Editor's Choice
Screening colonoscopy in seniors: common in patients with limited life expectancy and associated with higher complication risks
11 Apr, 2023 | 14:30h | UTCFrequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years – JAMA Internal Medicine (link to abstract – $ for full-text)
Related: Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
Commentary:
In older adults >75 years of age, most screening colonoscopies were in patients in patients with limited life expectancy (defined as <10 years) and associated with increased risk of adverse events. https://t.co/XOsy2UKNRx @Jessica_Halabi @MRothbergMD @burkegastrodoc
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2023
WHO Report | Dengue & Chikungunya cases spreading beyond known transmission zones in the Americas
10 Apr, 2023 | 14:04h | UTCCommentary: WHO: Concerning Spread of Dengue, Chikungunya in Latin America – JAMA
M-A | Benefits and harms of drug treatment for type 2 diabetes
10 Apr, 2023 | 14:03h | UTC
Umbrella review unveils benefits of cutting free sugars to 6 teaspoons/day
10 Apr, 2023 | 14:00h | UTCDietary sugar consumption and health: umbrella review – The BMJ
News Release: Limit added sugar to six teaspoons a day to improve health, urge experts – BMJ Newsroom
Brief Review | Ten tips on fever in the ICU
10 Apr, 2023 | 14:02h | UTCTen tips on fever – Intensive Care Medicine
Cohort Study | Antiphospholipid antibodies’ prevalence & link to cardiovascular events
10 Apr, 2023 | 13:59h | UTCNews Release: Antiphospholipid antibodies may increase heart disease risk in healthy people – Michigan Medicine
RCT | Maternal RSVpreF vaccination protects infants from severe RSV illness
10 Apr, 2023 | 13:56h | UTCBivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Vaccination during pregnancy could prevent RSV illness in infants – Charité – Universitätsmedizin Berlin
Commentary on Twitter
In a phase 3 trial, adults (≥60 years of age) received one 120-μg dose of RSVpreF vaccine or placebo. Vaccine efficacy against RSV-associated lower respiratory tract illness was 67 to 86%. https://t.co/R9u77iWjF9 pic.twitter.com/iPU8VAMQ9M
— NEJM (@NEJM) April 5, 2023
RCT | RSVpreF vaccine successfully prevents RSV-associated respiratory illness in seniors
10 Apr, 2023 | 13:54h | UTCEfficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)
Consensus Paper | Best management of patients with an acute sore throat
6 Apr, 2023 | 13:32h | UTC
Blood pressure targets in adults with hypertension | A clinical practice guideline from the AAFP
6 Apr, 2023 | 13:30h | UTCCommentary: AAFP Issues New Clinical Practice Guideline on Hypertension – Annals of Family Medicine
Consensus Paper | An approach to deprescribe antidepressants for depression in older adults
6 Apr, 2023 | 13:25h | UTCRelated:
Discontinuing antidepressants: Pearls and pitfalls.
A method for tapering antipsychotic treatment that may minimize the risk of relapse
Systematic Review: Managing Antidepressant Discontinuation
Randomized controlled trial: preventive cognitive therapy for prevention of depressive recurrence
Global epidemiology of cirrhosis — Etiology, trends and predictions
6 Apr, 2023 | 13:27h | UTC
Commentary on Twitter
New content online: Global epidemiology of cirrhosis — aetiology, trends and predictions https://t.co/EbgDWTjOyI pic.twitter.com/Cj7KFoWtLi
— Nature Reviews Gastroenterology & Hepatology (@NatRevGastroHep) March 28, 2023
RCT | Routine invasive approach fails to benefit frail older adults with non–ST-segment elevation acute myocardial infarction
6 Apr, 2023 | 13:23h | UTCEffect of Routine Invasive vs Conservative Strategy in Older Adults With Frailty and Non–ST-Segment Elevation Acute Myocardial Infarction: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
A routine invasive strategy did not improve clinical outcomes in frail patients with NSTEMI. Future trials should confirm whether a policy of watchful observation rather than routine invasive management may be effective for these patients. https://t.co/N4hAXg5fid
— JAMA Internal Medicine (@JAMAInternalMed) March 6, 2023
Review | Post-COVID syndrome
6 Apr, 2023 | 13:21h | UTCPost-COVID Syndrome – Deutsches Ärzteblatt International
Related:
Long COVID: major findings, mechanisms and recommendations – Nature Reviews Microbiology
WHO Report | 1 in 6 people globally affected by infertility
5 Apr, 2023 | 13:47h | UTCNews Release: 1 in 6 people globally affected by infertility – World Health Organization
Report: Infertility Prevalence Estimates, 1990–2021 – World Health Organization
Key facts: Infertility – World Health Organization
Commentaries:
Infertility affects a ‘staggering’ 1 in 6 people worldwide, WHO says – CNN
One in six people worldwide affected by infertility, WHO reports – The Guardian
Commentary on Twitter (thread – click for more)
Around 1 in 6 people is affected by infertility in their lifetime: 🆕 WHO research.
