Editor's Choice
RCT: Guided, internet based, cognitive behavioral therapy noninferior to individual face-to-face CBT for patients with post-traumatic stress disorder.
21 Jun, 2022 | 11:06h | UTC
Cohort Study: Cardiometabolic multimorbidity, genetic risk, and dementia.
21 Jun, 2022 | 11:01h | UTCNews Release: Multiple heart-related conditions linked to triple dementia risk regardless of genetics – University of Oxford
Related:
Genetic Risk, Midlife Life’s Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study – Neurology (link to abstract – $ for full-text) AND Commentary: Seven healthy habits linked to lower risk of dementia in those with genetic risk – American Academy of Neurology
Preventing dementia: what’s the evidence? – Evidently Cochrane
How common is long COVID? Why studies give different answers.
21 Jun, 2022 | 11:03h | UTCHow common is long COVID? Why studies give different answers – Nature
Cohort Study: Association of cardiovascular risk trajectory with cognitive decline and incident dementia.
21 Jun, 2022 | 10:58h | UTCCommentary: Heart Risk Factors Can Be Recipe for Dementia – HealthDay
Related:
Genetic Risk, Midlife Life’s Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study – Neurology (link to abstract – $ for full-text) AND Commentary: Seven healthy habits linked to lower risk of dementia in those with genetic risk – American Academy of Neurology
Preventing dementia: what’s the evidence? – Evidently Cochrane
Commentary on Twitter
Study findings show that the longitudinal, cumulative trajectory of #cardiovascular risk is predictive of #dementia risk and associated with the emergence of memory decline. Read the article: https://t.co/CT1NQ63sXO #NeuroTwitter pic.twitter.com/KMGAPLQFe7
— Neurology Journal (@GreenJournal) May 17, 2022
Cohort Study: Cardiometabolic multimorbidity linked to accelerated cognitive decline and dementia progression.
21 Jun, 2022 | 10:59h | UTCNews Release: Diabetes and cardiovascular disease increase dementia risk – Karolinska Institutet
Related:
Genetic Risk, Midlife Life’s Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study – Neurology (link to abstract – $ for full-text) AND Commentary: Seven healthy habits linked to lower risk of dementia in those with genetic risk – American Academy of Neurology
Preventing dementia: what’s the evidence? – Evidently Cochrane
WHO Situation Update: Multi-country monkeypox outbreak.
20 Jun, 2022 | 10:45h | UTCMulti-country monkeypox outbreak: situation update – World Health Organization
Related:
Monkeypox Genital Lesions – New England Journal of Medicine
Monkeypox vaccination begins — can the global outbreaks be contained? – Nature
Incubation period for monkeypox: Estimates from the Netherlands.
‘Discriminatory and stigmatizing’: Scientists push to rename monkeypox viruses – STAT
Rename monkeypox strains to remove geographic stigma, researchers say – Science
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
WHO report highlights urgent need to transform mental health and mental health care.
20 Jun, 2022 | 10:47h | UTCNews Release: WHO highlights urgent need to transform mental health and mental health care – World Health Organization
Report: World mental health report: Transforming mental health for all – World Health Organization
Commentary: Urgent Need to Transform Mental Health Care – WHO Says In Largest Review Ever – Health Policy Watch
Commentary on Twitter (thread – click for more)
WHO calls on all stakeholders to work together to deepen the value and commitment given to #MentalHealth, reshape the environments that influence mental health and strengthen the systems that care for people’s mental health: WHO #WorldMentalHealthReport https://t.co/J856BrylBB
— World Health Organization (WHO) (@WHO) June 17, 2022
RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.
20 Jun, 2022 | 10:51h | UTCRestriction of Intravenous Fluid in ICU Patients with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock – HealthDay
Related:
Fluid administration and monitoring in ARDS: which management? – Intensive Care Medicine
Commentary on Twitter
In this trial, a restrictive approach to intravenous fluid administration in critically ill patients with septic shock did not reduce mortality. #CCR22 https://t.co/UfY1936Qwb pic.twitter.com/FtSaDIIroj
— NEJM (@NEJM) June 17, 2022
WHO Interim statement on decision-making considerations for the use of variant updated COVID-19 vaccines.
