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RCT: Aspirin and unfractionated heparin increase the risk of symptomatic intracranial hemorrhage in patients undergoing endovascular treatment for ischemic stroke.

3 Mar, 2022 | 08:53h | UTC

Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

RCT: Nirsevimab for prevention of RSV in healthy late-preterm and term infants.

3 Mar, 2022 | 09:42h | UTC

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants – New England Journal of Medicine

Commentaries:

Nirsevimab Protects Late-Preterm, Term Infants from RSV-Related Lower RTI, Study Finds – AJMC

Nirsevimab Prophylaxis Wards Off RSV Infections in Healthy Infants— Monoclonal antibody showed 74.5% efficacy against RSV infections requiring medical care – MedPage Today (free registration required)

Related: Randomized trial: Single-dose nirsevimab for prevention of RSV in preterm infants

 

National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis.

3 Mar, 2022 | 08:51h | UTC

National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis – The Lancet Global Health

Invited commentary: Child and adolescent deaths: a call for strengthening mortality surveillance systems – The Lancet Global Health

 

Cohort Study: High-sensitivity Troponin I after cardiac surgery and 30-day mortality.

3 Mar, 2022 | 08:54h | UTC

High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Better assessment of risk from heart surgery results in better patient outcomes – McMaster University

NEJM study evaluates levels of HS Troponin after cardiac surgery and risk of death – MedicalResearch

Related: Retrospective cohort: Serial high-sensitivity cardiac troponin I after coronary artery bypass grafting may add prognostic information for post-operative decision-making.

 

Commentary on Twitter

 

[News release – not published yet] Study finds blood pressure cuff size matters, affects blood pressure readings.

3 Mar, 2022 | 08:47h | UTC

Study finds blood pressure cuff size matters, affects blood pressure readings – AHA Newsroom

 

M-A: Use of tocilizumab and sarilumab alone or in combination with corticosteroids for covid-19.

3 Mar, 2022 | 08:49h | UTC

Use of tocilizumab and sarilumab alone or in combination with corticosteroids for covid-19: systematic review and network meta-analysis – BMJ Medicine

Editorial: Treatment of severe covid-19 with interleukin 6 receptor inhibition – BMJ Medicine

Related study (just published): Mortality Rates Among Hospitalized Patients With COVID-19 Infection Treated With Tocilizumab and Corticosteroids: A Bayesian Reanalysis of a Previous Meta-analysis – JAMA Network Open

 

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

3 Mar, 2022 | 08:43h | UTC

Myocarditis Following COVID-19 BNT162b2 Vaccination Among Adolescents in Hong Kong – JAMA Pediatrics

Commentary: Study: Dosing change could reduce COVID-19 vaccine heart side effect in teens – UPI

Related:

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations.

3 Mar, 2022 | 08:46h | UTC

COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations – Nature Reviews Rheumatology

 

Commentary on Twitter

 

RCT: In patients with early-stage lung cancer, video-assisted thoracoscopic lobectomy is associated with better recovery of physical function at 5 weeks.

3 Mar, 2022 | 08:42h | UTC

Video-Assisted Thoracoscopic or Open Lobectomy in Early-Stage Lung Cancer – NEJM Evidence

 

Commentary on Twitter

 

Prescribing Nirmatrelvir–Ritonavir for Covid-19: How to recognize and manage drug–drug interactions.

2 Mar, 2022 | 09:01h | UTC

Prescribing Nirmatrelvir–Ritonavir: How to Recognize and Manage Drug–Drug Interactions – Annals of Internal Medicine

Related:

Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.

Pfizer antiviral pills may be risky with other medications – NBC News

The New COVID-19 Pill, Paxlovid, Interacts with Many Medications: Cardiac Patients Take Note – The Skeptical Cardiologist

 

Cluster RCT: In adults with out-of-hospital cardiac arrest, placement of a supraglottic airway device resulted in similar rates of sustained return of spontaneous circulations compared to endotracheal intubation.

2 Mar, 2022 | 09:07h | UTC

Effect of Placement of a Supraglottic Airway Device vs Endotracheal Intubation on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest in Taipei, Taiwan: A Cluster Randomized Clinical Trial – JAMA Network Open

Commentary: Cardiac Arrest Patients Don’t Necessarily Do Better With Intubation— Debate on prehospital advanced airway management continues – MedPage Today (free registration required)

 

Commentary on Twitter

 

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

2 Mar, 2022 | 09:03h | UTC

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week – Journal of the American College of Cardiology

Commentary: Review of Anticoagulation in Patients With COVID-19: Key Points – American College of Cardiology

 

RCT: Arthroscopic hip surgery compared with personalized hip therapy in people over 16 years old with femoroacetabular impingement syndrome.

2 Mar, 2022 | 09:04h | UTC

Abstract: Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT – Health Technology Assessment

Download Full Report

Related: Randomized Trial: Arthroscopic Hip Surgery vs. Physiotherapy and Activity Modification for the Treatment of Femoroacetabular Impingement

 

Wuhan market was epicenter of pandemic’s start, studies suggest.

2 Mar, 2022 | 08:59h | UTC

Wuhan market was epicentre of pandemic’s start, studies suggest – Nature

Related:

[Preprint] SARS-like viruses may jump from animals to people hundreds of thousands of times a year.

Did the coronavirus jump from animals to people twice? – Nature

The Origins of SARS-CoV-2: A Critical Review.

