Hospital
Original Study: Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease – JAMA Network Open
Related: No amount of alcohol is good for the heart, says World Heart Federation.
Commentary on Twitter
Cohort study found confounding factors mediate the J-shaped association between alcohol intake & CVD. Genetic epidemiology suggests any amount of alcohol is associated with increased CVD risk, with exponential risk increases at heavier consumption levels. https://t.co/PrPDmyt87q
— JAMA Network Open (@JAMANetworkOpen) March 25, 2022
Moderna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years.
28 Mar, 2022 | 10:01h | UTCModerna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years – STAT
Riding the Twitter wave: Enthusiasm for the social media platform changed science communication during the pandemic—but will it last?
28 Mar, 2022 | 09:56h | UTCRelated:
Perspective: How Twitter is Changing Medical Research
Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD
Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets
Rise of the Tweetorial – Precious Bodily Fluids
Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine
University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC
What’s your doctor reading? How social media is disrupting medical education – National Post
Commentary on Twitter
https://twitter.com/onisillos/status/1507398283416768515
Is there evidence of fabricated data in a Vitamin C trial published in CHEST?
28 Mar, 2022 | 09:58h | UTCEvidence of Fabricated Data in a Vitamin C trial by Paul E Marik et al in CHEST – This Scattrd Corn
Commentary on Twitter (thread – click for more)
Remember that Vitamin C cures sepsis paper that could never be replicated in 9 RCTs?
Turns out there is a good reason why: it’s very likely fraudulent.
More brilliant statistical sleuthing by @K_Sheldrick.https://t.co/eCayYZyeGo
1/— Nick Mark MD (@nickmmark) March 22, 2022
Cohort Study: SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses is associated with increased mortality.
28 Mar, 2022 | 10:03h | UTCCommentary: Patients with Covid and flu double the risk of dying, say scientists – The Guardian
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/kennethbaillie/status/1507501279181955076
Opinion: How we got herd immunity wrong.
28 Mar, 2022 | 09:50h | UTCHow we got herd immunity wrong – STAT
The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.
28 Mar, 2022 | 09:48h | UTCM-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy
Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
Commentary on Twitter
In this cohort study of more than 330,000 children, less than 5% were labeled with penicillin allergy with wide variation across practices, with 8% of those labeled despite not receiving any penicillin prescription. https://t.co/kvXcm1RKRd
— JAMA Network Open (@JAMANetworkOpen) March 15, 2022
Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.
28 Mar, 2022 | 09:51h | UTCAssociation of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes – JAMA
See also: Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes – JAMA
Editorial: COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy – JAMA
News Release: No increase in pregnancy complications after COVID-19 vaccination – Karolinska Institutet
M-A: Comparative effectiveness of statins on non-HDL cholesterol in people with diabetes and at risk of cardiovascular disease.
25 Mar, 2022 | 10:01h | UTCNews Release: Best statins for reducing cardiovascular risk in people with diabetes found – University of Manchester
Commentary on Twitter
This network meta-analysis indicated that rosuvastatin, at moderate and high intensity doses, and simvastatin and atorvastatin, at high intensity doses, were most effective at moderately reducing levels of non-HDL-C in patients with diabeteshttps://t.co/NwUf4sX5KA
— The BMJ (@bmj_latest) March 24, 2022
Cochrane Special Collection: Diagnosing tuberculosis.
25 Mar, 2022 | 09:57h | UTCDiagnosing tuberculosis – Cochrane Library
Studies show same-day discharge post–transcatheter aortic valve replacement is feasible.
25 Mar, 2022 | 09:58h | UTCStudy 1: Same-Day Discharge Post–Transcatheter Aortic Valve Replacement During the COVID-19 Pandemic: The Multicenter PROTECT TAVR Study – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Study 2: Feasibility and Safety of Same-Day Discharge Following Transfemoral Transcatheter Aortic Valve Replacement – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Editorial: Did the COVID-19 Pandemic Just Turn TAVR Into an Outpatient Procedure?
Commentary: ‘Right Time, Right Moment’: Same-Day Discharge After TAVI Safe, Feasible – TCTMD
3 orthopedic surgeries that might be doing patients (and their pockets) more harm than good.
25 Mar, 2022 | 09:54h | UTC
RCT: Among patients with heart failure and atrial fibrillation, an ablation-based rhythm-control strategy was not significantly better than a rate-control strategy for improving all-cause mortality and heart failure events (hazard ratio 0.71; 95% CI 0.49-1.03; p=0.066).
25 Mar, 2022 | 09:59h | UTCRelated:
Update on management of atrial fibrillation in heart failure: a focus on ablation.
Review: Cryoballoon ablation as initial treatment for atrial fibrillation.
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
25 Mar, 2022 | 09:56h | UTCCommentaries:
Sweeteners may be linked to increased cancer risk – new research – The Conversation
Expert reaction to observational study of sweeteners and cancer risk – Science Media Centre
[Preprint] Vaccine effectiveness of two and three doses of Pfizer and CoronaVac against COVID-19 in Hong Kong.
25 Mar, 2022 | 09:43h | UTC
Commentary on Twitter
New data from Hong Kong on Coronavac and Pfizer vaccines implicates lack of vaccination and boosters in people of advanced age, not type of vaccine, for extreme fatality rates.
2 doses: Coronavac less protective than Pfizer
3 doses: equivalent VEhttps://t.co/BSOGscPvmc pic.twitter.com/UZqYhN7zP5— Eric Topol (@EricTopol) March 23, 2022
[Preprint] Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study.
25 Mar, 2022 | 09:47h | UTC
Commentary on Twitter
Pleased to share our study showing that there is no evidence of an increased risk of death in young people after COVID-19 vaccination in England
Great collaboration with @kamleshkhunti @amibanerjee1 and others not on twitter!https://t.co/EV4xmDWeyB pic.twitter.com/VQy2PtCxeC
— Vahé Nafilyan (@Vnafilyan) March 24, 2022
[Preprint] RCT: Vitamin D supplements did not prevent Covid-19 or other acute respiratory infections.
25 Mar, 2022 | 09:49h | UTCRelated:
RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19
Commentary on Twitter (thread – click for more)
https://twitter.com/KarlPfleger/status/1506871284214337543
Did the COVID lockdowns work? Here’s what we know two years on.
25 Mar, 2022 | 09:44h | UTCDid the COVID lockdowns work? Here’s what we know two years on – The Conversation
Related:
RCT: Among premature infants with a gestational age of less than 30 weeks and intubated for at least 7 days at 14 to 28 days, hydrocortisone did not improve survival without bronchopulmonary dysplasia.
24 Mar, 2022 | 09:58h | UTCHydrocortisone to Improve Survival without Bronchopulmonary Dysplasia – New England Journal of Medicine (link to abstract – $ for full-text)
See also: Visual Abstract
Related:
State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.
ERS Guideline on Long-term Management of Children with Bronchopulmonary Dysplasia
Commentary on Twitter
In this trial involving preterm infants, there was little difference in survival without bronchopulmonary dysplasia or in the occurrence of neurodevelopmental impairment with hydrocortisone as compared with placebo. https://t.co/wzGQ1gohjA pic.twitter.com/yfrIaG3JLv
— NEJM (@NEJM) March 23, 2022