20 Jun, 2022 | 10:42h | UTCSee also: Interim statement on the composition of current COVID-19 vaccines – World Health Organization
Commentary on Twitter (thread – click for more)
Current #COVID19 vaccines provide high levels of protection against severe disease and death from all variants. They should continue to be used.
🆕 interim statement:https://t.co/bVzzx1HnG2 pic.twitter.com/CJlAJqFr3C
— World Health Organization (WHO) (@WHO) June 17, 2022
Opinion | Normalizing menopause – “Martha Hickey and colleagues argue that social and cultural attitudes contribute to the varied experience of menopause and that medicalization fuels negative perceptions”.
20 Jun, 2022 | 10:38h | UTCNormalizing menopause – The BMJ (free for a limited period)
News Release: Medicalizing menopause may be unhelpful for some women – British Medical Journal
Commentary: Menopause is not a disease. Experts call for new narrative for this natural stage of a woman’s life – CNN
Cohort Study: Association of gamma-glutamyltransferase levels with total mortality, liver-related and cardiovascular outcomes.
20 Jun, 2022 | 10:36h | UTC
Commentary on Twitter
Still remember working on this in 2019 but it's out today!
Gamma-GT level has a strong association with mortality outcomes and could add to the prediction of CV mortality
https://t.co/0lzqGfgiGc pic.twitter.com/C8tSZLWlI2— Fred Ho (@fredho42) May 13, 2022
Under a CC BY-NC-ND 4.0 license
Consensus Study: A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research.
20 Jun, 2022 | 10:31h | UTCNews Release: Key outcomes of Long COVID identified in international consensus study – King’s College London
Invited Commentary: Post-COVID-19 condition in children: a COS is urgently needed – The Lancet Respiratory Medicine
Commentary on Twitter
NEW POSITION PAPER—A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research
From Daniel Munblit & co https://t.co/zAxQ1ww6bT pic.twitter.com/WIitohP3Xo
— The Lancet Respiratory Medicine (@LancetRespirMed) June 15, 2022
Clues to long Covid: Scientists strive to unravel what is driving disabling symptoms.
20 Jun, 2022 | 10:30h | UTC
Case-control study: Risk of long COVID associated with delta vs. omicron variants of SARS-CoV-2.
20 Jun, 2022 | 10:34h | UTCRisk of long COVID associated with delta versus omicron variants of SARS-CoV-2 – The Lancet
News Release: Long COVID risk less during Omicron compared to Delta, study finds – King’s College London
Commentaries:
Omicron less likely to lead to long COVID, study finds – CIDRAP
Covid-19: Long covid risk is lower with omicron than delta, researchers find – The BMJ
Commentary on Twitter
Substantial (~50-75%) reduction of #LongCovid with Omicron compared with Delta variant, magnitude influenced by age and time since vaccination @TheLancet https://t.co/shAzJn8WSj pic.twitter.com/bXoct0sXd1
— Eric Topol (@EricTopol) June 17, 2022
[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.
20 Jun, 2022 | 10:28h | UTCRelated:
WHO recommends two new drugs to treat COVID-19 – World Health Organization
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary on Twitter
Preprint⚡⚡
Baricitinib Vs Tocilizumab open label RCT
Baricitinib was non-inferior to tocilizumab with regards to the composite outcome of mechanical ventilation or death by day 28 and the time to discharge by day 28 in patients with severe #COVID19 https://t.co/sQkhATkjEd— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 16, 2022
RCT: Routine use of intraoperative urinary catheters does not reduce the risk of postoperative urinary retention after laparoscopic inguinal hernia repair.
