Editor's Choice
Research shows ad libitum meal energy intake is influenced by energy density, eating rate and hyper-palatable foods
8 Feb, 2023 | 12:36h | UTCAd libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns – Nature Food (free for a limited period)
News Release: Research shows impact of ‘hyper-palatable’ foods across four diets – University of Kansas
Commentary from one of the authors on Twitter (thread – click for more)
What determines how many calories people eat during a meal? Our new study, led by Tera Fazzino @UnivOfKansas, was just published in @NatureFoodJnl & investigated the meal characteristics that influence ad libitum energy intake. https://t.co/Of2IzddLRd
— Kevin Hall (@KevinH_PhD) January 30, 2023
RCT | Outcomes in children of women with type 2 diabetes exposed to metformin vs. placebo during pregnancy
8 Feb, 2023 | 12:32h | UTCOutcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Crossover RCT | Effects of SGLT2 inhibition on sodium in patients with chronic syndrome of inappropriate antidiuresis
8 Feb, 2023 | 12:34h | UTC
Commentary on Twitter
The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. This study shows the SGLT2 inhibitor empagliflozin is a promising new treatment for chronic SIAD-induced hyponatremia, possibly improving neurocognitive function https://t.co/U26RNmVM9j pic.twitter.com/8pH6xqSs7D
— JASN_News (@JASN_News) December 12, 2022
Guideline | Assessment and management of complex fractures
7 Feb, 2023 | 14:19h | UTCFractures (complex): assessment and management – National Institute for Health and Care Excellence
Guideline | Delirium: prevention, diagnosis and management in hospital and long-term care
7 Feb, 2023 | 14:21h | UTC
SR | Calcium and vitamin D supplements do not increase bone mineral density or prevent fractures in premenopausal women
7 Feb, 2023 | 14:18h | UTCCalcium and vitamin D for increasing bone mineral density in premenopausal women – Cochrane Library
Summary: Calcium and vitamin D for improving bone health in healthy premenopausal women – Cochrane Library
SR | The current evidence does not support a role for Vitamin D in the management of asthma
7 Feb, 2023 | 14:16h | UTCVitamin D for the management of asthma – Cochrane Library
Commentary: Vitamin D for asthma: new evidence, new message – Evidently Cochrane
Review | Diagnosis and management of autoimmune hepatitis
7 Feb, 2023 | 14:14h | UTCDiagnosis and management of autoimmune hepatitis – The BMJ
Evaluation of a 12-gene pharmacogenetic panel to prevent adverse drug reactions
7 Feb, 2023 | 14:13h | UTCA 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study – The Lancet (link to abstract – $ for full-text)
News Releases:
Matching medication to DNA leads to 30% fewer side effects – University of Liverpool
Genetic analysis can reduce adverse drug reactions by 30 per cent – Karolinska Institutet
Commentary from one of the authors on Twitter
A journey which started in 2016 has led to the publication of the #PREPARE study in @TheLancet today. In this #randomised study, we show that a 12-gene panel can reduce #adverse_effects by 30%. https://t.co/vj7gYzgxyf @CDSS_Liverpool @pandtuol pic.twitter.com/tjgFWDuTQf
— Munir Pirmohamed (@MPUoL) February 3, 2023
Opinion | Let’s do the Cochrane review of physical measures to reduce the spread of viruses
7 Feb, 2023 | 14:11h | UTCOriginal Study: SR | Physical interventions to interrupt or reduce the spread of respiratory viruses
Related: Hospital masking should be optional – Sensible Medicine
RCT | Medial retropharyngeal nodal region sparing radiotherapy vs. standard radiotherapy in patients with nasopharyngeal carcinoma
7 Feb, 2023 | 14:09h | UTC
RCT | Paxlovid did not improve outcomes in hospitalized patients with Covid-19
7 Feb, 2023 | 14:08h | UTC
M-A | Heparin full-dose anticoagulation is beneficial for non-critically ill COVID-19 patients
7 Feb, 2023 | 14:06h | UTCRelated:
Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library
Updating international consensus on best practice in care of the dying: a Delphi study
6 Feb, 2023 | 13:41h | UTC
ACG Guideline | Management of patients with acute lower gastrointestinal bleeding
6 Feb, 2023 | 13:43h | UTCManagement of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline
Related:
Update guidelines for women with HIV who are virally suppressed incorporate breastfeeding their infants as a viable option
6 Feb, 2023 | 13:40h | UTC
Commentary on Twitter
Updated guidelines now incorporate breastfeeding options for PWH with suppressed VL on ART. https://t.co/JPR1K8zzv6
— Carlos del Rio (@CarlosdelRio7) February 3, 2023
Phase 2 RCT | Baxdrostat for treatment-resistant hypertension
6 Feb, 2023 | 13:38h | UTCPhase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
