Editor's Choice
Perspective | Pragmatism in clinical trials: essential, not optional.
15 Aug, 2022 | 12:15h | UTCPragmatism in clinical trials: essential, not optional – European Journal of Cardiology (free for a limited period)
Commentary on Twitter
A call for pragmatism in the design and running of clinical trials:https://t.co/bXQ4Wp0x1i#EHJ@escardio pic.twitter.com/ES1X12zTGv
— EHJ Editor-in-Chief (@ehj_ed) August 11, 2022
Harmonization of American and European hypertension guidelines: comparisons, reflections, and recommendations.
12 Aug, 2022 | 15:19h | UTCHarmonization of the American College of Cardiology/American Heart Association and European Society of Cardiology/European Society of Hypertension Blood Pressure/Hypertension Guidelines: Comparisons, Reflections, and Recommendations – European Heart Journal (also available at Circulation)
Supplement | Evidence for global health care interventions for preterm or low birth weight infants.
12 Aug, 2022 | 15:16h | UTCHomepage: Evidence for Global Health Care Interventions for Preterm or Low Birth Weight Infants – Pediatrics
Early Enteral Feeding for Preterm or Low Birth Weight Infants: a Systematic Review and Meta-analysis
Responsive Feeding for Preterm or Low Birth Weight Infants: A Systematic Review and Meta-analysis
Review | The COVID-19 pandemic and its consequences for chronic pain.
12 Aug, 2022 | 15:02h | UTCThe COVID-19 pandemic and its consequences for chronic pain: a narrative review – Anaesthesia
Commentary on Twitter
🔐Time to pay attention to the consequences of persistent pain in patients after any severity of COVID-19, with increased risk of post-intensive care syndrome in patients requiring ICU care?@harshamd5 @ANels_MD @NarouzeMD #FreeForAWeek
🔗https://t.co/NaafjxCbXz pic.twitter.com/Zj2OGIPniP
— 𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 (@Anaes_Journal) August 1, 2022
Review | Cardiovascular complications of pregnancy-associated COVID-19 infections.
12 Aug, 2022 | 15:14h | UTCCommentaries:
Cardiovascular Complications of COVID-19 in Pregnancy Reviewed – HealthDay
Mendelian randomization study of PCSK9 and HMG-CoA reductase inhibition and cognitive function.
12 Aug, 2022 | 15:11h | UTCCommentaries:
Genetic Study Hints at Cognitive Impact of Statins, but Experts Urge Caution – TCTMD
Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019.
12 Aug, 2022 | 14:58h | UTCInvited Commentary: Trends in the global burden of lower respiratory infections: the knowns and the unknowns – The Lancet Infectious Diseases
Commentary on Twitter (thread – click for more)
New Research: Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 https://t.co/rhV7lRaZvc (1/2) pic.twitter.com/I0INjaMh4I
— The Lancet Infectious Diseases (@TheLancetInfDis) August 12, 2022
Perspective | How to disseminate clinical research.
12 Aug, 2022 | 15:06h | UTCHow to disseminate clinical research – Anaesthesia
Commentary on Twitter
🔐How to disseminate clinical research.
"Traditionally, dissemination of scientific research ends at publication in a peer-reviewed journal. However, most clinicians and patients to whom the work is relevant will never read it."@GongGasGirl
🔗https://t.co/jQnfFSSt6m pic.twitter.com/IyeYWUCCiW
— 𝘈𝘯𝘢𝘦𝘴𝘵𝘩𝘦𝘴𝘪𝘢 (@Anaes_Journal) July 8, 2022
RCT | Removal of small, asymptomatic kidney stones and incidence of relapse.
11 Aug, 2022 | 12:23h | UTCRemoval of Small, Asymptomatic Kidney Stones and Incidence of Relapse – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Removal of small, asymptomatic kidney stones during surgery to remove ureteral or contralateral stones resulted in less relapse than nonremoval and in similar numbers of subsequent emergency department visits. https://t.co/MRgFUnF1C0 pic.twitter.com/19ahPuHyNS
— NEJM (@NEJM) August 10, 2022
Review | How can assessing hemodynamics help to assess volume status?
11 Aug, 2022 | 12:21h | UTCHow can assessing hemodynamics help to assess volume status? – Intensive Care Medicine (free for a limited period)
Review | Machines that save lives in the intensive care unit: the ultrasonography machine.
11 Aug, 2022 | 12:20h | UTCMachines that save lives in the intensive care unit: the ultrasonography machine – Intensive Care Medicine (if the link is paywalled, try this one in PMC)
Commentary on Twitter
Ultrasonography saves lives in #ICU!!
🖥 CCUS in constraints: utility in limited resource environment
🖥 machine design for under‐resourced vs well‐resourced ICU
🖥 training challenges
🖥 evidence: does CCUS really save lives?#POCUS #FOAMcc #FOAMus
🖇 https://t.co/Ht5tCPEyny pic.twitter.com/QacQcYYV4X— Intensive Care Medicine (@yourICM) August 9, 2022
RCT | In older patients undergoing total intravenous anesthesia, Etomidate is noninferior to Propofol regarding the risk of major postoperative complications.
11 Aug, 2022 | 12:18h | UTC
Commentary on Twitter
General anesthesia with etomidate does not increase postoperative morbidity, as indicated by the rate of major in-hospital post-op complications, in elderly patients undergoing abdominal surgery, as compared with propofol. https://t.co/vjPvle3DQj pic.twitter.com/2k6eSLupbH
— JAMA Surgery (@JAMASurgery) August 10, 2022
RCT | Tobramycin inhalation solution is effective in adults with bronchiectasis with pseudomonas aeruginosa infection.