17 Jun, 2022 | 11:47h | UTCEffect of Intraoperative Urinary Catheter Use on Postoperative Urinary Retention After Laparoscopic Inguinal Hernia Repair: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentaries: Urinary Catheters for Inguinal Hernia Repair—The Challenges of Deimplementation of Routine Procedures – JAMA Surgery (free for a limited period)
Intraoperative Catheter Disappoints for Urinary Retention After Hernia Repair – MedPage Today (free registration required)
Author interview: Intraoperative Urinary Catheter Use and Urinary Retention After Laparoscopic Inguinal Hernia Repair – JAMA
Commentary on Twitter
In this study, intraoperative urinary catheters did not reduce the risk of postoperative urinary retention after laparoscopic inguinal hernia repair. https://t.co/6M06HxR51f
— JAMA Surgery (@JAMASurgery) June 15, 2022
AHA Scientific Statement: Revascularization for renovascular disease.
17 Jun, 2022 | 11:50h | UTCTop Things to Know: Revascularization for Renovascular Disease – American Heart Association
Commentary: When is Renovascular Hypertension Amenable to Revascularization – American Heart Association
FDA advisers OK COVID-19 vaccines for youngest kids.
17 Jun, 2022 | 11:43h | UTCFDA advisers OK COVID-19 vaccines for youngest kids – CIDRAP
See also: FDA advisers endorse 1st COVID-19 shots for kids under 5 – Associated Press
Test-negative, case–control study: Effects of previous infection and vaccination on symptomatic omicron infections.
17 Jun, 2022 | 11:44h | UTCRelated:
Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2 – New England Journal of Medicine
Two new studies show vaccination provides additional protection after Covid-19 infection.
Commentary on Twitter
A study in Qatar assessed the effectiveness of previous infection, vaccination, and both against symptomatic SARS-CoV-2 caused by omicron BA.1 and BA.2 and against severe, critical, or fatal #COVID19. https://t.co/bEVD3Y1sUn pic.twitter.com/Y38a0xxead
— NEJM (@NEJM) June 15, 2022
Incubation period for monkeypox: Estimates from the Netherlands.
17 Jun, 2022 | 11:41h | UTCNews Release: Incubation period for monkeypox: Estimates from the Netherlands – European Centre for Disease Prevention and Control (ECDC)
Original Study: Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022 – Eurosurveillance
Commentary on Twitter (thread – click for more)
Our early investigation from @rivm on the incubation period for #monkeypox is now available @Eurosurveillanc.https://t.co/Vr9AChIAOV
Main finding: the mean incubation period was 8.5 days (5th to 95th percentiles: 4.2 to 17.3 days).
Details, caveats, and a few thoughts ⬇️🧵1/
— Fumi Miura (@FuminariMiura) June 16, 2022
NICE Guideline: Reducing sexually transmitted infections.
16 Jun, 2022 | 11:15h | UTCReducing sexually transmitted infections – National Institute for Health and Care Excellence
#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.
16 Jun, 2022 | 11:10h | UTCEffect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among acutely ill children clinically assessed to require noninvasive respiratory support in a pediatric critical care unit, HFNC met the criterion for noninferiority compared with CPAP for time to liberation from respiratory support. https://t.co/WvU2fKLDOJ #CCR22
— JAMA (@JAMA_current) June 16, 2022
#CCR22 – RCT: Intravenous Vitamin C increases the risk of death or persistent organ dysfunction in adults with sepsis in the intensive care unit.
16 Jun, 2022 | 11:13h | UTCRelated:
Commentary on Twitter
https://twitter.com/NEJM/status/1536991910006468608
#CCR22 – RCT: Among critically ill patients undergoing tracheal intubation, administering a 500 ml fluid bolus did not decrease the incidence of severely low blood pressure, cardiac arrest, or death.
16 Jun, 2022 | 11:08h | UTCEffect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, among critically ill adults undergoing tracheal intubation, administration of a fluid bolus did not significantly decrease the incidence of cardiovascular collapse. https://t.co/vPkfgLBF1n #CCR22
— JAMA (@JAMA_current) June 16, 2022
Perspective | Viruses that were on hiatus during Covid are back — and behaving in unexpected ways.
16 Jun, 2022 | 11:06h | UTCViruses that were on hiatus during Covid are back — and behaving in unexpected ways – STAT