Editor's Choice | Page 13 of 113 | Links Medicus Content Curation & Alerts in Medicine

USPSTF | Routine depression screening recommended for adults including pregnant and postpartum women

11 Jul, 2023 | 14:09h | UTC

Screening for Depression and Suicide Risk in Adults: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Depression and Suicide Risk Screening: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Screening for Depression and Suicide Risk in Adults – JAMA

Editorials:

Reframing the Key Questions Regarding Screening for Suicide Risk – JAMA

Suicidality Screening Guidelines Highlight the Need for Intervention Studies – JAMA Network Open

USPSTF Statement | Screening for anxiety is recommended in children and adolescents aged 8 to 18 years.

USPSTF Statement | Screening for depression and suicide risk is recommended in children and adolescents aged 12 to 18 years.

M-A | P2Y12 inhibitors show superior efficacy over aspirin for secondary prevention in CAD

11 Jul, 2023 | 14:06h | UTC

P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)

RCT | Clopidogrel is better than Aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

Meta-analysis of randomized trials: Clopidogrel is better than aspirin for the secondary prevention of cardiovascular events.

#ACC21 – RCT: Clopidogrel better than aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

Commentary on Twitter

Given superior efficacy & similar overall safety, #P2Y12 inhibitor monotherapy might be preferred over #aspirin monotherapy for long-term secondary prevention in pts w/ established #cvCAD. https://t.co/EehIEuWqOt #JACC #P2Y12i #CardioTwitter @FeliceGragnano @vlgmrc @Drroxmehran pic.twitter.com/betLycXGs5

— JACC Journals (@JACCJournals) July 5, 2023

Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk

11 Jul, 2023 | 14:04h | UTC

Menopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ

Editorial: Menopausal hormone therapy and dementia – The BMJ

News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom

Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre

Health advisory on social media use in adolescence

11 Jul, 2023 | 14:03h | UTC

Health advisory on social media use in adolescence – American Psychological Association

News Release: APA panel issues recommendations for adolescent social media use – American Psychological Association

Cohort Study | Fewer than half of new drugs add substantial therapeutic value over existing treatments

11 Jul, 2023 | 14:01h | UTC

News Release: Fewer than half of new drugs add substantial therapeutic value over existing treatments – BMJ Newsroom

Article: Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study – The BMJ

Editorial: Patients need better treatments, not just more of the same – The BMJ

Practice Recommendation | Strategies to prevent MRSA transmission and infection in hospitals

10 Jul, 2023 | 14:02h | UTC

SHEA/IDSA/APIC Practice Recommendation: Strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

News Release: Updated guidance shows how hospitals should protect patients from resistant infections – Society for Healthcare Epidemiology of America

Commentary: New guidelines recommend antibiotic stewardship for preventing MRSA – CIDRAP

Guideline | Acute liver failure

10 Jul, 2023 | 13:59h | UTC

Acute Liver Failure Guidelines – The American Journal of Gastroenterology

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

Acute-on-chronic liver failure: far to go—a review – Critical Care

RCT | Dual antiplatelet therapy proves noninferior to alteplase in minor ischemic stroke

10 Jul, 2023 | 13:58h | UTC

Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: ARAMIS Clinical Trial Demonstrates the Noninferiority of Dual Antiplatelet Therapy Compared with Intravenous Activase in Patients with Minor Nondisabling Acute Ischemic Stroke – Practical Neurology

RCT | No significant difference in weight loss between intermittent fasting and calorie restriction

10 Jul, 2023 | 13:56h | UTC

Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Intermittent fasting and traditional calorie counting shown to be about equal for weight loss – American College of Physicians

Commentary: Intermittent fasting and calorie counting about equal for weight loss – new study – The Conversation

RCT | Time-restricted eating not more effective than daily calorie restriction for managing nonalcoholic fatty liver disease

Health effects of the time-restricted eating in adults with obesity: A systematic review and meta-analysis – Frontiers in Nutrition

Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial – Cell Metabolism

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial – JAMA Internal Medicine

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials – Frontiers in Nutrition

Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition

Calorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine

Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials – JAMA Network Open

Global Burden of Disease Study | Understanding global trends of infectious diseases in younger population, 1990-2019

10 Jul, 2023 | 13:54h | UTC

The unfinished agenda of communicable diseases among children and adolescents before the COVID-19 pandemic, 1990–2019: a systematic analysis of the Global Burden of Disease Study 2019 – The Lancet

News Release: Global efforts to reduce infectious diseases must extend beyond early childhood – Murdoch Children’s Research Institute

Commentary: Global infectious disease burden shifting from younger to older youth – CIDRAP

Consensus Paper | Subcutaneous infusions of hydration and medication in adults

7 Jul, 2023 | 16:27h | UTC

International Consensus Recommendation Guidelines for Subcutaneous Infusions of Hydration and Medication in Adults: An e-Delphi Consensus Study – Journal of Infusion Nursing

RCT | Semont-plus maneuver yields faster recovery than Epley maneuver in posterior canal BPPV

7 Jul, 2023 | 16:26h | UTC

The Semont-Plus Maneuver or the Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo: A Randomized Clinical Study – JAMA Neurology (link to abstract – $ for full-text)

See also: Visual Abstract

Videos:

Demonstration of the Semont-Plus Self-maneuver for Right Posterior Canal Canalithiasis

Semont-Plus Maneuver for Right Posterior Canal Benign Paroxysmal Positional Vertigo

Demonstration of the Epley Self-maneuver for a Right Posterior Canal Canalithiasis