11 Aug, 2022 | 12:15h | UTCCommentary: Tobramycin Tames Infection in Bronchiectasis – Medscape (free registration required)
Trauma care in older people: charting a path from outlier to excellence.
11 Aug, 2022 | 12:16h | UTCTrauma care in older people: charting a path from outlier to excellence – Age and Ageing
Cohort Study | Risk of hip fracture in meat-eaters, pescatarians, and vegetarians.
11 Aug, 2022 | 12:11h | UTCNews Release: Vegetarian women are at a higher risk of hip fracture – University of Leeds
Systematic Review | Replacing salt with low‐sodium salt substitutes for cardiovascular health in adults, children and pregnant women.
10 Aug, 2022 | 15:38h | UTCRelated:
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
M-A | Effects of salt substitutes on clinical outcomes.
10 Aug, 2022 | 15:40h | UTCEffects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart
Commentary: Swapping salt for substitutes reduces risk of stroke and heart conditions – study – The Guardian
Related:
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Commentary from the author on Twitter
Our latest meta-analysis shows consistent effects of salt substitutes on BP across diverse geographies and populations. Protective effects on clinical outcomes are likely to be generalizable to countries worldwide. https://t.co/C273yK6Bek
— Xuejun Yin (@XuejunYin) August 10, 2022
RCT | Among patients with symptomatic intracranial stenosis, the addition of stenting to medical therapy is not better at reducing the risk of stroke or death compared to medical therapy alone.
10 Aug, 2022 | 15:36h | UTCEditorial: Therapeutic Strategies for Intracranial Atherosclerosis – JAMA (free for a limited period)
Commentary: Stenting Hits Another Wall in Intracranial Stenosis Stroke – MedPage Today (free registration required)
Commentary on Twitter
Findings of this #RandomizedClinicalTrial do not support the addition of percutaneous transluminal angioplasty and stenting to medical therapy for the treatment of patients with symptomatic severe intracranial atherosclerotic stenosis. https://t.co/X9qi3WQ0JC pic.twitter.com/rH6aDo4GjV
— JAMA (@JAMA_current) August 9, 2022
RCT | In patients with large vessel occlusion stroke, intravenous Tirofiban before endovascular thrombectomy does not improve functional outcomes.
10 Aug, 2022 | 15:34h | UTCEffect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: RESCUE BT: IV Tirofiban No Help During Stroke Thrombectomy – TCTMD
M-A | Association of dual antiplatelet therapy with ticagrelor with vein graft failure after coronary artery bypass graft surgery.
10 Aug, 2022 | 15:32h | UTCAssociation of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Editorial: Balancing the Risks and Benefits of Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery – JAMA (free for a limited period)
Author Interview: Coronary Artery Bypass Surgery in 2022 – JAMA
News Release: Two-medication strategy offers both benefit and risk after coronary artery bypass surgery – Weill Cornell Medicine
Viewpoint | Making electronic health records both SAFER and SMARTER.
10 Aug, 2022 | 15:28h | UTCMaking Electronic Health Records Both SAFER and SMARTER – JAMA (free for a limited period)
Author Interview: Making Electronic Health Records More Supportive for Clinicians – JAMA
Commentary: Opinion: physicians need to use smarter, safer EHRS – healthleaders
Related:
The EMR has changed the doctor-patient duet into a ménage-à-trois – STAT
The future of electronic health records – Nature
Cohort Study | Association of younger vs. older ages with changes in incidence of stroke and other vascular events, 2002-2018.
10 Aug, 2022 | 15:30h | UTCAssociation of Younger vs Older Ages With Changes in Incidence of Stroke and Other Vascular Events, 2002-2018 – JAMA (free for a limited period)
See also: Diverging Temporal Trends in Stroke Incidence in Younger vs Older People: A Systematic Review and Meta-analysis – JAMA Neurology (free for a limited period)
Commentaries on Twitter
Data from Oxford area in @JAMA_current show worrisome incr. in stroke rate in adults <55 yrs comparing two time periods. 67% incr seen in younger adults, 15% decr in older adults. Need further study of why young stroke rates are on the rise#MYStrokeCenterhttps://t.co/MG4MgUGAA4
— Seemant Chaturvedi (@ChaturvediNeuro) August 9, 2022
The consistently divergent temporal trend in stroke incidence at younger vs older ages highlights the urgent need to better understand etiology and prevention of stroke at younger ages. https://t.co/phhRcpWwRw
— JAMA Neurology (@JAMANeuro) August 9, 2022
RCT | Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity.
9 Aug, 2022 | 12:59h | UTCAuthor Interview: Effectiveness of Early Time-Restricted Eating for Weight Loss and Fat Loss in Adults With Obesity – JAMA
Commentaries:
Time-Restricted Eating to Improve Health—A Promising Idea in Need of Stronger Clinical Trial Evidence – JAMA Internal Medicine (free for a limited period)
Related:
Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition
Calorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine (link to abstract – $ for full-text)
AAP Guideline Update | Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation.
9 Aug, 2022 | 13:00h | UTC
RCT | Hughes abdominal closure vs. standard mass closure to reduce incisional hernias following surgery for colorectal cancer.
9 Aug, 2022 | 12:56h | UTC