Critical Care & Emergencies (all articles)
Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury
20 Jan, 2021 | 01:25h | UTC
Meta-analysis: Inconclusive evidence regarding a benefit of systematic early mobilization in mechanically ventilated adult ICU patients
20 Jan, 2021 | 01:24h | UTC
Post-resuscitation shock: Recent advances in pathophysiology and treatment
20 Jan, 2021 | 01:18h | UTC
Meta-analysis: Corticosteroid use in COVID-19 patients
19 Jan, 2021 | 01:56h | UTCRelated meta-analysis: Corticosteroids for Patients With Coronavirus Disease 2019 (COVID-19) With Different Disease Severity: A Meta-Analysis of Randomized Clinical Trials – Journal of Cardiothoracic and Vascular Anesthesia
Evidence summary and clinical decision algorithm to guide clinicians in the care of the hypoxemic, non-intubated patients with suspected Covid-19
19 Jan, 2021 | 01:57h | UTC
After return of spontaneous circulation in patients with out-of-hospital cardiac arrest, too early ECG acquisition (7 minutes or less) is associated with false-positive findings for STEMI
19 Jan, 2021 | 01:44h | UTCCommentary: Delaying Electrocardiography in Cardiac Arrest: A Pause for the Cause – JAMA Network Open
RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19
17 Jan, 2021 | 22:26h | UTCCommentary: Covid: ‘Convalescent plasma no benefit to hospital patients’ – BBC
Randomized trial: In patients hospitalized with community-acquired pneumonia, adjunctive oral dexamethasone reduced the length of stay and ICU admissions, with no difference in mortality rates
17 Jan, 2021 | 21:58h | UTCAdjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: A randomised clinical trial – European Respiratory Journal (link to abstract – $ for full-text)
Meta-analysis: Safety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation
17 Jan, 2021 | 21:42h | UTCSafety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation: a systematic review and meta-analysis of randomized trials – CHEST (link to abstract – $ for full-text)
Meta-analysis: Effect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation
17 Jan, 2021 | 21:41h | UTCEffect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation: a systematic review and meta-analysis of randomized controlled trials – CHEST (link to abstract – $ for full-text)
Observational study: Among patients hospitalized with Covid-19 not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels is linked to lower risk of death than transfusion of plasma with lower antibody levels
15 Jan, 2021 | 08:59h | UTCEditorial: (A Little) Clarity on Convalescent Plasma for Covid-19 – New England Journal of Medicine
Commentaries: Expert reaction to study looking at convalescent plasma antibody levels and risk of death from COVID-19 – Science Media Centre AND Antibody-rich convalescent plasma may lower risk of COVID death – CIDRAP
Opinion: RCTs don’t justify using convalescent plasma or antibody cocktails
15 Jan, 2021 | 08:58h | UTCRCTs don’t justify using convalescent plasma or antibody cocktails – PulmCrit
Perspective: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux?
15 Jan, 2021 | 08:51h | UTCRelated video: Ivermectin For COVID-19 | A Doctor Explains – ZDoggMD
NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19”
15 Jan, 2021 | 08:53h | UTC
Covid-19: When to start invasive ventilation is “the million dollar question”
15 Jan, 2021 | 08:48h | UTCCovid-19: When to start invasive ventilation is “the million dollar question” – The BMJ
Commentary on Twitter
Options for ventilating covid-19 patients have expanded since the first wave of the pandemic, but doctors are unsure of the best management pathway because evidence is lacking, reports @ingridtorjesenhttps://t.co/iKldASmahF
— The BMJ (@bmj_latest) January 14, 2021
Study: Pulmonary embolism detected in 6% of patients with COPD admitted to the hospital with acute worsening of respiratory symptoms
15 Jan, 2021 | 08:37h | UTCPrevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms – JAMA (link to abstract – $ for full-text)
Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem
15 Jan, 2021 | 08:24h | UTC
Commentary on Twitter
NEW ?? #CID @IDSAInfo
Risk of AKI & CDI with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin #IDTwitter @danlivorsi
TZP ⬆️ AKI risk, which was exacerbated by concurrent vancomycin.
FEP&MER ⬆️CDI risk relative to TZP. https://t.co/0pIurl7A7w pic.twitter.com/ZjjvN2rkWP— Antibiotic Steward? Bassam Ghanem (@ABsteward) December 31, 2020
Systematic review: Oral hygiene care with chlorhexidine mouthwash or gel in critically ill patients probably reduces the incidence of developing ventilator-associated pneumonia
15 Jan, 2021 | 08:09h | UTC
No ICU beds? Expect double the number of Covid-19 deaths
14 Jan, 2021 | 02:05h | UTCNo ICU beds? Expect double the number of Covid-19 deaths. – Vox
Guideline: Malignant hyperthermia 2020
14 Jan, 2021 | 01:45h | UTCMalignant hyperthermia 2020: Guideline from the Association of Anaesthetists – Anaesthesia
A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients
14 Jan, 2021 | 01:42h | UTC
Confirmed reinfection with SARS-CoV-2 variant VOC-202012/01
13 Jan, 2021 | 02:30h | UTCConfirmed Reinfection with SARS-CoV-2 Variant VOC-202012/01 – Clinical Infectious Diseases
Commentary on Twitter
A new case report of reinfection with SARS-CoV-2 with the second episode due to the ‘new variant’ VOC-202012/01 of lineage B.1.1.7. The initial infection was mild illness while the second infection caused severe and critical illness. @InfectiousDz #CID https://t.co/hhP3gUnQSZ
— Antibiotic Steward? Bassam Ghanem (@ABsteward) January 9, 2021
Six RCTs to answer one question: what is the role of tocilizumab in COVID-19?
13 Jan, 2021 | 02:28h | UTCSix RCTs to answer one question: what is the role of tocilizumab in COVID-19? – PulmCrit
Related (study and commentaries): Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
HEAR or HEART Pathway – Can We Drop Troponin?
13 Jan, 2021 | 01:59h | UTCHEAR or HEART Pathway – Can We Drop Troponin? – Journal Feed
Original Study: Identification of very low-risk acute chest pain patients without troponin testing – Emergency Medicine Journal
Observational study: Surgical decompression within 24 h of acute spinal cord injury is associated with improved sensorimotor recovery
13 Jan, 2021 | 01:49h | UTCThe influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter
.@TheLancetNeuro Surgical decompression within one day of acute #spinalcordinjury is linked with improved sensorimotor recovery. The first 24-36 hours following injury seem to represent a crucial time frame to reach optimal #neurological recovery. @UofT https://t.co/Fi53K2YKBk pic.twitter.com/RDESblOgoM
— Neurology Today (@NeurologyToday) December 28, 2020