The animal origin of SARS-CoV-2 – “Trading of animals susceptible to bat coronaviruses is the likely cause of the COVID-19 pandemic”.

Fauci says natural origins theory of coronavirus is still the most likely.

 

Commentary on Twitter

 

The management of diabetic ketoacidosis in adults—An updated guideline from the Joint British Diabetes Society for Inpatient Care.

1 Mar, 2022 | 09:00h | UTC

The management of diabetic ketoacidosis in adults—An updated guideline from the Joint British Diabetes Society for Inpatient Care

 

Guideline Update: Timing of elective surgery and risk assessment after SARS-CoV-2 infection – “The guidance remains that patients should avoid elective surgery within 7 weeks of infection, unless the benefits of doing so exceed the risk of waiting”.

1 Mar, 2022 | 08:58h | UTC

Timing of elective surgery and risk assessment after SARS-CoV-2 infection: an update – Anaesthesia

Related:

Perioperative cardiovascular considerations prior to elective noncardiac surgery in patients with a history of Covid-19.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

BJS commission on surgery and perioperative care post-COVID-19.

The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

 

Systematic review on inappropriate use of clinical practices in Canada identified 144 underused practices, 109 overused practices, and 25 practices that were both under- and overused.

1 Mar, 2022 | 08:52h | UTC

Inappropriate use of clinical practices in Canada: a systematic review – Canadian Medical Association Journal

Commentary: What problems in health care quality should we target as the world burns around us? – Canadian Medical Association Journal

News Release: Inappropriate use of 228 clinical practices in Canada – Canadian Medical Association Journal

 

[Preprint] Study shows significantly reduced effectiveness of the Pfizer vaccine in children 5 to 11 after the emergency of the Omicron variant.

1 Mar, 2022 | 08:54h | UTC

Effectiveness of the BNT162b2 vaccine among children 5-11 and 12-17 years in New York after the Emergence of the Omicron Variant – medRxiv

Commentaries:

Pfizer Covid vaccine is less effective in kids 5 to 11, study finds – STAT

Pfizer Covid-19 vaccine effectiveness fell quickly for kids during Omicron surge but still offered some protection against severe disease – CNN

More mask mandates fall as poor COVID vaccine protection noted in young kids – CIDRAP

 

RCT: Referral for early, supported exercise after breast cancer surgery improves shoulder function and health-related quality of life.

1 Mar, 2022 | 08:50h | UTC

Abstract: Exercise to prevent shoulder problems after breast cancer surgery: the PROSPER RCT – Health Technology Assessment

Full Report: Exercise to prevent shoulder problems after breast cancer surgery: the PROSPER RCT – Health Technology Assessment

Related: RCT: Prophylactic Use of Compression Sleeves Reduces the Incidence of Arm Swelling in Women at High Risk of Breast Cancer–Related Lymphedema.

 

New CDC interim guidance recommends a 4-month Rifapentine-Moxifloxacin regimen to treat drug-susceptible pulmonary tuberculosis.

27 Feb, 2022 | 22:49h | UTC

Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis — United States, 2022 – CDC Morbidity and Mortality Weekly Report

Related:

Summary | WHO recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

WHO Guideline: Screening for Tuberculosis Disease

New WHO Recommendations to Prevent Tuberculosis

CDC Guidelines for the Treatment of Latent Tuberculosis Infection

Guideline: Treatment of Drug-Resistant Tuberculosis

NICE Guideline: Tuberculosis

The Lancet Commission: Management of Multidrug-resistant and Incurable Tuberculosis

Regimens to Treat Multidrug-resistant Tuberculosis: Past, Present and Future Perspectives

Guidelines for the Management of TB in Adults Living with HIV

 

Commentary on Twitter

 

CDC issues long-awaited new guidance on when to wear masks.

27 Feb, 2022 | 22:45h | UTC

CDC issues long-awaited new guidance on when to wear masks – STAT

See also: As mask mandates fade, experts say use of masks likely will not – STAT

 

ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2.

27 Feb, 2022 | 22:47h | UTC

ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2 – Clinical Microbiology and Infection

 

Guideline: Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis.

27 Feb, 2022 | 22:40h | UTC

Plasma exchange and glucocorticoid dosing for patients with ANCA-associated vasculitis: a clinical practice guideline – The BMJ

See also: The effects of plasma exchange in patients with ANCA-associated vasculitis: an updated systematic review and meta-analysis – The BMJ

 

Commentary on Twitter

 

4 lessons from the life of global health visionary Paul Farmer.

27 Feb, 2022 | 22:42h | UTC

4 lessons from the life of global health visionary Paul Farmer – Vox

See also:

What I learned from Paul Farmer: Treat the systems around the patient, not just the disease – STAT

‘He showed us that the moral high ground can win’ – The Harvard Gazette

A Personal Tribute to Dr. Paul Farmer — Who Made Everyone Feel Important – HIV and ID Observations

Global health champion Dr. Paul Farmer has died – NPR

Health care advocate Paul Farmer was ‘a once-in-a-lifetime person,’ says Dr. Fauci – CBC

Opinion: How Paul Farmer helped save the lives of millions of people – The Washington Post

Dr. Sanjay Gupta: The man who inspired me to be more selfless – CNN

What I want people to know about Paul Farmer – wbur

 

Consensus Statement: Successfully implementing digital health to ensure future global health security during pandemics.

25 Feb, 2022 | 11:34h | UTC

Successfully Implementing Digital Health to Ensure Future Global Health Security During Pandemics: A Consensus Statement – JAMA Network Open

 

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