This shows an urgent need to increase access to affordable, high-quality fertility care https://t.co/od9QQ9Qjvj pic.twitter.com/R8JtezT0kZ
— World Health Organization (WHO) (@WHO) April 4, 2023
RCT | Assessing low-dose ketamine’s antidepressant & antisuicidal effects in patients with treatment-resistant depression
5 Apr, 2023 | 13:44h | UTC
Commentary on Twitter
RCT: ketamine infusion (0.5 mg/kg) is a safe and effective treatment for patients with TRD and prominent suicidal ideation vs. midazolam. Response was noted when the current depressive episode lasted for <24 months and the number of failed AD is ≤4 https://t.co/QKNy8bUKBK pic.twitter.com/GyfQp0pmpO
— P𝘧OL (@psychopharmacol) April 4, 2023
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
5 Apr, 2023 | 13:45h | UTC
Commentary on Twitter
Management of severe community-acquired pneumonia: @EuroRespSoc @ESICM @ESCMID @ALATorax international guidelines
➡️ evidence-based recommendations for diagnosis, empirical treatment, ABTs
➡️ current knowledge gaps
➡️ recommendations for future research
🖇️ https://t.co/qhe1wlgN9t pic.twitter.com/LMNCbauYfs— Intensive Care Medicine (@yourICM) April 4, 2023
Cohort Study | Pregnancy glucose intolerance, even below diabetes criteria, linked to increased risk of type 2 diabetes
5 Apr, 2023 | 13:42h | UTCGlucose intolerance in pregnancy and risk of early-onset type 2 diabetes: a population-based cohort study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Review | Diagnosis and treatment of acute myocarditis
5 Apr, 2023 | 13:40h | UTCDiagnosis and Treatment of Acute Myocarditis: A Review – JAMA (free for a limited period)
RCT | Endovascular treatment vs. no treatment after 6-24h in ischemic stroke patients with collateral flow on CT angiography
5 Apr, 2023 | 13:38h | UTCEndovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
5 Apr, 2023 | 13:36h | UTCCommentary: Take Your Meds – Science
Commentary on Twitter
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems https://t.co/WSyYu24Iw1 – a new review discussing how delivery systems can mitigate impediments to adherence such as frequent dosing, adverse effects and a delayed onset of action pic.twitter.com/xoSJYFo0Qs
— Nature Reviews Drug Discovery (@NatRevDrugDisc) March 28, 2023
RCT | Mindfulness therapy proves more effective and affordable than cognitive behavioral therapy for depression
4 Apr, 2023 | 14:04h | UTCSummary: The LIGHTMind Randomized Clinical Trial studied 410 adults with mild to moderate depression, comparing the clinical effectiveness and cost-effectiveness of practitioner-supported mindfulness-based cognitive therapy self-help (MBCT-SH) to practitioner-supported cognitive behavioral therapy self-help (CBT-SH). The trial provided participants with either an MBCT-SH or CBT-SH workbook and six support sessions with a trained practitioner. Depressive symptom severity was measured using the Patient Health Questionnaire (PHQ-9) score at 16 weeks after randomization.
Results showed that MBCT-SH led to significantly greater reductions in depressive symptoms and was more cost-effective than CBT-SH. The between-group difference was 1.5 PHQ-9 points, and MBCT-SH cost health services £526 ($631) less per participant over a 42-week follow-up period. A substantial portion of this cost difference was due to additional face-to-face individual psychological therapy accessed by CBT-SH participants outside of the study intervention.
The trial concluded that offering practitioner-supported MBCT-SH for mild to moderate depression could improve outcomes and save money compared to CBT-SH. To translate these findings into practice, proper training and supervision for practitioners delivering MBCT-SH are necessary. Future research should focus on corroborating and extending these findings, exploring factors contributing to MBCT-SH’s relative effectiveness, and examining potential barriers and facilitators for successful implementation in routine clinical practice.
Commentary:
Mindfulness better than CBT for treating depression, study finds – The Guardian
Practitioner-Supported Mindfulness-Based Cognitive Therapy Aids Depression – HealthDay
Commentary on Twitter
Practitioner-supported mindfulness-based cognitive therapy self-help for mild-moderate depression is clinically- and cost-effective compared to currently recommended practitioner-support CBT self-help. https://t.co/H23AfwiO7X pic.twitter.com/xTHzYG4oqg
— JAMA Psychiatry (@JAMAPsych) March 22, 2023
What is acute kidney injury? A visual guide
4 Apr, 2023 | 14:02h | UTCWhat is acute kidney injury? A visual guide – Nature
Opinion | AI-generated medical advice—GPT and beyond
4 Apr, 2023 | 14:00h | UTCAI-Generated Medical Advice—GPT and Beyond – JAMA (free for a limited period)
Related:
Chat GPT will change Medicine – Vinay Prasad’s Observations and Thoughts
The use of ChatGPT and other large language models in surgical science – BJS Open
ChatGPT vs. NCI: analyzing the quality of cancer information on myths and misconceptions
Artificial Intelligence in Medicine & ChatGPT: De-Tether the Physician – Journal of Medical Systems (if the link is paywalled, try this one)
Can artificial intelligence help for scientific writing? – Critical Care
Artificial intelligence in academic writing: a paradigm-shifting technological advance
Perspective | ChatGPT-assisted diagnosis: is the future suddenly here?
Perspective | Generating scholarly content with ChatGPT: ethical challenges for medical publishing
ChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine
ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)
ChatGPT: five priorities for research – Nature
The path forward for ChatGPT in academia – Lumo’s Newsletter
ChatGPT is fun, but not an author – Science
Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature
ChatGPT listed as author on research papers: many scientists disapprove – Nature
Abstracts written by ChatGPT fool scientists
RCT | No significant fracture reduction from monthly 60,000 IU vitamin D3 supplementation
4 Apr, 2023 | 13:58h | UTCThe effect of monthly vitamin D supplementation on fractures: a tertiary outcome from the population-based, double-blind, randomised, placebo-controlled D-Health trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Related:
RCT | Supplemental Vitamin D does not reduce incident fractures in midlife and older adults.