Commentary: Semont-plus Meneuver Offered Faster Recovery for Benign Paroxysmal Positional Vertigo – Neurology Today

RCT | Weekly Tirzepatide outperforms placebo in weight management for type 2 diabetes patients

7 Jul, 2023 | 16:24h | UTC

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Tirzepatide triumphs in significant weight reduction for people with type 2 diabetes – News Medical

Review | Post-COVID Conditions

7 Jul, 2023 | 16:21h | UTC

Post-COVID Conditions – Mayo Clinic Proceedings

Review | Management of premature ventricular complexes in the outpatient setting

7 Jul, 2023 | 16:22h | UTC

Management of Premature Ventricular Complexes in the Outpatient Setting – Mayo Clinic Proceedings

RCT | Personalized eHealth program hastens return to normal activity post major abdominal surgery

7 Jul, 2023 | 16:20h | UTC

Personalised electronic health programme for recovery after major abdominal surgery: a multicentre, single-blind, randomised, placebo-controlled trial – The Lancet Digital Health

Invited Commentary: Individualising the recovery process through eHealth – The Lancet Digital Health

News Release: eHealth app helps patients recover from major abdominal operations 30% faster – Amsterdam University Medical Centers/News Medical

ASA Consensus Guidance | Preoperative management of patients on GLP-1 agonists

5 Jul, 2023 | 01:17h | UTC

American Society of Anesthesiologists Consensus-Based Guidance on Preoperative Management of Patients (Adults and Children) on Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists – American Society of Anesthesiologists

Commentary: Anesthesiologists Say Ozempic, Wegovy Should Be Halted Prior to Surgery – HealthDay

RCT | Opioids not more effective than placebo for acute low back and neck pain

5 Jul, 2023 | 01:15h | UTC

Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

News Releases:

Opioids no more effective than placebo for acute back and neck pain – University of Sidney

Opioid pain relievers do not reduce acute lower back and neck pain, study suggests – The Lancet

Commentary from the authors: Opioids don’t relieve acute low back or neck pain – and can result in worse pain, new study finds – The Conversation

RCT | Transcranial direct current stimulation fails to outperform sham in major depressive disorder treatment

5 Jul, 2023 | 01:12h | UTC

Transcranial direct current stimulation as an additional treatment to selective serotonin reuptake inhibitors in adults with major depressive disorder in Germany (DepressionDC): a triple-blind, randomised, sham-controlled, multicentre trial – The Lancet (link to abstract – $ for full-text)

RCT | No statistically significant impact of vitamin D on major cardiovascular events

5 Jul, 2023 | 01:11h | UTC

Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial – The BMJ

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

RCT | Lower rates of treatment failure with standard-course vs. short-course therapy in pediatric UTIs

5 Jul, 2023 | 01:09h | UTC

Short-Course Therapy for Urinary Tract Infections in Children: The SCOUT Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: Treatment Failure Down With Standard-Course Therapy in Pediatric UTI – HealthDay

2023 ESH Guidelines for the management of arterial hypertension

3 Jul, 2023 | 14:34h | UTC

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH) – Journal of Hypertension

RCT | Weekly insulin Icodec proves effective in glucose control in insulin-naive type 2 diabetes patients

3 Jul, 2023 | 14:32h | UTC

Summary: The ONWARDS 3 randomized clinical trial studied the efficacy of once-weekly insulin icodec in comparison to once-daily insulin degludec for glucose control in insulin-naive type 2 diabetes patients. The double-masked, double-dummy trial was conducted from March 2021 to June 2022 across 92 sites in 11 countries, enrolling 588 adults with type 2 diabetes. The participants were randomly divided into two groups: 294 receiving once-weekly icodec and daily placebo, and 294 receiving daily degludec and weekly placebo.

The primary endpoint was the change in Hemoglobin A1c (HbA1c) from baseline to week 26. Insulin icodec showed a noninferior HbA1c change from the baseline (-1.6 percentage points) compared to insulin degludec (-1.4 percentage points) and demonstrated confirmed statistical superiority. However, the trial showed a higher rate of combined level 2 (clinically significant) or level 3 (severe) hypoglycemic events in the insulin icodec group than in the insulin degludec group, despite the overall low rates in both groups. There was no significant difference in weight changes between the two groups.

The study concluded that once-weekly insulin icodec demonstrated superior HbA1c reduction compared to once-daily degludec after 26 weeks of treatment in insulin-naive type 2 diabetes patients. The convenience of once-weekly administration should be considered against the slightly higher absolute risk of hypoglycemia. The study’s limitations include its short duration (26 weeks) and a lack of data on sustained effects, patient-reported outcomes, and continuous glucose monitoring.

Article: Once-Weekly Insulin Icodec vs Once-Daily Insulin Degludec in Adults With Insulin-Naive Type 2 Diabetes: The ONWARDS 3 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

See also: Visual Abstract

Related Study: Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin – New England Journal of Medicine (link to abstract – $ for full-text)

Open-label RCT | Weekly insulin Icodec proves noninferior to daily Glargine in type 2 diabetes

3 Jul, 2023 | 14:23h | UTC

Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin – New England Journal of Medicine (link to abstract – $ for full-text)

Scoping Review | High correlation of positive outcomes in oncology meta-analyses with industry funding

3 Jul, 2023 | 14:21h | UTC

Scoping Review: High Correlation of Positive Outcomes in Oncology Meta-analyses with Industry Funding – JAMA Network Open

Stay Updated in Your Specialty