Aldosterone has long been a pharmacologic target for the treatment of hypertension. However, a new small-molecule drug called baxdrostat inhibits aldosterone synthase in patients with treatment-resistant hypertension. 1/14 pic.twitter.com/F27WE4Wa1d
— NEJM (@NEJM) February 3, 2023
Opinion | Hospital masking should be optional
6 Feb, 2023 | 13:37h | UTCHospital masking should be optional – Sensible Medicine
Related: SR | Physical interventions to interrupt or reduce the spread of respiratory viruses
RCT | Personalized accelerated pacing may improve QOL in patients with heart failure with preserved EF
6 Feb, 2023 | 13:35h | UTCEffect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrillation in Patients With Preclinical and Overt Heart Failure With Preserved Ejection Fraction: The myPACE Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
News Release: Speeding up heart rate helps heart failure patients with stiff hearts – University of Minnesota Medical School
Commentary on Twitter
In study of patients with HFpEF and pacemakers, moderately accelerated pacing (median pacing rate 75bpm) improved health-related QOL, natriuretic peptide levels, activity levels, and Afib compared w/ standard 60 bpm setting. https://t.co/Ow3W3qD6DM @maggieinfeld @markusmeyermd
— JAMA Cardiology (@JAMACardio) February 1, 2023
Case-control study | Estimation of vaccine effectiveness of CoronaVac and BNT162b2 in patients with SARS-CoV-2 Omicron
6 Feb, 2023 | 13:32h | UTC
Commentary on Twitter
The CoronaVac and BNT162b2 (Pfizer) vaccines were effective against severe outcomes due to Omicron (74-77%), but protection among older individuals in Hong Kong was more likely to wane 6 months after the second dose; boosters can bring effectiveness >90%. https://t.co/kqgwryJ1kT
— JAMA Network Open (@JAMANetworkOpen) February 3, 2023
ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)
6 Feb, 2023 | 13:31h | UTCChatGPT and the Future of Medical Writing – Radiology
Editorials:
ChatGPT Is Shaping the Future of Medical Writing but Still Requires Human Judgment – Radiology
ChatGPT and Other Large Language Models Are Double-edged Swords – Radiology
Commentaries:
AI program ChatGPT now has a published article in Radiology—is it any good? – Health Imaging
Peer-Reviewed Journal Publishes Paper Written Almost Entirely by ChatGPT— It required close editing, human co-author said – MedPage Today (free registration required)
Related:
ChatGPT: five priorities for research – Nature
The path forward for ChatGPT in academia – Lumo’s Newsletter
ChatGPT is fun, but not an author – Science
Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature
ChatGPT listed as author on research papers: many scientists disapprove – Nature
Abstracts written by ChatGPT fool scientists
ChatGPT: five priorities for research
6 Feb, 2023 | 13:30h | UTCChatGPT: five priorities for research – Nature
Related:
ChatGPT and the Future of Medical Writing – Radiology
The path forward for ChatGPT in academia – Lumo’s Newsletter
ChatGPT is fun, but not an author – Science
Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature
ChatGPT listed as author on research papers: many scientists disapprove – Nature
Abstracts written by ChatGPT fool scientists
RCT | Machine perfusion is superior to therapeutic hypothermia for reducing delayed graft function after kidney transplantation
6 Feb, 2023 | 13:28h | UTCHypothermia or Machine Perfusion in Kidney Donors – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Machine Perfusion of Kidneys Protects Against Delayed Graft Function – HealthDay
Commentary with video on Twitter
Hypothermia of brain-dead kidney donors and machine perfusion of the kidney can reduce delayed graft function, but whether hypothermia is as effective as machine perfusion is unclear. New research findings are summarized in a short video. https://t.co/mL0YQZYoK1 pic.twitter.com/ANnJl27mkl
— NEJM (@NEJM) February 4, 2023
APA Guideline for the treatment of patients with eating disorders
3 Feb, 2023 | 14:26h | UTCNews Release: APA Releases Updated Guideline for Treating Eating Disorders – American Psychiatric Association
Cohort Study | Predictors of acute coronary occlusion in patients with out-of-hospital cardiac arrest without ST-segment elevation
3 Feb, 2023 | 14:20h | UTCAcute Coronary Occlusion in Patients With Non-ST-Segment Elevation Out-of-Hospital Cardiac Arrest – Journal of the American College of Cardiology (link to abstract – $ for full-text)
JACC Podcast: Acute Coronary Occlusion in Patients with Non-ST-segment Elevation Out-of-hospital Cardiac Arrest
Commentary: Coronary Occlusion in Patients With Non-ST Elevation Cardiac Arrest – American College of Cardiology
Related:
Emergency vs Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac Arrest: Results of the Randomized, Multicentric EMERGE Trial – JAMA Cardiology (link to abstract – $ for full-text)