RCT | Among patients with symptomatic intracranial stenosis, the addition of stenting to medical therapy is not better at reducing the risk of stroke or death compared to medical therapy alone.

Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial – JAMA

Editorial: Therapeutic Strategies for Intracranial Atherosclerosis – JAMA (free for a limited period)

Commentary: Stenting Hits Another Wall in Intracranial Stenosis Stroke – MedPage Today (free registration required)

Commentary on Twitter

Findings of this #RandomizedClinicalTrial do not support the addition of percutaneous transluminal angioplasty and stenting to medical therapy for the treatment of patients with symptomatic severe intracranial atherosclerotic stenosis. https://t.co/X9qi3WQ0JC pic.twitter.com/rH6aDo4GjV

— JAMA (@JAMA_current) August 9, 2022